therapeutics

Muscle

Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress.

Cancer-associated cachexia (CAC) is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss, which accounts for one-third of cancer-related deaths. No effective therapeutic approach that could fully reverse CAC is available. NF-κB signaling and oxidative stress play...

🗓️ 2024-04-08

📰 Publication: Genes & Diseases

cachexia / Cancer-associated_cachexia / muscles / Muscular_atrophy / neoplasms / Oxidative_stress / Safety / Stress,_physiological / therapeutics

Muscle

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions.

Sarcopenia is defined as a muscle-wasting syndrome that occurs with accelerated aging, while cachexia is a severe wasting syndrome associated with conditions such as cancer and immunodeficiency disorders, which cannot be fully addressed through conventional nutritional supplementation. Sarcopenia can be...

🗓️ 2025-01-05

cachexia / Genes / muscles / Sarcopenia / therapeutics / Wasting_syndrome

Muscle

Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways.

Sarcopenia, the age-related decline in muscle mass and function, is a significant contributor to increased frailty and mortality in the elderly. Currently, no FDA-approved treatment exists for sarcopenia. Here, we identified norharmane (NR), a β-carboline alkaloid, as a potential therapeutic...

🗓️ 2025-01-27

📰 Publication: Redox Biology

Aged / Aging / CELLS / Cellular_senescence / Genes / muscles / Myoblasts / Sarcopenia / Stress,_physiological / therapeutics

Cachexia

Metabolic interplays between the tumour and the host shape the tumour macroenvironment.

Metabolic reprogramming of cancer cells and the tumour microenvironment are pivotal characteristics of cancers, and studying these processes offer insights and avenues for cancer diagnostics and therapeutics. Recent advancements have underscored the impact of host systemic features, termed macroenvironment, on...

🗓️ 2025-01-20

📰 Publication: Nature Reviews Cancer

neoplasms / therapeutics

Muscle

Body composition alterations in patients with lung cancer.

Most patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because most studies have been cross-sectional, comparing patients with non-cancer controls or...

🗓️ 2025-01-31

📰 Publication: American Journal Of Physiology-Cell Physiology

Adipose_tissue / Adiposity / Body_composition / cachexia / Lung / Lung_neoplasms / Muscle,_skeletal / muscles / neoplasms / Sex / therapeutics / tissues

Muscle

Targeting Drug Delivery System to Skeletal Muscles: A Comprehensive Review of Different Approaches.

The skeletal muscle is one of the largest organs in the body and is responsible for the mechanical activity required for posture, movement and breathing. The effects of current pharmaceutical therapies for skeletal muscle diseases are far from satisfactory; approximately...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Drug_delivery_systems / Ligands / Muscle,_skeletal / muscles / Pharmaceutical_preparations / Sarcopenia / Small_molecules / therapeutics

Muscle

Multiomics Analysis Reveals Therapeutic Targets for Chronic Kidney Disease With Sarcopenia.

The presence of sarcopenia in patients with chronic kidney disease (CKD) is associated with poor prognosis. The mechanism underlying CKD-induced muscle wasting has not yet been fully explored. This study investigates the influence of renal secretions on muscles using multiomics...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Genes / Kidney / Kidney_diseases / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Muscular_atrophy / Recombinant_proteins / Sarcopenia / SERUM / therapeutics / Transcriptome

Muscle

Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.

Sarcopenia is a geriatric disorder characterized by a gradual loss of muscle mass and function. Despite its prevalence, the underlying mechanisms remain unclear, and there are currently no approved treatments. In this study, we conducted a comprehensive analysis of the...

🗓️ 2025-02-05

Aging / Amino_acids / Amino_acids,_branched-chain / Multiple_chronic_conditions / Muscle,_skeletal / muscles / Sarcopenia / therapeutics

Exercise

Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy.

Spinal muscular atrophy (SMA) is a health- and life-limiting neuromuscular disorder. Although varying degrees of mitochondrial abnormalities have been documented in SMA skeletal muscle, the influence of disease progression on pathways that govern organelle turnover and dynamics are poorly understood....

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagosomes / Autophagy / Disease_progression / Mitochondria / Mitochondria,_muscle / Mitochondrial_turnover / Mitophagy / Muscle,_skeletal / muscles / Muscular_atrophy / Muscular_atrophy,_spinal / Organelle_biogenesis / Organelles / Sarcopenia / Spine / therapeutics

Muscle

Low Skeletal Muscle Radiodensity Predicts Response to CDK4/6 Inhibitors Plus Aromatase Inhibitors in Advanced Breast Cancer.

