SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

Prevalence of sarcopenia in Africa: a systematic review and meta-analysis of observational studies.

Existing literature suggests that sarcopenia is a highly prevalent condition in older people. However, most studies to date reporting data on its prevalence have been mainly carried out in Western countries, while data on sarcopenia in Africa is scarce. With...

๐Ÿ“ฐ Journal: Aging Clinical And Experimental Research
Read MorePrevalence of sarcopenia in Africa: a systematic review and meta-analysis of observational studies.

Factors associated with multimodal care practices for cancer cachexia among registered dietitians.

This study aimed to determine factors associated with multimodal care practices for cancer cachexia among registered dietitians (RDs) working in cancer care. A secondary analysis was performed using RDs' data. Data on knowledge, skills, and confidence in multimodal care were...

๐Ÿ“ฐ Journal: Supportive Care In Cancer
Read MoreFactors associated with multimodal care practices for cancer cachexia among registered dietitians.

Fluid retention and weight loss in refractory cancer cachexia.

It is unknown to what extent the fluid retention (FR) status disrupts the detection of weight loss rate (WLR) in adult patients with advanced cancer. This study aimed to determine the association of FR status with WLR. This study was...

๐Ÿ“ฐ Journal: Bmj Supportive & Palliative Care
Read MoreFluid retention and weight loss in refractory cancer cachexia.

Impacts of fluid retention on prognostic abilities of cachexia diagnostic criteria in cancer patients with refractory cachexia.

The international cancer cachexia criteria with a cutoff of 5% weight loss (WL) was proposed in Western patients. The Asian Working Group for Cachexia (AWGC) developed new criteria in Asian patients. The AWGC criteria are not cancer-specific and employ a...

Read MoreImpacts of fluid retention on prognostic abilities of cachexia diagnostic criteria in cancer patients with refractory cachexia.

Effect of Sarcopenia on the Increase in Liver Volume and Function After Portal Vein Embolization.

Sarcopenia is associated with a decreased kinetic growth rate (KGR) of the future liver remnant (FLR) after portal vein embolization (PVE). However, little is known on the increase in FLR function (FLRF) after PVE. This study evaluated the effect of...

๐Ÿ“ฐ Journal: Cardiovascular And Interventional Radiology
Read MoreEffect of Sarcopenia on the Increase in Liver Volume and Function After Portal Vein Embolization.

Association between Sarcopenia and Reduced Bone Mass: Is Osteosarcopenic Obesity a New Phenotype to Consider in Weight Management Settings?

Sarcopenic obesity (SO) is a frequent phenotype in people with obesity; however, it is unclear whether this links with an impaired bone status. In this study, we aimed to investigate the association between SO and low bone mass, and to...

Read MoreAssociation between Sarcopenia and Reduced Bone Mass: Is Osteosarcopenic Obesity a New Phenotype to Consider in Weight Management Settings?

Cachexia and Sarcopenia in Oligometastatic Non-Small Cell Lung Cancer: Making a Potential Curable Disease Incurable?

Among patients with advanced NSCLC, there is a group of patients with synchronous oligometastatic disease (sOMD), defined as a limited number of metastases detected at the time of diagnosis. As cachexia and sarcopenia are linked to poor survival, incorporating this...

Read MoreCachexia and Sarcopenia in Oligometastatic Non-Small Cell Lung Cancer: Making a Potential Curable Disease Incurable?

Cachexia: A systemic consequence of progressive, unresolved disease

Cachexia, a systemic wasting condition, is considered a late consequence of diseases, including cancer, organ failure, or infections, and contributes to significant morbidity and mortality. The induction process and mechanistic progression of cachexia are incompletely understood. Refocusing academic efforts away...

๐Ÿ“ฐ Journal: Cell
Read MoreCachexia: A systemic consequence of progressive, unresolved disease

Body composition and lung cancer-associated cachexia in TRACERx.

Cancer-associated cachexia (CAC) is a major contributor to morbidity and mortality in individuals with non-small cell lung cancer. Key features of CAC include alterations in body composition and body weight. Here, we explore the association between body composition and body...

๐Ÿ“ฐ Journal: Nat Med
Read MoreBody composition and lung cancer-associated cachexia in TRACERx.

NAD repletion with niacin counteracts cancer cachexia.

Cachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer patients. It manifests especially with energy and mitochondrial metabolism aberrations that promote tissue wasting. We recently identified nicotinamide adenine dinucleotide (NAD) loss to associate with muscle mitochondrial dysfunction...

๐Ÿ“ฐ Journal: Nat Commun
Read MoreNAD repletion with niacin counteracts cancer cachexia.

An Evaluation of Multimodal Interventions for Co-morbid Frailty and Type 2 Diabetes Mellitus

This study investigates multimodal interventions for older adults with frailty and Type 2 Diabetes Mellitus (T2DM), focusing on the effects of physical, nutritional, and educational strategies on improving functional performance. Involving 843 individuals aged 70+, findings highlight improved mobility, especially gait speed, linked to adherence and baseline health. Published in 'Age and Ageing', the research by Alvarez-Bustos A, Laosa O, Marzetti E, et al., emphasizes tailored interventions' importance for T2DM and frailty in the elderly.

๐Ÿ“ฐ Journal: Age and Ageing
Read MoreAn Evaluation of Multimodal Interventions for Co-morbid Frailty and Type 2 Diabetes Mellitus

Assessing the Clinical Relevance of the C-Reactive Protein-Triglyceride-Glucose Index in Cancer Cachexia

This research uncovers the clinical significance of the C-reactive protein-triglyceride-glucose index (CTI) in predicting survival outcomes in cancer cachexia (CC). Demonstrating superior predictive accuracy over CRP or TyG indices alone, the study reveals CTI's correlation with increased mortality risks and its potential to refine patient management strategies in CC. Published in 'Cancer and Metabolism', January 2024, by Ruan GT, Deng L, Xie HL, et al., this work highlights CTI's pivotal role in enhancing prognosis and guiding treatment in CC.

๐Ÿ“ฐ Journal: Cancer and Metabolism
Read MoreAssessing the Clinical Relevance of the C-Reactive Protein-Triglyceride-Glucose Index in Cancer Cachexia

Cancer Cachexia: Molecular Mechanisms and Therapeutic Strategies

This comprehensive review sheds light on cancer cachexia (CC), a significant condition marked by muscle wasting in cancer patients, emphasizing its molecular mechanisms and potential treatments. Highlighting the challenge CC presents, especially in older individuals, the article discusses the multifaceted approach needed to combat this syndrome.

๐Ÿ“ฐ Journal: Clinical Nutrition
Read MoreCancer Cachexia: Molecular Mechanisms and Therapeutic Strategies

Sarcopenia Metrics and Quality of Life Components: What Is the Link?

Sarcopenia is known to be negatively associated with quality of life in affected patients. However, the individual impacts of its metrics, i.e. muscle mass, strength, and physical performance, on patientsโ€™ overall quality of life remain to be thoroughly investigated.

This pre-printed study aimed to characterise the associations between sarcopenia metrics and quality of life outcomes in community-dwelling older adults from the SOMMA (Study of Muscle, Mobility and Aging) study. Health-related quality of life was ascertained using the EQ-5D questionnaire, which measures 5 subcomponents: mobility, self-care, usual activities, pain and discomfort, as well as anxiety and depression.

Read MoreSarcopenia Metrics and Quality of Life Components: What Is the Link?

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