CELLS

Muscle

PrP Glycoprotein Is Indispensable for Maintenance of Skeletal Muscle Homeostasis During Aging.

The cellular prion protein (PrP), a glycoprotein encoded by the PRNP gene, is known to modulate muscle mass and exercise capacity. However, the role of PrP in the maintenance and regeneration of skeletal muscle during ageing remains unclear. This study...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aging / cachexia / Cardiotoxins / CELLS / Genes / Glycoproteins / Homeostasis / Maintenance / Mitochondria / Muscle,_skeletal / muscles / Sarcopenia / Stress,_physiological

Muscle

The Effect of Anti-Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice.

Anti-Activin Receptor Type IIA and Type IIB antibody (αActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle hypertrophy,...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Activin_receptors / Activins / BLOOD / Blood_cells / cachexia / Cancellous_bone / CELLS / Cortical_bone / Erythrocytes / Hematopoiesis / Injections / Ligands / Muscle,_skeletal / muscles / Osteoporosis / Paresis / Sarcopenia / therapeutics

Muscle

Characterization of SARS-CoV-2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection.

COVID-19 has been associated with both respiratory (diaphragm) and non-respiratory (limb) muscle atrophy. It is unclear if SARS-CoV-2 infection of skeletal muscle plays a role in these changes. This study sought to: 1) determine if cells comprising skeletal muscle tissue,...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagy / cachexia / CELLS / Covid-19 / Diaphragm / Genes / Infections / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Muscular_atrophy / Sarcopenia / Sars-cov-2 / Severe_acute_respiratory_syndrome-related_coronavirus / Ubiquitin / Virus_internalization

Muscle

Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways.

Sarcopenia, the age-related decline in muscle mass and function, is a significant contributor to increased frailty and mortality in the elderly. Currently, no FDA-approved treatment exists for sarcopenia. Here, we identified norharmane (NR), a β-carboline alkaloid, as a potential therapeutic...

🗓️ 2025-01-27

📰 Publication: Redox Biology

Aged / Aging / CELLS / Cellular_senescence / Genes / muscles / Myoblasts / Sarcopenia / Stress,_physiological / therapeutics

Cachexia

Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of ≥50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy.

This retrospective, multicenter cohort study aimed to determine whether cancer cachexia serves as a biomarker for determining the most effective treatment for patients having non-small-cell lung cancer (NSCLC) with high programmed death ligand 1 (PD-L1) expression treated with immune checkpoint...

🗓️ 2024-12-16

Cancer-associated_cachexia / Carcinoma,_non-small-cell_lung / CELLS / chemotherapy / Drug_therapy / Immune_checkpoint_inhibitors / Lung / Lung_neoplasms / neoplasms / Small_cell_lung_carcinoma / therapeutics / Treatment_outcome / Weight_loss

Muscle

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Sarcopenia is currently a life-threatening disease for the elderly. Polygonatum sibiricum polysaccharide (PSP) has anti-oxidative stress and anti-inflammatory effects. However, the effects of PSP on skeletal muscle aging, myoblast differentiation and mitochondrial dysfunction through PI3K/Akt/mTOR signaling pathway has not been...

🗓️ 2024-12-09

📰 Publication: Phytomedicine

Aging / CELLS / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Myoblasts / Oxidative_stress / Pharmacology / Polysaccharides / Sarcopenia / Stress,_physiological / therapeutics

