Oxidative_stress

Exercise

Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients.

Hospitalization in older adults often worsens sarcopenia due to prolonged bed rest, poor nutrition, and inactivity. This study examined how hospitalization impacts muscle mass, focusing on oxidative stress and gut-derived endotoxemia. Thirty-one hospitalized older adults were compared with 31 outpatients....

🗓️ 2025-03-01

Aged / Aging / Endotoxemia / Hospitalization / muscles / Nadp / Nadph_oxidase_2 / Nadph_oxidases / Outpatients / Oxidative_stress / Sarcopenia / Stress,_physiological

Muscle

ROS-responsive MnO mesoporous hydrogel to modulate liver-muscle crosstalk and mitigate NAFLD-associated sarcopenia via exosomal miR-582-5p delivery.

The interrelation between non-alcoholic fatty liver disease (NAFLD) and sarcopenia has emerged as a significant concern due to its systemic impact on metabolic health. However, therapeutic approaches targeting the liver-muscle axis remain underdeveloped. Oxidative stress and inflammatory pathways are key...

🗓️ 2025-03-21

📰 Publication: Theranostics

Hydrogel,_polyethylene_glycol_dimethacrylate / Hydrogels / muscles / Nanomedicine / Non-alcoholic_fatty_liver_disease / Oxidative_stress / Sarcopenia / Stress,_physiological / therapeutics

Sarcopenia

Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice.

A significant increase in mitochondrial fatty acid oxidation (FAO) is now increasingly recognized as one of the metabolic alterations in diabetic cardiomyopathy (DCM). However, the molecular mechanisms underlying mitochondrial FAO impairment in DCM remain to be fully elucidated. A type...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Apoptosis / Cardiomyopathies / Diabetes_mellitus / Fatty_acids / Hypertrophy / Mitochondria / Myocytes,_cardiac / Oxidative_stress / Oxidoreductases / therapeutics

Muscle

Accelerated Sarcopenia Phenotype in the DJ-1/-Knockout Zebrafish.

Age-dependent loss of muscle mass and function is associated with oxidative stress. DJ-1/ acts as an antioxidant through multiple signalling pathways. DJ-1-knockout zebrafish show a decline in swimming performance and loss of weight gain between 6 and 9 months of...

🗓️ 2024-12-11

Complement_c3a / Mitochondria / Muscle,_skeletal / muscles / Oxidative_stress / Oxidoreductases / Phenotype / Sarcopenia / Stress,_physiological

Muscle

Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress.

Cancer-associated cachexia (CAC) is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss, which accounts for one-third of cancer-related deaths. No effective therapeutic approach that could fully reverse CAC is available. NF-κB signaling and oxidative stress play...

🗓️ 2024-04-08

📰 Publication: Genes & Diseases

cachexia / Cancer-associated_cachexia / muscles / Muscular_atrophy / neoplasms / Oxidative_stress / Safety / Stress,_physiological / therapeutics

Muscle

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Sarcopenia is currently a life-threatening disease for the elderly. Polygonatum sibiricum polysaccharide (PSP) has anti-oxidative stress and anti-inflammatory effects. However, the effects of PSP on skeletal muscle aging, myoblast differentiation and mitochondrial dysfunction through PI3K/Akt/mTOR signaling pathway has not been...

🗓️ 2024-12-09

📰 Publication: Phytomedicine

Aging / CELLS / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Myoblasts / Oxidative_stress / Pharmacology / Polysaccharides / Sarcopenia / Stress,_physiological / therapeutics

