Research

Mitochondrial stress bridge: Could muscle-derived extracellular vesicles be the missing link between sarcopenia, insulin resistance, and chemotherapy-induced cardiotoxicity?

Sarcopenia is currently considered a systemic condition that goes beyond muscle atrophy to include multifunctional metabolic and cardiovascular dysfunction. The mediators between skeletal muscle loss and entire body insulin resistance and increased vulnerability to cardiotoxicity caused by chemotherapy are not...

๐Ÿ—“๏ธ 2025-11-21
๐Ÿ“ฐ Publication: Biomedicine & Pharmacotherapy
Read MoreMitochondrial stress bridge: Could muscle-derived extracellular vesicles be the missing link between sarcopenia, insulin resistance, and chemotherapy-induced cardiotoxicity?

Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review.

Population aging has become a widespread health problem that leads to huge socioeconomic burden. Skeletal muscle as an important component of motor system, gradually degenerates with age. Age-related muscle disorders, such as sarcopenia is associated with higher risks of falls,...

๐Ÿ—“๏ธ 2025-10-24
๐Ÿ“ฐ Publication: Aging And Disease
Read MoreAdvancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review.

Multispectral Optoacoustic Tomography of Skeletal Muscle Unveils Microcirculation and Oxygen Metabolism Alterations in Sarcopenia.

<p><b>BACKGROUND</b></p><p>Sarcopenia, a significant geriatric syndrome, faces challenges in accurate diagnosis due to limitations of current imaging techniques. This study explores the novel application of multispectral optoacoustic tomography (MSOT) in evaluating sarcopenia, focusing on quantifying oxygen dynamics and collagen distribution in...

๐Ÿ—“๏ธ 2025-10-21
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMultispectral Optoacoustic Tomography of Skeletal Muscle Unveils Microcirculation and Oxygen Metabolism Alterations in Sarcopenia.

Cachexia in Pancreatic Cancer: New Insights to Impact Quality of Life and Survival.

Introduction: Cancer cachexia is associated with systemic inflammation and metabolic derangement, leading to muscle atrophy, which affects over 80% of pancreatic cancer patients, the highest rate among all malignancies, negatively impacting quality of life and significantly reducing survival rate. Malnutrition,...

๐Ÿ—“๏ธ 2025-09-25
Read MoreCachexia in Pancreatic Cancer: New Insights to Impact Quality of Life and Survival.

A triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies.

<p><b>BACKGROUND</b></p><p>Rapid population aging has intensified the prevalence of malnutrition, sarcopenia, frailty, and oral dysfunction, significantly affecting healthcare outcomes and quality of life in older adults. A growing body of evidence suggests that integrating rehabilitation, nutrition support, and oral health management-a...

๐Ÿ—“๏ธ 2025-09-15
๐Ÿ“ฐ Publication: Nutrition
Read MoreA triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies.

New models for cancer cachexia and their application to drug discovery.

Cancer cachexia (CC) is a multifactorial syndrome characterized by progressive weight loss, anorexia, and loss of skeletal muscle and fat mass, resulting in reduced quality of life and poor prognosis. Currently, there are no approved pharmacological treatments for CC, highlighting...

๐Ÿ—“๏ธ 2025-10-03
๐Ÿ“ฐ Publication: Expert Opinion On Drug Discovery
Read MoreNew models for cancer cachexia and their application to drug discovery.

Adipose-Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation.

Sarcopenic obesity, characterized by the concurrent presence of excess adiposity and diminished skeletal muscle mass and function, is closely linked to frailty, chronic inflammation, and insulin resistance. The increasing prevalence of sarcopenic obesity is driven by the global aging population,...

๐Ÿ—“๏ธ 2025-08-13
๐Ÿ“ฐ Publication: Obesity Reviews
Read MoreAdipose-Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation.

Oral apigenin prevents obesity-related muscular atrophy, but not obesity itself, in middle-aged rats fed a high-calorie diet.

Obesity constitutes a growing global health concern, affecting individuals during the aging process. Flavonoids that increase tissue NAD+โ€ฏlevels, such as apigenin (Api), are proposed for the treatment of obesity and age-related diseases. Thus, this study aimed to provide initial preclinical...

๐Ÿ—“๏ธ 2025-07-12
๐Ÿ“ฐ Publication: Biomedicine & Pharmacotherapy
Read MoreOral apigenin prevents obesity-related muscular atrophy, but not obesity itself, in middle-aged rats fed a high-calorie diet.

Soyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1ฮฑ and PI3K pathway.

Sarcopenia, caused by aging, is characterized by the reduction of muscle mass and function. In this study, we investigated the effects of soyasapogenol B on skeletal muscle and the underlying mechanisms to determine its potential as a prevention for sarcopenia....

๐Ÿ—“๏ธ 2025-07-05
๐Ÿ“ฐ Publication: Biomedicine & Pharmacotherapy
Read MoreSoyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1ฮฑ and PI3K pathway.

Clarification and standardization of dual-energy X-ray absorptiometry terminology for accurate scientific communication and clinical diagnostic accuracy.

The evaluation of skeletal muscle (SM) mass has significant clinical and research relevance in the diagnosis and management of conditions such as malnutrition, sarcopenia, sarcopenic obesity, and cancer cachexia. Dual-energy X-ray absorptiometry (DXA) is now the most widely used method...

๐Ÿ—“๏ธ 2025-06-30
๐Ÿ“ฐ Publication: American Journal Of Clinical Nutrition
Read MoreClarification and standardization of dual-energy X-ray absorptiometry terminology for accurate scientific communication and clinical diagnostic accuracy.

Sarcopenia in Parkinson's disease: From pathogenesis to interventions.

Parkinson's disease (PD) and sarcopenia are prevalent age-related conditions that often coexist in affected individuals. Sarcopenia is particularly common among PD patients, with severe cases affecting approximately one in five individuals with the disease. Furthermore, sarcopenia is closely linked to...

๐Ÿ—“๏ธ 2025-04-19
๐Ÿ“ฐ Publication: Metabolism-Clinical And Experimental
Read MoreSarcopenia in Parkinson's disease: From pathogenesis to interventions.

A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti-Aging Mechanisms.

Skeletal muscle function and mass continuously decrease during aging. Most studies target limb muscles owing to their direct impact on mobility and falls risk. The diaphragm (DIA), also a type of skeletal muscle with different phenotype, has received less attention....

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreA Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti-Aging Mechanisms.

Multimodal interventions for cachexia management.

Cachexia (disease-related wasting) is a complex metabolic syndrome which occurs in people with chronic illnesses, including cancer, HIV/AIDS, kidney disease, heart disease, and chronic obstructive pulmonary disease (COPD). People with cachexia experience unintentional weight loss, muscle loss, fatigue, loss of...

๐Ÿ—“๏ธ 2025-03-25
๐Ÿ“ฐ Publication: Cochrane Database Of Systematic Reviews
Read MoreMultimodal interventions for cachexia management.

Causal relationships of circulating amino acids with sarcopenia-related traits: A bidirectional Mendelian randomization study.

Recent studies have indicated a correlation between certain Amino acids (AAs) and sarcopenia. However, the exact causal relationship among these associations is still unclear. This study aims to elucidate the causal relationships between 20 types of AAs and the phenotypic...

๐Ÿ—“๏ธ 2025-02-28
๐Ÿ“ฐ Publication: Clinical Nutrition
Read MoreCausal relationships of circulating amino acids with sarcopenia-related traits: A bidirectional Mendelian randomization study.

Detrimental Effects of ฮฒ2-Microglobulin on Muscle Metabolism: Evidence From Inย Vitro, Animal and Human Research.

ฮฒ2-Microglobulin (B2M) has garnered considerable interest as a potential pro-ageing factor, leading to speculation about its involvement in muscle metabolism and the development of sarcopenia, a key component of ageing phenotypes. To explore this hypothesis, we conducted a comprehensive investigation...

๐Ÿ—“๏ธ 2025-04-01
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDetrimental Effects of ฮฒ2-Microglobulin on Muscle Metabolism: Evidence From Inย Vitro, Animal and Human Research.

Selpercatinib mitigates cancer cachexia independent of anti-tumor activity in the HT1080 tumor model.

Anorexia is a major cause of cancer cachexia and is induced by growth differentiation factor-15 (GDF15), which activates the rearranged during transfection (RET) protein tyrosine kinase in the hindbrain through GDF family receptor ฮฑ-like (GFRAL), raising the possibility of targeting...

๐Ÿ—“๏ธ 2025-01-06
๐Ÿ“ฐ Publication: Cancer Letters
Read MoreSelpercatinib mitigates cancer cachexia independent of anti-tumor activity in the HT1080 tumor model.

Subscribe to the SCWD Newsletter

Stay Informed with the Latest Updates and Exclusive Insights!