Ageing is a complex multifactorial process, impacting all organs and tissues, with DNA damage accumulation serving as a common underlying cause. To decelerate ageing, various strategies have been applied to model organisms and evaluated for health and lifespan benefits. Dietary...
๐๏ธ 2024-09-08
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely acknowledged, unravelling the underlying molecular mechanisms poses ongoing challenges. Protein ubiquitylation, a crucial...
๐๏ธ 2024-09-16
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Degeneration of the motoneuron and neuromuscular junction (NMJ) and loss of motor units (MUs) contribute to age-related muscle wasting and weakness associated with sarcopenia. However, these features have not been comprehensively investigated in humans. This study aimed to compare neuromuscular...
๐๏ธ 2024-09-05
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Existing definitions of clinically important weight loss in patients with cancer do not specifically address weight loss in patients who are obese at presentation. This review explores the clinical impact of weight loss and depletion of the skeletal muscle mass...
๐๏ธ 2024-07-04
๐ฐ Publication: Current Opinion In Clinical Nutrition And Metabolic Care
Anorexia of aging (AA) is a condition in older adults that includes loss of appetite and reduced food intake. There is a lack of detailed analysis of the potential influence of educational initiatives in addressing AA. This study aimed to...
๐๏ธ 2024-08-21
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cachexia, a syndrome with high prevalence in non-small cell lung cancer patients, impairs quality of life and reduces tolerance and responsiveness to cancer therapy resulting in decreased survival. Optimal nutritional care is pivotal in the treatment of cachexia and a...
๐๏ธ 2024-07-04
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Finding sensitive clinical outcome measures has become crucial in natural history studies and therapeutic trials of neuromuscular disorders. Here, we focus on 1-year longitudinal data from quantitative magnetic resonance imaging (MRI) and phosphorus magnetic resonance spectroscopy (P MRS) in a...
๐๏ธ 2024-04-13
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Frailty is a severe, common co-morbidity associated with heart failure (HF) with preserved ejection fraction (HFpEF). The impact of frailty on HFpEF outcomes may affect treatment choices in HFpEF. The impact of frailty on HFpEF patients and any impact on...
๐๏ธ 2023-12-29
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Muscle and bone are physiologically interconnected, but joint changes of muscle and bone with aging, and whether the muscle-bone changes are different by sex and by country has been little studied. We examined longitudinal associations of bone mineral density (BMD)...
๐๏ธ 2024-02-08
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Accumulating evidence has demonstrated that chronic tobacco smoking directly contributes to skeletal muscle dysfunction independent of its pathological impact to the cardiorespiratory systems. The mechanisms underlying tobacco smoke toxicity in skeletal muscle are not fully resolved. In this study, the...
๐๏ธ 2024-02-09
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Frailty often coexists with heart failure (HF), which significantly aggravates the clinical outcomes of older adults. However, studies investigating the interplay between frailty and HF in older adults are scarce. We aimed to assess the prevalence of frailty using the...
๐๏ธ 2024-01-30
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The risk of subsequent cardiovascular disease (CVD) is high in cancer survivors. Although metabolic syndrome is an established risk factor for CVD, its association with cancer survivors has not yet been established. This study aimed to clarify whether metabolic syndrome...
๐๏ธ 2024-03-22
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value. The aim of this systematic review was to summarize and evaluate endpoints used to assess appetite...
๐๏ธ 2024-02-11
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. This review describes the frequency, variety, and reporting of...
๐๏ธ 2024-03-29
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Most studies on body composition in kidney cancer have been conducted among patients with metastatic disease. Given that aggressive tumours can adversely impact body composition and even non-metastatic tumours can be aggressive, we evaluated associations between pre-surgical body composition features...
๐๏ธ 2024-01-24
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Patients with pancreatic cancer often suffer from cachexia and experience gastrointestinal symptoms that may be related to intestinal smooth muscle cell (SMC) dysfunction. We hypothesized that pancreatic tumor organoids from cachectic patients release factors that perturb the SMC's contractile characteristics....
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