Prostaglandin E2 drives cancer-associated cachexia.
📰 Journal: Nature Reviews Drug Discovery
Read MoreProstaglandin E2 drives cancer-associated cachexia.SCWD Publications Digest
Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.
AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopeniaWasting Disorders
Lung Tumors Hack Nervous System to Drive Cachexia.
Researchers have found that some lung tumors in mice can cause cachexia by directly communicating with neurons to alter eating behavior. Further, researchers showed that efforts to reduce cachexia through feeding the mice a high-fat diet paradoxically worsened the problem.
📰 Journal: Cancer Discovery
Read MoreLung Tumors Hack Nervous System to Drive Cachexia.A C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.
Sarcopenia is a manifestation of musculoskeletal aging, yet no approved therapy is available. A major challenge is not the lack of potential interventions, but the difficulty of efficiently identifying which candidates should advance to aged-mammal validation. Sarcopenia is driven by...
📰 Journal: Aging And Disease
Read MoreA C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.Therapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice.
Cancer cachexia is a life-threatening wasting syndrome that can be driven by tumor-derived GDF15 signaling through the brainstem-restricted receptor GFRAL. Despite its clinical importance, central genetic interventions targeting this axis remain limited. Here, we develop a potent antisense oligonucleotide (Gfral-ASO,...
📰 Journal: Cell Reports Medicine
Read MoreTherapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice.Tracking Perioperative Inflammation over Time: A Prospective Observational Study on the Longitudinal Dynamics of CRP and GDF-15.
Background: C-reactive protein (CRP) is a well-established marker of systemic inflammation, while Growth Differentiation Factor-15 (GDF-15) has emerged as a potential biomarker of cellular stress. Their relative perioperative dynamics remain incompletely defined. This prospective observational study aimed to explicitly characterize...
YAP1-Driven Pathogenic Fibro-Adipogenic Progenitors Secrete IL-6 and FGF21 to Mediate Muscle-Bone Crosstalk and Promote Bone Loss.
Sarcopenia, an age-related degenerative disease of skeletal muscle, is closely associated with osteoporosis and other bone disorders, partly due to dysregulated endocrine function of skeletal muscle. However, the specific cellular sources and molecular mechanisms driving this pathological secretory phenotype remain...
Prevalence of sarcopenia and individual- and country-level risk factors in 36 countries: pooled analysis of nationally representative individual data.
BACKGROUND
Sarcopenia is an age-related condition that contributes to disability and healthcare burden worldwide. Yet cross-national evidence on prevalence and multi-level risk factors is limited.
METHODS
We pooled data from 10 nationally representative or population-based ageing studies, including 144 226 adults aged ≥50 years...
📰 Journal: Age And Ageing
Read MorePrevalence of sarcopenia and individual- and country-level risk factors in 36 countries: pooled analysis of nationally representative individual data.CXCL2 is a modifiable driver of sarcopenic inflammation attenuated by exercise in older women: Integrated transcriptomic and experimental evidence.
BACKGROUND
Sarcopenia is a progressive muscle-wasting condition driven in part by chronic inflammation; however, the specific inflammatory mediators that contribute to functional decline in humans and their responses to exercise remain poorly defined.
METHODS
We analyzed public ribonucleic acid (RNA) datasets to identify...
📰 Journal: Journal Of Sport And Health Science
Read MoreCXCL2 is a modifiable driver of sarcopenic inflammation attenuated by exercise in older women: Integrated transcriptomic and experimental evidence.Selective Small-Molecule AdipoR1 Agonist 3-Hydroxy Pterocarpan Salt (CDRI-1709S) Ameliorates Skeletal Muscle Atrophy.
BACKGROUND
Skeletal muscle atrophy is a frequent comorbidity of metabolic disorders and chronic diseases, and despite its high prevalence, no pharmacological therapy is available, representing a major unmet clinical need. Adiponectin and its receptors are key regulators of skeletal muscle metabolism,...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSelective Small-Molecule AdipoR1 Agonist 3-Hydroxy Pterocarpan Salt (CDRI-1709S) Ameliorates Skeletal Muscle Atrophy.New hope in the fight against cachexia – cancer's deadly co-conspirator.
📰 Journal: Nature
Read MoreNew hope in the fight against cachexia – cancer's deadly co-conspirator.Plasma Extracellular Vesicles-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts.
BACKGROUND
Sarcopenia is characterized by progressive loss of muscle mass, strength and physical performance, yet current diagnostic tools are limited for practical and longitudinal monitoring. Extracellular vesicles (EVs) encapsulate various biomolecules, including proteins, nucleic acids, lipids and metabolites and have emerged...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePlasma Extracellular Vesicles-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts.Biological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.
INTRODUCTION
Sarcopenia, the accelerated loss of muscle mass, strength and function with age, is associated with adverse health outcomes. DNA methylation accumulates across life and methylation clocks (which provide a measure of biological age) could potentially be used to predict individuals...
📰 Journal: Aging Clinical And Experimental Research
Read MoreBiological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.Association between GDF-15 and sarcopenia progression in older adults: results from a population-based study.
BACKGROUND
Growth differentiation factor-15 (GDF-15), a stress-induced cytokine, has been implicated in pathways related to muscle degeneration, although findings regarding its association with sarcopenia remain heterogeneous. This study investigated the association between serum levels of GDF-15 and sarcopenia progression in community-dwelling...
📰 Journal: Ebiomedicine
Read MoreAssociation between GDF-15 and sarcopenia progression in older adults: results from a population-based study.Understanding cachexia and muscle dysfunction in the context of metastatic breast cancer.
Cancer cachexia significantly impacts the quality of life of cancer patients, predicting therapy response and survival. Cachexia prevalence and severity increases over the course of disease progression, affecting up to 80% of patients with metastatic cancer. Despite this, cachexia is...
📰 Journal: Cancer And Metastasis Reviews
Read MoreUnderstanding cachexia and muscle dysfunction in the context of metastatic breast cancer.Pre-clinical cancer cachexia causes glucose hypermetabolism prior to overt weight loss.
PURPOSE
Cancer cachexia is a life-threatening complication of advanced malignancies, driven by profound systemic metabolic reprogramming and anorexia. Insulin action is markedly impaired in patients with cancer and may contribute directly to cachexia pathogenesis. However, the interplay between weight loss, food...
📰 Journal: Molecular Metabolism
Read MorePre-clinical cancer cachexia causes glucose hypermetabolism prior to overt weight loss.Radiation induced oral mucositis coincides with upregulation of growth differentiation factor 15 (GDF15) in rats.
📰 Journal: Cancer Letters
Read MoreRadiation induced oral mucositis coincides with upregulation of growth differentiation factor 15 (GDF15) in rats.