Muscle,_skeletal

Preoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.

BACKGROUND & AIMS

Cancer cachexia is associated with systemic skeletal muscle loss and poor survival; however, early muscle changes preceding systemic muscle loss remain unclear. Therefore, this study aimed to determine whether tongue-complex muscle area (TCMA) can serve as an early...

🗓️ 2026-07-30
📰 Publication: Clinical Nutrition
Read MorePreoperative swallowing muscle mass is associated with 1-year skeletal muscle loss and subsequent survival in lung cancer.

Imeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing.

BACKGROUND

Sarcopenia is a major contributor to frailty and mortality in ageing and obesity and is tightly linked to metabolic dysfunction. Imeglimin is a first-in-class oral hypoglycaemic agent targeting mitochondrial function; however, despite the central role of mitochondria in skeletal muscle...

🗓️ 2026-07-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImeglimin Attenuates Skeletal Muscle Atrophy in Mouse Models of Obesity and Ageing.

YAP1-Driven Pathogenic Fibro-Adipogenic Progenitors Secrete IL-6 and FGF21 to Mediate Muscle-Bone Crosstalk and Promote Bone Loss.

Sarcopenia, an age-related degenerative disease of skeletal muscle, is closely associated with osteoporosis and other bone disorders, partly due to dysregulated endocrine function of skeletal muscle. However, the specific cellular sources and molecular mechanisms driving this pathological secretory phenotype remain...

🗓️ 2026-07-27
Read MoreYAP1-Driven Pathogenic Fibro-Adipogenic Progenitors Secrete IL-6 and FGF21 to Mediate Muscle-Bone Crosstalk and Promote Bone Loss.

Selective Small-Molecule AdipoR1 Agonist 3-Hydroxy Pterocarpan Salt (CDRI-1709S) Ameliorates Skeletal Muscle Atrophy.

BACKGROUND

Skeletal muscle atrophy is a frequent comorbidity of metabolic disorders and chronic diseases, and despite its high prevalence, no pharmacological therapy is available, representing a major unmet clinical need. Adiponectin and its receptors are key regulators of skeletal muscle metabolism,...

🗓️ 2026-07-22
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSelective Small-Molecule AdipoR1 Agonist 3-Hydroxy Pterocarpan Salt (CDRI-1709S) Ameliorates Skeletal Muscle Atrophy.

Sex-divergent skeletal muscle remodeling emerges early in cancer cachexia.

Cancer cachexia is characterised by progressive skeletal muscle wasting and dysfunction, yet the early events that precede overt muscle wasting remain poorly defined. Here, we utilised a time-coursed C26 carcinoma model in male and female mice to define the pre-cachectic...

🗓️ 2026-07-17
📰 Publication: American Journal Of Physiology-Cell Physiology
Read MoreSex-divergent skeletal muscle remodeling emerges early in cancer cachexia.

Calcium Beta-Hydroxy-Beta-Methylbutyrate-Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial.

BACKGROUND

Dietary and pharmacologic weight loss can reduce skeletal muscle. Whether calcium beta-hydroxy-beta-methylbutyrate (CaHMB)-enriched supplementation preserves muscle while promoting fat loss in adults with obesity remains uncertain. We evaluated a CaHMB-enriched nutritional supplement during energy restriction.

METHODS

In this randomized, double-blind, controlled trial,...

🗓️ 2026-07-14
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCalcium Beta-Hydroxy-Beta-Methylbutyrate-Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial.

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue.

BACKGROUND

The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of...

🗓️ 2026-07-08
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDivergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue.

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration.

BACKGROUND

Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no...

🗓️ 2026-07-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDownstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration.

Li-ginseng powder alleviates cancer cachexia in mice by regulating the ubiquitin-proteasome pathway and reducing inflammation.

BACKGROUND

As a debilitating syndrome, cancer cachexia (CC) manifests as ongoing weight reduction and skeletal muscle atrophy, which severely compromise patients' well-being and life expectancy, with no approved treatment available to date. Rare ginsenosides such as Rh2, Rg5, Rk1, and Rh4...

