SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopeniaWasting Disorders

Sexually Dimorphic Response to Dietary Restriction-Induced Longevity and Muscle Preservation in Nothobranchius furzeri.

Age-related skeletal muscle decline (sarcopenia) contributes to frailty and mortality, yet how sex influences muscle aging and dietary interventions remains unclear. Using the short-lived vertebrate Nothobranchius furzeri, we investigated how sex and intermittent fasting (IF) interact to regulate lifespan and...

📰 Journal: Aging Cell
Read MoreSexually Dimorphic Response to Dietary Restriction-Induced Longevity and Muscle Preservation in Nothobranchius furzeri.

Bioactive isoprenylflavonoids contribute to the dual protective effects of Xianling Gubao against sarcopenia and osteoarthritis in SAMP8 mice.

BACKGROUND

Osteoarthritis and sarcopenia increasingly contribute to the burden of age-related musculoskeletal disorders. Xianling Gubao (XLGB), a traditional Chinese medicine formula, has been used for musculoskeletal conditions including osteoporosis and osteoarthritis; however, its effects on sarcopenia and structural joint degeneration, and...

📰 Journal: Journal Of Orthopaedic Translation
Read MoreBioactive isoprenylflavonoids contribute to the dual protective effects of Xianling Gubao against sarcopenia and osteoarthritis in SAMP8 mice.

Chronic Exercise Accelerates Disease Progression in a Rat Model of Desminopathy.

BACKGROUND

Desminopathy is a progressive myopathy and the most common intermediate filament disease in humans. Desmin is an essential part of the filamentous network that aligns myofibrils, anchors nuclei and mitochondria and connects the z discs to the sarcolemma. We challenged...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreChronic Exercise Accelerates Disease Progression in a Rat Model of Desminopathy.

Mitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca 2+ Overload-Mitophagy-Ferroptosis Circuit.

BACKGROUND

Denervation-induced muscle atrophy progresses during the interval between nerve injury and reinnervation, and depletion of muscle satellite cells (MuSCs) contributes to impaired functional recovery. Although mitochondrial dysfunction and impaired quality control are implicated in muscle wasting, whether excessive mitochondrial turnover...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca 2+ Overload-Mitophagy-Ferroptosis Circuit.

S100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

BACKGROUND

In patients with neuroblastoma (NB), skeletal muscle atrophy is a key factor linked to poor survival and decreased long-term quality of life. Nevertheless, there are still insufficient therapeutic methods that work, and the underlying mechanisms remain unclear. As persistent inflammation...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreS100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice.

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both sexes. Using different mouse models,...

📰 Journal: Nature Communications
Read MoreNeonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice.

Remodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

BACKGROUND

The global prevalence of iron deficiency anaemia (IDA) is about 25% and even higher in women of reproductive age and children. IDA can impair skeletal muscle by disrupting oxygen utilization, energy production and contractile function. Haematological effects of intravenous (IV)...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRemodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

Correction to "Sarcopenia, adiposity and large discordance between cystatin C and creatinine-based estimated glomerular filtration rate in patients with cancer".

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCorrection to "Sarcopenia, adiposity and large discordance between cystatin C and creatinine-based estimated glomerular filtration rate in patients with cancer".

Circulating lipocalin-2 is associated with systemic inflammation and cachexia-related features in patients with gastrointestinal cancer.

BACKGROUND

Cancer-associated anorexia (AN) and cachexia are frequent and debilitating complications of cancer, driven by systemic inflammation and metabolic dysregulation. Lipocalin 2 (LCN2) has been implicated in immune-metabolic integration and central appetite control, however data in cancer patients are limited. This...

📰 Journal: Frontiers In Nutrition
Read MoreCirculating lipocalin-2 is associated with systemic inflammation and cachexia-related features in patients with gastrointestinal cancer.

Interprofessional selection and integration of multimodal cachexia interventions into cancer care: an interpretive description study.

PURPOSE

Cancer cachexia negatively impacts health, quality of life and prognosis. Although clinical guidelines and evidence support multimodal management to improve patient outcomes, challenges remain in translating recommendations into clinical practice. This study describes how an interprofessional (IP) team selects and...

📰 Journal: Supportive Care In Cancer
Read MoreInterprofessional selection and integration of multimodal cachexia interventions into cancer care: an interpretive description study.

Baseline Physical Frailty Predicts Clinical Outcomes During Lecanemab Therapy in Early Alzheimer's Disease: A Prospective Real-World Cohort Study.

BACKGROUND

Physical frailty and sarcopenia are recognized as determinants of Alzheimer's disease (AD) progression, but their implications during anti-amyloid therapy remain unclear. We investigated their associations with longitudinal cognitive outcomes, treatment safety, tolerability, and plasma p-tau217 trajectories in patients with early...

📰 Journal: Aging And Disease
Read MoreBaseline Physical Frailty Predicts Clinical Outcomes During Lecanemab Therapy in Early Alzheimer's Disease: A Prospective Real-World Cohort Study.

NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway.

Cancer-associated cachexia (CAC) is a devastating multifactorial syndrome characterized by progressive skeletal muscle atrophy. Its mechanisms remain incompletely clarified, with limited effective therapeutic targets. NUB1, a negative regulator of ubiquitin-like proteins mediating protein degradation, has not been fully elucidated in...

Read MoreNUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway.

Associations of Coexisting Metabolic Dysfunction-Associated Steatotic Liver Disease and Sarcopenia-Related Abnormalities With Adverse Clinical Outcomes Across Obesity States.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with adverse liver and non-liver outcomes, but the impact of coexisting sarcopenia-related abnormalities (e.g., low muscle strength [MS], muscle mass, and physical performance) remains unclear. In a prospective UK Biobank cohort (n...

Read MoreAssociations of Coexisting Metabolic Dysfunction-Associated Steatotic Liver Disease and Sarcopenia-Related Abnormalities With Adverse Clinical Outcomes Across Obesity States.

Dual Neuromodulation Remodels Neuro-Immune Crosstalk and Chemokine Network for Combating Postoperative Progression of Prostate Cancer.

The autonomic nerves drive prostate cancer (PCa) progression, yet a strategy for dual modulation of sympathetic and parasympathetic nerves remains undeveloped. Here, building on the multicenter clinical findings, we develop a personalized nanotechnology-enabled dual neurotherapy (denoted as ADNT) for PCa....

📰 Journal: Advanced Materials
Read MoreDual Neuromodulation Remodels Neuro-Immune Crosstalk and Chemokine Network for Combating Postoperative Progression of Prostate Cancer.

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