Sarcopenia

Primary-Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity.

BACKGROUND

Colon cancer (CC), the third most common cancer worldwide, is accompanied by cachexia in 30% of patients. Its associated muscle loss directly impairs therapeutic response and survival. Early intervention is crucial, yet the underlying mechanisms of early-stage muscle dysfunction remain...

🗓️ 2025-11-12
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePrimary-Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity.

A Creatinine-CAR Composite Index (CCAR) Optimized by Machine Learning for Prognosis in Cancer Cachexia.

BACKGROUND

Cancer cachexia is a multifactorial syndrome associated with poor prognosis and impaired quality of life in cancer patients. However, survival prediction in cancer cachexia remains difficult due to the lack of reliable biomarkers.

METHODS

This retrospective cohort study analysed data from 1,367...

🗓️ 2025-11-11
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreA Creatinine-CAR Composite Index (CCAR) Optimized by Machine Learning for Prognosis in Cancer Cachexia.

STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

BACKGROUND

Mitochondrial homeostasis is vital for optimal skeletal muscle integrity. Mitochondrial quality control (MQC) mechanisms that are essential for maintaining proper functions of mitochondria include mitochondrial biogenesis, dynamics and mitophagy. Previously, Syntaxin 4 (STX4), traditionally considered a cell surface protein known...

🗓️ 2025-11-11
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSTX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

Lean Body Mass Associates With a Hypertensive Cardiovascular Phenotype in Men but Not in Women.

BACKGROUND

Lean body mass (LBM) is independently associated with the function and structure of the cardiovascular (CV) system in women and genetically predisposed men with low LBM. Yet, the relationship between LBM and the CV system remains uncertain in the general...

🗓️ 2025-11-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLean Body Mass Associates With a Hypertensive Cardiovascular Phenotype in Men but Not in Women.

Muscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia.

BACKGROUND

Adalimumab, a TNF-α inhibitor, is widely used clinically. Recent studies suggest Adalimumab can improve muscle damage after ischemic stroke (IS), but its protective mechanisms remain unclear. This study investigates the effect of adalimumab on muscle structure post-IS and the role...

🗓️ 2025-11-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia.

Targeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis.

BACKGROUND

Type 2 diabetes mellitus (T2D) arises from the interplay between peripheral insulin resistance and pancreatic β-cell dysfunction, ultimately leading to impaired glucose utilization and chronic hyperglycemia. Despite therapeutic advances, the multifactorial nature of T2D continues to demand the development of...

🗓️ 2025-11-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreTargeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis.

Rethinking Muscle Aging Through the Lens of Fibro-Adipogenic Progenitors.

Aging of skeletal muscles is accompanied by a progressive deposition of adipose and fibrotic tissue within the interstitial compartment. This process profoundly disrupts the structural integrity and contractile function of the muscle. Such maladaptive remodeling not only compromises muscle performance...

🗓️ 2025-11-10
📰 Publication: Aging And Disease
Read MoreRethinking Muscle Aging Through the Lens of Fibro-Adipogenic Progenitors.

An Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins.

BACKGROUND

Cystinosis is a rare multisystem, autosomal recessive disease caused by dysfunction or loss of cystinosin (CTNS), which results in lysosomal cystine accumulation, primarily affecting the kidneys. Advances in renal transplantation, cysteamine treatment and improved medical care have increased life expectancy,...

🗓️ 2025-11-10
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAn Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins.

Sarcopenia in Atrial Fibrillation: A Risk Factor for Adverse Outcomes in a UK Biobank Study.

BACKGROUND AND AIMS

Sarcopenia, characterized by reduced muscle mass and function, has been increasingly implicated in cardiovascular disorders. However, its prognostic relevance in atrial fibrillation (AF) remains unclear. This study evaluated the association between sarcopenia and adverse outcomes in individuals with...

🗓️ 2025-11-09
📰 Publication: Europace
Read MoreSarcopenia in Atrial Fibrillation: A Risk Factor for Adverse Outcomes in a UK Biobank Study.

Budget impact analysis of a muscle-targeted nutritional intervention for sarcopenia.

BACKGROUND

In old adult patients with sarcopenia hospitalized for rehabilitation, the superior clinical benefit of a muscle-targeted formula (MTF; whey protein-based enriched with leucine and vitamin D) over an iso-caloric protein-free one was assessed through the IRIS trial (NCT03120026). The aim...

🗓️ 2025-11-09
📰 Publication: Clinical Nutrition
Read MoreBudget impact analysis of a muscle-targeted nutritional intervention for sarcopenia.

Anabolic Effects of Salbutamol Are Lost Upon Immobilization.

BACKGROUND

Periods of muscle disuse occur during hospitalization, illness or the recovery from (sports) injury and lead to a rapid loss of muscle mass and the development of insulin resistance. Salbutamol is a fast-acting β2-adrenoreceptor agonist that may improve muscle protein...

🗓️ 2025-11-06
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAnabolic Effects of Salbutamol Are Lost Upon Immobilization.

Sarcopenia and MASLD: novel insights and the future.

Metabolic dysfunction-associated steatotic liver disease (MASLD; previously known as non-alcoholic fatty liver disease) is the leading cause of chronic liver disease worldwide and is closely linked to the obesity epidemic. MASLD often coexists with sarcopenia, an age-related loss of muscle...

🗓️ 2025-11-06
📰 Publication: Nature Reviews Endocrinology
Read MoreSarcopenia and MASLD: novel insights and the future.

Glucagon-like peptide-1 receptor agonists and sarcopenia-related markers in diabetes: A systematic review and meta-analysis.

AIMS

GLP-1 receptor agonists (GLP-1RAs) are first-line therapies for type 2 diabetes (T2DM) due to their additional weight-lowering and cardiovascular benefits. However, their impact on muscle mass is debated, posing a concern for sarcopenia in older adults with T2DM. This systematic...

🗓️ 2025-11-05
📰 Publication: Clinical Nutrition
Read MoreGlucagon-like peptide-1 receptor agonists and sarcopenia-related markers in diabetes: A systematic review and meta-analysis.

A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update.

The Asian Working Group for Sarcopenia (AWGS) presents an updated 2025 consensus reframing sarcopenia management through a life-course approach to muscle health promotion. While aligning with the Global Leadership Initiative in Sarcopenia (GLIS), this update provides healthcare providers with Asia-specific...

🗓️ 2025-11-05
Read MoreA focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update.

Postinactivity Exercise Training Improves Sarcopenia Traits in 40-60-Year-Old Women Regardless of Fortified Milk Supplementation.

BACKGROUND

The term sarcopenia was introduced to describe the age-related decline in muscle mass, but current definitions also include measures of muscle strength and function. Menopause increases sarcopenia risk and may exacerbate the adverse effects of physical inactivity. Exercise training is...

🗓️ 2025-11-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePostinactivity Exercise Training Improves Sarcopenia Traits in 40-60-Year-Old Women Regardless of Fortified Milk Supplementation.

Effect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China.

BACKGROUND

Understanding the relationship between relative skeletal muscle mass and newly proposed steatotic liver disease (SLD) is crucial, but research gaps still exist. Based on a cohort study, we investigated the impact of relative skeletal muscle mass on incident SLD and...

🗓️ 2025-11-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEffect of Skeletal Muscle Mass and Its Associated Mediators on the Development of Steatotic Liver Disease: A Cohort Study in China.

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