🗓️ 2026-07-03
📰 Publication: Journal Of Ginseng Research
Read MoreLi-ginseng powder alleviates cancer cachexia in mice by regulating the ubiquitin-proteasome pathway and reducing inflammation.

Myovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

Skeletal muscle health and regeneration are highly orchestrated processes governed by a complex interplay of muscle stem cells, fibro-adipogenic progenitors, immune cells, and endothelial cells. Among these cell types, endothelial cells play a central role not only by regulating blood...

🗓️ 2026-07-02
📰 Publication: Circulation Research
Read MoreMyovascular Niche: The Role of Endothelial Cells in Skeletal Muscle Health and Disease.

Cellular senescence in musculoskeletal diseases: biological mechanisms and clinical implications.

Cellular senescence is a persistent state of irreversible growth arrest that occurs when cells encounter various stress signals. It is marked by elevated expression of cell cycle inhibitors, dysregulated gene transcription, and secretion of the senescence-associated secretory phenotype (SASP). These...

🗓️ 2026-06-29
📰 Publication: Theranostics
Read MoreCellular senescence in musculoskeletal diseases: biological mechanisms and clinical implications.

Beyond body surface area: CT-derived body composition as a predictor of chemotherapy toxicity and survival in pancreatic ductal adenocarcinoma: a systematic review.

BACKGROUND

Pancreatic ductal adenocarcinoma (PDAC) is characterised by a high prevalence of severe muscle wasting (sarcopenia) and fatty muscle infiltration (myosteatosis), yet chemotherapy dosing still relies on body surface area (BSA), a metric that does not reflect individual patients' lean body...

🗓️ 2026-06-27
📰 Publication: Cancer Treatment Reviews
Read MoreBeyond body surface area: CT-derived body composition as a predictor of chemotherapy toxicity and survival in pancreatic ductal adenocarcinoma: a systematic review.

Deletion of Tgf-β1 From CD206 + M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle.

BACKGROUNDS

Obesity and diabetes impair the ability of the muscle to regenerate, repair and remodel, resulting in a gradual decrease in muscle mass and function. However, the underlying mechanisms and effective therapeutic strategies remain poorly understood. M2 macrophages within skeletal muscle...

🗓️ 2026-06-19
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeletion of Tgf-β1 From CD206 + M2 Macrophages Ameliorates Obesity-Induced Suppression of Myogenesis and AMPK Phosphorylation in Skeletal Muscle.

RNF10 Attenuates Age-Related Muscle Atrophy by Promoting p53 Degradation and Alleviating Oxidative Stress.

Evidence identifies proteostasis imbalance and oxidative stress serve as fundamental pathological hallmarks of muscular atrophy, yet ring finger protein 10 (RNF10), a novel E3 ubiquitin ligase, in age-related muscular atrophy remains poorly characterized. Employing a natural aging mouse model and...

🗓️ 2026-06-18
📰 Publication: Free Radical Biology And Medicine
Read MoreRNF10 Attenuates Age-Related Muscle Atrophy by Promoting p53 Degradation and Alleviating Oxidative Stress.

Muscle Ageing and Sarcopenia Study (MASS) Lifecourse: a valuable resource for understanding skeletal muscle ageing.

Advances in our understanding of the biology of skeletal muscle ageing are being made at pace, with great potential for these findings to inform the identification of novel treatments for sarcopenia. However, translation of findings from animal models to humans...

🗓️ 2026-06-15
Read MoreMuscle Ageing and Sarcopenia Study (MASS) Lifecourse: a valuable resource for understanding skeletal muscle ageing.

Hepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH.

A bidirectional relationship exists between metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), and sarcopenia, with each worsening the prevalence and prognosis of the other. Hepatokines have recently been shown to affect skeletal...

🗓️ 2026-06-11
📰 Publication: Molecular Metabolism
Read MoreHepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH.

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