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SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

Longitudinal Follow-Up of Patients With Duchenne Muscular Dystrophy Using Quantitative Na and H MRI.

Quantitative muscle MRI commonly evaluates disease activity and muscle wasting in Duchenne muscular dystrophy (DMD). Disturbances in ion homeostasis contribute to DMD pathophysiology, but their relationships with disease progression is unclear. Na MRI may provide insights into the disease course...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLongitudinal Follow-Up of Patients With Duchenne Muscular Dystrophy Using Quantitative Na and H MRI.

Effectiveness of Mind-Body Exercise in Older Adults With Sarcopenia and Frailty: A Systematic Review and Meta-Analysis.

Mind-body exercise (MBE) has shown promise in mitigating the effects of sarcopenia and frailty in older adults. Nevertheless, its effectiveness in enhancing muscle function and physical performance in this population has not been well established. This study aimed to investigate...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEffectiveness of Mind-Body Exercise in Older Adults With Sarcopenia and Frailty: A Systematic Review and Meta-Analysis.

Comment on "Intermittent Hypoxic-Hyperoxic Training During Inpatient Rehabilitation Improves Exercise Capacity and Functional Outcome in Patients With Long Covid: Results of a Controlled Clinical Pilot Trial" by Doehner etย al.

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreComment on "Intermittent Hypoxic-Hyperoxic Training During Inpatient Rehabilitation Improves Exercise Capacity and Functional Outcome in Patients With Long Covid: Results of a Controlled Clinical Pilot Trial" by Doehner etย al.

Prevalence, Characteristics, and Prognostic Associations of Cachexia Diagnosed Using Asian Working Group for Cachexia 2023 Criteria in Older Adults With Heart Failure.

Few studies have examined the characteristics of heart failure (HF) patients with cachexia using the Asian Working Group for Cachexia (AWGC) 2023 criteria. This study assessed the characteristics and clinical impact of cachexia in older adults with HF. Results of...

๐Ÿ“ฐ Journal: Circulation Journal
Read MorePrevalence, Characteristics, and Prognostic Associations of Cachexia Diagnosed Using Asian Working Group for Cachexia 2023 Criteria in Older Adults With Heart Failure.

Associations between sarcopenic, obesity, and sarcopenic obesity and metabolic syndrome in adults aged 45ย Years or older: A prospective cohort study from the China health and retirement longitudinal study.

Although previous studies have reported associations between sarcopenic obesity (SO) and metabolic syndrome (MetS), the findings remain inconsistent. This study aimed to investigate the associations between sarcopenia, obesity, and MetS, and to determine whether sarcopenic obesity synergistically increases the risk...

๐Ÿ“ฐ Journal: Clinical Nutrition
Read MoreAssociations between sarcopenic, obesity, and sarcopenic obesity and metabolic syndrome in adults aged 45ย Years or older: A prospective cohort study from the China health and retirement longitudinal study.

Distinct gut microbiota signatures in older people with sarcopenic obesity and sarcopenia without obesity.

Previous evidence suggests that gut dysbiosis plays an important role in the development and progression of sarcopenia and sarcopenic obesity (SO), but evidence supporting this association is lacking. Thus, this study aimed to investigate the characteristics of gut microbiota in...

๐Ÿ“ฐ Journal: Clinical Nutrition
Read MoreDistinct gut microbiota signatures in older people with sarcopenic obesity and sarcopenia without obesity.

INFLAMMATION IN CANCER CACHEXIA: STILL THE CENTRAL TENET OR JUST ANOTHER PLAYER?

Cancer cachexia, a multifactorial syndrome characterised by body weight loss, muscle and adipose tissue wasting, affects cancer patients. Over time, the definition of cachexia has been modified, including inflammation as one of the main causal factors. Evidences have suggested that...

๐Ÿ“ฐ Journal: American Journal Of Physiology-Cell Physiology
Read MoreINFLAMMATION IN CANCER CACHEXIA: STILL THE CENTRAL TENET OR JUST ANOTHER PLAYER?

GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice.

The survival rate for children and adolescents has increased to over 85%. However, there is limited understanding of the impact of pediatric cancers on muscle development and physiology. Given that brain tumors alone account for 26% of all pediatric cancers,...

๐Ÿ“ฐ Journal: American Journal Of Physiology-Regulatory Integrative And Comparative Physiology
Read MoreGL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice.

Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS-Bmal1 Mice.

Sarcopenia, a condition associated with aging, involves progressive loss of muscle mass, strength, and function, leading to impaired mobility, health, and increased mortality. The underlying mechanisms remain unclear, which limits the development of effective therapeutic interventions. Emerging evidence implicates chronodisruption...

๐Ÿ“ฐ Journal: Journal Of Pineal Research
Read MoreMelatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS-Bmal1 Mice.

Comprehensive Evaluation of Frailty and Sarcopenia Markers to Predict Survival in Glioblastoma Patients.

Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Patients with GBM are particularly susceptible to moderate-to-high frail. Frailty status has been associated with the outcome of many types of cancer, including GBM, although there is still...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreComprehensive Evaluation of Frailty and Sarcopenia Markers to Predict Survival in Glioblastoma Patients.

Transcriptional Intermediary Factor 1ฮณ-Induced Irisin in Skeletal Muscle Attenuates Renal Fibrosis in Diabetic Nephropathy.

Transcriptional intermediary factor 1ฮณ (TIF1ฮณ) is a negative regulator of TGF-ฮฒ1 signalling and has been associated with patient survival in renal cell carcinoma. However, its role in diabetes mellitus (DM), particularly in diabetic nephropathy (DN), remains unclear. DN is the...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreTranscriptional Intermediary Factor 1ฮณ-Induced Irisin in Skeletal Muscle Attenuates Renal Fibrosis in Diabetic Nephropathy.

Nutritional Status Predicts Functional Recovery and Adverse Outcomes in Older Adults: A Prospective Cohort Study.

Despite the high prevalence of malnutrition in acutely ill older patients, nutritional status is rarely assessed in emergency departments (EDs), and the impact of nutritional risk screening on functional recovery is poorly understood. This study aimed to investigate the association...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNutritional Status Predicts Functional Recovery and Adverse Outcomes in Older Adults: A Prospective Cohort Study.

HD6277 Suppresses Muscle Atrophy by Promoting Myogenic Factors and Inhibiting Proteolysis in Aged Mice.

G protein-coupled receptor 40 (GPR40) acts as a modulator of various physiological functions, including glycaemic lowering, anti-inflammation and antioxidative stress, in several tissues. However, the role of GPR40 in skeletal muscles remains unclear. To investigate the roles of muscle GPR40,...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHD6277 Suppresses Muscle Atrophy by Promoting Myogenic Factors and Inhibiting Proteolysis in Aged Mice.

Association of Appendicular Skeletal Muscle Mass Index and Insulin Resistance With Mortality in Multi-Nationwide Cohorts.

Although sarcopenia and insulin resistance are closely related, there is limited evidence regarding how they interact to influence mortality across different population groups. The purpose of this study was to examine the relationship between skeletal muscle mass and insulin resistance...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Appendicular Skeletal Muscle Mass Index and Insulin Resistance With Mortality in Multi-Nationwide Cohorts.

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