Multiple_chronic_conditions

Food-derived bioactive peptides in gut-muscle Axis regulation: Potential and challenges from microbiota homeostasis to muscle metabolism remodeling.

The global population is aging at an accelerating pace, and sarcopenia has emerged as a central challenge to elderly health. Food-derived bioactive peptides, as natural functional compounds, can interact significantly with the gut microbiota, thereby indirectly influencing muscle metabolism and...

🗓️ 2026-05-22
📰 Publication: Food Research International
Read MoreFood-derived bioactive peptides in gut-muscle Axis regulation: Potential and challenges from microbiota homeostasis to muscle metabolism remodeling.

Ageing-Associated Dysregulation of Myogenic Differentiation in Inclusion Body Myositis.

Skeletal muscle is a postmitotic tissue dependent on a complex and tightly regulated regeneration process involving numerous intracellular and extracellular factors, including myogenic regulatory factors (MRFs), cytokines and myokines. Quiescent satellite cells are activated by physiological stimuli, injury or other...

🗓️ 2026-05-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAgeing-Associated Dysregulation of Myogenic Differentiation in Inclusion Body Myositis.

An exploratory multi-biomarker panel including fecal calprotectin, Brain-Derived Neurotrophic Factor, Fibroblast-Growth Factor-21 and irisin shows poor diagnostic accuracy for detecting probable sarcopenia in community-dwelling older persons.

🗓️ 2026-04-06
📰 Publication: Aging Clinical And Experimental Research
Read MoreAn exploratory multi-biomarker panel including fecal calprotectin, Brain-Derived Neurotrophic Factor, Fibroblast-Growth Factor-21 and irisin shows poor diagnostic accuracy for detecting probable sarcopenia in community-dwelling older persons.

The Role of New Agents and Supportive Care in a Multimodal Approach to Cancer Cachexia.

Given the multi-faceted nature of cancer cachexia, a combination of pharmacologic and supportive measures such as exercise and nutrition seems intuitive to most clinicians. Clinical trials have also suggested that a multimodal approach to cancer cachexia (CC) is feasible and...

🗓️ 2026-02-27
Read MoreThe Role of New Agents and Supportive Care in a Multimodal Approach to Cancer Cachexia.

Multi-modal integrated intervention combining exercise, anti-inflammatory, and dietary advice (MMIEAD) for adults with kidney cachexia: protocol for a mixed-methods feasibility cluster randomised controlled trial and process evaluation.

BACKGROUND

Kidney cachexia is a debilitating and under-recognised complication of advanced chronic kidney disease (CKD), characterised by unintentional weight loss, muscle wasting, inflammation, and reduced functional capacity. Its profound impact on morbidity, quality of life, and healthcare utilisation underscores the need...

🗓️ 2026-02-20
Read MoreMulti-modal integrated intervention combining exercise, anti-inflammatory, and dietary advice (MMIEAD) for adults with kidney cachexia: protocol for a mixed-methods feasibility cluster randomised controlled trial and process evaluation.

Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer.

Cachexia is a wasting disorder associated with high morbidity and mortality in patients with cancer. Tumour-host interaction and maladaptive metabolic reprogramming are substantial, yet poorly understood, contributors to cachexia. Here we present a comprehensive overview of the spatio-temporal metabolic reprogramming...

🗓️ 2026-01-16
Read MoreMulti-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer.

Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study.

BACKGROUND

Ambient air pollution aggravates cardiovascular-kidney-metabolic (CKM) disorders and sarcopenia, yet the shared genetic and epigenetic mechanisms that underlie their frequent co-occurrence remain poorly understood.

METHODS

We integrated genome-wide association study (GWAS) data for CKM components (cardiovascular disease [CVD], chronic kidney disease [CKD],...

🗓️ 2025-11-22
📰 Publication: Metabolism-Clinical And Experimental
Read MoreAir pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study.

Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis.

