SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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An exploratory multi-biomarker panel including fecal calprotectin, Brain-Derived Neurotrophic Factor, Fibroblast-Growth Factor-21 and irisin shows poor diagnostic accuracy for detecting probable sarcopenia in community-dwelling older persons.

📰 Journal: Aging Clinical And Experimental Research
Read MoreAn exploratory multi-biomarker panel including fecal calprotectin, Brain-Derived Neurotrophic Factor, Fibroblast-Growth Factor-21 and irisin shows poor diagnostic accuracy for detecting probable sarcopenia in community-dwelling older persons.

Effects of Nandrolone Decanoate on Muscle Strength, Body Composition and Bone Density: A Systematic Review and Meta-Analysis.

BACKGROUND

Despite ongoing interest in anabolic therapies for sarcopenia and cachexia, pharmacological interventions are being developed to counteract age- and condition-related losses of muscle mass and strength. This systematic review and meta-analysis evaluated the effect of nandrolone decanoate on lean soft...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEffects of Nandrolone Decanoate on Muscle Strength, Body Composition and Bone Density: A Systematic Review and Meta-Analysis.

Systemic inflammation and body composition profiles are dependent on ethnicity in colorectal cancer.

INTRODUCTION

Changes in body composition (BC) are associated with outcomes in colorectal cancer (CRC), with adverse features such as sarcopenia, myosteatosis, and excess adiposity linked to the systemic inflammatory response (SIR). Whilst ethnic differences in BC have been identified in healthy...

📰 Journal: Supportive Care In Cancer
Read MoreSystemic inflammation and body composition profiles are dependent on ethnicity in colorectal cancer.

AI-assessed sarcopenia as an independent predictor of neoadjuvant chemotherapy outcomes in muscle-invasive bladder cancer.

PURPOSE

Sarcopenia has already been widely investigated as a potential indicator of negative outcomes in oncology patients. Our aim was to evaluate the potential predictive role of sarcopenia assessed using an Artificial Intelligence-powered software in response to neoadjuvant chemotherapy (NAC) in...

📰 Journal: Radiologia Medica
Read MoreAI-assessed sarcopenia as an independent predictor of neoadjuvant chemotherapy outcomes in muscle-invasive bladder cancer.

Association of Nutrition Impact Symptoms With Sleep Disturbance Among Patients With Advanced Cancer Referred to Palliative Care: A Secondary Analysis of a Multicenter Survey.

ObjectivesWe investigated the associations of nutrition impact symptoms (NISs) with sleep disturbance among advanced cancer patients receiving palliative care.MethodsA secondary analysis of a self-administered survey was performed. Participants evaluated 3 components of sleep disturbance (ie, difficulty falling asleep, difficulty staying...

📰 Journal: Journal Of Palliative Care
Read MoreAssociation of Nutrition Impact Symptoms With Sleep Disturbance Among Patients With Advanced Cancer Referred to Palliative Care: A Secondary Analysis of a Multicenter Survey.

Association between sarcopenic obesity and worsening physical performance in patients undergoing hemodialysis: The REPnet-HD study.

OBJECTIVE

Sarcopenic obesity, defined by excess fat mass with concurrent sarcopenia, is an emerging public health concern. In patients undergoing hemodialysis, reduced physical performance is associated with poor prognosis. This study aimed to investigate association between sarcopenic obesity and worsening physical...

📰 Journal: Journal Of Renal Nutrition
Read MoreAssociation between sarcopenic obesity and worsening physical performance in patients undergoing hemodialysis: The REPnet-HD study.

Blood and urine cell-free circulating DNA in older adults with sarcopenia: a hypothesis-generating study.

PURPOSE

This preliminary study evaluated effect sizes of differences in circulating cell-free DNA (cfDNA) levels in blood and urine between older adults with and without sarcopenia.

METHODS

This was a subanalysis of the 2021 Itabashi Longitudinal Study on Aging. Twenty-four participants were selected...

📰 Journal: European Geriatric Medicine
Read MoreBlood and urine cell-free circulating DNA in older adults with sarcopenia: a hypothesis-generating study.

Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.

BACKGROUND

Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome.

Moderate Aerobic Training Causes Muscle Wasting in a DMBA-Induced Sarcoma Rat Model.

Cancer cachexia, characterized by severe body weight loss, negatively affects patient quality of life and survival. Although moderate exercise benefits healthy and chronically ill individuals, and the effect of exercise in cachexia generally appears beneficial, conflicting results have been reported...

📰 Journal: International Journal Of Molecular Sciences
Read MoreModerate Aerobic Training Causes Muscle Wasting in a DMBA-Induced Sarcoma Rat Model.

Advancing sarcopenia assessment with wearable and app-based technology: a scoping review.

Sarcopenia, a condition characterized by loss of skeletal muscle mass (SMM) and strength, contributes to frailty, disability, and increased healthcare burden, yet remains underdiagnosed due to limitations of conventional assessment methods. Wearable and mobile technologies have emerged as potential tools...

📰 Journal: Journal Of Nutrition Health & Aging
Read MoreAdvancing sarcopenia assessment with wearable and app-based technology: a scoping review.

Muscle Movement and Metabolism: Exercise and Skeletal Muscle as Mediators of Health. A Report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.

Skeletal muscle is a crucial facilitator of many of the effects of exercise on metabolic health. Intrinsic myocellular mechanisms, exercise-induced myokine secretion, and crosstalk between multiple organ systems contribute to the maintenance of energy homeostasis, cardiovascular health, strength, cognition, and...

📰 Journal: American Journal Of Clinical Nutrition
Read MoreMuscle Movement and Metabolism: Exercise and Skeletal Muscle as Mediators of Health. A Report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.

Cerebral palsy (CP) is the most common cause of childhood-onset physical disability. It results from injury to the developing brain and is characterized by motor impairments, muscle weakness, and fatigue. CP is commonly associated with marked deficits in muscle mass...

📰 Journal: Faseb Journal
Read MoreDoes Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction.

Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis.

BACKGROUND

Cachexia is a debilitating syndrome associated with involuntary weight loss, often occurring in cancer patients. In both humans and animal models, alterations in endocannabinoid (eCB) signaling occur in association with both metabolic disorders and several types of tumors. The wider...

Read MoreChanges in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis.

Exploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

INTRODUCTION

People with chronic kidney disease (CKD) often experience poor muscle quality and elevations in skeletal muscle wasting and dysfunction, contributing to a reduced quality of life and an increased risk of morbidity and mortality. The adipokine chemerin is associated with...

📰 Journal: Translational Research
Read MoreExploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

A Novel Mouse Model to Identify Antigen-Specific Immune Responses in Pancreatic Cancer Cachexia.

BACKGROUND

Pancreatic Ductal Adenocarcinoma (PDAC) has a dismal five-year survival rate of 13% and is closely associated with cachexia. Cancer cachexia is a multifactorial syndrome characterized by irreversible wasting of skeletal muscles, fat loss and systemic inflammation. While cachexia is known...

Read MoreA Novel Mouse Model to Identify Antigen-Specific Immune Responses in Pancreatic Cancer Cachexia.

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