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  The Journal of Cachexia, Sarcopenia & Muscle ⟶
  The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing both research and clinical materials related to cachexia and sarcopenia from all fields of the life sciences.
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2025 CONFERENCE

Adipose_tissue

Muscle

The Monocrotaline Model of Hypertension Leads to Cachexia in Male but Not Female Mice.

<p><b>BACKGROUND</b></p><p>The monocrotaline (MCT) model of cardiac cachexia is a pharmaceutical approach to pulmonary hypertension that has been used to study heart failure and muscle wasting in rodents; however, little is known of how this pyrrolizidine alkaloid leads to peripheral changes...

🗓️ 2025-11-21

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / cachexia / FATIGUE / Gene_expression / Genes / heart / Hypertension / Monocrotaline / Muscle,_skeletal / muscles / Muscular_atrophy / Sarcopenia / Sex / tissues

Cachexia

Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG.

Browning of white adipose tissue (WAT) contributes to the sustained hypermetabolism observed in patients with burns. How glycogen metabolism in WAT is linked to burn-induced hypermetabolism remains unknown. We discover that burn-induced UCP1 expression in subcutaneous WAT is accompanied by...

🗓️ 2025-11-19

📰 Publication: Cell Reports

Adipose_tissue / Adipose_tissue,_white / Burns / Glycogen / Glycogen_synthase / tissues

Muscle

High Loss of Adipose Tissue During Neoadjuvant Chemotherapy Predicts Poor Prognosis in Patients With Gastric Cancer.

<p><b>BACKGROUND</b></p><p>Gastric cancer (GC) patients often have nutritional risks or malnutrition, and neoadjuvant chemotherapy (NAC) tends to exacerbate malnutrition. Body composition parameters are associated with the prognosis of GC patients. Little is known about body composition changes during NAC and its...

🗓️ 2025-10-31

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Body_composition / cachexia / chemotherapy / Drug_therapy / Incidence / Malnutrition / Muscle,_skeletal / muscles / neoplasms / Oxaliplatin / Prognosis / Sarcopenia / Stomach_neoplasms / tissues

Muscle

Subcutaneous Adipose Tissue Radiation Attenuation Is Associated With Increased 1-Year Mortality in Polytrauma Patients.

<p><b>BACKGROUND</b></p><p>Polytrauma patients with an Injury Severity Score (ISS) ≥ 16 have a high mortality rate. Early identification of patients at risk of mortality is key. Different risk stratification models are available; however, body composition on third lumbar computed tomography (L3 CT) is...

🗓️ 2025-10-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Body_composition / Comorbidity / Injury_severity_score / MORTALITY / Multiple_trauma / Muscle,_skeletal / muscles / Sarcopenia / Subcutaneous_fat / tissues / Wounds_and_injuries

Muscle

Sex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia.

Cancer cachexia, a multifactorial condition resulting in muscle and adipose tissue wasting, reduces the quality of life of many people with cancer. Cachexia is highly prevalent in people with pancreatic ductal adenocarcinoma (PDAC), and many animal models of pancreatic cancer...

🗓️ 2025-09-30

📰 Publication: Journal Of Applied Physiology

Adipose_tissue / Body_weight / cachexia / Environment / Growth / muscles / Pancreatic_neoplasms / Physical_exertion / Physiology / Respiration / Sex / Sex_characteristics / Tamoxifen / tissues

Muscle

Adipose-Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation.

Sarcopenic obesity, characterized by the concurrent presence of excess adiposity and diminished skeletal muscle mass and function, is closely linked to frailty, chronic inflammation, and insulin resistance. The increasing prevalence of sarcopenic obesity is driven by the global aging population,...

🗓️ 2025-08-13

📰 Publication: Obesity Reviews

Adipose_tissue / Extracellular_vesicles / Muscle,_skeletal / muscles / Obesity / Pathology / Research / Sarcopenia / therapeutics / tissues

Muscle

Cancer therapy and cachexia.

A central challenge in cancer therapy is the effective delivery of anticancer treatments while minimizing adverse effects on patient health. The potential dual impact of therapy is clearly illustrated in cancer-associated cachexia, a multifactorial syndrome characterized by involuntary weight loss,...

🗓️ 2025-08-01

📰 Publication: Journal Of Clinical Investigation

Adipose_tissue / Brain / cachexia / Cancer-associated_cachexia / chemotherapy / Drug_therapy / Food / liver / muscles / neoplasms / Nutrients / therapeutics / tissues

Cancer Cachexia

The role of body composition in the development of diabetes mellitus among childhood cancer survivors, and novel intervention strategies to mitigate diabetes risk.

The growing population of childhood cancer survivors (CCSs) experiences a large burden of comorbidities, including a markedly increased risk of diabetes mellitus. Among CCSs, prediabetes and diabetes are important risk factors for subsequent cardiovascular disease, which is a leading cause...

