Low bone density and low muscle mass are both independent risk factors for mortality in older men. However, it is unknown if these tissues interact to increase mortality risk. Elucidating this information is important as bone and muscle are modifiable...
Cellular senescence is a hallmark of organismal aging but how it drives aging in human tissues is not fully understood. Here we leverage single nucleus multiomics to profile senescence in mononucleated cells of human skeletal muscle and provide the first...
Cancer cachexia is a multifaceted metabolic syndrome characterized by severe loss of skeletal muscle and adipose tissue, diminishing both quality of life and survival in cancer patients. Despite its prevalence, effective treatments for cancer cachexia remain limited. The JAK/STAT signaling...
Sarcopenia is a degenerative muscular disease associated with aging, characterized by a reduction in muscle mass and strength. This disease poses a significant global health challenge, owing to its high prevalence and association with adverse outcomes such as increased frailty,...
Identifying individuals at risk of sarcopenia incidence or progression remains challenging. Serum creatinine- and cystatin C-derived indices are objective markers of muscle metabolism; however, their predictive value for sarcopenia progression remains uncertain. This study evaluated the association between a creatinine-...
Pancreatic ductal adenocarcinoma (PDAC) with cachexia-related muscle wasting as the main manifestation is associated with poor overall survival. Extracellular vesicles (EVs) are key mediators of inter-organ communication. Here, EVs and EV-microRNAs (miRNAs) are identified as mediate PDAC-skeletal muscle communication. EVs...
The evaluation of skeletal muscle (SM) mass has significant clinical and research relevance in the diagnosis and management of conditions such as malnutrition, sarcopenia, sarcopenic obesity, and cancer cachexia. Dual-energy X-ray absorptiometry (DXA) is now the most widely used method...
Cancer cachexia is a multifactorial syndrome involving muscle and fat wasting, inflammation, and metabolic dysfunction. Across cancer subtypes, pancreatic cancer has one of the highest cachexia incidence rates at โผ80%. Given the advanced age of most pancreatic cancer patients, we...
Type 2 diabetes mellitus accompanied by sarcopenia is an emerging clinical challenge in aging populations, characterized by coexisting metabolic dysfunction and the progressive loss of skeletal muscle mass and function. This comorbidity substantially elevates the risk of frailty, functional impairment,...
Sarcopenia, a progressive decline in skeletal muscle mass and function, has emerged as a critical geriatric syndrome affecting 10-40% of older adults, contributing to increased disability and mortality. This comprehensive review evaluates evidence-based strategies for sarcopenia management, from established interventions...
Sarcopenia, or age-related muscle dysfunction, contributes to morbidity and mortality. Besides decreases in muscle force, sarcopenia is associated with atrophy and fast-to-slow fiber type switching, which is typically secondary to denervation in humans and rodents. However, very little is known...
The main aim was to investigate the association of n-3 fatty acid intake and the n-6/n-3 fatty acid intake ratio with muscle mass and strength in older adults. This study included 61,381 individuals (28,187 men and 33,194 women) aged โฅ60...
Sarcopenia, defined as the progressive loss of skeletal muscle mass and function, has been associated with poor prognosis in patients with pancreatic cancer, particularly those with borderline resectable pancreatic cancer (BRPC). Although body composition can be extracted from routine CT...
