SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Do muscle strength cut-offs used to define sarcopenia affect trajectories of disability progression in basic activities of daily living in older adults?

OBJECTIVE

This study aims to analyse trajectories of disability progression in basic activities of daily living (BADLs) as a function of sarcopenia, using different cut-off points for defining low muscle strength (LMS).

METHODS

A longitudinal study included 3,328 participants from the English Longitudinal...

📰 Journal: Archives Of Gerontology And Geriatrics
Read MoreDo muscle strength cut-offs used to define sarcopenia affect trajectories of disability progression in basic activities of daily living in older adults?

Adenosine monophosphate-activated protein kinase: A golden mediator of exercise in metabolic dysfunction-associated diseases (review).

Metabolic diseases represent a major threat to human health and are largely associated with excessive energy intake and insufficient energy expenditure. Increasing evidence indicates that obesity, diabetes, metabolic dysfunction-associated fatty liver disease, sarcopenia, Alzheimer's disease, and cancer are closely associated...

📰 Journal: International Journal Of Biological Macromolecules
Read MoreAdenosine monophosphate-activated protein kinase: A golden mediator of exercise in metabolic dysfunction-associated diseases (review).

Body Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

BACKGROUND

Metabolic and musculoskeletal abnormalities in patients with heart failure (HF) may not be fully captured by body mass index.

OBJECTIVES

Body composition was studied in participants with HF and matched control subjects in the UK Biobank Imaging Study, and findings were compared...

📰 Journal: Jacc-Heart Failure
Read MoreBody Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.

Preoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.

BACKGROUND & AIMS

Cancer cachexia is associated with systemic skeletal muscle loss and poor survival; however, early muscle changes preceding systemic muscle loss remain unclear. Therefore, this study aimed to determine whether tongue-complex muscle area (TCMA) can serve as an early...

📰 Journal: Clinical Nutrition
Read MorePreoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.

Type 5 Diabetes Mellitus: Pathophysiology, Clinical Phenotype, and Nutritional Management.

Type 5 Diabetes Mellitus (T5DM) is an emerging diabetes phenotype linked to chronic undernutrition. It predominantly affects young, lean individuals in low- and middle-income countries. After its formal recognition by the International Diabetes Federation in 2025, T5DM resurfaced as a...

📰 Journal: Diabetes-Metabolism Research And Reviews
Read MoreType 5 Diabetes Mellitus: Pathophysiology, Clinical Phenotype, and Nutritional Management.

Bile salt hydrolase-active bifidobacterium animalis improves sarcopenia via the gut microbiota-bile acid-FXR-FGF15 axis and its functional fermented milk preparation.

Sarcopenia is a major global health challenge associated with aging, and effective pharmacological treatments are lacking. This study investigated how bile salt hydrolase (BSH)-active probiotics alleviate sarcopenia through bile acid deconjugation and remodeling, activating the intestinal FXR-FGF15/19 signaling pathway, and...

📰 Journal: Food Chemistry
Read MoreBile salt hydrolase-active bifidobacterium animalis improves sarcopenia via the gut microbiota-bile acid-FXR-FGF15 axis and its functional fermented milk preparation.

Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing.

BACKGROUND

Sarcopenia is a major contributor to frailty and mortality in ageing and obesity and is tightly linked to metabolic dysfunction. Imeglimin is a first-in-class oral hypoglycaemic agent targeting mitochondrial function; however, despite the central role of mitochondria in skeletal muscle...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing.

The Muscle-Liver Immunometabolic Axis in Liver Transplantation: A Decisive Role in Outcomes and Mechanisms.

Liver transplantation has transformed survival for end-stage liver disease, shifting clinical attention from acute rejection to longer-term vulnerability driven by metabolic dysfunction and loss of skeletal-muscle reserve. In this Review, we examine liver transplantation through the muscle-liver immunometabolic axis across...

📰 Journal: International Journal Of Biological Sciences
Read MoreThe Muscle-Liver Immunometabolic Axis in Liver Transplantation: A Decisive Role in Outcomes and Mechanisms.

A C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.

Sarcopenia is a manifestation of musculoskeletal aging, yet no approved therapy is available. A major challenge is not the lack of potential interventions, but the difficulty of efficiently identifying which candidates should advance to aged-mammal validation. Sarcopenia is driven by...

📰 Journal: Aging And Disease
Read MoreA C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.

Therapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice.

Cancer cachexia is a life-threatening wasting syndrome that can be driven by tumor-derived GDF15 signaling through the brainstem-restricted receptor GFRAL. Despite its clinical importance, central genetic interventions targeting this axis remain limited. Here, we develop a potent antisense oligonucleotide (Gfral-ASO,...

📰 Journal: Cell Reports Medicine
Read MoreTherapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice.

Tracking Perioperative Inflammation over Time: A Prospective Observational Study on the Longitudinal Dynamics of CRP and GDF-15.

Background: C-reactive protein (CRP) is a well-established marker of systemic inflammation, while Growth Differentiation Factor-15 (GDF-15) has emerged as a potential biomarker of cellular stress. Their relative perioperative dynamics remain incompletely defined. This prospective observational study aimed to explicitly characterize...

Read MoreTracking Perioperative Inflammation over Time: A Prospective Observational Study on the Longitudinal Dynamics of CRP and GDF-15.

YAP1-Driven Pathogenic Fibro-Adipogenic Progenitors Secrete IL-6 and FGF21 to Mediate Muscle-Bone Crosstalk and Promote Bone Loss.

Sarcopenia, an age-related degenerative disease of skeletal muscle, is closely associated with osteoporosis and other bone disorders, partly due to dysregulated endocrine function of skeletal muscle. However, the specific cellular sources and molecular mechanisms driving this pathological secretory phenotype remain...

Read MoreYAP1-Driven Pathogenic Fibro-Adipogenic Progenitors Secrete IL-6 and FGF21 to Mediate Muscle-Bone Crosstalk and Promote Bone Loss.

Prevalence of sarcopenia and individual- and country-level risk factors in 36 countries: pooled analysis of nationally representative individual data.

BACKGROUND

Sarcopenia is an age-related condition that contributes to disability and healthcare burden worldwide. Yet cross-national evidence on prevalence and multi-level risk factors is limited.

METHODS

We pooled data from 10 nationally representative or population-based ageing studies, including 144 226 adults aged ≥50 years...

📰 Journal: Age And Ageing
Read MorePrevalence of sarcopenia and individual- and country-level risk factors in 36 countries: pooled analysis of nationally representative individual data.

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