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / Adenoma,_pleomorphic / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipocytes,_brown / Adipocytes,_white / Adipogenesis / Adiponectin / Adipose_tissue / Adiposity / Administration,_intranasal / Administration,_oral / Adolescent / Adrenal_cortex_hormones / Adrenocorticotropic_hormone / Adult_stem_cells / Advance_care_planning / Adverse_childhood_experiences / Advertising / Aeromonas_veronii / Aerosols / Aflatoxin_m1 / Aflatoxins / African_swine_fever / Aftercare / Agar / Agaricales / Age_distribution / Aged / Agent_orange / Aggregatibacter / Aggregatibacter_aphrophilus / Aggression / Aging,_premature / Agranulocytosis / Agricultural_irrigation / Agriculture / Agrochemicals / Aids-related_complex / Air_pollution / Alanine / Alcohol_drinking / Alcoholics / Aldehydes / Aldosterone / Alendronate / Alginates / Algorithms / Alkaline_phosphatase / Alkalosis / Alkanesulfonates / Alkynes / Alleles / Allergens / Allografts / Allopurinol / Alloys / Alopecia / Alopecia_areata / Alpha_1-antitrypsin / Alpha_1-antitrypsin_deficiency / Alpha-glucosidases / Alpha-linolenic_acid / Alpha-synuclein / Alphapapillomavirus / Altitude / Alzheimer_disease / Amanita / Ambulances / Ambulatory_care / Ambulatory_care_facilities / Amikacin / Amine_oxidase_(copper-containing) / Amines / Amino_acid_sequence / Amino_acid_substitution / Amino_acids / Amino_acids,_branched-chain / Amino_acids,_sulfur / Amino_alcohols / Aminolevulinic_acid / Amlodipine / Amoxicillin / Amphetamines / Amphotericin_b / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyloidosis / Amylopectin / Amyotrophic_lateral_sclerosis / Analgesia / Analgesics / Analysis_of_variance / Anaphylaxis / Anastomotic_leak / Anemia / Anemia,_aplastic / Anemia,_iron-deficiency / Anemia,_sickle_cell / Anesthesia / Anesthesia,_conduction / Anesthesia,_epidural / Anesthesia,_intravenous / Anesthesia,_local / Anesthesia,_obstetrical / Anesthesiologists / Anesthesiology / Anesthetics / Anesthetics,_local / Aneuploidy / Aneurysm,_false / Anger / Angina_pectoris / Angioedema / Angioedemas,_hereditary / Angiopoietins / Angiotensins / Anhydrides / Aniline_compounds / Animal_communication / Anisometropia / Ankle / Ankyloglossia / Ankylosis / Annexin_a5 / Annexins / Anoikis / Anosmia / Anterior_chamber / Anterior_cruciate_ligament_injuries / Anthelmintics / Anthocyanins / Anthracyclines / Anthropology / Anthropometry / Anti-bacterial_agents / Anti-inflammatory_agents,_non-steroidal / Antibiotic_prophylaxis / Antibodies / Antibodies,_antineutrophil_cytoplasmic / Antibodies,_blocking / Antibodies,_monoclonal / Antibodies,_neutralizing / Antibody_formation / Anticoagulants / Antidepressive_agents / Antigen-presenting_cells / Antigens,_nuclear / Antigens,_surface / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antipyretics / Antiviral_agents / Anxiety_disorders / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_aneurysm,_thoracic / Aortic_aneurysm,_thoracoabdominal / Aortic_diseases / Aortic_dissection / Aortic_rupture / Aortic_valve / Aortic_valve_disease / Apathy / Apelin / Aphasia / Apigenin / Apolipoproteins / Apoprotein(a) / Apoptosis / Appendectomy / Appendicitis / Appendix / Appetite / Aquaculture / Aquatic_organisms / Arachnoiditis / Archaea / Archives / Area_under_curve / Arginine / Argon_plasma_coagulation / Aristolochic_acids / Arrestin / Arrhythmias,_cardiac / Arterial_occlusive_diseases / Arterioles / Arteriovenous_fistula / Arteriovenous_malformations / Arterivirus / Arthritis,_psoriatic / Arthritis,_reactive / Arthritis,_rheumatoid / Arthrodermataceae / Arthroplasty,_replacement,_knee / Arthroscopy / Artificial_intelligence / Artificial_limbs / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillus / Aspergillus_niger / Aspirin / Asthma / Astigmatism / Astringents / Astrocytes / Astrocytoma / Ataxia / Atenolol / Atherosclerosis / Athletes / Athletic_performance / Atmosphere / Atorvastatin / Atrial_appendage / Atrial_fibrillation / Atrial_flutter / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Audiometry / Audiovisual_aids / Augmented_reality / Autism_spectrum_disorder / Autistic_disorder / Autoantigens / Autoimmune_diseases / Autoimmunity / Automation / Autophagosomes / Autophagy / Autopsy / Axenic_culture / Axial_spondyloarthritis / Axillary_vein / Axons / Azacitidine / Azathioprine / Azoospermia / Azospirillum / Azospirillum_brasilense / B-lymphocytes / Bacillus / Bacillus_amyloliquefaciens / Bacillus_subtilis / Back_pain / Bacterial_adhesion / Bacterial_infections / Bacterial_load / Bacteriocins / Bacteriophages / Bacteroides / Bacteroides_fragilis / Badnavirus / Bariatric_surgery / Bartonella / Bartonella_quintana / Basal_ganglia / Basal_nucleus_of_meynert / Basement_membrane / Basidiomycota / Basolateral_nuclear_complex / Beauty / Beckwith-wiedemann_syndrome / Beds / Begomovirus / Behavior_therapy / Behavior,_animal / Behavioral_symptoms / Benchmarking / Benserazide / Benzene / Benzocaine / Benzodiazepines / Benzyl_alcohol / Berberine / Beta-lactams / Betaine / Betaine-homocysteine_s-methyltransferase / Bevacizumab / Beverages / Bezafibrate / Bezoars / Bias / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bifidobacterium / Bifidobacterium_longum / Bile / Bile_ducts / Biliary_tract / Bilirubin / Binge-eating_disorder / Biocompatible_materials / Biodegradable_plastics / Biodegradation,_environmental / Biodiversity / Biofeedback,_psychology / Biofilms / Biological_assay / Biological_availability / Biological_science_disciplines / Biological_therapy / Biomarkers / Biomarkers,_tumor / Biomass / Biomedical_research / Biometry / Biomimetics / Bioprinting / Biosimilar_pharmaceuticals / Biosurveillance / Biotransformation / Bipolar_disorder / Birth_certificates / Birth_order / Birth_weight / Bleomycin / Blindness / BLOOD / Blood_cell_count / Blood_cells / Blood_circulation / Blood_coagulation_factors / Blood_component_removal / Blood_culture / Blood_donors / Blood_glucose / Blood_platelets / Blood_pressure / Blood_pressure_monitoring,_ambulatory / Blood_substitutes / Blood_transfusion,_intrauterine / Blood_urea_nitrogen / Blood_vessels / Blood_volume / Blotting,_western / Body_composition / Body_contouring / Body_image / Body_mass_index / Body_size / Body_weight / Bone_cements / Bone_cysts / Bone_diseases / Bone_marrow / Bone_neoplasms / Bone_regeneration / Bone_transplantation / Bony_callus / Borates / Botany / Botulinum_toxins / Botulinum_toxins,_type_a / Botulism / Bowen's_disease / Bradycardia / Bradykinin / Brain / Brain_diseases / Brain_injuries / Brain_injuries,_traumatic / Brain_ischemia / Brain_stem / Brain_stem_infarctions / Bread / Breast / Breast_cancer_lymphedema / Breast_feeding / Breast_neoplasms / Bronchiectasis / Bronchiolitis_obliterans_syndrome / Bronchitis / Bronchogenic_cyst / Bronchopulmonary_sequestration / Bronchoscopy / Brucella / Brucellosis / Brugada_syndrome / Budesonide / Buffers / Bulimia / Bundle-branch_block / Bupropion / Burning_mouth_syndrome / Burnout,_psychological / Burns / Butter / Butyrylcholinesterase / C-peptide / C-reactive_protein / Ca-19-9_antigen / cachexia / Caco-2_cells / Cadherins / Caffeine / Calcitonin_gene-related_peptide / Calcium / Calcium_channel_blockers / Calcium_channels / Calcium_signaling / Cancer_vaccines / Cancer-associated_cachexia / Cancer-associated_fibroblasts / Candidemia / Candidiasis / Candidiasis,_invasive / Candidiasis,_vulvovaginal / Cannabidiol / Cannula / Capacity_building / Capillaries / Capsaicin / Capsid / Capsules / Car-t_cell / Carbamazepine / Carbapenems / Carbidopa / Carbohydrates / Carboxylic_acids / Carcinogenesis / Carcinogens / Carcinoid_tumor / Carcinoma_in_situ / Carcinoma,_basal_cell / Carcinoma,_hepatocellular / Carcinoma,_intraductal,_noninfiltrating / Carcinoma,_non-small-cell_lung / Carcinoma,_ovarian_epithelial / Carcinoma,_renal_cell / Carcinoma,_squamous_cell / Cardiac_catheters / Cardiac_output / Cardiac_rehabilitation / Cardiac_resynchronization_therapy / Cardiac_volume / Cardiology / Cardiomyopathy,_restrictive / Cardiopulmonary_bypass / Cardiopulmonary_resuscitation / Cardiotoxicity / Cardiovascular_diseases / Cardiovascular_system / Caregivers / Carotenoids / Carotid_arteries / Carotid_artery,_internal / Carrier_proteins / Case-control_studies / Caseins / Caspase_3 / Caspase_9 / Caspases / Castleman_disease / Castration / Catalase / Cataract / Catastrophization / Catechin / Catechol_o-methyltransferase / Catecholamines / Catenins / Catheter_ablation / Catheterization / Causality / Caveolins / Cecum / Cefazolin / Cefoperazone / Cefotaxime / Ceftazidime / Ceftriaxone / Celiac_disease / Cell_aggregation / Cell_biology / Cell_body / Cell_communication / Cell_count / Cell_culture_techniques / Cell_cycle / Cell_death / Cell_differentiation / Cell_fusion / Cell_line / Cell_membrane / Cell_proliferation / Cell_survival / Cell_transplantation / Cell_wall / Cell-free_nucleic_acids / CELLS / Cellular_senescence / Cellulose / Censuses / Centers_for_disease_control_and_prevention,_u.s. / Central_amygdaloid_nucleus / Central_nervous_system / Central_nervous_system_diseases / Central_nervous_system_sensitization / Central_venous_catheters / Centromere / Cephalosporins / Ceramics / Ceramidases / Ceramides / Cerebellar_ataxia / Cerebellum / Cerebral_arteries / Cerebral_cortex / Cerebral_hemorrhage / Cerebral_infarction / Cerebral_palsy / Cerebral_small_vessel_diseases / Cerebrospinal_fluid_leak / Cerebrospinal_fluid_rhinorrhea / Cerebrovascular_circulation / Cerebrovascular_disorders / Cervical_cord / Cervical_vertebrae / Cervix_uteri / Cesarean_section / Chagas_disease / Chaperonins / Charcot-marie-tooth_disease / Cheese / Chemical_safety / Chemistry,_clinical / Chemokine_ccl11 / Chemokine_ccl22 / Chemokine_cx3cl1 / Chemokine_cxcl12 / Chemokines / Chemokines,_cxc / Chemoprevention / Chemoradiotherapy / Chemotherapy,_adjuvant / Chest_pain / Chick_embryo / Chickenpox / Chikungunya_virus / Child_abuse,_sexual / Child_custody / Child_development / Child_health / Child_health_services / Child,_hospitalized / Child,_preschool / Chimera / Chimerism / Chitin / Chitosan / Chlamydia / Chloramphenicol / Chlorogenic_acid / Chlorophyll / Chlorophyll_a / Chloroplasts / Chlortetracycline / Cholangiocarcinoma / Cholangiography / Cholangitis / Cholecalciferol / Cholecystectomy / Cholecystitis / Cholecystitis,_acute / Choledocholithiasis / Cholera / Cholestasis / Cholestasis,_intrahepatic / Cholesterol / Cholesterol_esters / Cholesterol,_hdl / Cholesterol,_ldl / Cholinergic_agents / Chondrocytes / Chondrogenesis / Chondroitin / Chondroitin_sulfates / Chordoma / Chorea / Chorioamnionitis / Chromatin / Chromatin_immunoprecipitation / Chromogranin_a / Chromogranins / Chromosome_aberrations / Chronic_disease / Chronic_pain / Chylothorax / Chylous_ascites / Cicatrix / Cilia / Ciprofloxacin / Circadian_clocks / Circovirus / Circulating_microrna / Circulating_tumor_dna / Citalopram / Citizen_science / Citric_acid / Citrinin / Citrobacter / Citrobacter_rodentium / Citrulline / Cladribine / Classical_swine_fever / Clathrin / Clay / Climacteric / Climate / Clinical_alarms / Clinical_decision-making / Clinical_laboratory_techniques / Clitoris / Clobazam / Clone_cells / Clonidine / Clostridioides / Clostridioides_difficile / Clostridium / Cloud_computing / Clozapine / Cluster_analysis / Clustered_regularly_interspaced_short_palindromic_repeats / Clutch_size / Coagulase / Coal / Coal_industry / Coccidioidomycosis / Cochlear_implants / Cochlear_nucleus / Coconut_oil / Codon / Coffee / Cognition_disorders / Cognitive_behavioral_therapy / Cognitive_dissonance / Cognitive_dysfunction / Cognitive_restructuring / Cognitive_training / Cohort_studies / Coinfection / Colchicine / Cold_temperature / Colectomy / Colic / Colistin / Colitis / Colitis,_ulcerative / Collagen / Collagen_type_i / Collagen_type_ii / Collagenases / Collectins / Colletotrichum / Collodion / COLON / Colon,_ascending / Colon,_sigmoid / Colon,_transverse / Colonic_neoplasms / Colonoscopy / Colony-stimulating_factors / Colorectal_neoplasms / Colorectal_surgery / Colostomy / Colposcopy / Coma,_post-head_injury / Commerce / Common_variable_immunodeficiency / Communicable_diseases / Communicable_diseases,_emerging / Communication / Community_health_workers / Community_participation / Comorbidity / Compartment_syndromes / Complement_activation / Complement_c1_inhibitor_protein / Complement_c1q / Complement_c3a / Complement_inactivating_agents / Complement_system_proteins / Complementary_therapies / Complex_regional_pain_syndromes / Composite_resins / Composting / Computational_chemistry / Computed_tomography_angiography / Computers / Conditioning,_psychological / Confidence_intervals / Confined_spaces / Conflict_of_interest / Conflict,_psychological / Congo_red / Connective_tissue / Consciousness / Consent_forms / Conservative_treatment / Constipation / Contact_lenses / Continuous_glucose_monitoring / Contraceptive_agents / Contracture / Contraindications / Contusions / Conversion_disorder / Conversion_to_open_surgery / Cooperative_behavior / Coral_reefs / Cornea / Coronary_artery_bypass / Coronary_artery_disease / Coronary_disease / Coronary_sinus / Coronavirus_infections / Cost_of_illness / Cost_savings / Coumarins / Covid-19 / Covid-19_testing / Cranial_nerves / Craniopharyngioma / Craniotomy / Craving / Creatine / Creativity / Creutzfeldt-jakob_syndrome / Criminal_law / Critical_care / Critical_illness / Critical_period,_psychological / Crohn_disease / Cronobacter / Cronobacter_sakazakii / Crop_production / Cross_infection / Cross-over_studies / Cross-sectional_studies / Crowdsourcing / Crowns / Cryogels / Cryoglobulinemia / Cryoglobulins / Cryopreservation / Cryosurgery / Cryotherapy / Cryptochromes / Cryptorchidism / Cubital_tunnel_syndrome / Culture_media,_conditioned / Curcumin / Curriculum / Cushing_syndrome / Cyanobacteria / Cycloaddition_reaction / Cyclodextrins / Cyclophosphamide / Cyclosporine / Cystadenocarcinoma / Cystadenocarcinoma,_serous / Cystatins / Cysteine / Cysteine_proteases / Cystine / Cysts / Cytochrome_p-450_enzyme_system / Cytochromes / Cytogenetics / Cytokinins / Cytology / Cytoplasm / Cytoskeleton / Dairy_products / Data_analysis / Data_collection / Data_management / Data_mining / Data_science / Data_warehousing / Databases,_protein / Deafness / Death,_sudden,_cardiac / Debridement / Decision_making / Decision_making,_shared / Decision_support_systems,_clinical / Decompression / Decontamination / Deep_brain_stimulation / Deep_learning / Default_mode_network / Defibrillators / Defibrillators,_implantable / Deglutition / Deglutition_disorders / Dehydration / Delayed_diagnosis / Delirium / Dementia / Demography / 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Diet,_healthy / Diet,_ketogenic / Diet,_mediterranean / Diet,_vegan / Diet,_vegetarian / Dietary_exposure / Dietary_fats / Dietary_fiber / Dietary_patterns / Dietary_supplements / Diethylhexyl_phthalate / Diffusion_tensor_imaging / Digeorge_syndrome / Digestion / Digital_health / Digital_technology / Digital_therapeutics / Diglycerides / Dioxins / Dipeptidyl_peptidase_4 / Dipeptidyl-peptidase_iv_inhibitors / Diphosphonates / Disabled_children / Disabled_persons / Disaster_medicine / Discriminant_analysis / Disease_management / Disease_progression / Disease_transmission,_infectious / Disease-free_survival / Disinfectants / Diskectomy / Displacement,_psychological / Dissection,_thoracic_aorta / Disseminated_intravascular_coagulation / Distemper_virus,_canine / Disulfides / Disulfiram / Diuretics / Diverticular_diseases / Diverticulitis / Diverticulum / Diving / Dizziness / Dna_damage / Dna_glycosylases / Dna_gyrase / Dna_methylation / Dna_nucleotidylexotransferase / Dna_replication / 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/ Eating / Ebstein_anomaly / Echocardiography / Ecological_momentary_assessment / Ecology / Economics / Economics,_behavioral / Ecosystem / Ectopia_lentis / Ectropion / Eczema / Edaravone / Edible_grain / Education,_medical / Education,_medical,_continuing / Education,_medical,_undergraduate / Egg_yolk / Eggs / Eicosapentaenoic_acid / Ejaculation / Elasticity_imaging_techniques / Elastomers / Electric_power_supplies / Electroacupuncture / Electrocardiography / Electroconvulsive_therapy / Electrodes / Electroencephalography / Electronic_health_records / Electronic_medical_record / Electronic_nicotine_delivery_systems / Electrophysiology / Electroporation / Embolism,_fat / Embryo_transfer / Embryonic_development / Emergencies / Emergency_medical_services / Emergency_medicine / Emergency_responders / Emergency_service,_hospital / Emergency_shelter / Emotional_regulation / Emotions / Employment / Empowerment / Emulsions / Endarterectomy / Endocannabinoids / Endocarditis / Endocytosis / 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Protein_isoforms / Protein_kinases / Protein_phosphatase_1 / Protein_processing,_post-translational / Protein_serine-threonine_kinases / Protein-tyrosine_kinases / Proteogenomics / Proteome / Proteomics / Prothrombin / Prothrombin_time / Proton_pump_inhibitors / Proton_pumps / Proton_therapy / Pruritus / Pseudogenes / Pseudomonas / Pseudomonas_aeruginosa / Pseudomonas_stutzeri / Pseudouridine / Psoriasis / Psychiatrists / Psychological_distress / Psychological_well-being / Psychology,_positive / Psychometrics / Psychosocial_intervention / Psychotherapy / Psychotic_disorders / Psychotropic_drugs / Public_health / Public_health_surveillance / Public_sector / Pulmonary_arterial_hypertension / Pulmonary_disease,_chronic_obstructive / Pulmonary_embolism / Pulmonary_fibrosis / Pulmonary_surfactant-associated_protein_a / Pulmonary_valve / Pulpectomy / Pulpotomy / Pulse / Punctures / Punishment / Pupa / Pupil / Purpura / Purpura,_thrombocytopenic / Putamen / Pyoderma / Pyoderma_gangrenosum / 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A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antitubercular_agents / Antiviral_agents / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_dissection / Aortic_valve / Aphasia / Aphasia,_primary_progressive / Apicoplasts / Apolipoproteins / Apoptosis / Apoptosis_regulatory_proteins / Appendiceal_neoplasms / Appendicitis / Appendix / Appetite / Arboviruses / Arenavirus / Arginine / Arrhythmias,_cardiac / Arteriovenous_malformations / Arthralgia / Arthritis / Arthritis,_rheumatoid / Arthroplasty / Arthroplasty,_replacement,_knee / Artificial_intelligence / Artificially_sweetened_beverages / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillosis / Aspergillosis,_allergic_bronchopulmonary / Asthenozoospermia / Astrocytes / Astrocytoma / Astronauts / Ataxia / Ataxia_telangiectasia / Atherectomy / Atherosclerosis / Athletes / Atrasentan / Atrial_fibrillation / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Attitude_to_health / Audiology / Augmented_reality / Authorship / Autism_spectrum_disorder / Autistic_disorder / Autoantibodies / Autoimmune_diseases / Autophagy / Autopsy / Axial_spondyloarthritis / Axons / B-lymphocytes / Back_pain / Bacterial_adhesion / Bacteriocins / Bacteriophages / Balantidiasis / Bariatric_surgery / Bartonella / Base_sequence / Basement_membrane / Basophils / Beds / Begomovirus / Behcet_syndrome / Benzene / Benzimidazoles / Benzocaine / Bevacizumab / Bezafibrate / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bilirubin / Biochemistry / Biocompatible_materials / Biodiversity / Biofilms / Biogenic_amines / Biological_availability / Biological_factors / Biological_monitoring / Biological_oxygen_demand_analysis / Biological_therapy / Biomarkers / Biomass / Biomedical_research / Biomimetics / Biophysics / Biopolymers / Biopsy / Biosimilar_pharmaceuticals / Biostatistics / Biotechnology / Birth_rate / Birth_weight / Blepharoplasty / Blindness / Blister / BLOOD / Blood_circulation / Blood_component_removal / Blood_culture / Blood_glucose / Blood_platelet_disorders / Blood_platelets / Blood_pressure / Blood_urea_nitrogen / Blood_vessels / Blood_volume / Blood-brain_barrier / Bocavirus / Body_composition / Body_mass_index / Body_size / Body_temperature / Body_weight / Bone_conduction / Bone_density / Bone_regeneration / Bone_transplantation / Botulinum_toxins / Brachytherapy / Brain_diseases / Brain_injuries / Brain_injuries,_traumatic / Brain_neoplasms / Bread / Breast_diseases / Breast_feeding / Breast_implants / Breast_neoplasms / Breeding / Bronchiectasis / Bronchiolitis_obliterans_syndrome / Bronchoalveolar_lavage / Bronchopulmonary_dysplasia / Bronchoscopy / Bruxism / Buffers / Burns / Butter / Calcinosis / Calcitonin / Calcium / Calcium_signaling / Camptothecin / Cancer_pain / Candy / Cannabidiol / Cannula / Capillaries / Capsaicin / Capsules / 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Lysophosphatidylcholines / Lysosomes / Machine_learning / Macrophages / Macrophages,_alveolar / Magnetic_resonance_imaging / Maintenance / Malnutrition / Mammaplasty / Mannans / Mannitol / Mannose-binding_lectin / Mannosyltransferases / Margins_of_excision / Marijuana_use / Marketing / Masculinity / Masks / Mast_cells / Mastitis / Mastitis,_bovine / Mastoiditis / Maternal_mortality / Mathematics / Meals / Meat / Mechanistic_target_of_rapamycin_complex_1 / Medial_tibial_stress_syndrome / Mediation_analysis / Medical_laboratory_science / Medical_marijuana / Medical_oncology / Medical_records / Medical_staff / Medical_waste / Medicare / Medication_adherence / Medication_errors / Medicine,_chinese_traditional / Medicine,_traditional / Meditation / Medulloblastoma / Melanins / Melanoma / Meloxicam / Membrane_proteins / Membranes / Memory / Menarche / Mendelian_randomization_analysis / Meninges / Meningioma / Meningitis / Menstruation / Mental_disorders / Mental_health / 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Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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Oligospermia / Olive_oil / Oncologists / Only_child / Oocyte_donation / Oocytes / Oogenesis / Operative_time / Ophthalmology / Optic_atrophy,_autosomal_dominant / Optic_disk / Optic_nerve / Optic_nerve_diseases / Optogenetics / Oral_hygiene / Oral_microbiome / Organelle_biogenesis / Organoids / Ornithine / Orthomyxoviridae / Orthopedics / Osseointegration / Osteoarthritis / Osteoblasts / Osteoclasts / Osteogenesis / Osteomalacia / Osteonecrosis / Osteoporosis / Osteosarcoma / Otitis / Otitis_media / Otolaryngology / Outpatients / Ovarian_neoplasms / Ovariectomy / Ovary / Overweight / Oviposition / Ovum / Ownership / Oxacillin / Oxaliplatin / Oxidants / Oxidative_stress / Oxidoreductases / Oximetry / Paclitaxel / Paecilomyces / Pain_management / Pain,_postoperative / Paint / Palate / Palliative_care / Palmitic_acid / Pancreas / Pancreatic_cyst / Pancreatic_pseudocyst / Pancreaticoduodenectomy / Pancreatitis / Pandemics / Papillomavirus_infections / Parabens / Paraffin / Paralysis / Paraneoplastic_syndromes / Parasites / Parasitology / Parent-child_relations / Parenteral_nutrition / Parenting / Parkinson_disease / Parotitis / Particulate_matter / Parturition / Pathologists / Patient_care / Patient_discharge / Patient_education_as_topic / Patient_participation / Patient_preference / Patient_reported_outcome_measures / Patient_safety / Patient_satisfaction / Pediatric_emergency_medicine / Pediatrics / Peer_review / Pelvic_pain / Pemphigoid,_bullous / Pemphigus / Penile_prosthesis / Penis / Peptide_hydrolases / Percutaneous_coronary_intervention / Periaqueductal_gray / Pericardium / Periodontitis / Perioperative_care / Peripheral_arterial_disease / Peroxidases / Peroxides / Personality / Perylene / Pesticides / Phaeohyphomycosis / Phagocytes / Phagocytosis / Pharmaceutical_preparations / Pharmaceutical_services / Pharmaceutical_vehicles / Pharmacists / Pharmacokinetics / Pharmacology / Pharmacology,_clinical / Pharmacovigilance / Pharmacy / Pharynx / Phenazines / 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Muscle