Sarcopenia, a prevalent age-related degenerative disorder, poses significant challenges in geriatric care. Chinese leek demonstrates therapeutic potential against sarcopenia progression, with emerging evidence suggesting its extracellular vesicles (EVs) may mediate these effects. Notably, plant-derived EVs have garnered increasing attention due...

🗓️ 2025-11-20
📰 Publication: Journal Of Nanobiotechnology
Read MoreChinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis.

Association of cachexia with activities of daily living and discharge destinations among inpatients with dysphagia in a convalescent rehabilitation phase; A multi-center cohort study.

Although a recent study reported an association between cachexia, as defined by the Asian Working Group for Cachexia (AWGC), and lower functional recovery at discharge among post-stroke patients capable of oral intake during the convalescent rehabilitation phase, its impact on...

🗓️ 2025-09-30
Read MoreAssociation of cachexia with activities of daily living and discharge destinations among inpatients with dysphagia in a convalescent rehabilitation phase; A multi-center cohort study.

Symphony of regulated cell death: Unveiling therapeutic horizons in sarcopenia.

Sarcopenia is a progressive musculoskeletal condition associated with aging, marked by a decline in muscle mass, strength, and performance. This condition not only compromises functional independence in older individuals but also contributes to escalating healthcare and economic burdens. Although the...

🗓️ 2025-07-31
📰 Publication: Metabolism-Clinical And Experimental
Read MoreSymphony of regulated cell death: Unveiling therapeutic horizons in sarcopenia.

The predictive and prognostic role of radiologically defined sarcopenia in head and neck cancer: a systematic review and multi-level meta-analysis.

Radiologically defined sarcopenia (RS), defined as a lack of skeletal muscle mass (SMM) measured on cross-sectional CT or MR imaging, is increasingly recognized as a significant prognostic determinant in head and neck cancer (HNC). A systematic literature search of Embase...

🗓️ 2025-06-02
📰 Publication: British Journal Of Cancer
Read MoreThe predictive and prognostic role of radiologically defined sarcopenia in head and neck cancer: a systematic review and multi-level meta-analysis.

Myo-Guide: A Machine Learning-Based Web Application for Neuromuscular Disease Diagnosis With MRI.

Neuromuscular diseases (NMDs) are rare disorders characterized by progressive muscle fibre loss, leading to replacement by fibrotic and fatty tissue, muscle weakness and disability. Early diagnosis is critical for therapeutic decisions, care planning and genetic counselling. Muscle magnetic resonance imaging...

🗓️ 2025-06-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMyo-Guide: A Machine Learning-Based Web Application for Neuromuscular Disease Diagnosis With MRI.

Association of Appendicular Skeletal Muscle Mass Index and Insulin Resistance With Mortality in Multi-Nationwide Cohorts.

Although sarcopenia and insulin resistance are closely related, there is limited evidence regarding how they interact to influence mortality across different population groups. The purpose of this study was to examine the relationship between skeletal muscle mass and insulin resistance...

🗓️ 2025-04-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Appendicular Skeletal Muscle Mass Index and Insulin Resistance With Mortality in Multi-Nationwide Cohorts.

Correction to "The Prevalence Patterns and Risk Factor Profiles of Poor Muscle Health and Its Associated Components in Multi-Ethnic Older Asians: The PIONEER Study".

🗓️ 2025-04-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCorrection to "The Prevalence Patterns and Risk Factor Profiles of Poor Muscle Health and Its Associated Components in Multi-Ethnic Older Asians: The PIONEER Study".

An Attention-Aware Multi-Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia.

Sarcopenia presents a pressing public health concern due to its association with age-related muscle mass decline, strength loss and reduced physical performance, particularly in the growing older population. Given the absence of approved pharmacological therapies for sarcopenia, the need to...

🗓️ 2025-04-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAn Attention-Aware Multi-Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia.

Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.

Sarcopenia is a geriatric disorder characterized by a gradual loss of muscle mass and function. Despite its prevalence, the underlying mechanisms remain unclear, and there are currently no approved treatments. In this study, we conducted a comprehensive analysis of the...

🗓️ 2025-02-05
Read MoreMulti-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.

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