Chest computed tomography (CT) is a valuable tool for diagnosing and predicting the severity of coronavirus disease 2019 (COVID-19) and assessing extrapulmonary organs. Reduced muscle mass and visceral fat accumulation are important features of a body composition phenotype in which...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cardiolipin, a unique phospholipid predominantly present in the inner mitochondrial membrane, is critical for maintaining mitochondrial integrity and function. Its dimeric structure and role in supporting mitochondrial dynamics, energy production, and mitophagy make it indispensable for skeletal muscle health. This...
Age-dependent loss of muscle mass and function is associated with oxidative stress. DJ-1/ acts as an antioxidant through multiple signalling pathways. DJ-1-knockout zebrafish show a decline in swimming performance and loss of weight gain between 6 and 9 months of...
Despite muscle power derived from the 5-rep sit-to-stand (STS) test having been demonstrated to be a valuable biomarker in older individuals, there is limited information regarding muscle power derived from the 30-s STS test, a widely used test in the...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Anti-Activin Receptor Type IIA and Type IIB antibody (ฮฑActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle hypertrophy,...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The mechanisms underlying muscle alteration associated to alcoholic liver disease (ALD) are not fully understood and the physiopathologic mediators of the liver-muscle interplay remains elusive. We investigated the role of circulating extracellular vesicles (EVs) in ALD as potential mediators of...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Falls and sarcopenia are significant public health issues in Vietnam. Despite muscle strength being a critical predictor for these conditions, reference data on muscle strength within the Vietnamese population are lacking. To establish the reference ranges for muscle strength among...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
ฮฒ-Hydroxy-ฮฒ-methyl butyrate (HMB) is a metabolite of the amino acid leucine, known for its ergogenic effects on body composition and strength. Despite these benefits, the magnitude of these effects remains unclear due to variability among studies. This umbrella review aims...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is a gradual decline in skeletal muscle mass and strength, which eventually leads to reduced physical performance. 50% of people aged 60-80โyears suffer from sarcopenia. Considering the devastating outcomes and the importance of promoting healthy ageing, the diagnosis and...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
In adipose tissue-muscle crosstalk mechanisms, the interaction of adipokines and myokines is known to be critical for maintaining the body's metabolic balance in age-related metabolic disorders. The aim of the study investigate the effects of 12โweeks of aerobic and resistance...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cancer cachexia represents a debilitating muscle wasting condition that is highly prevalent in gastrointestinal cancers, including pancreatic ductal adenocarcinoma (PDAC). Cachexia is estimated to contribute to ~30% of cancer-related deaths, with deterioration of respiratory muscles suspected to be a key...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is highly prevalent in patients with liver cirrhosis (LC), adversely affecting their quality of life and life expectancy. Exercise and nutrition represent common interventions to ameliorate sarcopenia in these patients, although there exists inconsistency in the reported effectiveness of...
๐๏ธ 2024-07-05
๐ฐ Publication: Hepatobiliary Surgery And Nutrition
The global prevalence of obesity among elderly patients continues to rise. Despite the availability of new antiobesity medications, bariatric surgery remains an effective treatment option for carefully selected candidates. However, it is not risk-free, especially in a vulnerable population, predisposing...
๐๏ธ 2025-02-08
๐ฐ Publication: Reviews In Endocrine & Metabolic Disorders
COVID-19 has been associated with both respiratory (diaphragm) and non-respiratory (limb) muscle atrophy. It is unclear if SARS-CoV-2 infection of skeletal muscle plays a role in these changes. This study sought to: 1) determine if cells comprising skeletal muscle tissue,...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
With a decline of 17ฮฒ-estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female mice, testing the hypothesis that...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general population. The study participants were 3324 community...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
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