EXERCISE

Moderate Aerobic Training Causes Muscle Wasting in a DMBA-Induced Sarcoma Rat Model.

Cancer cachexia, characterized by severe body weight loss, negatively affects patient quality of life and survival. Although moderate exercise benefits healthy and chronically ill individuals, and the effect of exercise in cachexia generally appears beneficial, conflicting results have been reported...

🗓️ 2026-03-14
📰 Publication: International Journal Of Molecular Sciences
Read MoreModerate Aerobic Training Causes Muscle Wasting in a DMBA-Induced Sarcoma Rat Model.

Muscle Movement and Metabolism: Exercise and Skeletal Muscle as Mediators of Health. A Report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.

Skeletal muscle is a crucial facilitator of many of the effects of exercise on metabolic health. Intrinsic myocellular mechanisms, exercise-induced myokine secretion, and crosstalk between multiple organ systems contribute to the maintenance of energy homeostasis, cardiovascular health, strength, cognition, and...

🗓️ 2026-03-12
📰 Publication: American Journal Of Clinical Nutrition
Read MoreMuscle Movement and Metabolism: Exercise and Skeletal Muscle as Mediators of Health. A Report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025.

Muscle-immune metabolic crosstalk: shared pathways in cachexia and exercise.

Skeletal muscle and the immune system continuously exchange metabolites and signals that are essential for homeostasis. Disruption of this communication, such as during infection, inflammation, or cancer, triggers cachexia, a severe wasting syndrome characterized by altered amino acid flux, mitochondrial...

🗓️ 2026-02-21
📰 Publication: Current Opinion In Biotechnology
Read MoreMuscle-immune metabolic crosstalk: shared pathways in cachexia and exercise.

Multi-modal integrated intervention combining exercise, anti-inflammatory, and dietary advice (MMIEAD) for adults with kidney cachexia: protocol for a mixed-methods feasibility cluster randomised controlled trial and process evaluation.

BACKGROUND

Kidney cachexia is a debilitating and under-recognised complication of advanced chronic kidney disease (CKD), characterised by unintentional weight loss, muscle wasting, inflammation, and reduced functional capacity. Its profound impact on morbidity, quality of life, and healthcare utilisation underscores the need...

🗓️ 2026-02-20
Read MoreMulti-modal integrated intervention combining exercise, anti-inflammatory, and dietary advice (MMIEAD) for adults with kidney cachexia: protocol for a mixed-methods feasibility cluster randomised controlled trial and process evaluation.

Association of the "Weekend Warrior" Exercise Pattern With Sarcopenia in Middle-Aged and Older Adults: Comparison With Regular Activity and Inactivity Patterns.

PURPOSE

Although the "weekend warrior (WW)" physical activity (PA) pattern has known health benefits, its association with sarcopenia is unclear. This study examined whether the WW PA pattern is associated with a lower likelihood of sarcopenia compared with the inactive and...

🗓️ 2026-01-30
Read MoreAssociation of the "Weekend Warrior" Exercise Pattern With Sarcopenia in Middle-Aged and Older Adults: Comparison With Regular Activity and Inactivity Patterns.

HQ8: Do Nutritional Interventions Prevent the Onset and Progression of Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

🗓️ 2026-01-15
📰 Publication: Geriatrics & Gerontology International
Read MoreHQ8: Do Nutritional Interventions Prevent the Onset and Progression of Frailty in Older Adults?: English Translation of the Japanese Guideline for Digital Health for the Prevention and Improvement of Sarcopenia and Frailty.

Screening for Malnutrition, Sarcopenia, and Physical Frailty Beyond One Year after Liver Transplantation.

BACKGROUND/AIMS

Malnutrition, sarcopenia, and frailty negatively impact quality of life and increase mortality following liver transplantation (LT). However, long-term follow-up data remain limited. This study aimed primarily to assess the malnutrition risk at 1-, 2-, and 3-years post-LT. Secondary objectives included...

🗓️ 2026-01-15
Read MoreScreening for Malnutrition, Sarcopenia, and Physical Frailty Beyond One Year after Liver Transplantation.

Skeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.

The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development of diabetes and obesity. The tumour suppressor...

🗓️ 2024-07-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.

Change in physical activity and its association with decline in kidney function: A UK Biobank-based cohort study.

Previous research on the association between physical activity (PA) and kidney function is inconsistent. The association between muscle mass and serum creatinine (SCr) may have implications for interpreting the effect of PA on estimated glomerular filtration rate (eGFR). Few studies...

🗓️ 2024-08-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreChange in physical activity and its association with decline in kidney function: A UK Biobank-based cohort study.

Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi-centre factorial randomized trial.

Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations. This hypothesis-generating analysis used biospecimens collected from a multi-centre 2 × 2 factorial...

🗓️ 2024-06-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEffects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi-centre factorial randomized trial.

The maternal lifestyle in pregnancy: Implications for foetal skeletal muscle development.

The world is facing a global nutrition crisis, as evidenced by the rising incidence of metabolic disorders such as obesity, insulin resistance and chronic inflammation. Skeletal muscle is the largest tissue in humans and plays an important role in movement...

🗓️ 2024-08-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe maternal lifestyle in pregnancy: Implications for foetal skeletal muscle development.

Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.

Due to increasing older populations worldwide, injuries, disabilities and deaths caused by falls among the elderly represent a growing human and societal problem. We aimed to improve health among men of at least 70 years of age with low-normal to low...

🗓️ 2024-06-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBeneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.

Telerehabilitation improves cardiorespiratory and muscular fitness and body composition in older people with post-COVID-19 syndrome.

The effects of post-coronavirus disease 2019 (COVID-19) syndrome on the cardiorespiratory and muscular fitness in older people are of utmost relevance. This study aimed to evaluate the effects of a 12-week telerehabilitation programme on cardiorespiratory and muscular fitness and body...

🗓️ 2024-06-27
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreTelerehabilitation improves cardiorespiratory and muscular fitness and body composition in older people with post-COVID-19 syndrome.

Cross-sectional interactive associations of physical activity and sedentary behaviour with physical capacity across adulthood.

The way physical activity (PA) and sedentary behaviour (SB) independently and interactively modify the age-related decline in physical capacity remains poorly understood. This cross-sectional study investigated the independent and interactive associations of PA and SB with physical function and performance...

🗓️ 2024-04-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCross-sectional interactive associations of physical activity and sedentary behaviour with physical capacity across adulthood.

Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates.

Mitochondria represent key organelles influencing cellular homeostasis and have been implicated in the signalling events regulating protein synthesis. We examined whether mitochondrial bioenergetics (oxidative phosphorylation and reactive oxygen species (HO) emission, ROS) measured in vitro in permeabilized muscle fibres represent...

🗓️ 2024-07-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates.

Lean body mass and the cardiorespiratory phenotype: An ethnic-specific relationship in Hans Chinese women and men.

Lean body mass (LBM) and the functional capacity of cardiovascular (CV) and respiratory systems constitute a female-specific relationship in European-American individuals. Whether this recent finding be extrapolated to the world's largest ethnic group, that is, Hans Chinese (HC, a population...

🗓️ 2024-04-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLean body mass and the cardiorespiratory phenotype: An ethnic-specific relationship in Hans Chinese women and men.

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