SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Beyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.

BACKGROUND

Metabolic and bariatric surgery (MBS) produces substantial and sustained weight loss, but concerns remain about skeletal muscle loss and sarcopenia.

METHODS

We conducted a systematic review of longitudinal and cross-sectional studies evaluating changes in muscle quantity, strength, and physical performance following MBS...

📰 Journal: Obesity Reviews
Read MoreBeyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.

Prevalence and risk factors of malnutrition among older adults with sarcopenia: a protocol of systematic review and meta-analysis.

BACKGROUND

Sarcopenia and malnutrition are closely interrelated geriatric syndromes that significantly contribute to frailty, functional decline, and increased mortality in older adults. Although a growing body of evidence suggests a strong association between these conditions, reported prevalence rates and associated risk...

Read MorePrevalence and risk factors of malnutrition among older adults with sarcopenia: a protocol of systematic review and meta-analysis.

Gut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

BACKGROUND

Ageing is an inevitable biological process that contributes to increased prevalence of age-associated diseases, including sarcopenia, defined by progressive loss of muscle mass, functional decline and a heightened risk of injury. Developing effective interventions remains a critical clinical priority. This...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreGut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia.

Skeletal muscle mass and force decline with age, and the loss of muscle force precedes muscle atrophy. However, the underlying mechanisms remain unclear. Here, we investigated the role of the myosin co-chaperone, uncoordinated mutant number-45 myosin chaperone B (UNC45B), in...

📰 Journal: Aging Cell
Read MoreUNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia.

Effects of Tai Chi combined with elastic band training on muscle and executive inhibitory function in older adults with sarcopenia: a randomized controlled trial based on fNIRS.

BACKGROUND

Resistance training benefits patients with sarcopenia. However, trials demonstrating the effectiveness of Tai Chi combined with elastic band training are sparse, and the underlying neurocognitive mechanisms remain unclear.

METHODS

Forty-nine older sarcopenia patients (≥60 years) were recruited and randomly assigned to three groups:...

📰 Journal: Age And Ageing
Read MoreEffects of Tai Chi combined with elastic band training on muscle and executive inhibitory function in older adults with sarcopenia: a randomized controlled trial based on fNIRS.

Associations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.

BACKGROUND

Longitudinal associations between age-related changes in body composition, physical performance and incident diabetes mellitus (DM) in older adults and the mediating role of branched-chain amino acids (BCAAs) remain understudied.

METHODS

This prospective cohort study included 4000 community-dwelling older adults at baseline. Longitudinal...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.

Cancer cachexia: A tumor-driven disorder of whole-body homeostasis.

Cancer cachexia is a systemic metabolic syndrome driven by tumor-induced disruption of whole-body homeostasis. Characterized by skeletal muscle atrophy and adipose tissue loss, cachexia leads to functional decline, impaired quality of life, reduced treatment tolerance, and poor survival across multiple...

📰 Journal: Cancer Cell
Read MoreCancer cachexia: A tumor-driven disorder of whole-body homeostasis.

Sarcopenic Obesity in Children: An Emerging Complication Evidenced by Clinical Data and a Juvenile Mouse Model.

BACKGROUND

Sarcopenic obesity (SO) is well-characterized in older adults, but its impact on muscle development in children remains poorly understood. This study investigated the effects of childhood obesity on musculoskeletal health and the underlying mechanisms.

METHODS

We enrolled 1447 children (31.4% girls; median...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenic Obesity in Children: An Emerging Complication Evidenced by Clinical Data and a Juvenile Mouse Model.

Dual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.

Skeletal muscle accounts for approximately 40% of total body mass and is essential for locomotion, metabolic regulation and systemic homeostasis. Adipose tissue is increasingly recognized as an active component of the muscle's regenerative microenvironment. During muscle repair, adipose tissue contributes...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.

Sarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.

Sarcopenic obesity (SO; defined as obesity with low skeletal muscle function and mass) has been recently recognized as a relevant obesity phenotype, with substantial negative clinical impact. The prevalence of SO is likely increasing, due to the growing prevalence of...

📰 Journal: Clinical Nutrition
Read MoreSarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.

The Crossroads between Osteosarcopenia and Intrinsic Capacity – A Narrative Review.

Intrinsic Capacity (IC) is defined as the composite of physical and mental abilities an individual possesses, encompassing five domains: cognition, psychological health, sensory function, vitality, and locomotion. This construct is central to the World Health Organization's framework for assessing functional...

📰 Journal: Journals Of Gerontology Series A-Biological Sciences And Medical Sciences
Read MoreThe Crossroads between Osteosarcopenia and Intrinsic Capacity – A Narrative Review.

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a,...

📰 Journal: Aging Cell
Read MoreGhrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Chronic Wasting Disease in Farmed Cervids, South Korea, 2001-2024.

Chronic wasting disease (CWD) was identified in imported elk in South Korea in 2001 and has spread among cervids nationwide. The country's surveillance and control policy culls cervids from any CWD-positive farms, and prevalence during 2020-2024 was <0.5%. Maintaining low...

📰 Journal: Emerging Infectious Diseases
Read MoreChronic Wasting Disease in Farmed Cervids, South Korea, 2001-2024.

Development of a spatially defined 3D in vitro coculture construct modelling pancreatic cancer-associated cachexia.

Pancreatic cancer-associated cachexia is marked by adipose tissue wasting, thermogenic remodeling, and a state of hypermetabolism, yet robust preclinical models to study these phenomena are lacking. In this study, we present a spatially defined three-dimensional (3D) coreshell microcuboid coculture platform...

📰 Journal: Biofabrication
Read MoreDevelopment of a spatially defined 3D in vitro coculture construct modelling pancreatic cancer-associated cachexia.

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

BACKGROUND

Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults is unknown. This exploratory trial assessed whether once-weekly sirolimus (rapamycin) 6 mg...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreExercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

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