🗓️ 2025-07-15

📰 Publication: Cancer

Adipose_tissue / Body_composition / Cancer_survivors / Diabetes_mellitus / Monitoring,_ambulatory / Muscle,_skeletal / muscles / neoplasms / Obesity / Sarcopenia / therapeutics / tissues

Muscle

Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia.

Although the decline in muscle mass, function and increased visceral obesity are attracting substantial attention in the ageing society, approved treatment modalities for sarcopenia/sarcopenic obesity (SO) remain limited. Elucidating effects and mechanisms of adipose tissue and lipids on skeletal muscle...

🗓️ 2025-01-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Athletes / cachexia / CELLS / Insulin / Lipid_droplets / Muscle_cells / Muscle,_skeletal / muscles / Obesity / Organelle_biogenesis / Oxidative_stress / Sarcopenia / Stress,_physiological / therapeutics / tissues

Muscle

Integrating Body Composition and Nutritional Indices: A Novel Prognostic Tool for Survival in Pancreatic Cancer.

Sarcopenia and malnutrition have been independently associated with a poorer prognosis in pancreatic ductal adenocarcinoma (PDAC), but their combined association with patient outcomes is not fully understood. This study aimed to systematically evaluate the synergistic effects of body composition parameters...

🗓️ 2025-08-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Body_composition / cachexia / Muscle,_skeletal / muscles / Pancreatic_neoplasms / Prognosis / Sarcopenia / Sex / tissues

Muscle

Androgen Deprivation Therapy-Induced Muscle Loss and Fat Gain Predict Cardiovascular Events in Prostate Cancer Patients.

Androgen deprivation therapy (ADT) increases the risk of adverse cardiovascular events in patients with prostate cancer. ADT can induce body composition change; however, the association between body composition change and cardiovascular outcomes remains unclear. This study aimed to determine the...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Androgens / Body_composition / cachexia / Cardiovascular_diseases / muscles / neoplasms / Prostate / Prostatic_neoplasms / Sarcopenia / Subcutaneous_fat / therapeutics / tissues

Muscle

Myosteatosis as a New Risk Factor of Surgical Complications in Kidney Transplant Recipients: A Retrospective Study.

Computed tomography (CT) scan-defined myosteatosis is a common feature in ESKD patients receiving kidney transplantation (KT) and is associated with mortality after KT. We aimed to explore the impact of myosteatosis and other CT scan based morphometric data on the...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / cachexia / Kidney / muscles / Postoperative_complications / Retrospective_studies / Risk_factors / Sarcopenia / Skin / tissues / Transplants

Cachexia

Low Visceral Adipose Tissue Predicts the Outcome of Neoadjuvant Chemotherapy for Colorectal Liver Metastases: A Multicentre Real-World Study.

Visceral obesity (VO), associated with excessive visceral adipose tissue (VAT), has been extensively studied in cancer. However, whether low VAT can predict the prognosis of colorectal liver metastases (CRLM) undergoing neoadjuvant chemotherapy (NAC) remains unknown. This multicentre real-world cohort study...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / chemotherapy / Colorectal_neoplasms / Drug_therapy / liver / Neoplasm_metastasis / Sarcopenia / tissues

Muscle

The Impact of Radiation Dose on CT-Based Body Composition Analysis: A Large-Animal Study.

CT-based body composition analysis (BCA) enables the extraction of biomarkers from routine CT data. The influence of body composition on the prognosis of different patient groups has been highlighted in recent years. Typically, the segmentation of muscle and fat compartments...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adipose_tissue / Body_composition / cachexia / Deep_learning / Genes,_tat / muscles / Sarcopenia / tissues

Nutrition

Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia: A retrospective cohort study.

Brown adipose tissue (BAT) has been mainly investigated as a potential target against cardiometabolic disease, but it has also been linked to cancer-related outcomes. Although preclinical data support that BAT and the thermogenic adipocytes in white adipose tissue may play...

🗓️ 2024-12-30

📰 Publication: Clinical Nutrition

Adipose_tissue / Adipose_tissue,_brown / Body_weight / cachexia / Cancer-associated_cachexia / Cohort_studies / Demography / DIAGNOSIS / Enteral_nutrition / neoplasms / Positron_emission_tomography_computed_tomography / TEMPERATURE / tissues / Tomography / Weight_loss

Muscle

Body composition alterations in patients with lung cancer.

Most patients with lung cancer experience cancer cachexia (CC), a syndrome of skeletal muscle and adipose tissue wasting. Knowledge of body composition changes in patients is limited, however, because most studies have been cross-sectional, comparing patients with non-cancer controls or...

🗓️ 2025-01-31

📰 Publication: American Journal Of Physiology-Cell Physiology

Adipose_tissue / Adiposity / Body_composition / cachexia / Lung / Lung_neoplasms / Muscle,_skeletal / muscles / neoplasms / Sex / therapeutics / tissues

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