SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Are we making progress in the diagnosis and management of sarcopenia? Results from a UK-wide survey.

PURPOSE

To describe current practice in diagnosis and management of sarcopenia in older people in the United Kingdom (UK).

METHODS

Healthcare professionals from UK organisations were invited to complete an online survey about sarcopenia diagnosis and management.

RESULTS

One hundred and one responses were analysed....

📰 Journal: European Geriatric Medicine
Read MoreAre we making progress in the diagnosis and management of sarcopenia? Results from a UK-wide survey.

Emerging basic science concepts in geriatric fracture fixation and patient recovery.

In recent history, human life expectancy has increased significantly, resulting in a high burden of late-life morbidity and geriatric fractures. Changes to the body as a result of aging, such as degeneration of the bone marrow, osteoblast apoptosis, and a...

Read MoreEmerging basic science concepts in geriatric fracture fixation and patient recovery.

High "sarcopenia index" reduce all-cause mortality in patients with acute myocardial infarction.

BACKGROUNDThe product of serum creatinine and cystatin C-based estimated glomerular filtration rate (hereinafter referred to as "Cr × eGFRcys"), serving as the formula for the Sarcopenia Index (SI), could be regarded as a representative marker for sarcopenia. However, no studies...

📰 Journal: Clinical Nutrition
Read MoreHigh "sarcopenia index" reduce all-cause mortality in patients with acute myocardial infarction.

Silencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.

Maintaining skeletal muscle mass is crucial for health, as muscle atrophy caused by drugs, cancer, or aging poses serious risks. However, there are few effective pharmacological interventions targeting muscle atrophy, highlighting the need for new therapeutic strategies. In this study,...

📰 Journal: Advanced Healthcare Materials
Read MoreSilencing Myostatin Using In Vivo Self-Assembled siRNA Protects Against Cancer- and Dexamethasone-Induced Muscle Atrophy.

New models for cancer cachexia and their application to drug discovery.

Cancer cachexia (CC) is a multifactorial syndrome characterized by progressive weight loss, anorexia, and loss of skeletal muscle and fat mass, resulting in reduced quality of life and poor prognosis. Currently, there are no approved pharmacological treatments for CC, highlighting...

📰 Journal: Expert Opinion On Drug Discovery
Read MoreNew models for cancer cachexia and their application to drug discovery.

Cachexia progression differs among mouse models of metastatic triple-negative breast cancer.

Cancer-associated cachexia decreases quality of life, reduces therapy response, and diminishes survival prospects. Effective cachexia countermeasures remain a significant unmet need. Research into cancer cachexia has made extensive use of models of colon, lung and pancreatic cancers. However, while cachexia...

📰 Journal: American Journal Of Physiology-Cell Physiology
Read MoreCachexia progression differs among mouse models of metastatic triple-negative breast cancer.

Muscle-Specific Strength Better Predicts Physical Performance Decline Than Conventional Metrics: The I-Lan Longitudinal Aging Study.

Muscle-specific strength (MSS), defined as grip strength normalized to arm muscle mass, may better reflect muscle efficiency than grip strength. Despite its potential utility in diagnosing sarcopenia, longitudinal studies evaluating MSS as a predictor of sarcopenia-related outcomes remain limited. This...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle-Specific Strength Better Predicts Physical Performance Decline Than Conventional Metrics: The I-Lan Longitudinal Aging Study.

Impact of Relative Energy Deficiency in Sport (REDs) on Bone Health in Elite Athletes: A Retrospective Analysis.

Relative energy deficiency in sport (REDs) is associated with impaired performance and compromised bone health in elite athletes. While reduced bone mineral density (BMD) and increased risk for bone stress injuries are well documented, the underlying metabolic mechanisms remain poorly...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImpact of Relative Energy Deficiency in Sport (REDs) on Bone Health in Elite Athletes: A Retrospective Analysis.

CSE/H 2S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization-Induced Muscle Atrophy in Mice.

Hydrogen sulphide (H 2S), a gasotransmitter synthesized by cystathionine-γ-lyase (CSE), exhibits antioxidant properties and may mimic exercise-induced muscle protection. However, its mechanistic role in muscle atrophy and exercise intervention remains unclear. Six-month-old male wild-type (WT) and SESN2 knockout (SESN2 -/-)...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCSE/H 2S/SESN2 Signalling Mediates the Protective Effect of Exercise Against Immobilization-Induced Muscle Atrophy in Mice.

Muscle Abnormalities in Nonhospitalised Patients With Post-COVID-19 Condition.

Post-COVID condition (PCC) affects ~10% of SARS-CoV-2-infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the skeletal muscle of these patients and compare them with healthy controls. Biopsies were...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Abnormalities in Nonhospitalised Patients With Post-COVID-19 Condition.

Sex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia.

Cancer cachexia, a multifactorial condition resulting in muscle and adipose tissue wasting, reduces the quality of life of many people with cancer. Cachexia is highly prevalent in people with pancreatic ductal adenocarcinoma (PDAC), and many animal models of pancreatic cancer...

📰 Journal: Journal Of Applied Physiology
Read MoreSex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia.

Association of cachexia with activities of daily living and discharge destinations among inpatients with dysphagia in a convalescent rehabilitation phase; A multi-center cohort study.

Although a recent study reported an association between cachexia, as defined by the Asian Working Group for Cachexia (AWGC), and lower functional recovery at discharge among post-stroke patients capable of oral intake during the convalescent rehabilitation phase, its impact on...

Read MoreAssociation of cachexia with activities of daily living and discharge destinations among inpatients with dysphagia in a convalescent rehabilitation phase; A multi-center cohort study.

Body composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study.

Appendicular lean mass index is a major determinant of cardiorespiratory fitness in patients with obesity-related heart failure with preserved ejection fraction (HFpEF). Moreover, appendicular lean mass index can be used to diagnose sarcopenia and sarcopenic obesity in this population. We...

📰 Journal: Journal Of Parenteral And Enteral Nutrition
Read MoreBody composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study.

Assessing the need for multimodal care in anorexia and cachexia patients with advanced cancer referred to palliative care: a secondary analysis of a multicenter survey in Japan.

There are no methods for assessing the need for multimodal care in cancer cachexia. We examined nine components in evaluating needs among advanced cancer patients. This was a self-administered survey. Participants rated their nutrition impact symptoms (NISs) using a numerical...

📰 Journal: Supportive Care In Cancer
Read MoreAssessing the need for multimodal care in anorexia and cachexia patients with advanced cancer referred to palliative care: a secondary analysis of a multicenter survey in Japan.

Pre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: the ColoCare Study.

Cachexia accounts for about 20% of all cancer-related deaths and it is indicative of poor prognosis and progressive functional impairment. The role of the gut microbiome in the development of cachexia in colorectal cancer (CRC) patients has not been established....

📰 Journal: Cancer Causes & Control
Read MorePre-surgery gut microbial diversity and abundance are associated with post-surgery onset of cachexia in colorectal cancer patients: the ColoCare Study.

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