Recent evidence indicates that a dysregulated host metabolism influences treatment outcomes in patients with breast cancer. We investigated the association of computed tomography (CT)-derived body composition indices with therapeutic responses in patients with hormone receptor-positive, HER2-negative advanced breast cancer (ABC)...

🗓️ 2024-12-17

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aromatase / Aromatase_inhibitors / Body_composition / Breast / Breast_neoplasms / cachexia / Menopause / Muscle,_skeletal / muscles / Neoplasm_metastasis / Sarcopenia / therapeutics

Cachexia

Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of ≥50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy.

This retrospective, multicenter cohort study aimed to determine whether cancer cachexia serves as a biomarker for determining the most effective treatment for patients having non-small-cell lung cancer (NSCLC) with high programmed death ligand 1 (PD-L1) expression treated with immune checkpoint...

🗓️ 2024-12-16

Cancer-associated_cachexia / Carcinoma,_non-small-cell_lung / CELLS / chemotherapy / Drug_therapy / Immune_checkpoint_inhibitors / Lung / Lung_neoplasms / neoplasms / Small_cell_lung_carcinoma / therapeutics / Treatment_outcome / Weight_loss

Muscle

Lonafarnib Protects Against Muscle Atrophy Induced by Dexamethasone.

Muscle atrophy, including glucocorticoid-induced muscle wasting from treatments such as dexamethasone (DEX), results in significant reductions in muscle mass, strength and function. This study investigates the potential of lonafarnib, a farnesyltransferase inhibitor, to counteract DEX-induced muscle atrophy by targeting key...

🗓️ 2024-12-17

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Dexamethasone / Hand_strength / Muscle_fibers,_skeletal / muscles / Muscular_atrophy / Sarcopenia / therapeutics

Muscle

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Sarcopenia is currently a life-threatening disease for the elderly. Polygonatum sibiricum polysaccharide (PSP) has anti-oxidative stress and anti-inflammatory effects. However, the effects of PSP on skeletal muscle aging, myoblast differentiation and mitochondrial dysfunction through PI3K/Akt/mTOR signaling pathway has not been...

🗓️ 2024-12-09

📰 Publication: Phytomedicine

Aging / CELLS / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Myoblasts / Oxidative_stress / Pharmacology / Polysaccharides / Sarcopenia / Stress,_physiological / therapeutics

