SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study.

<p><b>BACKGROUND</b></p><p>Ambient air pollution aggravates cardiovascular-kidney-metabolic (CKM) disorders and sarcopenia, yet the shared genetic and epigenetic mechanisms that underlie their frequent co-occurrence remain poorly understood.</p><p><b>METHODS</b></p><p>We integrated genome-wide association study (GWAS) data for CKM components (cardiovascular disease [CVD], chronic kidney disease [CKD],...

๐Ÿ“ฐ Journal: Metabolism-Clinical And Experimental
Read MoreAir pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study.

Peak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.

<p><b>BACKGROUND</b></p><p>Current evidence indicates an association between peak expiratory flow (PEF) and frailty in older adults, yet critical gaps persist regarding: the longitudinal dynamics of PEF trajectories, their temporal relationships with frailty progression and underlying biological mechanisms. This study aimed to...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePeak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.

Statin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score.

<p><b>BACKGROUND</b></p><p>Statins are cholesterol-lowering drugs widely prescribed for preventing cardiovascular diseases. They may cause adverse effects on skeletal muscle, but it remains unclear whether they affect muscle function and mass. We aimed to evaluate the association between statin use and muscle...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreStatin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score.

The Monocrotaline Model of Hypertension Leads to Cachexia in Male but Not Female Mice.

<p><b>BACKGROUND</b></p><p>The monocrotaline (MCT) model of cardiac cachexia is a pharmaceutical approach to pulmonary hypertension that has been used to study heart failure and muscle wasting in rodents; however, little is known of how this pyrrolizidine alkaloid leads to peripheral changes...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Monocrotaline Model of Hypertension Leads to Cachexia in Male but Not Female Mice.

Mitochondrial stress bridge: Could muscle-derived extracellular vesicles be the missing link between sarcopenia, insulin resistance, and chemotherapy-induced cardiotoxicity?

Sarcopenia is currently considered a systemic condition that goes beyond muscle atrophy to include multifunctional metabolic and cardiovascular dysfunction. The mediators between skeletal muscle loss and entire body insulin resistance and increased vulnerability to cardiotoxicity caused by chemotherapy are not...

๐Ÿ“ฐ Journal: Biomedicine & Pharmacotherapy
Read MoreMitochondrial stress bridge: Could muscle-derived extracellular vesicles be the missing link between sarcopenia, insulin resistance, and chemotherapy-induced cardiotoxicity?

Exploring the potential of ginseng-derived compounds in treating cancer cachexia.

Cancer cachexia is a complex wasting syndrome characterized by significant loss of body weight and muscle mass in patients with advanced cancer. The disease is associated with increased systemic inflammation, altered neurohormonal signaling, and, in particular, an increased catabolic rate...

๐Ÿ“ฐ Journal: Journal Of Ginseng Research
Read MoreExploring the potential of ginseng-derived compounds in treating cancer cachexia.

Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

<p><b>AIM</b></p><p>To investigate effects of host- and gut microbiota (GM)-altering interventions on sarcopenia (parameters).</p><p><b>METHODS</b></p><p>Upon PROSPERO registration (CRD42022347363), six databases and one registry were searched until January 5th 2024 and updated on June 10th 2025 for diet, pre-, pro-, or synbiotics mono-interventions...

๐Ÿ“ฐ Journal: Aging Clinical And Experimental Research
Read MoreEffect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.

Air Pollution Exposure and Muscle Mass and Strength Decline in Older Adults: Results From a Swedish Population-Based Study.

<p><b>BACKGROUND</b></p><p>Emerging evidence suggests that air quality may impact muscle health. However, most studies are limited by cross-sectional designs or short follow-ups. We assessed the association of long-term exposure to ambient air pollutants with changes in muscle mass and strength in...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAir Pollution Exposure and Muscle Mass and Strength Decline in Older Adults: Results From a Swedish Population-Based Study.

Utilizing accelerated and delayed murine models of aging to address the "healthspan issue" – A review of skeletal muscle health.

The gap between lifespan and healthspan is increasing globally, resulting in millions of individuals spending additional years burdened by frailty or disease. This disparity, paired with the increasingly aged populations of Western nations, poses a palpable predicament to public health...

๐Ÿ“ฐ Journal: Ageing Research Reviews
Read MoreUtilizing accelerated and delayed murine models of aging to address the "healthspan issue" – A review of skeletal muscle health.

Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis.

Sarcopenia, a prevalent age-related degenerative disorder, poses significant challenges in geriatric care. Chinese leek demonstrates therapeutic potential against sarcopenia progression, with emerging evidence suggesting its extracellular vesicles (EVs) may mediate these effects. Notably, plant-derived EVs have garnered increasing attention due...

๐Ÿ“ฐ Journal: Journal Of Nanobiotechnology
Read MoreChinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis.

Revisiting Cancer Cachexia Staging: Introducing an "At Risk" Category Based on AWGC Components.

Cancer cachexia is a multifactorial syndrome characterized by progressive weight loss, muscle wasting, and systemic inflammation. Early identification of individuals at risk for cachexia is essential for timely intervention, yet a universally accepted definition of the "at risk" stage remains...

๐Ÿ“ฐ Journal: Thoracic Cancer
Read MoreRevisiting Cancer Cachexia Staging: Introducing an "At Risk" Category Based on AWGC Components.

Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG.

Browning of white adipose tissue (WAT) contributes to the sustained hypermetabolism observed in patients with burns. How glycogen metabolism in WAT is linked to burn-induced hypermetabolism remains unknown. We discover that burn-induced UCP1 expression in subcutaneous WAT is accompanied by...

๐Ÿ“ฐ Journal: Cell Reports
Read MoreBlocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG.

Alternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1.

<p><b>BACKGROUND</b></p><p>Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder characterized by CTG repeat expansion in the 3' untranslated region of the dystrophia myotonica protein kinase coding gene. The presence of expanded CTG repeats in DMPK mRNAs leads to the...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAlternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1.

The canonical ER stress IRE1ฮฑ/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.

Cancer cachexia is a debilitating syndrome characterized by the progressive loss of skeletal muscle mass with or without fat loss. Recent studies have implicated dysregulation of the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) pathways in skeletal muscle under...

๐Ÿ“ฐ Journal: Embo Molecular Medicine
Read MoreThe canonical ER stress IRE1ฮฑ/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.

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