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  Annual Conference 2025
  
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  Are you ready to share your groundbreaking research and innovative ideas with leading experts in the field? We invite you to submit your abstract for the 2025 conference.
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  Explore our Publications Digest ⟶
  
  Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments.
  
  The Journal of Cachexia, Sarcopenia & Muscle ⟶
  The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing both research and clinical materials related to cachexia and sarcopenia from all fields of the life sciences.
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Aging

Muscle

Normative data for age-specific skeletal muscle area based on computed tomography in Korean population.

Sarcopenia, a progressive loss of muscle mass and function, increases health risks in older adults, especially in rapidly ageing populations like Korea. Computed tomography (CT) imaging at the third lumbar vertebra (L3) level is a gold standard for assessing skeletal...

🗓️ 2025-05-03

📰 Publication: Age And Ageing

Aging / Muscle,_skeletal / muscles / PREVALENCE / Sarcopenia / Sex / Tomography

Frailty

Osteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study.

Osteosarcopenia is suggested to be on the causal pathway to frailty; however, data on this topic is scarce, and it is unclear if osteosarcopenia is associated with frailty risk. To investigate if osteosarcopenia is associated with frailty risk in community-dwelling...

🗓️ 2025-05-02

📰 Publication: Archives Of Gerontology And Geriatrics

Aging / Geriatrics / Local_area_networks / Osteoporosis / Sarcopenia

Muscle

Iron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control.

In older adults with reduced physical performance, an increase in the labile iron pool within skeletal muscle is observed. This accumulation is associated with an altered expression of mitochondrial quality control (MQC) markers and increased mitochondrial DNA damage, supporting the...

🗓️ 2025-05-03

Aging / Autophagy / Cell_death / CELLS / cytokines / Ferritins / Ferroptosis / Hepcidins / Lysosomes / Mitophagy / muscles / Quality_control / Sarcopenia / therapeutics / Transferrin

Muscle

Prevalence of sarcopenia in middle-aged and older adults with cognitive impairment: a meta-analysis.

Cognitive impairment, dementia and sarcopenia significantly reduce the quality of life in middle-aged and older adults by impairing daily functioning, making cognitive decline a major concern for healthcare professionals. To estimate the prevalence of sarcopenia and probable sarcopenia in middle-aged...

🗓️ 2025-05-03

📰 Publication: Age And Ageing

Aged / Aging / Cognition_disorders / Cognitive_dysfunction / Dementia / Geriatrics / muscles / PREVALENCE / Sarcopenia

Muscle

A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti-Aging Mechanisms.

Skeletal muscle function and mass continuously decrease during aging. Most studies target limb muscles owing to their direct impact on mobility and falls risk. The diaphragm (DIA), also a type of skeletal muscle with different phenotype, has received less attention....

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aging / cachexia / Diaphragm / Genes / Lung / muscles / Research / Running / Sarcopenia / Spermine / Transcriptome / Vital_capacity

Exercise

Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients.

Hospitalization in older adults often worsens sarcopenia due to prolonged bed rest, poor nutrition, and inactivity. This study examined how hospitalization impacts muscle mass, focusing on oxidative stress and gut-derived endotoxemia. Thirty-one hospitalized older adults were compared with 31 outpatients....

🗓️ 2025-03-01

Aged / Aging / Endotoxemia / Hospitalization / muscles / Nadp / Nadph_oxidase_2 / Nadph_oxidases / Outpatients / Oxidative_stress / Sarcopenia / Stress,_physiological

Cachexia

Comment on "Survey on the Knowledge and Practices in Anorexia of Aging Diagnosis and Management in Japan" by Takagi et al.-The Authors' Reply.

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aging / Anorexia / DIAGNOSIS / Sarcopenia

Muscle

Plasma brain-derived neurotrophic factor concentrations are elevated in community-dwelling adults with sarcopenia.