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / Adenoma,_pleomorphic / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipocytes,_brown / Adipocytes,_white / Adipogenesis / Adiponectin / Adipose_tissue / Adiposity / Administration,_intranasal / Administration,_oral / Adolescent / Adrenal_cortex_hormones / Adrenocorticotropic_hormone / Adult_stem_cells / Advance_care_planning / Adverse_childhood_experiences / Advertising / Aeromonas_veronii / Aerosols / Aflatoxin_m1 / Aflatoxins / African_swine_fever / Aftercare / Agar / Agaricales / Age_distribution / Aged / Agent_orange / Aggregatibacter / Aggregatibacter_aphrophilus / Aggression / Aging,_premature / Agranulocytosis / Agricultural_irrigation / Agriculture / Agrochemicals / Aids-related_complex / Air_pollution / Alanine / Alcohol_drinking / Alcoholics / Aldehydes / Aldosterone / Alendronate / Alginates / Algorithms / Alkaline_phosphatase / Alkalosis / Alkanesulfonates / Alkynes / Alleles / Allergens / Allografts / Allopurinol / Alloys / Alopecia / Alopecia_areata / Alpha_1-antitrypsin / Alpha_1-antitrypsin_deficiency / Alpha-glucosidases / Alpha-linolenic_acid / Alpha-synuclein / Alphapapillomavirus / Altitude / Alzheimer_disease / Amanita / Ambulances / Ambulatory_care / Ambulatory_care_facilities / Amikacin / Amine_oxidase_(copper-containing) / Amines / Amino_acid_sequence / Amino_acid_substitution / Amino_acids / Amino_acids,_branched-chain / Amino_acids,_sulfur / Amino_alcohols / Aminolevulinic_acid / Amlodipine / Amoxicillin / Amphetamines / Amphotericin_b / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyloidosis / Amylopectin / Amyotrophic_lateral_sclerosis / Analgesia / Analgesics / Analysis_of_variance / Anaphylaxis / Anastomotic_leak / Anemia / Anemia,_aplastic / Anemia,_iron-deficiency / Anemia,_sickle_cell / Anesthesia / Anesthesia,_conduction / Anesthesia,_epidural / Anesthesia,_intravenous / Anesthesia,_local / Anesthesia,_obstetrical / Anesthesiologists / Anesthesiology / Anesthetics / 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Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_aneurysm,_thoracic / Aortic_aneurysm,_thoracoabdominal / Aortic_diseases / Aortic_dissection / Aortic_rupture / Aortic_valve / Aortic_valve_disease / Apathy / Apelin / Aphasia / Apigenin / Apolipoproteins / Apoprotein(a) / Apoptosis / Appendectomy / Appendicitis / Appendix / Appetite / Aquaculture / Aquatic_organisms / Arachnoiditis / Archaea / Archives / Area_under_curve / Arginine / Argon_plasma_coagulation / Aristolochic_acids / Arrestin / Arrhythmias,_cardiac / Arterial_occlusive_diseases / Arterioles / Arteriovenous_fistula / Arteriovenous_malformations / Arterivirus / Arthritis,_psoriatic / Arthritis,_reactive / Arthritis,_rheumatoid / Arthrodermataceae / Arthroplasty,_replacement,_knee / Arthroscopy / Artificial_intelligence / Artificial_limbs / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillus / Aspergillus_niger / Aspirin / Asthma / Astigmatism / Astringents / Astrocytes / Astrocytoma / Ataxia / Atenolol / Atherosclerosis / Athletes / Athletic_performance / Atmosphere / Atorvastatin / Atrial_appendage / Atrial_fibrillation / Atrial_flutter / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Audiometry / Audiovisual_aids / Augmented_reality / Autism_spectrum_disorder / Autistic_disorder / Autoantigens / Autoimmune_diseases / Autoimmunity / Automation / Autophagosomes / Autophagy / Autopsy / Axenic_culture / Axial_spondyloarthritis / Axillary_vein / Axons / Azacitidine / Azathioprine / Azoospermia / Azospirillum / Azospirillum_brasilense / B-lymphocytes / Bacillus / Bacillus_amyloliquefaciens / Bacillus_subtilis / Back_pain / Bacterial_adhesion / Bacterial_infections / Bacterial_load / Bacteriocins / Bacteriophages / Bacteroides / Bacteroides_fragilis / Badnavirus / Bariatric_surgery / Bartonella / Bartonella_quintana / Basal_ganglia / Basal_nucleus_of_meynert / Basement_membrane / Basidiomycota / Basolateral_nuclear_complex / Beauty / Beckwith-wiedemann_syndrome / Beds / Begomovirus / Behavior_therapy / Behavior,_animal / Behavioral_symptoms / Benchmarking / Benserazide / Benzene / Benzocaine / Benzodiazepines / Benzyl_alcohol / Berberine / Beta-lactams / Betaine / Betaine-homocysteine_s-methyltransferase / Bevacizumab / Beverages / Bezafibrate / Bezoars / Bias / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bifidobacterium / Bifidobacterium_longum / Bile / Bile_ducts / Biliary_tract / Bilirubin / Binge-eating_disorder / Biocompatible_materials / Biodegradable_plastics / Biodegradation,_environmental / Biodiversity / Biofeedback,_psychology / Biofilms / Biological_assay / Biological_availability / Biological_science_disciplines / Biological_therapy / Biomarkers / Biomarkers,_tumor / Biomass / Biomedical_research / Biometry / Biomimetics / Bioprinting / Biosimilar_pharmaceuticals / Biosurveillance / Biotransformation / Bipolar_disorder / Birth_certificates / Birth_order / Birth_weight / Bleomycin / Blindness / BLOOD / Blood_cell_count / Blood_cells / Blood_circulation / Blood_coagulation_factors / Blood_component_removal / Blood_culture / Blood_donors / Blood_glucose / Blood_platelets / Blood_pressure / Blood_pressure_monitoring,_ambulatory / Blood_substitutes / Blood_transfusion,_intrauterine / Blood_urea_nitrogen / Blood_vessels / Blood_volume / Blotting,_western / Body_composition / Body_contouring / Body_image / Body_mass_index / Body_size / Body_weight / Bone_cements / Bone_cysts / Bone_diseases / Bone_marrow / Bone_neoplasms / Bone_regeneration / Bone_transplantation / Bony_callus / Borates / Botany / Botulinum_toxins / Botulinum_toxins,_type_a / Botulism / Bowen's_disease / Bradycardia / Bradykinin / Brain / Brain_diseases / Brain_injuries / Brain_injuries,_traumatic / Brain_ischemia / Brain_stem / Brain_stem_infarctions / Bread / Breast / Breast_cancer_lymphedema / Breast_feeding / Breast_neoplasms / Bronchiectasis / Bronchiolitis_obliterans_syndrome / Bronchitis / Bronchogenic_cyst / Bronchopulmonary_sequestration / Bronchoscopy / Brucella / Brucellosis / Brugada_syndrome / Budesonide / Buffers / Bulimia / Bundle-branch_block / Bupropion / Burning_mouth_syndrome / Burnout,_psychological / Burns / Butter / Butyrylcholinesterase / C-peptide / C-reactive_protein / Ca-19-9_antigen / cachexia / Caco-2_cells / Cadherins / Caffeine / Calcitonin_gene-related_peptide / Calcium / Calcium_channel_blockers / Calcium_channels / Calcium_signaling / Cancer_vaccines / Cancer-associated_cachexia / Cancer-associated_fibroblasts / Candidemia / Candidiasis / Candidiasis,_invasive / Candidiasis,_vulvovaginal / Cannabidiol / Cannula / Capacity_building / Capillaries / Capsaicin / Capsid / Capsules / Car-t_cell / Carbamazepine / Carbapenems / Carbidopa / Carbohydrates / Carboxylic_acids / Carcinogenesis / Carcinogens / Carcinoid_tumor / Carcinoma_in_situ / Carcinoma,_basal_cell / Carcinoma,_hepatocellular / Carcinoma,_intraductal,_noninfiltrating / Carcinoma,_non-small-cell_lung / Carcinoma,_ovarian_epithelial / Carcinoma,_renal_cell / Carcinoma,_squamous_cell / Cardiac_catheters / Cardiac_output / Cardiac_rehabilitation / Cardiac_resynchronization_therapy / Cardiac_volume / Cardiology / Cardiomyopathy,_restrictive / Cardiopulmonary_bypass / Cardiopulmonary_resuscitation / Cardiotoxicity / Cardiovascular_diseases / Cardiovascular_system / Caregivers / Carotenoids / Carotid_arteries / Carotid_artery,_internal / Carrier_proteins / Case-control_studies / Caseins / Caspase_3 / Caspase_9 / Caspases / Castleman_disease / Castration / Catalase / Cataract / Catastrophization / Catechin / Catechol_o-methyltransferase / Catecholamines / Catenins / Catheter_ablation / Catheterization / Causality / Caveolins / Cecum / Cefazolin / Cefoperazone / Cefotaxime / Ceftazidime / Ceftriaxone / Celiac_disease / Cell_aggregation / Cell_biology / Cell_body / Cell_communication / Cell_count / Cell_culture_techniques / Cell_cycle / Cell_death / 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Chemokine_cx3cl1 / Chemokine_cxcl12 / Chemokines / Chemokines,_cxc / Chemoprevention / Chemoradiotherapy / Chemotherapy,_adjuvant / Chest_pain / Chick_embryo / Chickenpox / Chikungunya_virus / Child_abuse,_sexual / Child_custody / Child_development / Child_health / Child_health_services / Child,_hospitalized / Child,_preschool / Chimera / Chimerism / Chitin / Chitosan / Chlamydia / Chloramphenicol / Chlorogenic_acid / Chlorophyll / Chlorophyll_a / Chloroplasts / Chlortetracycline / Cholangiocarcinoma / Cholangiography / Cholangitis / Cholecalciferol / Cholecystectomy / Cholecystitis / Cholecystitis,_acute / Choledocholithiasis / Cholera / Cholestasis / Cholestasis,_intrahepatic / Cholesterol / Cholesterol_esters / Cholesterol,_hdl / Cholesterol,_ldl / Cholinergic_agents / Chondrocytes / Chondrogenesis / Chondroitin / Chondroitin_sulfates / Chordoma / Chorea / Chorioamnionitis / Chromatin / Chromatin_immunoprecipitation / Chromogranin_a / Chromogranins / Chromosome_aberrations / Chronic_disease / Chronic_pain / Chylothorax / Chylous_ascites / Cicatrix / Cilia / Ciprofloxacin / Circadian_clocks / Circovirus / Circulating_microrna / Circulating_tumor_dna / Citalopram / Citizen_science / Citric_acid / Citrinin / Citrobacter / Citrobacter_rodentium / Citrulline / Cladribine / Classical_swine_fever / Clathrin / Clay / Climacteric / Climate / Clinical_alarms / Clinical_decision-making / Clinical_laboratory_techniques / Clitoris / Clobazam / Clone_cells / Clonidine / Clostridioides / Clostridioides_difficile / Clostridium / Cloud_computing / Clozapine / Cluster_analysis / Clustered_regularly_interspaced_short_palindromic_repeats / Clutch_size / Coagulase / Coal / Coal_industry / Coccidioidomycosis / Cochlear_implants / Cochlear_nucleus / Coconut_oil / Codon / Coffee / Cognition_disorders / Cognitive_behavioral_therapy / Cognitive_dissonance / Cognitive_dysfunction / Cognitive_restructuring / Cognitive_training / Cohort_studies / Coinfection / Colchicine / Cold_temperature / Colectomy / Colic / Colistin / Colitis / Colitis,_ulcerative / Collagen / Collagen_type_i / Collagen_type_ii / Collagenases / Collectins / Colletotrichum / Collodion / COLON / Colon,_ascending / Colon,_sigmoid / Colon,_transverse / Colonic_neoplasms / Colonoscopy / Colony-stimulating_factors / Colorectal_neoplasms / Colorectal_surgery / Colostomy / Colposcopy / Coma,_post-head_injury / Commerce / Common_variable_immunodeficiency / Communicable_diseases / Communicable_diseases,_emerging / Communication / Community_health_workers / Community_participation / Comorbidity / Compartment_syndromes / Complement_activation / Complement_c1_inhibitor_protein / Complement_c1q / Complement_c3a / Complement_inactivating_agents / Complement_system_proteins / Complementary_therapies / Complex_regional_pain_syndromes / Composite_resins / Composting / Computational_chemistry / Computed_tomography_angiography / Computers / Conditioning,_psychological / Confidence_intervals / Confined_spaces / Conflict_of_interest / Conflict,_psychological / Congo_red / Connective_tissue / Consciousness / Consent_forms / Conservative_treatment / Constipation / Contact_lenses / Continuous_glucose_monitoring / Contraceptive_agents / Contracture / Contraindications / Contusions / Conversion_disorder / Conversion_to_open_surgery / Cooperative_behavior / Coral_reefs / Cornea / Coronary_artery_bypass / Coronary_artery_disease / Coronary_disease / Coronary_sinus / Coronavirus_infections / Cost_of_illness / Cost_savings / Coumarins / Covid-19 / Covid-19_testing / Cranial_nerves / Craniopharyngioma / Craniotomy / Craving / Creatine / Creativity / Creutzfeldt-jakob_syndrome / Criminal_law / Critical_care / Critical_illness / Critical_period,_psychological / Crohn_disease / Cronobacter / Cronobacter_sakazakii / Crop_production / Cross_infection / Cross-over_studies / Cross-sectional_studies / Crowdsourcing / Crowns / Cryogels / Cryoglobulinemia / Cryoglobulins / Cryopreservation / Cryosurgery / Cryotherapy / Cryptochromes / Cryptorchidism / Cubital_tunnel_syndrome / Culture_media,_conditioned / Curcumin / Curriculum / Cushing_syndrome / Cyanobacteria / Cycloaddition_reaction / Cyclodextrins / Cyclophosphamide / Cyclosporine / Cystadenocarcinoma / Cystadenocarcinoma,_serous / Cystatins / Cysteine / Cysteine_proteases / Cystine / Cysts / Cytochrome_p-450_enzyme_system / Cytochromes / Cytogenetics / Cytokinins / Cytology / Cytoplasm / Cytoskeleton / Dairy_products / Data_analysis / Data_collection / Data_management / Data_mining / Data_science / Data_warehousing / Databases,_protein / Deafness / Death,_sudden,_cardiac / Debridement / Decision_making / Decision_making,_shared / Decision_support_systems,_clinical / Decompression / Decontamination / Deep_brain_stimulation / Deep_learning / Default_mode_network / Defibrillators / Defibrillators,_implantable / Deglutition / Deglutition_disorders / Dehydration / Delayed_diagnosis / Delirium / Dementia / Demography / Dendrites / Dendritic_cells / Dengue / Dengue_virus / Denosumab / Dental_cements / Dental_debonding / Dental_enamel / Dental_implants / Dental_materials / Dental_prosthesis / Dental_pulp_capping / Dental_pulp_necrosis / Dentate_gyrus / Dentin / Dentistry / Dentists / Dentition / Dentition,_mixed / Dentures / Deoxyuridine / Dependency,_psychological / Depression / Depression,_postpartum / Depressive_disorder / Depressive_disorder,_major / Dermatitis / Dermatitis,_atopic / Dermatology / Dermis / Detergents / Developing_countries / Developmental_biology / Developmental_disabilities / Dexmedetomidine / Dextrocardia / Diabetes_mellitus / Diabetes_mellitus,_type_1 / Diabetes_mellitus,_type_2 / Diabetes,_gestational / Diabetic_cardiomyopathies / Diabetic_foot / Diabetic_nephropathies / Diabetic_neuropathies / Diabetic_retinopathy / Diagnosis-related_groups / Diagnostic_imaging / Diamines / Diapause / Diaphragm / Diarrhea / Diazomethane / Diestrus / Diet / Diet_records / Diet,_gluten-free / 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Exercise

