Sarcopenia, the gradual and generalized loss of muscle mass and function with ageing, is one of the major health problems in older adults, given its high prevalence and substantial socioeconomic implications. Despite the extensive efforts to reach consensus on definition...
๐๏ธ 2024-07-15
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is associated with unfavourable long-term survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). However, the impact of myosteatosis and muscle loss on patient prognosis has not been investigated. Seven hundred fifty-six HCC patients who received LT...
๐๏ธ 2024-08-27
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Tumour-induced skeletal muscle wasting in the context of cancer cachexia is a condition with profound implications for patient survival. The loss of muscle mass is a significant clinical obstacle and is linked to reduced tolerance to chemotherapy and increased frailty....
๐๏ธ 2024-07-13
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is characterized by loss of skeletal muscle mass and function, and is a major risk factor for disability and independence in the elderly. Effective medication is not available. Dietary restriction (DR) has been found to attenuate aging and aging-related...
๐๏ธ 2024-04-30
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Many studies support the idea that sarcopenic obesity (SO) could be considered a potential risk factor for negative health outcomes. These results have been inconsistent, and no umbrella reviews exist regarding this topic. Several databases until November 2023 were searched...
๐๏ธ 2024-06-19
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Muscle strength is essential for healthy ageing. Handgrip strength (HGS) has been recommended by expert bodies as the preferred measure of muscle strength, in addition to being considered a strong predictor of overall health. Cross-sectional studies have shown several potential...
๐๏ธ 2024-08-26
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development of diabetes and obesity. The tumour suppressor...
๐๏ธ 2024-07-15
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations. This hypothesis-generating analysis used biospecimens collected from a multi-centre 2ย รย 2 factorial...
๐๏ธ 2024-06-18
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is an important indicator of ill health and is linked to increased mortality and a reduced quality of life. Age-associated muscle mass indices provide a critical tool to help understand the development of sarcopenia. This study aimed to develop...
๐๏ธ 2024-07-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The world is facing a global nutrition crisis, as evidenced by the rising incidence of metabolic disorders such as obesity, insulin resistance and chronic inflammation. Skeletal muscle is the largest tissue in humans and plays an important role in movement...
๐๏ธ 2024-08-18
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Due to increasing older populations worldwide, injuries, disabilities and deaths caused by falls among the elderly represent a growing human and societal problem. We aimed to improve health among men of at least 70ย years of age with low-normal to low...
๐๏ธ 2024-06-18
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Chronic subdural haematoma (CSDH) drainage is a common neurosurgical procedure. CSDHs cause excess mortality, which is exacerbated by frailty. Sarcopenia contributes to frailty - its key component, low muscle mass, can be assessed using cross-sectional imaging. We aimed to examine...
๐๏ธ 2024-05-08
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Intensive care unit-acquired weakness (ICU-AW) is a syndrome characterized by a long-term muscle weakness often observed in sepsis-surviving patients during the chronic phase. Although ICU-AW is independently associated with increased mortality, effective therapies have yet to be established. Programmed death-1...
๐๏ธ 2024-07-17
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The effects of post-coronavirus disease 2019 (COVID-19) syndrome on the cardiorespiratory and muscular fitness in older people are of utmost relevance. This study aimed to evaluate the effects of a 12-week telerehabilitation programme on cardiorespiratory and muscular fitness and body...
๐๏ธ 2024-06-27
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Increasing interest surrounds the utility of blood-based biomarkers for diagnosing sarcopenia. C-terminal agrin fragment (CAF), a marker of neuromuscular junction stability, is amongst the most promising candidates; however, a dearth of reference data impedes the incorporation of its use in...
๐๏ธ 2024-06-07
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Mitochondria represent key organelles influencing cellular homeostasis and have been implicated in the signalling events regulating protein synthesis. We examined whether mitochondrial bioenergetics (oxidative phosphorylation and reactive oxygen species (HO) emission, ROS) measured in vitro in permeabilized muscle fibres represent...
๐๏ธ 2024-07-15
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
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