Adipocyte methionine reduction promotes cancer cachexia.
🗓️ 2026-09-23
📰 Publication: Nature Cancer
Read MoreAdipocyte methionine reduction promotes cancer cachexia.neoplasms
An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.
Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning in both physiological...
🗓️ 2026-09-23
📰 Publication: Nature Cancer
Read MoreAn iron-regulated methionine redox axis governs adipose browning and cancer cachexia.Integrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics.
BACKGROUND
Sarcopenia is a common condition in patients with gastric cancer that is associated with poor survival and adverse clinical outcomes. Conventional diagnostic approaches are time-consuming, limiting large-scale clinical implementation. This study aimed to develop and validate a multimodal model that...
🗓️ 2026-09-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIntegrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics.Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.
UNLABELLED
Cancer cachexia is a devastating wasting syndrome with no approved therapies. In this study, we identify the tumor-derived glycoprotein ADAMTSL4 as a circulating factor associated with body weight loss in preclinical cachexia models and patients with colorectal and lung cancers....
🗓️ 2026-09-01
📰 Publication: Cancer Discovery
Read MoreTumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.Systemic Inflammatory Biomarkers and Cancer-Associated Cachexia: A Narrative Review.
Cancer-associated cachexia (CAC) is a multifactorial syndrome characterized by systemic inflammation, muscle wasting, and progressive functional decline, affecting up to 80% of patients with advanced cancer. The inconsistent diagnostic criteria limit comparability across studies and hinder translation into clinical practice....
🗓️ 2026-08-26
📰 Publication: Current Oncology
Read MoreSystemic Inflammatory Biomarkers and Cancer-Associated Cachexia: A Narrative Review.Antisense oligonucleotides against Il6ra ameliorate cancer cachexia in mice.
Mounting evidence indicates that interleukin-6 (IL-6) plays an essential role in the development of cancer cachexia. Particularly, recent work showed that IL-6 drives cancer cachexia through neurons in the area postrema of the brainstem. However, there are currently no approved...
🗓️ 2026-08-20
📰 Publication: Molecular Therapy
Read MoreAntisense oligonucleotides against Il6ra ameliorate cancer cachexia in mice.Circulating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia pre-clinical models.
Cancer cachexia, affecting up to 80% of patients with advanced cancer, is characterized by metabolic and inflammatory dysregulation driven by tumour- and host-derived factors. Although cytokines are central to cachexia pathogenesis, their circulating profiles and transcriptional relevance across models and...
🗓️ 2026-08-13
📰 Publication: Experimental Physiology
Read MoreCirculating granulocyte colony-stimulating factor as a sex-unbiased global marker of lung and colorectal cancer cachexia pre-clinical models.Correction to 'A Prospective Observational Study of Anamorelin During Chemoimmunotherapy in Non-Small Cell Lung Cancer With Cachexia (SPIRAL-ANA)'.
🗓️ 2026-08-05
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCorrection to 'A Prospective Observational Study of Anamorelin During Chemoimmunotherapy in Non-Small Cell Lung Cancer With Cachexia (SPIRAL-ANA)'.Preoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.
BACKGROUND & AIMS
Cancer cachexia is associated with systemic skeletal muscle loss and poor survival; however, early muscle changes preceding systemic muscle loss remain unclear. Therefore, this study aimed to determine whether tongue-complex muscle area (TCMA) can serve as an early...
🗓️ 2026-07-30
📰 Publication: Clinical Nutrition
Read MorePreoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.Prostaglandin E2 drives cancer-associated cachexia.
🗓️ 2026-07-29
📰 Publication: Nature Reviews Drug Discovery
Read MoreProstaglandin E2 drives cancer-associated cachexia.Lung Tumors Hack Nervous System to Drive Cachexia.
Researchers have found that some lung tumors in mice can cause cachexia by directly communicating with neurons to alter eating behavior. Further, researchers showed that efforts to reduce cachexia through feeding the mice a high-fat diet paradoxically worsened the problem.
🗓️ 2026-07-29
📰 Publication: Cancer Discovery
Read MoreLung Tumors Hack Nervous System to Drive Cachexia.Therapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice.
Cancer cachexia is a life-threatening wasting syndrome that can be driven by tumor-derived GDF15 signaling through the brainstem-restricted receptor GFRAL. Despite its clinical importance, central genetic interventions targeting this axis remain limited. Here, we develop a potent antisense oligonucleotide (Gfral-ASO,...
🗓️ 2026-07-28
📰 Publication: Cell Reports Medicine
Read MoreTherapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice.Pre-clinical cancer cachexia causes glucose hypermetabolism prior to overt weight loss.
PURPOSE
Cancer cachexia is a life-threatening complication of advanced malignancies, driven by profound systemic metabolic reprogramming and anorexia. Insulin action is markedly impaired in patients with cancer and may contribute directly to cachexia pathogenesis. However, the interplay between weight loss, food...
🗓️ 2026-07-18
📰 Publication: Molecular Metabolism
Read MorePre-clinical cancer cachexia causes glucose hypermetabolism prior to overt weight loss.Radiation induced oral mucositis coincides with upregulation of growth differentiation factor 15 (GDF15) in rats.
🗓️ 2026-07-17
📰 Publication: Cancer Letters
Read MoreRadiation induced oral mucositis coincides with upregulation of growth differentiation factor 15 (GDF15) in rats.Sex-divergent skeletal muscle remodeling emerges early in cancer cachexia.
Cancer cachexia is characterised by progressive skeletal muscle wasting and dysfunction, yet the early events that precede overt muscle wasting remain poorly defined. Here, we utilised a time-coursed C26 carcinoma model in male and female mice to define the pre-cachectic...
🗓️ 2026-07-17
📰 Publication: American Journal Of Physiology-Cell Physiology
Read MoreSex-divergent skeletal muscle remodeling emerges early in cancer cachexia.Reframing cancer cachexia: from malnutrition to treatable disease.
🗓️ 2026-07-15
📰 Publication: Nature Reviews Endocrinology
Read MoreReframing cancer cachexia: from malnutrition to treatable disease.