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

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Protein_isoforms / Protein_kinases / Protein_phosphatase_1 / Protein_processing,_post-translational / Protein_serine-threonine_kinases / Protein-tyrosine_kinases / Proteogenomics / Proteome / Proteomics / Prothrombin / Prothrombin_time / Proton_pump_inhibitors / Proton_pumps / Proton_therapy / Pruritus / Pseudogenes / Pseudomonas / Pseudomonas_aeruginosa / Pseudomonas_stutzeri / Pseudouridine / Psoriasis / Psychiatrists / Psychological_distress / Psychological_well-being / Psychology,_positive / Psychometrics / Psychosocial_intervention / Psychotherapy / Psychotic_disorders / Psychotropic_drugs / Public_health / Public_health_surveillance / Public_sector / Pulmonary_arterial_hypertension / Pulmonary_disease,_chronic_obstructive / Pulmonary_embolism / Pulmonary_fibrosis / Pulmonary_surfactant-associated_protein_a / Pulmonary_valve / Pulpectomy / Pulpotomy / Pulse / Punctures / Punishment / Pupa / Pupil / Purpura / Purpura,_thrombocytopenic / Putamen / Pyoderma / Pyoderma_gangrenosum / 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A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antitubercular_agents / Antiviral_agents / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_dissection / Aortic_valve / Aphasia / Aphasia,_primary_progressive / Apicoplasts / Apolipoproteins / Apoptosis / Apoptosis_regulatory_proteins / Appendiceal_neoplasms / Appendicitis / Appendix / Appetite / Arboviruses / Arenavirus / Arginine / Arrhythmias,_cardiac / Arteriovenous_malformations / Arthralgia / Arthritis / Arthritis,_rheumatoid / Arthroplasty / Arthroplasty,_replacement,_knee / Artificial_intelligence / Artificially_sweetened_beverages / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillosis / Aspergillosis,_allergic_bronchopulmonary / Asthenozoospermia / Astrocytes / Astrocytoma / Astronauts / Ataxia / Ataxia_telangiectasia / Atherectomy / Atherosclerosis / Athletes / Atrasentan / Atrial_fibrillation / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Attitude_to_health / Audiology / Augmented_reality / Authorship / Autism_spectrum_disorder / Autistic_disorder / Autoantibodies / Autoimmune_diseases / Autophagy / Autopsy / Axial_spondyloarthritis / Axons / B-lymphocytes / Back_pain / Bacterial_adhesion / Bacteriocins / Bacteriophages / Balantidiasis / Bariatric_surgery / Bartonella / Base_sequence / Basement_membrane / Basophils / Beds / Begomovirus / Behcet_syndrome / Benzene / Benzimidazoles / Benzocaine / Bevacizumab / Bezafibrate / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bilirubin / Biochemistry / Biocompatible_materials / Biodiversity / Biofilms / Biogenic_amines / Biological_availability / Biological_factors / Biological_monitoring / Biological_oxygen_demand_analysis / Biological_therapy / Biomarkers / Biomass / Biomedical_research / Biomimetics / Biophysics / Biopolymers / Biopsy / Biosimilar_pharmaceuticals / Biostatistics / Biotechnology / Birth_rate / Birth_weight / Blepharoplasty / Blindness / Blister / BLOOD / Blood_circulation / Blood_component_removal / Blood_culture / Blood_glucose / Blood_platelet_disorders / Blood_platelets / Blood_pressure / Blood_urea_nitrogen / Blood_vessels / Blood_volume / Blood-brain_barrier / Bocavirus / Body_composition / Body_mass_index / Body_size / Body_temperature / Body_weight / Bone_conduction / Bone_density / Bone_regeneration / Bone_transplantation / Botulinum_toxins / Brachytherapy / Brain_diseases / Brain_injuries / Brain_injuries,_traumatic / Brain_neoplasms / Bread / Breast_diseases / Breast_feeding / Breast_implants / Breast_neoplasms / Breeding / Bronchiectasis / Bronchiolitis_obliterans_syndrome / Bronchoalveolar_lavage / Bronchopulmonary_dysplasia / Bronchoscopy / Bruxism / Buffers / Burns / Butter / Calcinosis / Calcitonin / Calcium / Calcium_signaling / Camptothecin / Cancer_pain / Candy / Cannabidiol / Cannula / Capillaries / Capsaicin / Capsules / 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Lysophosphatidylcholines / Lysosomes / Machine_learning / Macrophages / Macrophages,_alveolar / Magnetic_resonance_imaging / Maintenance / Malnutrition / Mammaplasty / Mannans / Mannitol / Mannose-binding_lectin / Mannosyltransferases / Margins_of_excision / Marijuana_use / Marketing / Masculinity / Masks / Mast_cells / Mastitis / Mastitis,_bovine / Mastoiditis / Maternal_mortality / Mathematics / Meals / Meat / Mechanistic_target_of_rapamycin_complex_1 / Medial_tibial_stress_syndrome / Mediation_analysis / Medical_laboratory_science / Medical_marijuana / Medical_oncology / Medical_records / Medical_staff / Medical_waste / Medicare / Medication_adherence / Medication_errors / Medicine,_chinese_traditional / Medicine,_traditional / Meditation / Medulloblastoma / Melanins / Melanoma / Meloxicam / Membrane_proteins / Membranes / Memory / Menarche / Mendelian_randomization_analysis / Meninges / Meningioma / Meningitis / Menstruation / Mental_disorders / Mental_health / 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Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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Oligospermia / Olive_oil / Oncologists / Only_child / Oocyte_donation / Oocytes / Oogenesis / Operative_time / Ophthalmology / Optic_atrophy,_autosomal_dominant / Optic_disk / Optic_nerve / Optic_nerve_diseases / Optogenetics / Oral_hygiene / Oral_microbiome / Organelle_biogenesis / Organoids / Ornithine / Orthomyxoviridae / Orthopedics / Osseointegration / Osteoarthritis / Osteoblasts / Osteoclasts / Osteogenesis / Osteomalacia / Osteonecrosis / Osteoporosis / Osteosarcoma / Otitis / Otitis_media / Otolaryngology / Outpatients / Ovarian_neoplasms / Ovariectomy / Ovary / Overweight / Oviposition / Ovum / Ownership / Oxacillin / Oxaliplatin / Oxidants / Oxidative_stress / Oxidoreductases / Oximetry / Paclitaxel / Paecilomyces / Pain_management / Pain,_postoperative / Paint / Palate / Palliative_care / Palmitic_acid / Pancreas / Pancreatic_cyst / Pancreatic_pseudocyst / Pancreaticoduodenectomy / Pancreatitis / Pandemics / Papillomavirus_infections / Parabens / Paraffin / Paralysis / Paraneoplastic_syndromes / Parasites / Parasitology / Parent-child_relations / Parenteral_nutrition / Parenting / Parkinson_disease / Parotitis / Particulate_matter / Parturition / Pathologists / Patient_care / Patient_discharge / Patient_education_as_topic / Patient_participation / Patient_preference / Patient_reported_outcome_measures / Patient_safety / Patient_satisfaction / Pediatric_emergency_medicine / Pediatrics / Peer_review / Pelvic_pain / Pemphigoid,_bullous / Pemphigus / Penile_prosthesis / Penis / Peptide_hydrolases / Percutaneous_coronary_intervention / Periaqueductal_gray / Pericardium / Periodontitis / Perioperative_care / Peripheral_arterial_disease / Peroxidases / Peroxides / Personality / Perylene / Pesticides / Phaeohyphomycosis / Phagocytes / Phagocytosis / Pharmaceutical_preparations / Pharmaceutical_services / Pharmaceutical_vehicles / Pharmacists / Pharmacokinetics / Pharmacology / Pharmacology,_clinical / Pharmacovigilance / Pharmacy / Pharynx / Phenazines / 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Muscle

Reactive oxygen species in skeletal muscle injury, fatigue, regeneration and ageing: In memory of John Faulkner.

One of the most critical factors impacting healthspan in the elderly is the loss of muscle mass and function, clinically referred to as sarcopenia. Muscle atrophy and weakness lead to loss of mobility, increased risk of injury, metabolic changes and...

🗓️ 2024-11-27

📰 Publication: Free Radical Biology And Medicine

Aged / Atrophy / FATIGUE / Memory / Muscle,_skeletal / muscles / Oxidative_stress / Sarcopenia / Stress,_physiological

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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Oxidative_stress

Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients.

ROS-responsive MnO mesoporous hydrogel to modulate liver-muscle crosstalk and mitigate NAFLD-associated sarcopenia via exosomal miR-582-5p delivery.

Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice.

Accelerated Sarcopenia Phenotype in the DJ-1/-Knockout Zebrafish.

Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress.

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Reactive oxygen species in skeletal muscle injury, fatigue, regeneration and ageing: In memory of John Faulkner.

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