Muscle,_skeletal

A Murinized Bimagrumab Analogue Increases Skeletal Muscle Mass and Improves Cardiometabolic Remodelling in Experimental Hypertrophic Cardiomyopathy.

BACKGROUND

Hypertrophic cardiomyopathy (HCM) involves left ventricular hypertrophy and metabolic dysfunction. Given the role of skeletal muscle in systemic metabolism, we investigated whether activin type II receptor inhibition with CDD866, a murinized bimagrumab analogue that induces skeletal muscle hypertrophy, improves physical...

🗓️ 2026-11-11
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreA Murinized Bimagrumab Analogue Increases Skeletal Muscle Mass and Improves Cardiometabolic Remodelling in Experimental Hypertrophic Cardiomyopathy.

ZIF-8-Based Nanodelivery of Tectorigenin for Alleviating Skeletal Muscle Atrophy via Inhibition of Oxidative Stress and Inflammation.

BACKGROUND

Skeletal muscle atrophy is a pathological condition characterized by a progressive loss of muscle mass and function. Its core mechanisms involve an imbalance between protein synthesis and degradation, caused by oxidative stress and inflammation. Tectorigenin (TG) shows therapeutic potential but...

🗓️ 2026-11-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreZIF-8-Based Nanodelivery of Tectorigenin for Alleviating Skeletal Muscle Atrophy via Inhibition of Oxidative Stress and Inflammation.

Deuterium-Oxide Labelling Proteomics Illustrates the Importance of Sample Timing and the Limitations of Serial Biopsies.

BACKGROUND

Measuring in vivo protein synthesis is important for testing how interventions, disease and ageing remodel the proteome. A limitation of approaches using short-term infusions of labelled amino acids was that long-term changes had to be extrapolated from short-term measurements. Deuterium oxide...

🗓️ 2026-11-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeuterium-Oxide Labelling Proteomics Illustrates the Importance of Sample Timing and the Limitations of Serial Biopsies.

Molecular targets for the treatment of sarcopenia: a geroscience approach.

INTRODUCTION

Sarcopenia is increasingly recognized as a multisystem geroscience condition. The limited efficacy of first-generation anabolic therapies has challenged the paradigm that increasing muscle mass is sufficient to restore physical performance, highlighting the need for therapeutic strategies that address the biological...

🗓️ 2026-11-08
📰 Publication: Expert Opinion On Therapeutic Targets
Read MoreMolecular targets for the treatment of sarcopenia: a geroscience approach.

Sexually Dimorphic Response to Dietary Restriction-Induced Longevity and Muscle Preservation in Nothobranchius furzeri.

Age-related skeletal muscle decline (sarcopenia) contributes to frailty and mortality, yet how sex influences muscle aging and dietary interventions remains unclear. Using the short-lived vertebrate Nothobranchius furzeri, we investigated how sex and intermittent fasting (IF) interact to regulate lifespan and...

🗓️ 2026-11-06
📰 Publication: Aging Cell
Read MoreSexually Dimorphic Response to Dietary Restriction-Induced Longevity and Muscle Preservation in Nothobranchius furzeri.

Mitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca 2+ Overload-Mitophagy-Ferroptosis Circuit.

BACKGROUND

Denervation-induced muscle atrophy progresses during the interval between nerve injury and reinnervation, and depletion of muscle satellite cells (MuSCs) contributes to impaired functional recovery. Although mitochondrial dysfunction and impaired quality control are implicated in muscle wasting, whether excessive mitochondrial turnover...

🗓️ 2026-11-05
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMitochondrial Transplantation Preserves Regenerative Capacity of Denervated Skeletal Muscle by Disrupting a Ca 2+ Overload-Mitophagy-Ferroptosis Circuit.

S100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

BACKGROUND

In patients with neuroblastoma (NB), skeletal muscle atrophy is a key factor linked to poor survival and decreased long-term quality of life. Nevertheless, there are still insufficient therapeutic methods that work, and the underlying mechanisms remain unclear. As persistent inflammation...

🗓️ 2026-11-05
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreS100A9 Mediates Neuroblastoma-Associated Skeletal Muscle Atrophy via O-GlcNAcylation Repression and Activate Mitophagy Activation.

Remodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

BACKGROUND

The global prevalence of iron deficiency anaemia (IDA) is about 25% and even higher in women of reproductive age and children. IDA can impair skeletal muscle by disrupting oxygen utilization, energy production and contractile function. Haematological effects of intravenous (IV)...

🗓️ 2026-11-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRemodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy.

NUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway.

Cancer-associated cachexia (CAC) is a devastating multifactorial syndrome characterized by progressive skeletal muscle atrophy. Its mechanisms remain incompletely clarified, with limited effective therapeutic targets. NUB1, a negative regulator of ubiquitin-like proteins mediating protein degradation, has not been fully elucidated in...

🗓️ 2026-11-01
Read MoreNUB1 Regulates Muscle Atrophy in Lung Cancer Cachexia via NF-κB Signaling Pathway.

Sulforaphane as a Therapeutic Target for Sarcopenia in Type 2 Diabetes: Mechanistic Insights and Translational Evidence.

Sulforaphane, a bioactive isothiocyanate abundant in cruciferous vegetables, has emerged as a potential multi-target therapeutic agent capable of mitigating these pathological processes. Here, using evidence from preclinical and clinical literature, we review the mechanistic and translational evidence linking sulforaphane with...

🗓️ 2026-10-27
Read MoreSulforaphane as a Therapeutic Target for Sarcopenia in Type 2 Diabetes: Mechanistic Insights and Translational Evidence.

Aquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline.

BACKGROUND

Impaired muscle regeneration is a key contributor to age-related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin-4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that...

🗓️ 2026-10-27
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline.

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.

Skeletal muscle aging is a major cause of frailty, metabolic dysfunction, and loss of independence in later life, yet it cannot be explained by muscle mass loss alone. Recent single-cell, multi-omics, and translational studies show that aged muscle is shaped...

🗓️ 2026-09-22
Read MoreAging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.

Appendicular Skeletal Muscle Mass and Sarcopenia as Prognostic Markers in Amyotrophic Lateral Sclerosis.

BACKGROUND

Amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle wasting and functional decline. Prognostic assessment in clinical practice relies largely on functional scales and traditional anthropometric measures. The prognostic relevance of muscle mass, muscle strength and sarcopenia in ALS remains...

🗓️ 2026-09-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAppendicular Skeletal Muscle Mass and Sarcopenia as Prognostic Markers in Amyotrophic Lateral Sclerosis.

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