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / 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Lysophosphatidylcholines / Lysosomes / Machine_learning / Macrophages / Macrophages,_alveolar / Magnetic_resonance_imaging / Maintenance / Malnutrition / Mammaplasty / Mannans / Mannitol / Mannose-binding_lectin / Mannosyltransferases / Margins_of_excision / Marijuana_use / Marketing / Masculinity / Masks / Mast_cells / Mastitis / Mastitis,_bovine / Mastoiditis / Maternal_mortality / Mathematics / Meals / Meat / Mechanistic_target_of_rapamycin_complex_1 / Medial_tibial_stress_syndrome / Mediation_analysis / Medical_laboratory_science / Medical_marijuana / Medical_oncology / Medical_records / Medical_staff / Medical_waste / Medicare / Medication_adherence / Medication_errors / Medicine,_chinese_traditional / Medicine,_traditional / Meditation / Medulloblastoma / Melanins / Melanoma / Meloxicam / Membrane_proteins / Membranes / Memory / Menarche / Mendelian_randomization_analysis / Meninges / Meningioma / Meningitis / Menstruation / Mental_disorders / Mental_health / 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Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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Sarcopenia

Feature Engineering for the Prediction of Scoliosis in 5q-Spinal Muscular Atrophy.

5q-Spinal muscular atrophy (SMA) is now one of the 5% treatable rare diseases worldwide. As disease-modifying therapies alter disease progression and patient phenotypes, paediatricians and consulting disciplines face new unknowns in their treatment decisions. Conclusions made from historical patient data...

🗓️ 2024-12-05

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Contracture / Disease_progression / Machine_learning / Muscular_atrophy / Muscular_atrophy,_spinal / Physicians / Rare_diseases / Scoliosis / Spine / therapeutics / Ventilation / Walk_test

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The Journal of Cachexia, Sarcopenia & Muscle ⟶

therapeutics

Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress.

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions.

Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways.

Metabolic interplays between the tumour and the host shape the tumour macroenvironment.

Body composition alterations in patients with lung cancer.

Targeting Drug Delivery System to Skeletal Muscles: A Comprehensive Review of Different Approaches.

Multiomics Analysis Reveals Therapeutic Targets for Chronic Kidney Disease With Sarcopenia.

Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.

Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy.

Low Skeletal Muscle Radiodensity Predicts Response to CDK4/6 Inhibitors Plus Aromatase Inhibitors in Advanced Breast Cancer.

Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of ≥50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy.

Lonafarnib Protects Against Muscle Atrophy Induced by Dexamethasone.

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Feature Engineering for the Prediction of Scoliosis in 5q-Spinal Muscular Atrophy.

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