NEJM at ESMO – Ponsegromab in Cancer Cachexia.
๐๏ธ 2024-09-14
๐ฐ Publication: New England Journal Of Medicine
Read MoreNEJM at ESMO – Ponsegromab in Cancer Cachexia.neoplasms
Immunomodulation: A new approach to cancer cachexia, potentially suitable for aging.
Cancer cachexia is the prototypical example of comorbidity, occurring in most of cancer patients. It is a direct consequence of tumor growth and of the associated inflammatory/immune response. Cachexia can be exacerbated by anti-cancer therapies, frequently resulting in dose limitation...
๐๏ธ 2024-09-10
๐ฐ Publication: Molecular Aspects Of Medicine
Read MoreImmunomodulation: A new approach to cancer cachexia, potentially suitable for aging.-mutated NSCLC is Dependent on Tumor-secreted GDF15.
Cachexia is a wasting syndrome comprised of adipose, muscle, and weight loss observed in cancer patients. Tumor loss-of-function mutations in , a regulator of the energy sensor AMP-activated protein kinase, induce cancer cachexia (CC) in preclinical models and are associated...
๐๏ธ 2024-06-17
Read More-mutated NSCLC is Dependent on Tumor-secreted GDF15.Defining and Addressing Research Priorities in Cancer Cachexia through Transdisciplinary Collaboration.
For many patients, the cancer continuum includes a syndrome known as cancer-associated cachexia (CAC), which encompasses the unintended loss of body weight and muscle mass, and is often associated with fat loss, decreased appetite, lower tolerance and poorer response to...
๐๏ธ 2024-06-27
Read MoreDefining and Addressing Research Priorities in Cancer Cachexia through Transdisciplinary Collaboration.Correlates and predictors of sarcopenia among men with metastatic castrate-resistant prostate cancer.
Sarcopenia is a predictor of clinical outcomes in men with metastatic castrate-resistant prostate cancer (mCRPC); however, correlates and predictors of sarcopenia are poorly understood in this population. The aim of this study was to examine correlates and predictors of sarcopenia...
๐๏ธ 2024-07-15
๐ฐ Publication: Cuaj-Canadian Urological Association Journal
Read MoreCorrelates and predictors of sarcopenia among men with metastatic castrate-resistant prostate cancer.Medical imaging in cancer cachexia.
Cancer cachexia, often referred to as "wasting syndrome," is characterized by fatigue, weakness, and involuntary weight loss. This syndrome is concomitant with progressive skeletal muscle atrophy with or without adipose tissue loss and is frequently accompanied by systemic inflammation. Understanding...
๐๏ธ 2024-07-12
Read MoreMedical imaging in cancer cachexia.Assessing cachexia in obesity: contradiction or perfectly possible?
Existing definitions of clinically important weight loss in patients with cancer do not specifically address weight loss in patients who are obese at presentation. This review explores the clinical impact of weight loss and depletion of the skeletal muscle mass...
๐๏ธ 2024-07-04
๐ฐ Publication: Current Opinion In Clinical Nutrition And Metabolic Care
Read MoreAssessing cachexia in obesity: contradiction or perfectly possible?Validity of dietary intake methods in cancer cachexia.
Accurate assessment of dietary intake, especially energy and protein intake, is crucial for optimizing nutritional care and outcomes in patients with cancer. Validation of dietary assessment methods is necessary to ensure accuracy, but the validity of these methods in patients...
๐๏ธ 2024-07-08
๐ฐ Publication: Current Opinion In Supportive And Palliative Care
Read MoreValidity of dietary intake methods in cancer cachexia.Skeletal Muscle Proteome Modifications following Antibiotic-Induced Microbial Disturbances in Cancer Cachexia.
Cancer cachexia is an involuntary loss of body weight, mostly of skeletal muscle. Previous research favors the existence of a microbiota-muscle crosstalk, so the aim of the study was to evaluate the impact of microbiota alterations induced by antibiotics on...
๐๏ธ 2024-06-19
๐ฐ Publication: Journal Of Proteome Research
Read MoreSkeletal Muscle Proteome Modifications following Antibiotic-Induced Microbial Disturbances in Cancer Cachexia.Circulating adipose-tissue miRNAs in gastrointestinal cancer patients and their association with the level and type of adiposity at body composition analysis.
Adipose tissue (AT) wasting in cancer is an early catabolic event with negative impact on outcomes. Circulating miRNAs may promote body weight loss and cachexia. We measured circulating miRNAs linked to AT alterations and compared their levels between i) gastrointestinal...
๐๏ธ 2024-07-30
Read MoreCirculating adipose-tissue miRNAs in gastrointestinal cancer patients and their association with the level and type of adiposity at body composition analysis.Targeted nutritional intervention attenuates experimental lung cancer cachexia.
Cachexia, a syndrome with high prevalence in non-small cell lung cancer patients, impairs quality of life and reduces tolerance and responsiveness to cancer therapy resulting in decreased survival. Optimal nutritional care is pivotal in the treatment of cachexia and a...
๐๏ธ 2024-07-04
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreTargeted nutritional intervention attenuates experimental lung cancer cachexia.In support of rigor and reproducibility in cancer cachexia research.
๐๏ธ 2024-07-31
๐ฐ Publication: Current Opinion In Supportive And Palliative Care
Read MoreIn support of rigor and reproducibility in cancer cachexia research.KLF10: a point of convergence in cancer cachexia.
Cancer-associated cachexia is a wasting syndrome entailing loss in body mass and a shortened life expectancy. There is currently no effective treatment to abrogate this syndrome, which leads to 20-30% of deaths in patients with cancer. While there have been...
๐๏ธ 2024-07-15
๐ฐ Publication: Current Opinion In Supportive And Palliative Care
Read MoreKLF10: a point of convergence in cancer cachexia.Effect of resistance training on physical function during chemotherapy in colon cancer.
The decline of physical function during chemotherapy predicts poor quality of life and premature death. It is unknown if resistance training prevents physical function decline during chemotherapy in colon cancer survivors. This multicenter trial randomly assigned 181 colon cancer survivors...
๐๏ธ 2024-07-16
Read MoreEffect of resistance training on physical function during chemotherapy in colon cancer.Body composition is associated with postoperative complications in perihilar cholangiocarcinoma.
Perihilar cholangiocarcinoma (pCCA) is a malignant tumor of the hepatobiliary system which is still associated with a challenging prognosis. Postoperative complications play a crucial role in determining the overall prognosis of patients with pCCA. Changes in body composition (BC) have...
๐๏ธ 2024-01-01
๐ฐ Publication: Cancer Medicine
Read MoreBody composition is associated with postoperative complications in perihilar cholangiocarcinoma.Cancer cachexia: biomarkers and the influence of age.
Cancer cachexia (Ccx) is a complex metabolic condition characterized by pronounced muscle and fat wasting, systemic inflammation, weakness and fatigue. Up to 30% of cancer patients succumb directly to Ccx, yet therapies that effectively address this perturbed metabolic state are...
๐๏ธ 2024-02-27
๐ฐ Publication: Molecular Oncology
Read MoreCancer cachexia: biomarkers and the influence of age.