SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

Alternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1.

<p><b>BACKGROUND</b></p><p>Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder characterized by CTG repeat expansion in the 3' untranslated region of the dystrophia myotonica protein kinase coding gene. The presence of expanded CTG repeats in DMPK mRNAs leads to the...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAlternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1.

The canonical ER stress IRE1ฮฑ/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.

Cancer cachexia is a debilitating syndrome characterized by the progressive loss of skeletal muscle mass with or without fat loss. Recent studies have implicated dysregulation of the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) pathways in skeletal muscle under...

๐Ÿ“ฐ Journal: Embo Molecular Medicine
Read MoreThe canonical ER stress IRE1ฮฑ/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.

Is Appendicular Lean Soft Tissue Mass a Clinically Valid Diagnostic Marker for Sarcopenia?

<p><b>AIM</b></p><p>Geriatric experts have long debated the inclusion of appendicular lean soft tissue mass (ALSTM) in the diagnostic criteria for sarcopenia. This study examined whether a diagnostic model for sarcopenia that excludes appendicular lean soft tissue mass (ALSTM) is equivalent to...

๐Ÿ“ฐ Journal: Geriatrics & Gerontology International
Read MoreIs Appendicular Lean Soft Tissue Mass a Clinically Valid Diagnostic Marker for Sarcopenia?

Small-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms.

<p><b>BACKGROUND</b></p><p>Mechanical inactivity rapidly induces diaphragm muscle fibres' contractile dysfunction and atrophy. Diaphragm weakness can impair respiratory function, quality of life and increase risks of morbidity and mortality. Muscle RING-finger protein-1 (MuRF1) expression is upregulated during denervation and muscle inactivity and...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSmall-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms.

Rise and Fall of Physical Capacity in a General Population: A 47-Year Longitudinal Study.

<p><b>BACKGROUND</b></p><p>As we age, there is a progressive decline in skeletal muscle tissue and function that can become clinically significant in the sixth decade of life affecting independent living and health. Longitudinal observations in elite athletes show that peak physical performance...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRise and Fall of Physical Capacity in a General Population: A 47-Year Longitudinal Study.

3D Body Scanning-Derived Normative Values of Appendicular Circumferences: A Novel Tool for Sarcopenia Screening in Chinese Adults.

<p><b>BACKGROUND</b></p><p>Appendicular circumferences (ACs) are critical predictors of skeletal health, cardiovascular disease risk and mortality. Currently, comprehensive reference values and associated factors for thigh (TC), calf (CC), upper arm (UAC) and forearm (FC) circumferences remain unestablished in Chinese adults.</p><p><b>METHODS</b></p><p>This community-based cross-sectional...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read More3D Body Scanning-Derived Normative Values of Appendicular Circumferences: A Novel Tool for Sarcopenia Screening in Chinese Adults.

Pathways Contributing to Chemotherapy-Induced Myotoxicity Are Attenuated by EPAโ€‰+โ€‰DHA in a Clinically Relevant Model of Colorectal Cancer.

<p><b>BACKGROUND</b></p><p>Skeletal muscle loss is a well-recognized consequence of cancer, and chemotherapy exacerbates myotoxicity through multiple mechanisms. Retaining muscle mass improves tumour response to therapies and tolerance to chemotherapy; hence, interventions to mitigate myotoxicity warrant investigations. This study aimed to investigate...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePathways Contributing to Chemotherapy-Induced Myotoxicity Are Attenuated by EPAโ€‰+โ€‰DHA in a Clinically Relevant Model of Colorectal Cancer.

Differences in peak oxygen uptake in heart failure patients with and without cachexia: A systematic review and meta-analysis.

Chronic heart failure (CHF) is characterized by reduced peak oxygen consumption (VO 2peak). Cachexia may exacerbate the decline in VO 2peak from reductions in muscle mass and strength. We sought to assess differences in VO 2peak between patients with CHF...

Read MoreDifferences in peak oxygen uptake in heart failure patients with and without cachexia: A systematic review and meta-analysis.

Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.

<p><b>BACKGROUND</b></p><p>Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.</p><p><b>METHODS</b></p><p>A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and...

๐Ÿ“ฐ Journal: Ebiomedicine
Read MoreSkeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.

Different Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.

Sarcopenia, characterized by decreased skeletal muscle mass and strength, is classified as "primary" (due to aging) or "secondary" (due to diseases). MicroRNA-22-3p (miR-22) regulates muscle differentiation and function. We assessed the diagnostic value of circulating miR-22 levels in patients with...

๐Ÿ“ฐ Journal: Aging Cell
Read MoreDifferent Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.

<p><b>BACKGROUND</b></p><p>Systemic muscle wasting is a prevalent condition that predicts adverse health outcomes in aging and disease. Despite its clinical relevance, the development of predictive biomarkers and effective pharmacological therapies remains limited. Peptides have recently gained attention for their diverse bioactive...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRole of Peptides in Skeletal Muscle Wasting: A Scoping Review.

Impaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia.

Skeletal muscle wasting is a defining feature of cancer cachexia, a multifactorial syndrome that drastically compromises patient quality of life and treatment outcomes. Mitochondrial dysfunction is a major contributor to skeletal muscle wasting in cancer cachexia, yet the upstream molecular...

Read MoreImpaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia.

Primary-Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity.

<p><b>BACKGROUND</b></p><p>Colon cancer (CC), the third most common cancer worldwide, is accompanied by cachexia in 30% of patients. Its associated muscle loss directly impairs therapeutic response and survival. Early intervention is crucial, yet the underlying mechanisms of early-stage muscle dysfunction remain...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePrimary-Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity.

Advancements of investigational agents for cancer cachexia: what clinical progress have we seen in the last 5โ€‰years?

<p><b>INTRODUCTION</b></p><p>Cancer cachexia is a multifactorial syndrome affecting up to 80% of advanced cancer patients, associated with poor quality of life, increased cancer-treatment toxicity, and reduced survival. Despite its clinical burden, no FDA- or EMA-approved pharmacologic therapies currently exist.</p><p><b>AREAS COVERED</b></p><p>This review...

๐Ÿ“ฐ Journal: Expert Opinion On Investigational Drugs
Read MoreAdvancements of investigational agents for cancer cachexia: what clinical progress have we seen in the last 5โ€‰years?

A Creatinine-CAR Composite Index (CCAR) Optimized by Machine Learning for Prognosis in Cancer Cachexia.

<p><b>BACKGROUND</b></p><p>Cancer cachexia is a multifactorial syndrome associated with poor prognosis and impaired quality of life in cancer patients. However, survival prediction in cancer cachexia remains difficult due to the lack of reliable biomarkers.</p><p><b>METHODS</b></p><p>This retrospective cohort study analysed data from 1,367...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreA Creatinine-CAR Composite Index (CCAR) Optimized by Machine Learning for Prognosis in Cancer Cachexia.

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