Exercise

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Association of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance With Lung Cancer Survival: A Nationwide Cohort Study.

<p><b>BACKGROUND</b></p><p>Physical activity (PA) is important for improving life expectancy and is suggested as a prognostic factor for various diseases. However, the association between PA and mortality outcomes in survivors of lung cancer remains unclear. Therefore, this study aimed to determine...

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance With Lung Cancer Survival: A Nationwide Cohort Study.

Sarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

<p><b>BACKGROUND</b></p><p>Sarcopenic obesity (SO) is a clinical condition defined by the coexistence of high body fat mass and low muscle function and mass, which increases the risk of adverse health outcomes, including disability and mortality. Early detection and frequent monitoring of...

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

Skeletal Muscle PGC-1ฮฑ Remodels Mitochondrial Phospholipidome but Does Not Alter Energy Efficiency for ATP Synthesis.

<p><b>BACKGROUND</b></p><p>The coupling of oxygen consumption to ATP synthesis via oxidative phosphorylation (OXPHOS) is central for cellular energy homeostasis. Some studies suggest exercise training increases the efficiency of ATP synthesis, but the molecular mechanisms are unclear. We have previously shown that...

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle PGC-1ฮฑ Remodels Mitochondrial Phospholipidome but Does Not Alter Energy Efficiency for ATP Synthesis.

Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.

Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged...

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Aging Cell
Read MoreExperimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.

CSE/H 2S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization-Induced Muscle Atrophy in Mice.

Hydrogen sulphide (H 2S), a gasotransmitter synthesized by cystathionine-ฮณ-lyase (CSE), exhibits antioxidant properties and may mimic exercise-induced muscle protection. However, its mechanistic role in muscle atrophy and exercise intervention remains unclear. Six-month-old male wild-type (WT) and SESN2 knockout (SESN2 -/-)...

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCSE/H 2S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization-Induced Muscle Atrophy in Mice.

Muscle Abnormalities in Nonhospitalised Patients With Post-COVID-19 Condition.

Post-COVID condition (PCC) affects ~10% of SARS-CoV-2-infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the skeletal muscle of these patients and compare them with healthy controls. Biopsies were...

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Abnormalities in Nonhospitalised Patients With Post-COVID-19 Condition.

Voluntary Activity Wheel Running Improves Hyperammonaemia-Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice.

Voluntary exercise improves clinical outcomes in healthy subjects, but increased muscle ammoniagenesis may limit beneficial responses during hyperammonaemia in chronic diseases. Responses to 4-weeks voluntary wheel running (VWR) were compared with usual activity (UA) to determine if hyperammonaemia alters VWR...

๐Ÿ—“๏ธ 2025-08-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreVoluntary Activity Wheel Running Improves Hyperammonaemia-Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice.

Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial.

Treatments aimed at improving physical function and body composition, including reducing fat mass (FM) and increasing muscle mass, may benefit individuals with advanced knee osteoarthritis (OA) and obesity. We investigated the feasibility and efficacy of a multimodal behavioural intervention compared...

๐Ÿ—“๏ธ 2025-08-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImproving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial.

Corrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

๐Ÿ—“๏ธ 2025-07-07
๐Ÿ“ฐ Publication: Metabolism-Clinical And Experimental
Read MoreCorrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

Corrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

๐Ÿ—“๏ธ 2025-07-07
๐Ÿ“ฐ Publication: Metabolism-Clinical And Experimental
Read MoreCorrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

A serum creatinine-cystatin C-derived index as a predictive marker for sarcopenia incidence and progression in community-dwelling older adults: a prospective cohort study.

Identifying individuals at risk of sarcopenia incidence or progression remains challenging. Serum creatinine- and cystatin C-derived indices are objective markers of muscle metabolism; however, their predictive value for sarcopenia progression remains uncertain. This study evaluated the association between a creatinine-...

๐Ÿ—“๏ธ 2025-07-01
๐Ÿ“ฐ Publication: Age And Ageing
Read MoreA serum creatinine-cystatin C-derived index as a predictive marker for sarcopenia incidence and progression in community-dwelling older adults: a prospective cohort study.

Exercise-Induced Short-Chain Fatty Acids: A Novel Therapeutic Target in Type 2 Diabetes Mellitus with Sarcopenia.

Type 2 diabetes mellitus accompanied by sarcopenia is an emerging clinical challenge in aging populations, characterized by coexisting metabolic dysfunction and the progressive loss of skeletal muscle mass and function. This comorbidity substantially elevates the risk of frailty, functional impairment,...

๐Ÿ—“๏ธ 2025-06-20
๐Ÿ“ฐ Publication: Aging And Disease
Read MoreExercise-Induced Short-Chain Fatty Acids: A Novel Therapeutic Target in Type 2 Diabetes Mellitus with Sarcopenia.

Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise.

Sarcopenia, or age-related muscle dysfunction, contributes to morbidity and mortality. Besides decreases in muscle force, sarcopenia is associated with atrophy and fast-to-slow fiber type switching, which is typically secondary to denervation in humans and rodents. However, very little is known...

๐Ÿ—“๏ธ 2025-06-30
๐Ÿ“ฐ Publication: Aging Cell
Read MoreAltered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise.

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