muscles

Nutrition in the prevention and treatment of skeletal muscle ageing and sarcopenia: a single nutrient, a whole food, and a whole diet approach.

Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults and associated with an increased risk of disability, frailty, and premature death. Finding cost-effective prevention and treatment strategies for sarcopenia for the growing ageing population is therefore...

๐Ÿ—“๏ธ 2024-10-17
๐Ÿ“ฐ Publication: Proceedings Of The Nutrition Society
Read MoreNutrition in the prevention and treatment of skeletal muscle ageing and sarcopenia: a single nutrient, a whole food, and a whole diet approach.

Durable Muscle Extracellular Matrix Engineered with Adhesive Phenolic Moieties for Effective Skeletal Muscle Regeneration in Muscle Atrophy.

Muscle atrophy detrimentally impacts health and exacerbates physical disability, leading to increased mortality. In particular, sarcopenia, aging-related degenerative muscle loss, necessitates urgent remedies. Current approaches for treating muscle atrophy include exercise and nutrition, while drug exploration remains in its early...

๐Ÿ—“๏ธ 2024-10-17
๐Ÿ“ฐ Publication: Advanced Healthcare Materials
Read MoreDurable Muscle Extracellular Matrix Engineered with Adhesive Phenolic Moieties for Effective Skeletal Muscle Regeneration in Muscle Atrophy.

Rodent model intervention for prevention and optimal management of sarcopenia: A systematic review on the beneficial effects of nutrients & non-nutrients and exercise to improve skeletal muscle health.

Sarcopenia is a common musculoskeletal disorder characterized by degenerative processes and is strongly linked to an increased susceptibility to falls, fractures, physical limitations, and mortality. Several models have been used to explore therapeutic and preventative measures as well as to...

๐Ÿ—“๏ธ 2024-10-18
๐Ÿ“ฐ Publication: Ageing Research Reviews
Read MoreRodent model intervention for prevention and optimal management of sarcopenia: A systematic review on the beneficial effects of nutrients & non-nutrients and exercise to improve skeletal muscle health.

Emerging Targets and Treatments for Sarcopenia: A Narrative Review.

Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health and quality of life in older adults. This narrative review explores emerging targets and potential treatments for sarcopenia, aiming to provide a...

๐Ÿ—“๏ธ 2024-09-27
Read MoreEmerging Targets and Treatments for Sarcopenia: A Narrative Review.

Masseter Muscle Volume and Its Association with Sarcopenia and Muscle Determinants in Older Japanese Adults: the Bunkyo Health Study.

Sarcopenia has been with a decrease in masseter muscle (MM) thickness in high-risk older populations. However, the relationship between sarcopenia and determinants of MM volume (MMV) in the general elderly population remains unclear. In a cross-sectional study of 1,484 older...

๐Ÿ—“๏ธ 2024-10-14
๐Ÿ“ฐ Publication: Archives Of Medical Research
Read MoreMasseter Muscle Volume and Its Association with Sarcopenia and Muscle Determinants in Older Japanese Adults: the Bunkyo Health Study.

Nutritional strategies for improving sarcopenia outcomes in older adults: A narrative review.

Sarcopenia is characterized by a decline in muscle strength, generalized loss of skeletal muscle mass, and impaired physical performance, which are common outcomes used to screen, diagnose, and determine severity of sarcopenia in older adults. These outcomes are associated with...

๐Ÿ—“๏ธ 2024-10-01
๐Ÿ“ฐ Publication: Pharmacology Research & Perspectives
Read MoreNutritional strategies for improving sarcopenia outcomes in older adults: A narrative review.

Mitochondrial pathways and sarcopenia in the geroscience era.

Sarcopenia is associated with structural, ultrastructural, and molecular abnormalities of skeletal muscle. Mitochondrial dysfunction is a pivotal factor involved in muscle aging and sarcopenia. Mitochondrial bioenergetics are significantly reduced in muscles of older adults which is associated with whole-body aerobic...

๐Ÿ—“๏ธ 2024-10-19
๐Ÿ“ฐ Publication: Journal Of Nutrition Health & Aging
Read MoreMitochondrial pathways and sarcopenia in the geroscience era.

Impact of sarcopenia and muscle strength on postoperative complication risk following pancreatic resection.

