Although sarcopenia and insulin resistance are closely related, there is limited evidence regarding how they interact to influence mortality across different population groups. The purpose of this study was to examine the relationship between skeletal muscle mass and insulin resistance...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Non-steroidal anti-inflammatory drugs (NSAIDs) may influence musculoskeletal health. The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6โweeks of aerobic...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Fasting shows promise for public health, but concerns about muscle loss hinder its acceptance, particularly among the elderly. We explored the impact of long-term fasting (12โdays, 250โkcal/day) on muscle structure, metabolism and performance. We prospectively assessed muscle volume, composition, relaxometry...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Programmed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy remains unclear. Ferroptosis in...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
As society ages, identifying individuals at risk of sarcopenia becomes essential. Several plasma biomarkers are used to assess musculoskeletal status, but their results are inconsistent. Extracellular vesicles (EVs) are investigated as disease biomarkers due to their role in transporting molecules...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Falls constitute a significant public health concern among older adults, particularly those with diminished muscle health integrity. The relative contributions of reduced muscle mass versus impaired muscle function to fall risk remain debated. Discrepant conclusions in previous studies exist due...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Additional tools are needed to assess mortality risk among patients with cancer. Patients with chronic graft vs. host disease (cGVHD) after allogeneic haematopoietic cell transplantation (HCT) represent a high-risk cancer population with mortality risk explained by cGVHD severity, but also...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cellular senescence (CS) is a key aging process that leads to irreversible cell cycle arrest and an altered secretory phenotype. In skeletal muscle (SkM), the accumulation of senescent cells contributes to sarcopenia. Despite exercise being a known intervention for maintaining...
Macrophages are key innate immune cells in the muscle environment of sarcopenia patients, significantly influencing muscle stem cell (MuSC) proliferation and differentiation. However, prolonged activation of macrophages can hinder muscle recovery. In this study, it synthesizes lipoic acid-modified gold nanoparticles...
Treatment for metastatic renal cell carcinoma (mRCC) has shifted from tyrosine kinase inhibitor (TKI) therapy to immune checkpoint inhibitor (ICI)-based therapy, improving outcomes but with variable individual responses. This study investigated the prognostic implications of pretreatment low skeletal muscle mass...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The aim of this study was to develop a new, less cumbersome index for determining sarcopenia using axial slice images from computed tomography (CT) as a surrogate for the skeletal muscle index (SMI) measured by bioelectrical impedance analysis (BIA). We...
Age-related conditions, such as osteoporosis and sarcopenia, alongside chronic diseases, can result in significant musculoskeletal tissue loss. This impacts individuals' quality of life and increases risk of falls and fractures. Computed tomography (CT) has been widely used for assessing musculoskeletal...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
While decreased protein intake is associated with muscle mass loss, it is unclear whether a decrease in carbohydrate intake adversely affects muscle atrophy independently of protein intake. Herein, we examined whether a low-carbohydrate (low-CHO) diet exacerbates denervation-induced muscle atrophy under...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Obesity is common in the heart failure (HF) population and is regarded as an important risk factor for developing HF. Greater skeletal muscle mass has shown to be the underlying protective factor against cardiac failure. Since diabetic mellitus (DM) can...
Osteosarcopenia refers to the co-occurrence of osteoporosis and sarcopenia, which are characterized by progressive bone density and muscle mass loss, respectively. Muscle and bone are regulated by many common genes and pathways, enabling potential co-treatment. Because keratocan protects against osteoporosis,...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The scalability of a blood-based sarcopenia assessment has generated interest in circulating markers that may enhance management strategies. Data regarding the relevance of brain derived neurotrophic factor (BDNF), a regulator of neuroplasticity, to sarcopenia in community-dwelling adults are scarce. We...
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