Sarcopenia

Myostatin, activin-A and follistatin are produced by the tumor in head and neck cancer and likely contribute to sarcopenia: a case-control, cross-sectional exploratory study.

BACKGROUND AND AIMS

Myostatin (M), activin-A (A) and follistatin (F), three TGF-β superfamily members, play a role in cancer sarcopenia. The aim of our study was to assess the association of MAF in head and neck cancer (HNC) skeletal muscle loss.

MATERIALS...

🗓️ 2025-12-04
Read MoreMyostatin, activin-A and follistatin are produced by the tumor in head and neck cancer and likely contribute to sarcopenia: a case-control, cross-sectional exploratory study.

Mechanosensitive Piezo1 Channels Mediate Diaphragm Fibrosis Induced by Prolonged Mechanical Ventilation.

BACKGROUND

Ventilator-induced diaphragmatic dysfunction (VIDD) is a major complication in critically ill patients. Prolonged mechanical ventilation (MV) triggers diaphragmatic fibrotic remodelling, but the underlying mechanisms remain unclear. This study investigated the role of the mechanosensitive channel Piezo1 in this process.

METHODS

A rat...

🗓️ 2025-12-03
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMechanosensitive Piezo1 Channels Mediate Diaphragm Fibrosis Induced by Prolonged Mechanical Ventilation.

Umbilical cord mesenchymal stromal cells in sarcopenia: benefits and strategies for enhancing efficacy.

Sarcopenia is a progressive age-related condition characterized by the decline of skeletal muscle mass and function. Its development involves multiple cellular and molecular mechanisms, including chronic inflammation, apoptosis, mitochondrial dysfunction, and impaired muscle regeneration. Human umbilical cord mesenchymal stromal cells...

🗓️ 2025-12-03
Read MoreUmbilical cord mesenchymal stromal cells in sarcopenia: benefits and strategies for enhancing efficacy.

Evaluation of Weight Gain and Overall Survival of Men Versus Women With Advanced Non-Small Cell Lung Cancer.

BACKGROUND

Weight stabilization or gain during cancer treatment is associated with increased survival. Analyses of weight gain by sex during cancer treatment and the effects of weight on survival have not been fully studied. This post hoc analysis retrospectively examined the...

🗓️ 2025-12-03
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEvaluation of Weight Gain and Overall Survival of Men Versus Women With Advanced Non-Small Cell Lung Cancer.

Postmenopausal Sarcopenia and Alzheimer's disease: The interplay of Mitochondria, Insulin resistance, and Myokines.

As life expectancy increases, cognitive impairments such as Alzheimer's disease (AD) create serious problems for older adults. Women regardless of ethnicity and age group, are disproportionately affected, accounting for two-thirds of AD cases, with post-menopausal women representing over 60% of...

🗓️ 2025-12-02
📰 Publication: Neuroscience And Biobehavioral Reviews
Read MorePostmenopausal Sarcopenia and Alzheimer's disease: The interplay of Mitochondria, Insulin resistance, and Myokines.

A Simplified Frailty Measure Improves Risk Stratification in Patients Undergoing Percutaneous Mitral Valve Repair.

OBJECTIVE

The aim of this study was to examine frailty measures for risk prediction in patients undergoing percutaneous mitral valve repair (PMVR).

BACKGROUND

Performance of current risk prediction models based on organ morbidity is only moderate.

METHODS

The frailty domains exhaustion, slowness, inactivity, weakness, and...

🗓️ 2025-12-02
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreA Simplified Frailty Measure Improves Risk Stratification in Patients Undergoing Percutaneous Mitral Valve Repair.

Negative Impact of p21-Activated Kinase 4-Mediated AMP-Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans.

We recently identified that AMP-activated protein kinase (AMPK) α2 phosphorylation at S491 is mediated by p21-activated kinase 4 (PAK4), leading to muscular and systemic insulin resistance. This study examined how muscle PAK4 deletion affects atrophy in male mice and its...

🗓️ 2025-12-02
Read MoreNegative Impact of p21-Activated Kinase 4-Mediated AMP-Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans.

Peak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.

BACKGROUND

Current evidence indicates an association between peak expiratory flow (PEF) and frailty in older adults, yet critical gaps persist regarding: the longitudinal dynamics of PEF trajectories, their temporal relationships with frailty progression and underlying biological mechanisms. This study aimed to...

🗓️ 2025-11-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePeak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.

Statin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score.

BACKGROUND

Statins are cholesterol-lowering drugs widely prescribed for preventing cardiovascular diseases. They may cause adverse effects on skeletal muscle, but it remains unclear whether they affect muscle function and mass. We aimed to evaluate the association between statin use and muscle...

🗓️ 2025-11-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreStatin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score.

The Monocrotaline Model of Hypertension Leads to Cachexia in Male but Not Female Mice.

BACKGROUND

The monocrotaline (MCT) model of cardiac cachexia is a pharmaceutical approach to pulmonary hypertension that has been used to study heart failure and muscle wasting in rodents; however, little is known of how this pyrrolizidine alkaloid leads to peripheral changes...

🗓️ 2025-11-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Monocrotaline Model of Hypertension Leads to Cachexia in Male but Not Female Mice.

Mitochondrial stress bridge: Could muscle-derived extracellular vesicles be the missing link between sarcopenia, insulin resistance, and chemotherapy-induced cardiotoxicity?

Sarcopenia is currently considered a systemic condition that goes beyond muscle atrophy to include multifunctional metabolic and cardiovascular dysfunction. The mediators between skeletal muscle loss and entire body insulin resistance and increased vulnerability to cardiotoxicity caused by chemotherapy are not...

🗓️ 2025-11-21
📰 Publication: Biomedicine & Pharmacotherapy
Read MoreMitochondrial stress bridge: Could muscle-derived extracellular vesicles be the missing link between sarcopenia, insulin resistance, and chemotherapy-induced cardiotoxicity?

Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

AIM

To investigate effects of host- and gut microbiota (GM)-altering interventions on sarcopenia (parameters).

METHODS

Upon PROSPERO registration (CRD42022347363), six databases and one registry were searched until January 5th 2024 and updated on June 10th 2025 for diet, pre-, pro-, or synbiotics mono-interventions...

🗓️ 2025-11-21
📰 Publication: Aging Clinical And Experimental Research
Read MoreEffect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

Utilizing accelerated and delayed murine models of aging to address the "healthspan issue" – A review of skeletal muscle health.

The gap between lifespan and healthspan is increasing globally, resulting in millions of individuals spending additional years burdened by frailty or disease. This disparity, paired with the increasingly aged populations of Western nations, poses a palpable predicament to public health...

🗓️ 2025-11-20
📰 Publication: Ageing Research Reviews
Read MoreUtilizing accelerated and delayed murine models of aging to address the "healthspan issue" – A review of skeletal muscle health.

Air Pollution Exposure and Muscle Mass and Strength Decline in Older Adults: Results From a Swedish Population-Based Study.

BACKGROUND

Emerging evidence suggests that air quality may impact muscle health. However, most studies are limited by cross-sectional designs or short follow-ups. We assessed the association of long-term exposure to ambient air pollutants with changes in muscle mass and strength in...

🗓️ 2025-11-20
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAir Pollution Exposure and Muscle Mass and Strength Decline in Older Adults: Results From a Swedish Population-Based Study.

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