SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Induced-fit anti-GFRAL antibody ameliorates cancer cachexia and attenuates sympathetic outflow in tumor-bearing mice.

The GDF15-GFRAL-RET neuroendocrine axis is a key regulator of body-weight homeostasis and metabolic control. GFRAL, a hindbrain-restricted receptor for the stress-responsive cytokine GDF15, signals by assembling a ternary complex with GDF15 and the tyrosine kinase RET. Pathological hyperactivation of this...

📰 Journal: Science Advances
Read MoreInduced-fit anti-GFRAL antibody ameliorates cancer cachexia and attenuates sympathetic outflow in tumor-bearing mice.

Adaptive Mitochondrial Specialization in Lung Adenocarcinoma: Redox Homeostasis, Hypoxia Adaptation, and Therapeutic Resistance.

Lung adenocarcinoma (LUAD) exhibits metabolic flexibility that transcends the classical interpretation of the Warburg effect. This review proposes the concept of "adaptive mitochondrial specialization (AMS)", an integrative framework in which mitochondria undergo coordinated, context-dependent remodeling of bioenergetic metabolism, redox homeostasis,...

Read MoreAdaptive Mitochondrial Specialization in Lung Adenocarcinoma: Redox Homeostasis, Hypoxia Adaptation, and Therapeutic Resistance.

Sulforaphane as a Therapeutic Target for Sarcopenia in Type 2 Diabetes: Mechanistic Insights and Translational Evidence.

Sulforaphane, a bioactive isothiocyanate abundant in cruciferous vegetables, has emerged as a potential multi-target therapeutic agent capable of mitigating these pathological processes. Here, using evidence from preclinical and clinical literature, we review the mechanistic and translational evidence linking sulforaphane with...

Read MoreSulforaphane as a Therapeutic Target for Sarcopenia in Type 2 Diabetes: Mechanistic Insights and Translational Evidence.

Aquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline.

BACKGROUND

Impaired muscle regeneration is a key contributor to age-related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin-4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline.

Frailty Rather Than Sonographic Muscle Measurement Predicts Outcome in Liver Cirrhosis.

BACKGROUND

Sarcopenia and frailty are frequent in patients with liver cirrhosis and are associated with morbidity and mortality. Given the limitations of computed tomography (CT) for routine assessment of muscle loss and the need for practical bedside assessment, we aimed to...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFrailty Rather Than Sonographic Muscle Measurement Predicts Outcome in Liver Cirrhosis.

Disruption of the Muscle-Brain Axis in Ageing: Role of Myokines in Sarcopenia and Neurodegeneration.

This narrative review analyzes how myokines act as key links in communication between skeletal muscle and the brain, focusing on the impact of aging on this axis. Although the current literature links defects in this signaling pathway to sarcopenia, neurodegeneration,...

Read MoreDisruption of the Muscle-Brain Axis in Ageing: Role of Myokines in Sarcopenia and Neurodegeneration.

Circulating MicroRNAs Reflect Systemic Inflammation and Metabolic Dysfunction in Oesophageal Squamous Cell Carcinoma-Associated Cachexia.

BACKGROUND

Cachexia in oesophageal squamous cell carcinoma is driven by systemic inflammation and malnutrition and is associated with poor survival. We evaluated whether circulating miRNAs can identify ESCC cachexia and reflect its inflammatory-nutritional phenotype.

METHODS

We enrolled 126 participants: 42 healthy controls and...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCirculating MicroRNAs Reflect Systemic Inflammation and Metabolic Dysfunction in Oesophageal Squamous Cell Carcinoma-Associated Cachexia.

Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice.

Age-related weakness is strongly associated with disability and mortality in older adults. While muscle atrophy contributes to weakness, strength declines at a faster rate than muscle mass, implicating neural mechanisms such as changes at the spinal cord and neuromuscular junction....

📰 Journal: Aging Cell
Read MoreMotor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice.

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes.

BACKGROUND

Urolithin A (UA) and urolithin B (UB) are gut microbiota-derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined. We characterized UA- and UB-induced molecular responses...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreExploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes.

A probiotic Bifidobacterium pseudocatenulatum converts hesperidin to bioactive hesperetin and improves metabolic dysfunction in aging mice.

Dietary flavonoids often require microbial metabolism to generate bioactive metabolites that influence host physiology. Hesperidin, a citrus flavanone glycoside, exhibits limited intestinal absorption and depends on gut microbial biotransformation to yield its active aglycone, hesperetin. Hesperetin activates CDGSH iron-sulfur domain...

📰 Journal: Gut Microbes
Read MoreA probiotic Bifidobacterium pseudocatenulatum converts hesperidin to bioactive hesperetin and improves metabolic dysfunction in aging mice.

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.

Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning in both physiological...

📰 Journal: Nature Cancer
Read MoreAn iron-regulated methionine redox axis governs adipose browning and cancer cachexia.

Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.

BACKGROUND

Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.

Skeletal muscle aging is a major cause of frailty, metabolic dysfunction, and loss of independence in later life, yet it cannot be explained by muscle mass loss alone. Recent single-cell, multi-omics, and translational studies show that aged muscle is shaped...

Read MoreAging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.

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