SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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A Murinized Bimagrumab Analogue Increases Skeletal Muscle Mass and Improves Cardiometabolic Remodelling in Experimental Hypertrophic Cardiomyopathy.

BACKGROUND

Hypertrophic cardiomyopathy (HCM) involves left ventricular hypertrophy and metabolic dysfunction. Given the role of skeletal muscle in systemic metabolism, we investigated whether activin type II receptor inhibition with CDD866, a murinized bimagrumab analogue that induces skeletal muscle hypertrophy, improves physical...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreA Murinized Bimagrumab Analogue Increases Skeletal Muscle Mass and Improves Cardiometabolic Remodelling in Experimental Hypertrophic Cardiomyopathy.

ZIF-8-Based Nanodelivery of Tectorigenin for Alleviating Skeletal Muscle Atrophy via Inhibition of Oxidative Stress and Inflammation.

BACKGROUND

Skeletal muscle atrophy is a pathological condition characterized by a progressive loss of muscle mass and function. Its core mechanisms involve an imbalance between protein synthesis and degradation, caused by oxidative stress and inflammation. Tectorigenin (TG) shows therapeutic potential but...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreZIF-8-Based Nanodelivery of Tectorigenin for Alleviating Skeletal Muscle Atrophy via Inhibition of Oxidative Stress and Inflammation.

Deuterium-Oxide Labelling Proteomics Illustrates the Importance of Sample Timing and the Limitations of Serial Biopsies.

BACKGROUND

Measuring in vivo protein synthesis is important for testing how interventions, disease and ageing remodel the proteome. A limitation of approaches using short-term infusions of labelled amino acids was that long-term changes had to be extrapolated from short-term measurements. Deuterium oxide...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeuterium-Oxide Labelling Proteomics Illustrates the Importance of Sample Timing and the Limitations of Serial Biopsies.

The effect of tilt-table robot-assisted training on functional outcomes in people with stroke and sarcopenia: a retrospective cohort study.

BACKGROUND

This study compared changes in physical function following tilt-table robot-assisted training between stroke patients with and without sarcopenia. The aim was to investigate whether sarcopenia influences functional recovery during rehabilitation.

METHODS

A total of 74 stroke patients who received tilt-table robot-assisted training...

Read MoreThe effect of tilt-table robot-assisted training on functional outcomes in people with stroke and sarcopenia: a retrospective cohort study.

Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle.

Cancer cachexia is a debilitating syndrome of involuntary body mass loss featuring profound skeletal muscle wasting and high mortality. Cardiac muscle wasting is prominent in cancer patients and cancer survivors. We developed a human induced pluripotent stem cell-derived cardiac myocyte...

Read MoreElucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle.

Metabolomics Reveals Multiple Metabolic Alterations and Biomarkers of Disease Severity in Facioscapulohumeral Muscle Dystrophy.

BACKGROUND

Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is one of the most common adult-onset myopathies and is causally associated with a contraction of the D4Z4 macrosatellite repeat array on chromosome 4. It presents with a variable pattern of progressive muscle weakness...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMetabolomics Reveals Multiple Metabolic Alterations and Biomarkers of Disease Severity in Facioscapulohumeral Muscle Dystrophy.

Atovaquone impedes muscle wasting in pancreatic cancer by AMPK modulation.

Cancer-induced cachexia is a multifactorial syndrome characterized by systemic inflammation and progressive skeletal muscle and fat wasting. More than 80% pancreatic cancer patients exhibit a cachectic phenotype, which significantly contributes to the overall mortality of cancer patients. Till now, there...

📰 Journal: Cancer Letters
Read MoreAtovaquone impedes muscle wasting in pancreatic cancer by AMPK modulation.

Molecular targets for the treatment of sarcopenia: a geroscience approach.

INTRODUCTION

Sarcopenia is increasingly recognized as a multisystem geroscience condition. The limited efficacy of first-generation anabolic therapies has challenged the paradigm that increasing muscle mass is sufficient to restore physical performance, highlighting the need for therapeutic strategies that address the biological...

📰 Journal: Expert Opinion On Therapeutic Targets
Read MoreMolecular targets for the treatment of sarcopenia: a geroscience approach.

Sexually Dimorphic Response to Dietary Restriction-Induced Longevity and Muscle Preservation in Nothobranchius furzeri.

Age-related skeletal muscle decline (sarcopenia) contributes to frailty and mortality, yet how sex influences muscle aging and dietary interventions remains unclear. Using the short-lived vertebrate Nothobranchius furzeri, we investigated how sex and intermittent fasting (IF) interact to regulate lifespan and...

📰 Journal: Aging Cell
Read MoreSexually Dimorphic Response to Dietary Restriction-Induced Longevity and Muscle Preservation in Nothobranchius furzeri.

Bioactive isoprenylflavonoids contribute to the dual protective effects of Xianling Gubao against sarcopenia and osteoarthritis in SAMP8 mice.

BACKGROUND

Osteoarthritis and sarcopenia increasingly contribute to the burden of age-related musculoskeletal disorders. Xianling Gubao (XLGB), a traditional Chinese medicine formula, has been used for musculoskeletal conditions including osteoporosis and osteoarthritis; however, its effects on sarcopenia and structural joint degeneration, and...

📰 Journal: Journal Of Orthopaedic Translation
Read MoreBioactive isoprenylflavonoids contribute to the dual protective effects of Xianling Gubao against sarcopenia and osteoarthritis in SAMP8 mice.

Chronic Exercise Accelerates Disease Progression in a Rat Model of Desminopathy.

BACKGROUND

Desminopathy is a progressive myopathy and the most common intermediate filament disease in humans. Desmin is an essential part of the filamentous network that aligns myofibrils, anchors nuclei and mitochondria and connects the z discs to the sarcolemma. We challenged...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreChronic Exercise Accelerates Disease Progression in a Rat Model of Desminopathy.

Mitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca 2+ Overload-Mitophagy-Ferroptosis Circuit.

BACKGROUND

Denervation-induced muscle atrophy progresses during the interval between nerve injury and reinnervation, and depletion of muscle satellite cells (MuSCs) contributes to impaired functional recovery. Although mitochondrial dysfunction and impaired quality control are implicated in muscle wasting, whether excessive mitochondrial turnover...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca 2+ Overload-Mitophagy-Ferroptosis Circuit.

S100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

BACKGROUND

In patients with neuroblastoma (NB), skeletal muscle atrophy is a key factor linked to poor survival and decreased long-term quality of life. Nevertheless, there are still insufficient therapeutic methods that work, and the underlying mechanisms remain unclear. As persistent inflammation...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreS100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice.

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both sexes. Using different mouse models,...

📰 Journal: Nature Communications
Read MoreNeonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice.

Remodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

BACKGROUND

The global prevalence of iron deficiency anaemia (IDA) is about 25% and even higher in women of reproductive age and children. IDA can impair skeletal muscle by disrupting oxygen utilization, energy production and contractile function. Haematological effects of intravenous (IV)...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRemodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

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