SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.

<p><b>BACKGROUND</b></p><p>In order to identify patients with sarcopenia, the use of routine imaging could provide valuable support. One of the most common radiological examinations, especially in geriatric inpatient care, is CT thoracic imaging. Therefore, it would be desirable to generate muscle...

๐Ÿ“ฐ Journal: Aging Clinical And Experimental Research
Read More3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.

Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.

<p><b>BACKGROUND</b></p><p>Sarcopenia (SP) is characterized by progressive loss of skeletal muscle mass and function, and is a significant health burden in an aging society. Existing therapies have limited effectiveness. While ferroptosis plays a key role in sarcopenia, its regulatory mechanism remains...

๐Ÿ“ฐ Journal: Phytomedicine
Read MoreCistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.

Sarcopenia and gender disparities in liver transplant waiting lists: evaluating predictive scores and delisting risks.

<p><b>BACKGROUND</b></p><p>The model for end-stage liver disease (MELD) and model for end-stage liver disease-sodium (MELD-Na) scores are the most widely used for prioritizing patients on the liver transplant (LT) waiting list. However, the quality and accuracy of these scores are questionable....

๐Ÿ“ฐ Journal: Hepatobiliary Surgery And Nutrition
Read MoreSarcopenia and gender disparities in liver transplant waiting lists: evaluating predictive scores and delisting risks.

Association of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance With Lung Cancer Survival: A Nationwide Cohort Study.

<p><b>BACKGROUND</b></p><p>Physical activity (PA) is important for improving life expectancy and is suggested as a prognostic factor for various diseases. However, the association between PA and mortality outcomes in survivors of lung cancer remains unclear. Therefore, this study aimed to determine...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance With Lung Cancer Survival: A Nationwide Cohort Study.

Sarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

<p><b>BACKGROUND</b></p><p>Sarcopenic obesity (SO) is a clinical condition defined by the coexistence of high body fat mass and low muscle function and mass, which increases the risk of adverse health outcomes, including disability and mortality. Early detection and frequent monitoring of...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

GFRAL-Fc disarms GDF15 to reprogram tumor immunity and amplify PD-1 efficacy in hepatocellular carcinoma.

<p><b>BACKGROUND</b></p><p>Checkpoint inhibitors have revolutionized hepatocellular carcinoma (HCC) treatment, yet their efficacy remains limited in advanced stages, with suboptimal objective response rates. Growth differentiation factor 15 (GDF15), a dual-functional cytokine implicated in tumor progression and immunosuppression, represents a promising therapeutic target....

Read MoreGFRAL-Fc disarms GDF15 to reprogram tumor immunity and amplify PD-1 efficacy in hepatocellular carcinoma.

Cachexia in Pancreatic Cancer: New Insights to Impact Quality of Life and Survival.

Introduction: Cancer cachexia is associated with systemic inflammation and metabolic derangement, leading to muscle atrophy, which affects over 80% of pancreatic cancer patients, the highest rate among all malignancies, negatively impacting quality of life and significantly reducing survival rate. Malnutrition,...

Read MoreCachexia in Pancreatic Cancer: New Insights to Impact Quality of Life and Survival.

A triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies.

<p><b>BACKGROUND</b></p><p>Rapid population aging has intensified the prevalence of malnutrition, sarcopenia, frailty, and oral dysfunction, significantly affecting healthcare outcomes and quality of life in older adults. A growing body of evidence suggests that integrating rehabilitation, nutrition support, and oral health management-a...

๐Ÿ“ฐ Journal: Nutrition
Read MoreA triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies.

Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.

<p><b>BACKGROUND</b></p><p>The relationship between regional adiposity and dementia remains poorly understood.</p><p><b>METHODS</b></p><p>This study included 440โ€‰861 UK Biobank participants initially free of dementia, stroke and cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia across quartiles of waist circumference (WC) or...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Android and Gynoid Fatness With Incident Dementia and Brain Structure.

Association of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

<p><b>BACKGROUND AND AIMS</b></p><p>Sarcopenia and frailty have been associated with hormonal dysregulation in non-cirrhotic populations. The aim of the study was to evaluate hypothalamic-pituitary-adrenal and gonadal (HPA-HPG) axes as well as growth hormone/insulin-like growth factor-1 (GH/IGF-1) levels in patients with cirrhosis...

๐Ÿ“ฐ Journal: Liver International
Read MoreAssociation of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

Interplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in maintaining skeletal muscle homeostasis by regulating cell growth, protein degradation, and nutrient sensing. Beyond its role in muscle growth and atrophy, recent findings suggest that mTORC1 also...

๐Ÿ“ฐ Journal: Free Radical Biology And Medicine
Read MoreInterplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

Leveraging Sarcopenia index by automated CT body composition analysis for pan cancer prognostic stratification.

This study evaluates the CT-based volumetric sarcopenia index (SI) as a baseline prognostic factor for overall survival (OS) in 10,340 solid tumor patients (40% female). Automated body composition analysis was applied to internal baseline abdomen CTs and to thorax CTs....

Read MoreLeveraging Sarcopenia index by automated CT body composition analysis for pan cancer prognostic stratification.

Impact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis.

<p><b>BACKGROUND</b></p><p>While obesity confers a survival advantage, weight loss adversely affects the survival of patients undergoing haemodialysis. However, given the limited information regarding its long-term effects on mortality and cardiovascular events, the health benefits of weight gain remain uncertain, particularly in...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImpact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis.

CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models.

<p><b>BACKGROUND</b></p><p>Skeletal muscle mass is regulated by secretory factors derived from myofibers and muscle-resident cells. Identifying these factors and understanding their mechanisms is critical for combating muscle wasting disorders. This experimental study investigates the role of CXCL14, a chemokine primarily secreted...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models.

Association Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.

<p><b>BACKGROUND</b></p><p>Sarcopenia and intervertebral disc degeneration (IDD) are both highly prevalent among the elderly and have a substantial impact on their quality of life. However, the association between sarcopenia and IDD remains unclear. This study aimed to investigate whether sarcopenia is...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.

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