Targeting GDF-15 in cancer cachexia and immunity.
๐ฐ Journal: Nature Medicine
Read MoreTargeting GDF-15 in cancer cachexia and immunity.SCWD Publications Digest
Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.
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Correction to "The Prevalence Patterns and Risk Factor Profiles of Poor Muscle Health and Its Associated Components in Multi-Ethnic Older Asians: The PIONEER Study".
๐ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCorrection to "The Prevalence Patterns and Risk Factor Profiles of Poor Muscle Health and Its Associated Components in Multi-Ethnic Older Asians: The PIONEER Study".Body Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease.
Additional tools are needed to assess mortality risk among patients with cancer. Patients with chronic graft vs. host disease (cGVHD) after allogeneic haematopoietic cell transplantation (HCT) represent a high-risk cancer population with mortality risk explained by cGVHD severity, but also...
๐ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBody Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease.Metformin and physical performance in older people with probable sarcopenia and physical prefrailty or frailty in Englandย (MET-PREVENT): a double-blind, randomised, placebo-controlled trial.
Metformin has effects on multiple biological systems relevant to ageing and has been posited as a candidate therapy for sarcopenia and physical frailty. We aimed to test the efficacy and safety of metformin, a candidate geroprotector, to improve physical performance...
A Dynamic Time Warping Extension to Consensus Weight-Based Cachexia Criteria Improves Prediction of Cancer Patient Outcomes.
Cachexia is a complex syndrome that impacts up to half of patients with cancer. Criteria systems have been developed for the purpose of diagnosing and grading cachexia severity in clinical settings. One of the most widely known is those developed...
Prevalence and Prognostic Value of Global Leadership Initiative on Malnutrition (GLIM) Phenotypic Cachexia Criteria in Cancer Patients: A Systematic Review and Meta-Analysis.
The Global Leadership Initiative on Malnutrition (GLIM) criteria provide a framework for evaluating cachexia in cancer patients, yet variability in diagnostic application hinders its use. The aim of the present study was to examine the prevalence and prognostic value of...
Physical training reduces cell senescence and associated insulin resistance in skeletal muscle.
Cellular senescence (CS) is a key aging process that leads to irreversible cell cycle arrest and an altered secretory phenotype. In skeletal muscle (SkM), the accumulation of senescent cells contributes to sarcopenia. Despite exercise being a known intervention for maintaining...
๐ฐ Journal: Molecular Metabolism
Read MorePhysical training reduces cell senescence and associated insulin resistance in skeletal muscle.Multimodal interventions for cachexia management.
Cachexia (disease-related wasting) is a complex metabolic syndrome which occurs in people with chronic illnesses, including cancer, HIV/AIDS, kidney disease, heart disease, and chronic obstructive pulmonary disease (COPD). People with cachexia experience unintentional weight loss, muscle loss, fatigue, loss of...
๐ฐ Journal: Cochrane Database Of Systematic Reviews
Read MoreMultimodal interventions for cachexia management.A Novel Definition and Grading Diagnostic Criteria for Tumour-Type-Specific Comprehensive Cachexia Risk.
The existing diagnostic criteria for cancer cachexia do not meet clinical needs. We aimed to establish novel comprehensive evaluation scales for cachexia specific to patients with solid tumours. This study included 12โ651 patients (males: 6793 [53.7%]; females: 5858 [46.3%]; medium...
๐ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreA Novel Definition and Grading Diagnostic Criteria for Tumour-Type-Specific Comprehensive Cachexia Risk.Nanoparticle-Driven Skeletal Muscle Repair and Regeneration Through Macrophage-Muscle Stem Cell Interaction.
Macrophages are key innate immune cells in the muscle environment of sarcopenia patients, significantly influencing muscle stem cell (MuSC) proliferation and differentiation. However, prolonged activation of macrophages can hinder muscle recovery. In this study, it synthesizes lipoic acid-modified gold nanoparticles...
๐ฐ Journal: Small
Read MoreNanoparticle-Driven Skeletal Muscle Repair and Regeneration Through Macrophage-Muscle Stem Cell Interaction.Looking Towards More Comprehensive Management of Interstitial Lung Disease.
๐ฐ Journal: Respirology
Read MoreLooking Towards More Comprehensive Management of Interstitial Lung Disease.Sarcopenic obesity and the risk of atrial fibrillation in non-diabetic older adults: A prospective cohort study.
Evidence of an association between sarcopenic obesity (SO) and the risk of long-term atrial fibrillation (AF) is lacking, and the underlying involvement of insulin resistance (IR) and inflammation is not clear. This community-based prospective cohort study evaluated sarcopenia, obesity, and...
๐ฐ Journal: Clinical Nutrition
Read MoreSarcopenic obesity and the risk of atrial fibrillation in non-diabetic older adults: A prospective cohort study.Temporalis muscle thickness correlates with premorbid frailty in patients resuscitated from cardiac arrest.
Frailty is associated with mortality and functional outcome after cardiac arrest. Temporalis muscle thickness (TMT) is a measure of sarcopenia, which represents one dimension of frailty. We assessed the correlation between TMT, measured on head computed tomography (CT), and Clinical...
๐ฐ Journal: Resuscitation
Read MoreTemporalis muscle thickness correlates with premorbid frailty in patients resuscitated from cardiac arrest.Butyrate (short-chain fatty acid) alleviates lipopolysaccharide-binding proteins and improves physical function in knee osteoarthritis patients.
Knee-osteoarthritis (OA) is often associated with increased intestinal permeability, potentially causing sarcopenia, and mobility issues. Current treatments are ineffective. The objective of this study was to investigate if butyrate improves sarcopenia and physical function in knee-OA patients, and if improvements...
๐ฐ Journal: International Journal Of Biological Macromolecules
Read MoreButyrate (short-chain fatty acid) alleviates lipopolysaccharide-binding proteins and improves physical function in knee osteoarthritis patients.Causal relationships of circulating amino acids with sarcopenia-related traits: A bidirectional Mendelian randomization study.
Recent studies have indicated a correlation between certain Amino acids (AAs) and sarcopenia. However, the exact causal relationship among these associations is still unclear. This study aims to elucidate the causal relationships between 20 types of AAs and the phenotypic...
๐ฐ Journal: Clinical Nutrition
Read MoreCausal relationships of circulating amino acids with sarcopenia-related traits: A bidirectional Mendelian randomization study.Efficacy of nutrient supplements in managing malnutrition and sarcopenia in Chronic Obstructive Pulmonary Disease (COPD) patients: a protocol for systematic review and meta-analysis.
COPD patients suffering from malnutrition or sarcopenia often incur higher healthcare costs and experience adverse clinical outcomes. Despite this, the effectiveness of nutrient supplements in this population remains uncertain. Two reviewers will independently search seven databases-PubMed, Embase, Web of Science,...