Cancer cachexia contender enters first pivotal trial.
📰 Journal: Nature Reviews Drug Discovery
Read MoreCancer cachexia contender enters first pivotal trial.SCWD Publications Digest
Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.
AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia
Pancreatic Damage in Ovarian Cancer-Associated Cachexia Is Driven by Activin A Signalling.
BACKGROUND
Cancer-associated cachexia (CAC) is a severe metabolic disorder characterized by involuntary weight loss, skeletal muscle atrophy and adipose tissue depletion. It is a major contributor to morbidity and mortality in the advanced stages of various cancers. However, the impact of...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePancreatic Damage in Ovarian Cancer-Associated Cachexia Is Driven by Activin A Signalling.Sarcopenia and Its Individual Traits Independently Predict Mortality in Patients on Dialysis: A Systematic Review and Meta-Analysis.
BACKGROUND
Loss of muscle mass, muscle weakness and the combination of the two are commonly observed in patients on dialysis and may have a negative impact on their survival. In this systematic review and meta-analysis (MA), we evaluated the consistency and...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenia and Its Individual Traits Independently Predict Mortality in Patients on Dialysis: A Systematic Review and Meta-Analysis.Skeletal Muscle PGC-1α Remodels Mitochondrial Phospholipidome but Does Not Alter Energy Efficiency for ATP Synthesis.
BACKGROUND
The coupling of oxygen consumption to ATP synthesis via oxidative phosphorylation (OXPHOS) is central for cellular energy homeostasis. Some studies suggest exercise training increases the efficiency of ATP synthesis, but the molecular mechanisms are unclear. We have previously shown that...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle PGC-1α Remodels Mitochondrial Phospholipidome but Does Not Alter Energy Efficiency for ATP Synthesis.Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.
Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged...
📰 Journal: Aging Cell
Read MoreExperimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.Clues to why the weight-loss condition cachexia arises when cancer occurs.
📰 Journal: Nature
Read MoreClues to why the weight-loss condition cachexia arises when cancer occurs.Microenvironment-driven satellite cell regeneration and repair in aging-related sarcopenia: mechanisms and therapeutic frontiers.
Sarcopenia, a progressive age-related decline in skeletal muscle mass and function, is closely linked to impaired regenerative capacity of satellite cells (SCs), also known as satellite cells. Age-dependent SCs dysfunction, driven by intrinsic senescence and niche dysregulation, disrupts activation, proliferation,...
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Sarcopenia, a degenerative condition marked by progressive skeletal muscle atrophy and impaired regeneration, is closely associated with aging, chronic inflammation, and disrupted proteostasis. While macroautophagy has been extensively studied in this context, little of the role of chaperone-mediated autophagy (CMA)...
📰 Journal: Cell Death & Disease
Read MoreCTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.Management of Children Awaiting Liver Transplantation: Sarcopenia, Cholestasis and Beyond.
Sarcopenia has been increasingly recognized as a risk factor for worse outcomes in liver transplantation; however, the data remain limited on pediatric-specific outcomes. These gaps in knowledge are in part due to the lack of a standardized definition, challenges inherent...
📰 Journal: Pediatric Transplantation
Read MoreManagement of Children Awaiting Liver Transplantation: Sarcopenia, Cholestasis and Beyond.Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies.
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes and undermine quality of life among older adults with cancer. Despite their prognostic value and negative effects on older patients' well-being, sarcopenia and...
📰 Journal: Drugs & Aging
Read MoreSarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies.Adipose-tumor crosstalk in colorectal cancer: Identifying (Epi)genetic biomarkers for tumor progression and cachexia.
Colorectal cancer (CRC) is a leading cause of cancer-related deaths and obesity is a known risk factor for its development and poor prognosis. Adipose tissue (AT) actively contributes to CRC progression and cachexia. Here, we investigated molecular crosstalk between tumor...
📰 Journal: Cell Death & Disease
Read MoreAdipose-tumor crosstalk in colorectal cancer: Identifying (Epi)genetic biomarkers for tumor progression and cachexia.ARC-18 Improved Motor Performance Through Inhibiting ACLY-Mediated Smad2/3 Acetylation in a Model of Duchenne Muscular Dystrophy.
BACKGROUND
Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle weakness, with inflammation and fibrosis contributing to its pathogenesis. Despite advancements in genetic disease-modifying treatment, there is currently no effective pharmacological treatment for DMD.
METHODS
New compound ARC-18, a derivative...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreARC-18 Improved Motor Performance Through Inhibiting ACLY-Mediated Smad2/3 Acetylation in a Model of Duchenne Muscular Dystrophy.Are we making progress in the diagnosis and management of sarcopenia? Results from a UK-wide survey.
PURPOSE
To describe current practice in diagnosis and management of sarcopenia in older people in the United Kingdom (UK).
METHODS
Healthcare professionals from UK organisations were invited to complete an online survey about sarcopenia diagnosis and management.
RESULTS
One hundred and one responses were analysed....
📰 Journal: European Geriatric Medicine
Read MoreAre we making progress in the diagnosis and management of sarcopenia? Results from a UK-wide survey.Emerging basic science concepts in geriatric fracture fixation and patient recovery.
In recent history, human life expectancy has increased significantly, resulting in a high burden of late-life morbidity and geriatric fractures. Changes to the body as a result of aging, such as degeneration of the bone marrow, osteoblast apoptosis, and a...
High "sarcopenia index" reduce all-cause mortality in patients with acute myocardial infarction.
BACKGROUNDThe product of serum creatinine and cystatin C-based estimated glomerular filtration rate (hereinafter referred to as "Cr × eGFRcys"), serving as the formula for the Sarcopenia Index (SI), could be regarded as a representative marker for sarcopenia. However, no studies...
📰 Journal: Clinical Nutrition
Read MoreHigh "sarcopenia index" reduce all-cause mortality in patients with acute myocardial infarction.Unravelling the Diversity Observed in Cancer Cachexia.
📰 Journal: American Journal Of Physiology-Cell Physiology
Read MoreUnravelling the Diversity Observed in Cancer Cachexia.