Melatonin ameliorates age-related sarcopenia by inhibiting fibrogenic conversion of satellite cell.

The fibrogenic conversion of satellite cells contributes to the atrophy and fibrosis of skeletal muscle, playing a significant role in the pathogenesis of age-related sarcopenia. Melatonin, a hormone secreted by the pineal gland, exhibits anti-aging and anti-fibrotic effects in various...

🗓️ 2024-11-30

📰 Publication: Molecular Medicine

Aging / CELLS / Fibrosis / Galactose / Melatonin / muscles / Sarcopenia / therapeutics

Muscle

Skeletal Muscle P MR Spectroscopy Surpasses CT in Predicting Patient Survival After Liver Transplantation.

Skeletal muscle alterations are associated with higher mortality and morbidity in patients with liver cirrhosis. Assessing these changes seems to be a promising method for identifying patients at a high risk of poor outcomes following liver transplantation (LT). This is...

🗓️ 2024-11-23

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

BLOOD / Blood_cells / cachexia / CELLS / Erythrocyte_transfusion / Erythrocytes / liver / Liver_transplantation / Muscle,_skeletal / muscles / Sarcopenia

Muscle

Targeting Metastasis in Head and Neck Squamous Cell Carcinoma Using Follistatin mRNA Lipid Nanoparticles.

