SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

BACKGROUND

Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults is unknown. This exploratory trial assessed whether once-weekly sirolimus (rapamycin) 6 mg...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreExercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

PBK-Loaded secretory autophagosomes drive radiotherapy-induced systemic adipose depletion via MAPK/ERK-PRKA/PKA-LIPE/HSL signaling: a therapeutic target for esophageal cancer cachexia.

Radiotherapy, while a cornerstone treatment for esophageal squamous cell carcinoma (ESCC), is paradoxically associated with significant weight loss that portends poor patient outcomes. The mechanisms driving this metabolic complication remain elusive. Here, we identified adipose depletion - rather than muscle...

📰 Journal: Autophagy
Read MorePBK-Loaded secretory autophagosomes drive radiotherapy-induced systemic adipose depletion via MAPK/ERK-PRKA/PKA-LIPE/HSL signaling: a therapeutic target for esophageal cancer cachexia.

Disuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.

BACKGROUND

Exercise has been proposed as both a preventive and therapeutic countermeasure; however, its effectiveness across different disuse conditions and timings of implementation remains uncertain.

METHODS

This systematic review and meta-analysis (PROSPERO: CRD42021256599) searched ClinicalTrials.gov, Cochrane Central, PubMed, SPORTDiscus, Web of Science, Scopus,...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDisuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.

MCC950-Loaded M12-Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis-Induced Muscle Atrophy.

BACKGROUND

Sepsis-induced myopathy (SIM) is a severe complication that contributes to late-stage mortality and functional impairment in sepsis patients. The NLRP3 inflammasome plays a pivotal role in the pathogenesis of SIM, and its selective inhibitor MCC950 has shown promising therapeutic potential....

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMCC950-Loaded M12-Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis-Induced Muscle Atrophy.

Muscle Atrophy-Related Adverse Events of Antidiabetic Drug Classes: A Pharmacovigilance Analysis Using VigiBase Data.

BACKGROUND

Diabetes mellitus-a chronic metabolic disorder associated with an increased risk of muscle atrophy-can significantly impact patients' quality of life and overall health outcomes. While antidiabetic medications are crucial for managing blood glucose levels, some have been linked to muscle-related adverse...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Atrophy-Related Adverse Events of Antidiabetic Drug Classes: A Pharmacovigilance Analysis Using VigiBase Data.

HQ1: Do Interventions and Assessments Using Digital Health Services Prevent Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

📰 Journal: Geriatrics & Gerontology International
Read MoreHQ1: Do Interventions and Assessments Using Digital Health Services Prevent Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

HQ5: Do Intervention and Evaluation Using Digital Health Services Prevent Sarcopenia in High-Risk Non-Older Adults? English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

📰 Journal: Geriatrics & Gerontology International
Read MoreHQ5: Do Intervention and Evaluation Using Digital Health Services Prevent Sarcopenia in High-Risk Non-Older Adults? English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

HQ2: Do Interventions and Assessments Using Digital Health Services Prevent Frailty in High-Risk Non-Older Adults Who Are at Risk of Frailty?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

📰 Journal: Geriatrics & Gerontology International
Read MoreHQ2: Do Interventions and Assessments Using Digital Health Services Prevent Frailty in High-Risk Non-Older Adults Who Are at Risk of Frailty?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

HQ7: Does Exercise Prevent the Onset and Progression of Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

📰 Journal: Geriatrics & Gerontology International
Read MoreHQ7: Does Exercise Prevent the Onset and Progression of Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

HQ11: Does EMS (Electrical Muscle Stimulation) Prevent the Onset and Progression of Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

📰 Journal: Geriatrics & Gerontology International
Read MoreHQ11: Does EMS (Electrical Muscle Stimulation) Prevent the Onset and Progression of Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

HQ4: Do Interventions and Assessments That Use Digital Health Services Prevent Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

📰 Journal: Geriatrics & Gerontology International
Read MoreHQ4: Do Interventions and Assessments That Use Digital Health Services Prevent Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

HQ9: Do Exercise Interventions Prevent the Onset and Progression of Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

📰 Journal: Geriatrics & Gerontology International
Read MoreHQ9: Do Exercise Interventions Prevent the Onset and Progression of Sarcopenia in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

The sarcopenia-pain connection: why mechanisms matter for patient care?

Sarcopenia and pain are two highly prevalent conditions in aging populations, each exerting profound effects on mobility, independence, and quality of life. Emerging evidence demonstrates that these conditions are not merely coincidental but are closely interconnected through shared biological, mechanical,...

Read MoreThe sarcopenia-pain connection: why mechanisms matter for patient care?

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