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muscles

Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients.

Hospitalization in older adults often worsens sarcopenia due to prolonged bed rest, poor nutrition, and inactivity. This study examined how hospitalization impacts muscle mass, focusing on oxidative stress and gut-derived endotoxemia. Thirty-one hospitalized older adults were compared with 31 outpatients....

๐Ÿ—“๏ธ 2025-03-01
Read MoreImpact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients.

ROS-responsive MnO mesoporous hydrogel to modulate liver-muscle crosstalk and mitigate NAFLD-associated sarcopenia via exosomal miR-582-5p delivery.

The interrelation between non-alcoholic fatty liver disease (NAFLD) and sarcopenia has emerged as a significant concern due to its systemic impact on metabolic health. However, therapeutic approaches targeting the liver-muscle axis remain underdeveloped. Oxidative stress and inflammatory pathways are key...

๐Ÿ—“๏ธ 2025-03-21
๐Ÿ“ฐ Publication: Theranostics
Read MoreROS-responsive MnO mesoporous hydrogel to modulate liver-muscle crosstalk and mitigate NAFLD-associated sarcopenia via exosomal miR-582-5p delivery.

Physical exercise for primary sarcopenia: an expert opinion.

Sarcopenia is the age-related loss of skeletal muscle mass and function. Recently, research has focused on defining diagnostic criteria for this condition, now recognized as a muscle disease with a specific identifying code (ICD-10: M62.84). The diagnostic process for sarcopenia...

๐Ÿ—“๏ธ 2025-03-28
Read MorePhysical exercise for primary sarcopenia: an expert opinion.

Ibuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats.

Non-steroidal anti-inflammatory drugs (NSAIDs) may influence musculoskeletal health. The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6โ€‰weeks of aerobic...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIbuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats.

Impact of Long-Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function Using P/H MRS and MRI.

Fasting shows promise for public health, but concerns about muscle loss hinder its acceptance, particularly among the elderly. We explored the impact of long-term fasting (12โ€‰days, 250โ€‰kcal/day) on muscle structure, metabolism and performance. We prospectively assessed muscle volume, composition, relaxometry...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImpact of Long-Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function Using P/H MRS and MRI.

Nestin Regulates Autophagy-Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B.

Programmed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy remains unclear. Ferroptosis in...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNestin Regulates Autophagy-Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B.

Blood-Brain Barrier-Penetrating Nanocarriers Enable Microglial-Specific Drug Delivery in Hypothalamic Neuroinflammation.

Hypothalamic inflammation plays a pivotal role in appetite dysregulation across various pathological conditions, including cancer cachexia. However, delivering anti-inflammatory agents to microglia, key mediators of hypothalamic inflammation, remains challenging due to the unsurmountable blood-brain barrier (BBB). To overcome this challenge,...

๐Ÿ—“๏ธ 2025-04-03
๐Ÿ“ฐ Publication: Advanced Healthcare Materials
Read MoreBlood-Brain Barrier-Penetrating Nanocarriers Enable Microglial-Specific Drug Delivery in Hypothalamic Neuroinflammation.

Nuciferine Attenuates Cancer Cachexia-Induced Muscle Wasting in Mice via HSP90AA1.

Around 80% of patients with advanced cancer have cancer cachexia (CC), a serious complication for which there are currently no FDA-approved treatments. Nuciferine (NF) is the main active ingredient of lotus leaf, which has anti-inflammatory, anti-tumour and other effects. The...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNuciferine Attenuates Cancer Cachexia-Induced Muscle Wasting in Mice via HSP90AA1.

Correction to "The Prevalence Patterns and Risk Factor Profiles of Poor Muscle Health and Its Associated Components in Multi-Ethnic Older Asians: The PIONEER Study".

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCorrection to "The Prevalence Patterns and Risk Factor Profiles of Poor Muscle Health and Its Associated Components in Multi-Ethnic Older Asians: The PIONEER Study".

Body Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease.

Additional tools are needed to assess mortality risk among patients with cancer. Patients with chronic graft vs. host disease (cGVHD) after allogeneic haematopoietic cell transplantation (HCT) represent a high-risk cancer population with mortality risk explained by cGVHD severity, but also...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBody Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease.

Prevalence and Prognostic Value of Global Leadership Initiative on Malnutrition (GLIM) Phenotypic Cachexia Criteria in Cancer Patients: A Systematic Review and Meta-Analysis.

The Global Leadership Initiative on Malnutrition (GLIM) criteria provide a framework for evaluating cachexia in cancer patients, yet variability in diagnostic application hinders its use. The aim of the present study was to examine the prevalence and prognostic value of...

๐Ÿ—“๏ธ 2025-03-25
Read MorePrevalence and Prognostic Value of Global Leadership Initiative on Malnutrition (GLIM) Phenotypic Cachexia Criteria in Cancer Patients: A Systematic Review and Meta-Analysis.

Physical training reduces cell senescence and associated insulin resistance in skeletal muscle.

Cellular senescence (CS) is a key aging process that leads to irreversible cell cycle arrest and an altered secretory phenotype. In skeletal muscle (SkM), the accumulation of senescent cells contributes to sarcopenia. Despite exercise being a known intervention for maintaining...

๐Ÿ—“๏ธ 2025-03-22
๐Ÿ“ฐ Publication: Molecular Metabolism
Read MorePhysical training reduces cell senescence and associated insulin resistance in skeletal muscle.

Nanoparticle-Driven Skeletal Muscle Repair and Regeneration Through Macrophage-Muscle Stem Cell Interaction.

Macrophages are key innate immune cells in the muscle environment of sarcopenia patients, significantly influencing muscle stem cell (MuSC) proliferation and differentiation. However, prolonged activation of macrophages can hinder muscle recovery. In this study, it synthesizes lipoic acid-modified gold nanoparticles...

๐Ÿ—“๏ธ 2025-03-20
๐Ÿ“ฐ Publication: Small
Read MoreNanoparticle-Driven Skeletal Muscle Repair and Regeneration Through Macrophage-Muscle Stem Cell Interaction.

Temporalis muscle thickness correlates with premorbid frailty in patients resuscitated from cardiac arrest.

Frailty is associated with mortality and functional outcome after cardiac arrest. Temporalis muscle thickness (TMT) is a measure of sarcopenia, which represents one dimension of frailty. We assessed the correlation between TMT, measured on head computed tomography (CT), and Clinical...

๐Ÿ—“๏ธ 2025-03-12
๐Ÿ“ฐ Publication: Resuscitation
Read MoreTemporalis muscle thickness correlates with premorbid frailty in patients resuscitated from cardiac arrest.

Causal relationships of circulating amino acids with sarcopenia-related traits: A bidirectional Mendelian randomization study.

Recent studies have indicated a correlation between certain Amino acids (AAs) and sarcopenia. However, the exact causal relationship among these associations is still unclear. This study aims to elucidate the causal relationships between 20 types of AAs and the phenotypic...

๐Ÿ—“๏ธ 2025-02-28
๐Ÿ“ฐ Publication: Clinical Nutrition
Read MoreCausal relationships of circulating amino acids with sarcopenia-related traits: A bidirectional Mendelian randomization study.

Paradoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma.

Treatment for metastatic renal cell carcinoma (mRCC) has shifted from tyrosine kinase inhibitor (TKI) therapy to immune checkpoint inhibitor (ICI)-based therapy, improving outcomes but with variable individual responses. This study investigated the prognostic implications of pretreatment low skeletal muscle mass...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreParadoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma.

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