The scalability of a blood-based sarcopenia assessment has generated interest in circulating markers that may enhance management strategies. Data regarding the relevance of brain derived neurotrophic factor (BDNF), a regulator of neuroplasticity, to sarcopenia in community-dwelling adults are scarce. We...

🗓️ 2025-02-02

📰 Publication: Age And Ageing

Aging / Biomarkers / Brain / Brain-derived_neurotrophic_factor / Geriatrics / Muscle,_skeletal / muscles / Nerve_growth_factors / PLASMA / Sarcopenia

Sarcopenia

An mTOR paradox in sarcopenia via BCAA catabolism.

🗓️ 2025-02-13

Aging

Exercise

Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca handling across the adult lifespan in men.

Aging-related muscle atrophy and weakness contribute to loss of mobility, falls, and disability. Mitochondrial dysfunction is widely considered a key contributing mechanism to muscle aging. However, mounting evidence positions physical activity as a confounding factor, making unclear whether muscle mitochondria...

🗓️ 2025-02-06

📰 Publication: Cell Reports Medicine

Aging / Biological_science_disciplines / Calcium / Mitochondria / Mitochondria,_muscle / Mitochondrial_permeability_transition_pore / muscles / Sarcopenia

Muscle

PrP Glycoprotein Is Indispensable for Maintenance of Skeletal Muscle Homeostasis During Aging.

The cellular prion protein (PrP), a glycoprotein encoded by the PRNP gene, is known to modulate muscle mass and exercise capacity. However, the role of PrP in the maintenance and regeneration of skeletal muscle during ageing remains unclear. This study...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aging / cachexia / Cardiotoxins / CELLS / Genes / Glycoproteins / Homeostasis / Maintenance / Mitochondria / Muscle,_skeletal / muscles / Sarcopenia / Stress,_physiological

Muscle

Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis.

Regenerative capacity of skeletal muscles decreases with age. Deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) is associated with skeletal muscle weakness as well as epithelial cell senescence. However, whether and how CFTR plays a role in skeletal muscle regeneration...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aging / Autophagy / cachexia / Cystic_fibrosis / Cystic_fibrosis_transmembrane_conductance_regulator / Fibrosis / Genes / Mitochondria / Muscle,_skeletal / muscles / Myoblasts / Sarcopenia / tissues

Muscle

Transcriptomic Profiling Reveals 17β-Estradiol Treatment Represses Ubiquitin-Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice.

With a decline of 17β-estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female mice, testing the hypothesis that...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aging / Estradiol / Estrogens / Genes / Muscle,_skeletal / muscles / Promoter_regions,_genetic / Sarcopenia / therapeutics / Ubiquitin

Muscle

Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways.

Sarcopenia, the age-related decline in muscle mass and function, is a significant contributor to increased frailty and mortality in the elderly. Currently, no FDA-approved treatment exists for sarcopenia. Here, we identified norharmane (NR), a β-carboline alkaloid, as a potential therapeutic...

🗓️ 2025-01-27

📰 Publication: Redox Biology

Aged / Aging / CELLS / Cellular_senescence / Genes / muscles / Myoblasts / Sarcopenia / Stress,_physiological / therapeutics

Muscle

Why are we not exploring the potential of lower limb muscle power to identify people with sarcopenia?

Sarcopenia refers to a neuromuscular disease characterized by age-related declines in muscle mass and function. Since Professor Rosenberg first introduced the concept of sarcopenia in 1989, numerous operational paradigms have been proposed, tested, and validated against negative outcomes. The most...

🗓️ 2025-01-14

📰 Publication: Ageing Research Reviews

Aging / Muscle_strength / muscles / Sarcopenia

Muscle

Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.

Sarcopenia is a geriatric disorder characterized by a gradual loss of muscle mass and function. Despite its prevalence, the underlying mechanisms remain unclear, and there are currently no approved treatments. In this study, we conducted a comprehensive analysis of the...

🗓️ 2025-02-05

Aging / Amino_acids / Amino_acids,_branched-chain / Multiple_chronic_conditions / Muscle,_skeletal / muscles / Sarcopenia / therapeutics

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