SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopeniaWasting Disorders

Positive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.

The muscle nicotinic acetylcholine receptor (AChR) is the key mediator of neuromuscular signal transmission and is essential for all voluntary movement in our body. In this study, we present DC-98-LC74, a positive allosteric modulator (PAM) for the adult skeletal muscle-type...

📰 Journal: Proceedings Of The National Academy Of Sciences Of The United States Of America
Read MorePositive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.

Prognostic impact of weight loss during first-line chemotherapy in extensive-disease small cell lung cancer.

PURPOSE

The adverse prognostic impact of cancer cachexia is well recognized. We aimed to evaluate the prognostic impact of weight loss during first-line platinum-based chemo(immuno)therapy in patients with extensive-disease small-cell lung cancer (ED-SCLC).

METHODS

We retrospectively reviewed 187 of 346 ED-SCLC patients (54%)...

📰 Journal: Supportive Care In Cancer
Read MorePrognostic impact of weight loss during first-line chemotherapy in extensive-disease small cell lung cancer.

Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice.

BACKGROUND

Cancer cachexia is a debilitating syndrome marked by involuntary weight loss resulting from reduced food intake and intricate metabolic reprogramming. Despite its high prevalence, cancer cachexia remains undertreated, with a lack of effective and approved pharmacotherapies. Ghrelin has emerged as...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNovel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice.

Longitudinal Assessment of Muscle Involvement in Late-Onset Pompe Disease Using Quantitative MRI: A Prospective Cohort Study.

BACKGROUND

Late-onset Pompe disease (LOPD) is a progressive metabolic myopathy characterised by lysosomal glycogen accumulation and leading to secondary disruptions in autophagy and cellular energy metabolism. While enzyme replacement therapy (ERT) has improved outcomes, early detection remains critical, because irreversible muscle...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLongitudinal Assessment of Muscle Involvement in Late-Onset Pompe Disease Using Quantitative MRI: A Prospective Cohort Study.

Restoration of circadian rhythm as novel targets against sarcopenia.

Sarcopenia, characterized by the age-related decline in skeletal muscle mass, strength, and function, is associated with high healthcare costs and significant health risks, including falls, fractures, functional decline, and mortality. Despite its prevalence and extensive research, there are currently no...

📰 Journal: Chinese Medical Journal
Read MoreRestoration of circadian rhythm as novel targets against sarcopenia.

Glial remodeling and neuroprotective effects of L-glutamine supplementation on the enteric nervous system in walker-256 tumor-bearing rats.

Cancer cachexia is characterized by systemic inflammation and severe metabolic imbalance, which may compromise the cellular components of the enteric nervous system (ENS). Oxidative stress associated with tumor growth can contribute to enteric neuropathy and gastrointestinal dysfunction. This study investigated...

📰 Journal: Tissue & Cell
Read MoreGlial remodeling and neuroprotective effects of L-glutamine supplementation on the enteric nervous system in walker-256 tumor-bearing rats.

Cluster Randomized Trial of Reablement Strategies Targeting Sarcopenia (ReStart-S) in Long-Term Care Settings.

BACKGROUND

Sarcopenia prevalence is high in long-term care settings (LTCS), yet existing guidelines often overlook this population. The Reablement Strategies targeting Sarcopenia (ReStart-S) program was developed to address this gap. This study evaluated its effects on muscle outcomes, physical performance, quality...

📰 Journal: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences
Read MoreCluster Randomized Trial of Reablement Strategies Targeting Sarcopenia (ReStart-S) in Long-Term Care Settings.

Sema4A Protects Against Muscle Atrophy and Promotes Repair by Regulating Intracellular Metabolic Signalling.

BACKGROUND

Skeletal muscle atrophy is a debilitating condition associated with diverse diseases and clinical interventions. Although triggers such as glucocorticoid excess or direct muscle injury disrupt the balance between protein homeostasis and tissue repair, the upstream molecular signals that actively preserve...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSema4A Protects Against Muscle Atrophy and Promotes Repair by Regulating Intracellular Metabolic Signalling.

Handgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

BACKGROUND

Muscular fitness, particularly handgrip strength, is increasingly recognized as a robust marker of cardiometabolic risk (CMR) in children and adolescents. However, evidence-based diagnostic thresholds for identifying at-risk individuals remain scarce, particularly in children. This study aimed to (1) establish sex-specific...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHandgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis.

Artificial intelligence analysis of temporalis muscle thickness for monitoring sarcopenia and clinical outcomes in individuals with paediatric brain tumours: a retrospective cohort study.

BACKGROUND

People with and who have survived paediatric brain tumour (PBT) have a poor quality of life due to physiological frailty, a primary component of which is sarcopenia (ie, low lean muscle mass) and the associated condition, sarcopenic overweight. MRI-based temporalis...

Read MoreArtificial intelligence analysis of temporalis muscle thickness for monitoring sarcopenia and clinical outcomes in individuals with paediatric brain tumours: a retrospective cohort study.

Eating-related distress in cancer cachexia: multicentre self-reported questionnaire study.

OBJECTIVES

The Asian Working Group for Cachexia (AWGC) updated the diagnostic criteria for cachexia, emphasising its multidimensional influence. We hypothesised that patients meeting the AWGC criteria would exhibit higher levels of eating-related distress (ERD) than those meeting the European Palliative Care...

📰 Journal: Bmj Supportive & Palliative Care
Read MoreEating-related distress in cancer cachexia: multicentre self-reported questionnaire study.

Sarcopenia in Diabetes: A proposal on integrating muscle assessment and nutritional intervention in people living with diabetes.

Sarcopenia is a progressive muscle disease characterized by loss of skeletal muscle mass and strength, commonly associated with ageing and chronic diseases. Type 2 diabetes mellitus (T2DM) accelerates its development through insulin resistance, chronic inflammation, oxidative stress, and hyperglycaemia. Sarcopenia...

📰 Journal: Diabetes Research And Clinical Practice
Read MoreSarcopenia in Diabetes: A proposal on integrating muscle assessment and nutritional intervention in people living with diabetes.

Limited transmission of cervid prions to nonhuman primates provides insights into the zoonotic potential of chronic wasting disease.

Chronic wasting disease (CWD) is an expanding prion disease of cervids. CWD prions persist in the environment, are shed in excreta, and accumulate in tissues of infected cervids, raising concerns about its zoonotic potential. Using cynomolgus macaques, we explored the...

📰 Journal: Science Advances
Read MoreLimited transmission of cervid prions to nonhuman primates provides insights into the zoonotic potential of chronic wasting disease.

Exploring the role of parathyroid hormone in sarcopenia: A review.

PURPOSE OF REVIEW

Sarcopenia is a progressive, multifactorial geriatric syndrome linked to increased risk of falls, fractures, disability, frailty, and all-cause mortality. The pathophysiology of this complex syndrome remains unclear. Emerging evidence suggests that chronically elevated parathyroid hormone (PTH) concentration may...

Read MoreExploring the role of parathyroid hormone in sarcopenia: A review.

Circulating biomarkers in older adults with and without sarcopenia: a systematic review and meta-analysis.

BACKGROUND

Sarcopenia, the age-related loss of muscle mass and strength, poses a significant health and economic burden. This systematic review and meta-analysis evaluates circulating biomarkers (activin A, follistatin, growth differentiation factor (GDF-15), myostatin, growth hormone, insulin growth factor-1 (IGF-1), free and...

📰 Journal: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences
Read MoreCirculating biomarkers in older adults with and without sarcopenia: a systematic review and meta-analysis.

Formation of Liver Metastases Is Accompanied by Accelerated Musculoskeletal Deficits in LLC Tumor Hosts.

Lung cancer is a leading cause of death worldwide and is often accompanied by declines in musculoskeletal health (i.e., cachexia). Despite affecting a majority of lung cancer patients, cachexia remains understudied and currently has no cure. We have previously demonstrated...

📰 Journal: International Journal Of Molecular Sciences
Read MoreFormation of Liver Metastases Is Accompanied by Accelerated Musculoskeletal Deficits in LLC Tumor Hosts.

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