Aging

Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review.

Population aging has become a widespread health problem that leads to huge socioeconomic burden. Skeletal muscle as an important component of motor system, gradually degenerates with age. Age-related muscle disorders, such as sarcopenia is associated with higher risks of falls,...

๐Ÿ—“๏ธ 2025-10-24
๐Ÿ“ฐ Publication: Aging And Disease
Read MoreAdvancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review.

3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.

<p><b>BACKGROUND</b></p><p>In order to identify patients with sarcopenia, the use of routine imaging could provide valuable support. One of the most common radiological examinations, especially in geriatric inpatient care, is CT thoracic imaging. Therefore, it would be desirable to generate muscle...

๐Ÿ—“๏ธ 2025-10-21
๐Ÿ“ฐ Publication: Aging Clinical And Experimental Research
Read More3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.

Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.

Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged...

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Aging Cell
Read MoreExperimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.

Microenvironment-driven satellite cell regeneration and repair in aging-related sarcopenia: mechanisms and therapeutic frontiers.

Sarcopenia, a progressive age-related decline in skeletal muscle mass and function, is closely linked to impaired regenerative capacity of satellite cells (SCs), also known as satellite cells. Age-dependent SCs dysfunction, driven by intrinsic senescence and niche dysregulation, disrupts activation, proliferation,...

๐Ÿ—“๏ธ 2025-10-07
Read MoreMicroenvironment-driven satellite cell regeneration and repair in aging-related sarcopenia: mechanisms and therapeutic frontiers.

CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.

Sarcopenia, a degenerative condition marked by progressive skeletal muscle atrophy and impaired regeneration, is closely associated with aging, chronic inflammation, and disrupted proteostasis. While macroautophagy has been extensively studied in this context, little of the role of chaperone-mediated autophagy (CMA)...

๐Ÿ—“๏ธ 2025-10-07
๐Ÿ“ฐ Publication: Cell Death & Disease
Read MoreCTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.

Emerging basic science concepts in geriatric fracture fixation and patient recovery.

In recent history, human life expectancy has increased significantly, resulting in a high burden of late-life morbidity and geriatric fractures. Changes to the body as a result of aging, such as degeneration of the bone marrow, osteoblast apoptosis, and a...

๐Ÿ—“๏ธ 2025-10-01
Read MoreEmerging basic science concepts in geriatric fracture fixation and patient recovery.

Muscle-Specific Strength Better Predicts Physical Performance Decline Than Conventional Metrics: The I-Lan Longitudinal Aging Study.

Muscle-specific strength (MSS), defined as grip strength normalized to arm muscle mass, may better reflect muscle efficiency than grip strength. Despite its potential utility in diagnosing sarcopenia, longitudinal studies evaluating MSS as a predictor of sarcopenia-related outcomes remain limited. This...

๐Ÿ—“๏ธ 2025-10-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle-Specific Strength Better Predicts Physical Performance Decline Than Conventional Metrics: The I-Lan Longitudinal Aging Study.

Therapeutic silicate biomaterials for sarcopenia treatment by inhibiting inflammation and enhancing muscle regeneration through regulation of Sarcolipin/SIRT signaling pathway.

Based on the observation of silicon content decrease in the muscles and serum with aging, this study proposes a silicate bioactive material based therapy for treating sarcopenia. Two therapeutic strategies were designed. One utilizes calcium silicate (CS) hydrogel for localized...

๐Ÿ—“๏ธ 2025-06-26
๐Ÿ“ฐ Publication: Bioactive Materials
Read MoreTherapeutic silicate biomaterials for sarcopenia treatment by inhibiting inflammation and enhancing muscle regeneration through regulation of Sarcolipin/SIRT signaling pathway.

hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.

Sarcopenia, a multifactorial syndrome characterized by progressive loss of skeletal muscle mass and strength, combined with impaired physical function, is associated primarily with aging but also driven by chronic inflammation, immobility, and endocrine dysregulation. It leads to increased risks of...

๐Ÿ—“๏ธ 2025-08-02
Read MorehUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.

Genome-wide association and epidemiological evidence linking air pollution to aging mechanisms.

This study aimed to investigate the effects of air pollution on aging and aging-related diseases, focusing on potential causal relationships and molecular mechanisms. The first part involved a comprehensive analysis of global studies, examining the associations among PM 2.5 exposure,...

๐Ÿ—“๏ธ 2025-07-16
๐Ÿ“ฐ Publication: Journal Of Hazardous Materials
Read MoreGenome-wide association and epidemiological evidence linking air pollution to aging mechanisms.

EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization.

Muscle atrophy has a poor prognosis, caused by various factors. Identifying a shared treatment target could address an unmet clinical need. The exon junction complex (EJC), a protein complex assembly that binds to RNA, facilitates post-transcriptional regulation by participating in...

๐Ÿ—“๏ธ 2025-08-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization.

Interactions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77-101ย years).

Low bone density and low muscle mass are both independent risk factors for mortality in older men. However, it is unknown if these tissues interact to increase mortality risk. Elucidating this information is important as bone and muscle are modifiable...

๐Ÿ—“๏ธ 2025-07-01
๐Ÿ“ฐ Publication: Age And Ageing
Read MoreInteractions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77-101ย years).

Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.

Cellular senescence is a hallmark of organismal aging but how it drives aging in human tissues is not fully understood. Here we leverage single nucleus multiomics to profile senescence in mononucleated cells of human skeletal muscle and provide the first...

๐Ÿ—“๏ธ 2025-07-05
๐Ÿ“ฐ Publication: Nature Communications
Read MoreMultiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.

Aging induces sarcopenia by disrupting the crosstalk between the skeletal muscle microenvironment and myofibers.

Sarcopenia is a degenerative muscular disease associated with aging, characterized by a reduction in muscle mass and strength. This disease poses a significant global health challenge, owing to its high prevalence and association with adverse outcomes such as increased frailty,...

๐Ÿ—“๏ธ 2025-07-03
๐Ÿ“ฐ Publication: Journal Of Advanced Research
Read MoreAging induces sarcopenia by disrupting the crosstalk between the skeletal muscle microenvironment and myofibers.

A serum creatinine-cystatin C-derived index as a predictive marker for sarcopenia incidence and progression in community-dwelling older adults: a prospective cohort study.

Identifying individuals at risk of sarcopenia incidence or progression remains challenging. Serum creatinine- and cystatin C-derived indices are objective markers of muscle metabolism; however, their predictive value for sarcopenia progression remains uncertain. This study evaluated the association between a creatinine-...

๐Ÿ—“๏ธ 2025-07-01
๐Ÿ“ฐ Publication: Age And Ageing
Read MoreA serum creatinine-cystatin C-derived index as a predictive marker for sarcopenia incidence and progression in community-dwelling older adults: a prospective cohort study.

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