SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

Contemporary Rationale for Delivering Enteral Nutrition in Critically Ill Adults.

To review the rationale for and timing, dose, and monitoring of enteral nutrition and protein delivery in critically ill adults. Medline searches to identify relevant studies, systematic reviews and meta-analyses, and guidelines informing the phases of critical illness, enteral nutrition...

๐Ÿ“ฐ Journal: Critical Care Medicine
Read MoreContemporary Rationale for Delivering Enteral Nutrition in Critically Ill Adults.

Desensitizing Effect of Intra-Tumoral GDF-15 on Immunotherapy in Patients With Advanced Non-Small Cellย Lung Cancer.

Serum growth/differentiation factor 15 (GDF-15) suppresses anti-tumor immunity and predicts prognosis in several malignancies. Elevated GDF-15 levels are linked to cancer cachexia, characterized by weight loss and systemic inflammation, adversely affecting patient outcomes and therapy response. However, serum GDF-15 is...

๐Ÿ“ฐ Journal: Thoracic Cancer
Read MoreDesensitizing Effect of Intra-Tumoral GDF-15 on Immunotherapy in Patients With Advanced Non-Small Cellย Lung Cancer.

Osteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study.

Osteosarcopenia is suggested to be on the causal pathway to frailty; however, data on this topic is scarce, and it is unclear if osteosarcopenia is associated with frailty risk. To investigate if osteosarcopenia is associated with frailty risk in community-dwelling...

๐Ÿ“ฐ Journal: Archives Of Gerontology And Geriatrics
Read MoreOsteosarcopenia and frailty risk in community-dwelling older adults: A follow-up of the I-Lan Longitudinal Aging Study.

Association of the Dietary Index for Gut Microbiota With Severity, Renal Function, and Sarcopenia in Patients With Chronic Kidney Disease: A Population-Based Cross-Sectional Study.

The aim of this research was to clarify the relationship between the Dietary Index for Gut Microbiota (DI-GM) and the severity of chronic kidney disease (CKD), renal function, and the prevalence of sarcopenia in patients with CKD, as well as...

Read MoreAssociation of the Dietary Index for Gut Microbiota With Severity, Renal Function, and Sarcopenia in Patients With Chronic Kidney Disease: A Population-Based Cross-Sectional Study.

Iron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control.

In older adults with reduced physical performance, an increase in the labile iron pool within skeletal muscle is observed. This accumulation is associated with an altered expression of mitochondrial quality control (MQC) markers and increased mitochondrial DNA damage, supporting the...

Read MoreIron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control.

Potential framework of the Global Leadership Initiative in Sarcopenia (GLIS) criteria based on muscle mass and/or strength for predicting survival in cancer patients: A nationwide multicenter cohort study.

The Global Leadership Initiative on Sarcopenia (GLIS) was proposed recently by creating a widely recognized conceptual definition of sarcopenia, however, the diagnostic framework of GLIS in cancer patients remains unclear. This study aims to evaluate the potential framework of GLIS...

๐Ÿ“ฐ Journal: Clinical Nutrition
Read MorePotential framework of the Global Leadership Initiative in Sarcopenia (GLIS) criteria based on muscle mass and/or strength for predicting survival in cancer patients: A nationwide multicenter cohort study.

MG53 deficiency mediated skeletal muscle dysfunction in chronic obstructive pulmonary disease via impairing mitochondrial fission.

Myokine dysregulation and mitochondrial dysfunction are implicated in the pathogenesis of sarcopenia in chronic obstructive pulmonary disease. The objective of this study is to explore the role of myokines and mitochondrial dysfunction in sarcopenia in chronic obstructive pulmonary disease. We...

๐Ÿ“ฐ Journal: Redox Biology
Read MoreMG53 deficiency mediated skeletal muscle dysfunction in chronic obstructive pulmonary disease via impairing mitochondrial fission.

The potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.

Cancer cachexia, a multifactorial metabolic syndrome impacts 50-80% cancer patients, is mainly characterized by skeletal muscle atrophy. In this study, we demonstrated that the thousand-and-one amino acid kinase 1 (TAOK1) was activated in both C2C12 myotubes treated with simulated cancer...

๐Ÿ“ฐ Journal: Pharmacological Research
Read MoreThe potential of TAOK1 as a new therapeutic target for the treatment of cancer cachexia-associated muscle atrophy.

Association between cumulative pack-year smoking exposure and sarcopenia: a KoGES cohort study.

Sarcopenia is the age-related involuntary loss of skeletal muscle mass and strength. Many factors, such as ageing and behaviour, may affect the risk of sarcopenia. However, no study had confirmed the association between cumulative exposure to smoking and the risk...

๐Ÿ“ฐ Journal: International Journal Of Epidemiology
Read MoreAssociation between cumulative pack-year smoking exposure and sarcopenia: a KoGES cohort study.

Prevalence of sarcopenia in middle-aged and older adults with cognitive impairment: a meta-analysis.

Cognitive impairment, dementia and sarcopenia significantly reduce the quality of life in middle-aged and older adults by impairing daily functioning, making cognitive decline a major concern for healthcare professionals. To estimate the prevalence of sarcopenia and probable sarcopenia in middle-aged...

๐Ÿ“ฐ Journal: Age And Ageing
Read MorePrevalence of sarcopenia in middle-aged and older adults with cognitive impairment: a meta-analysis.

Artificial Intelligence in the Management of Malnutrition in Cancer Patients: A Systematic Review.

Malnutrition is a critical complication among cancer patients, affecting up to 80% of individuals depending on cancer type, stage, and treatment. Artificial Intelligence (AI) has emerged as a promising tool in healthcare, with potential applications in nutritional management to improve...

Read MoreArtificial Intelligence in the Management of Malnutrition in Cancer Patients: A Systematic Review.

Comment on "Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage" by Korhonen etย al.-The authors' reply.

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreComment on "Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage" by Korhonen etย al.-The authors' reply.

Sarcopenia in heart failure: Comparison of prognostic value between the Asian working Group for Sarcopenia 2014 and 2019 criteria.

Sarcopenia is a prevalent comorbidity among older patients with heart failure. This study aimed to evaluate the differences between sarcopenia diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2014 and 2019 criteria in older patients with heart failure. This...

๐Ÿ“ฐ Journal: Geriatrics & Gerontology International
Read MoreSarcopenia in heart failure: Comparison of prognostic value between the Asian working Group for Sarcopenia 2014 and 2019 criteria.

Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement.

Sarcopenia and knee osteoarthritis (KOA) are common conditions in older adults, but the relationship is controversial. We aimed to examine the potential role of sarcopenia in KOA progression and subsequent knee replacement (KR). Using data from the Osteoarthritis Initiative (OAI),...

๐Ÿ“ฐ Journal: Arthritis & Rheumatology
Read MoreLongitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement.

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