From Molecular Insights to Clinical Strategies: Delve into the complexities of cachexia, encompassing cancer cachexia, molecular mechanisms, and evolving therapeutic approaches. Discover the forefront of research aimed at understanding and combating this debilitating condition.
Previous studies reveal inconsistent associations between serum lipid traits and the risks of fractures and osteoporosis in the general population. This prospective cohort study analysed data from 414โ302 UK Biobank participants (223โ060 women and 191โ242 men, aged 37-73โyears) with serum...
๐๏ธ 2024-10-29
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cancer cachexia complicates advanced non-small cell lung cancer (NSCLC); however, it remains unclear how often cachexia occurs and how it affects the course of chemotherapy in patients receiving first-line systemic therapy. We conducted a multicentre, prospective observational study and enrolled...
๐๏ธ 2024-10-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Chronic kidney disease is common, affecting up to 13 % of the global population, and is predicted to become the fifth leading cause of 'life years lost' by 2040. Individuals with end-stage kidney disease commonly develop complications such as protein-energy...
Nuclear receptor interaction protein (NRIP) is versatile and engages with various proteins to execute its diverse biological function. NRIP deficiency was reported to cause small myofibre size in adult muscle regeneration, indicating a crucial role of NRIP in myoblast fusion....
๐๏ธ 2024-09-25
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
In 2023, the concept of metabolic dysfunction-associated steatotic liver disease (MASLD) was introduced as an alternative to non-alcoholic fatty liver disease (NAFLD). We aimed to assess the quantity and quality of skeletal muscle using each of these diagnostic classifications. This...
๐๏ธ 2024-07-16
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia, the gradual and generalized loss of muscle mass and function with ageing, is one of the major health problems in older adults, given its high prevalence and substantial socioeconomic implications. Despite the extensive efforts to reach consensus on definition...
๐๏ธ 2024-07-15
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Tumour-induced skeletal muscle wasting in the context of cancer cachexia is a condition with profound implications for patient survival. The loss of muscle mass is a significant clinical obstacle and is linked to reduced tolerance to chemotherapy and increased frailty....
๐๏ธ 2024-07-13
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is associated with unfavourable long-term survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). However, the impact of myosteatosis and muscle loss on patient prognosis has not been investigated. Seven hundred fifty-six HCC patients who received LT...
๐๏ธ 2024-08-27
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Insulin resistance and diabetes are associated with an increased risk of frailty, and frailty is associated with cardiovascular disease and premature mortality. We aim to investigate the impact of long-term insulin resistance trajectories on future frailty and cardiovascular risk among...
๐๏ธ 2024-06-20
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
It is well reported that malnutrition in acute care is associated with poorer health outcomes including increased mortality. However, the consequences of malnutrition on survival in community settings is uncertain. Malnutrition in people 65ย years or over is often cited. Nevertheless,...
๐๏ธ 2024-08-29
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is characterized by loss of skeletal muscle mass and function, and is a major risk factor for disability and independence in the elderly. Effective medication is not available. Dietary restriction (DR) has been found to attenuate aging and aging-related...
๐๏ธ 2024-04-30
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Many studies support the idea that sarcopenic obesity (SO) could be considered a potential risk factor for negative health outcomes. These results have been inconsistent, and no umbrella reviews exist regarding this topic. Several databases until November 2023 were searched...
๐๏ธ 2024-06-19
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Muscle strength is essential for healthy ageing. Handgrip strength (HGS) has been recommended by expert bodies as the preferred measure of muscle strength, in addition to being considered a strong predictor of overall health. Cross-sectional studies have shown several potential...
๐๏ธ 2024-08-26
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development of diabetes and obesity. The tumour suppressor...
๐๏ธ 2024-07-15
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Previous research on the association between physical activity (PA) and kidney function is inconsistent. The association between muscle mass and serum creatinine (SCr) may have implications for interpreting the effect of PA on estimated glomerular filtration rate (eGFR). Few studies...
๐๏ธ 2024-08-18
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cachexia has been defined as a loss of lean tissue mass, involving a weight loss greater than 5% of body weight in 12โmonths or less in the presence of chronic illness or as a body mass index (BMI) lower than 20โkg/m2. In addition, usually three of the following five criteria are required: decreased muscle strength, fatigue, anorexia, low fat-free mass index, increase of inflammation markers such as C-reactive protein or interleukin (IL)-6 as well as anaemia or low serum albumin.
Cachexia can occur in most major diseases including infections, cancer, heart disease, chronic kidney disease, chronic obstructive pulmonary disease, and stroke.
REFERENCES
Evans WJ, Morley JE, Argiles J, Bales C, Baracos V, Guttridge D, et al. Cachexia: a new definition. Clin Nutr 2008;27:793โ799
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011;12:489โ495.
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