The association between sarcopenia and postoperative complications has been widely reported in patients with cancer. Yet, the lack of standardized population-specific diagnostic cut-off points and assessments of muscle strength is hampering prospective clinical utilization. Therefore, we aimed to examine the...

๐Ÿ—“๏ธ 2024-10-11
Read MoreImpact of sarcopenia and muscle strength on postoperative complication risk following pancreatic resection.

Frailty or sarcopenia: which is a better indicator of mortality risk in older adults?

Despite the different conditions, frailty and sarcopenia overlap regarding their common link: the assessment of walking speed and muscle strength. This study aimed to compare the frailty phenotype to the sarcopenia using different cut-off points for low grip strength to...

๐Ÿ—“๏ธ 2024-10-11
๐Ÿ“ฐ Publication: Journal Of Epidemiology And Community Health
Read MoreFrailty or sarcopenia: which is a better indicator of mortality risk in older adults?

Myofiber-specific FoxP1 knockout protects against pancreatic cancer-induced muscle wasting in male but not female mice.

Cancer cachexia affects up to 80% of cancer patients and results in reduced quality of life and survival. We previously demonstrated that the transcriptional repressor Forkhead box P1 (FoxP1) is upregulated in skeletal muscle of cachectic mice and people with...

๐Ÿ—“๏ธ 2024-09-21
Read MoreMyofiber-specific FoxP1 knockout protects against pancreatic cancer-induced muscle wasting in male but not female mice.

Sarcopenic obesity in patients with head and neck cancer is predictive of critical weight loss during radiotherapy.

The impact of computed tomography-defined sarcopenia on outcomes in head and neck cancer has been well described. Sarcopenic obesity (SO) (depleted muscle mass combined with obesity) may pose a more serious risk than either condition alone. We investigated SO and...

๐Ÿ—“๏ธ 2024-09-30
๐Ÿ“ฐ Publication: British Journal Of Nutrition
Read MoreSarcopenic obesity in patients with head and neck cancer is predictive of critical weight loss during radiotherapy.

LRRK2 Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease.

While the gradually aggravated motor and non-motor disorders of Parkinson's disease (PD) lead to progressive disability and frequent falling, skeletal muscle impairment may contribute to this condition. The leucine-rich repeat kinase2 (LRRK2) is a common disease-causing gene in PD. Little...

๐Ÿ—“๏ธ 2024-09-23
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLRRK2 Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease.

The Innovative Role of Nuclear Receptor Interaction Protein in Orchestrating Invadosome Formation for Myoblast Fusion.

Nuclear receptor interaction protein (NRIP) is versatile and engages with various proteins to execute its diverse biological function. NRIP deficiency was reported to cause small myofibre size in adult muscle regeneration, indicating a crucial role of NRIP in myoblast fusion....

๐Ÿ—“๏ธ 2024-09-25
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Innovative Role of Nuclear Receptor Interaction Protein in Orchestrating Invadosome Formation for Myoblast Fusion.

Association between metabolic dysfunction-associated steatotic liver disease and myosteatosis measured by computed tomography.

In 2023, the concept of metabolic dysfunction-associated steatotic liver disease (MASLD) was introduced as an alternative to non-alcoholic fatty liver disease (NAFLD). We aimed to assess the quantity and quality of skeletal muscle using each of these diagnostic classifications. This...

๐Ÿ—“๏ธ 2024-07-16
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation between metabolic dysfunction-associated steatotic liver disease and myosteatosis measured by computed tomography.

Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia.

Sarcopenia, the gradual and generalized loss of muscle mass and function with ageing, is one of the major health problems in older adults, given its high prevalence and substantial socioeconomic implications. Despite the extensive efforts to reach consensus on definition...

๐Ÿ—“๏ธ 2024-07-15
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreProteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia.

Myosteatosis and muscle loss impact liver transplant outcomes in male patients with hepatocellular carcinoma.

Sarcopenia is associated with unfavourable long-term survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). However, the impact of myosteatosis and muscle loss on patient prognosis has not been investigated. Seven hundred fifty-six HCC patients who received LT...

๐Ÿ—“๏ธ 2024-08-27
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMyosteatosis and muscle loss impact liver transplant outcomes in male patients with hepatocellular carcinoma.

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