Metastatic progression significantly reduces survival rates and complicates treatment strategies in various cancers. Our study introduces an mRNA therapy for metastasis inhibition by targeting activin A overexpression, a pivotal driver of metastasis and cachexia. Utilizing follistatin mRNA lipid nanoparticles, we...

🗓️ 2024-11-21

📰 Publication: Acs Nano

Activins / cachexia / Carcinoma,_squamous_cell / CELLS / Follistatin / Lipid_nanoparticles / muscles / Nanoparticles / Nanotechnology / Neoplasm_metastasis / neoplasms / Rna,_messenger / Squamous_cell_carcinoma_of_head_and_neck / therapeutics

Exercise

Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise-dependent manner.

Exercise preserves neuromuscular function in aging through unknown mechanisms. Skeletal muscle fibroblasts (FIB) and stem cells (MuSC) are abundant in skeletal muscle and reside close to neuromuscular junctions, but their relative roles in motor neuron maintenance remain undescribed. Using direct...

🗓️ 2024-11-18

📰 Publication: Aging Cell

Aging / CELLS / Fibroblasts / Growth / Microscopy,_electron,_scanning_transmission / Motor_neurons / Muscle,_skeletal / muscles / Neuronal_plasticity / Neurons / Sarcopenia / Stem_cells

Muscle

Durable Muscle Extracellular Matrix Engineered with Adhesive Phenolic Moieties for Effective Skeletal Muscle Regeneration in Muscle Atrophy.

Muscle atrophy detrimentally impacts health and exacerbates physical disability, leading to increased mortality. In particular, sarcopenia, aging-related degenerative muscle loss, necessitates urgent remedies. Current approaches for treating muscle atrophy include exercise and nutrition, while drug exploration remains in its early...

🗓️ 2024-10-17

📰 Publication: Advanced Healthcare Materials

Adhesives / CELLS / Extracellular_matrix / Hydrogels / Muscle,_skeletal / muscles / Muscular_atrophy / Pharmaceutical_preparations / Sarcopenia / therapeutics

Muscle

Emerging Targets and Treatments for Sarcopenia: A Narrative Review.

Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health and quality of life in older adults. This narrative review explores emerging targets and potential treatments for sarcopenia, aiming to provide a...

🗓️ 2024-09-27

CELLS / Food / Genes / muscles / Neuromuscular_junction / Sarcopenia / therapeutics

Cachexia

Impact of Cachexia and First-Line Systemic Therapy for Previously Untreated Advanced Non-Small Cell Lung Cancer: NEJ050A.

Cancer cachexia complicates advanced non-small cell lung cancer (NSCLC); however, it remains unclear how often cachexia occurs and how it affects the course of chemotherapy in patients receiving first-line systemic therapy. We conducted a multicentre, prospective observational study and enrolled...

🗓️ 2024-10-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Anorexia / Cancer-associated_cachexia / Carcinoma,_non-small-cell_lung / CELLS / chemotherapy / Drug_therapy / Lung / Lung_neoplasms / neoplasms / Quality_of_life / Sarcopenia / Small_cell_lung_carcinoma / therapeutics

Sarcopenia Muscle

LRRK2 Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease.

While the gradually aggravated motor and non-motor disorders of Parkinson's disease (PD) lead to progressive disability and frequent falling, skeletal muscle impairment may contribute to this condition. The leucine-rich repeat kinase2 (LRRK2) is a common disease-causing gene in PD. Little...

🗓️ 2024-09-23

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

CELLS / Electromyography / Genes / Mitochondria / Muscle,Skeletal / muscles / Mutation / Parkinsondisease / Sarcopenia

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CELLS

PrP Glycoprotein Is Indispensable for Maintenance of Skeletal Muscle Homeostasis During Aging.

The Effect of Anti-Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice.

Characterization of SARS-CoV-2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection.

Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways.

Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of ≥50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy.

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Melatonin ameliorates age-related sarcopenia by inhibiting fibrogenic conversion of satellite cell.

Skeletal Muscle P MR Spectroscopy Surpasses CT in Predicting Patient Survival After Liver Transplantation.

Targeting Metastasis in Head and Neck Squamous Cell Carcinoma Using Follistatin mRNA Lipid Nanoparticles.

Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise-dependent manner.

Durable Muscle Extracellular Matrix Engineered with Adhesive Phenolic Moieties for Effective Skeletal Muscle Regeneration in Muscle Atrophy.

Emerging Targets and Treatments for Sarcopenia: A Narrative Review.

Impact of Cachexia and First-Line Systemic Therapy for Previously Untreated Advanced Non-Small Cell Lung Cancer: NEJ050A.

LRRK2 Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease.

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