muscles

Systemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology-Specific End-Stage Liver Disease.

BACKGROUND

Patients with end-stage liver disease (ESLD) often present with sarcopenia, defined as loss of skeletal muscle mass and quality, which is associated with reduced quality of life and increased mortality. However, the molecular mechanisms driving sarcopenia in ESLD are not...

🗓️ 2026-04-27
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSystemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology-Specific End-Stage Liver Disease.

Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.

BACKGROUND

Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific...

🗓️ 2026-04-24
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.

A comprehensive review of cancer-induced cardiac wasting.

Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural...

🗓️ 2026-04-23
📰 Publication: British Journal Of Pharmacology
Read MoreA comprehensive review of cancer-induced cardiac wasting.

Wearable Hybrid Strain-Myoelectric Sensing System for Machine-Learning-Assisted Sarcopenia Screening.

The early screening of sarcopenia represents a critical clinical need amid the accelerating global aging population. Current diagnostic methods, relying on bioelectrical impedance analysis (BIA), handgrip strength testing, and other clinical examinations, depend on costly medical equipment and struggle to...

🗓️ 2026-04-23
Read MoreWearable Hybrid Strain-Myoelectric Sensing System for Machine-Learning-Assisted Sarcopenia Screening.

Beyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.

BACKGROUND

Metabolic and bariatric surgery (MBS) produces substantial and sustained weight loss, but concerns remain about skeletal muscle loss and sarcopenia.

METHODS

We conducted a systematic review of longitudinal and cross-sectional studies evaluating changes in muscle quantity, strength, and physical performance following MBS...

🗓️ 2026-04-22
📰 Publication: Obesity Reviews
Read MoreBeyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.

Gut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

BACKGROUND

Ageing is an inevitable biological process that contributes to increased prevalence of age-associated diseases, including sarcopenia, defined by progressive loss of muscle mass, functional decline and a heightened risk of injury. Developing effective interventions remains a critical clinical priority. This...

🗓️ 2026-04-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreGut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia.

Skeletal muscle mass and force decline with age, and the loss of muscle force precedes muscle atrophy. However, the underlying mechanisms remain unclear. Here, we investigated the role of the myosin co-chaperone, uncoordinated mutant number-45 myosin chaperone B (UNC45B), in...

🗓️ 2026-04-21
📰 Publication: Aging Cell
Read MoreUNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia.

Effects of Tai Chi combined with elastic band training on muscle and executive inhibitory function in older adults with sarcopenia: a randomized controlled trial based on fNIRS.

BACKGROUND

Resistance training benefits patients with sarcopenia. However, trials demonstrating the effectiveness of Tai Chi combined with elastic band training are sparse, and the underlying neurocognitive mechanisms remain unclear.

METHODS

Forty-nine older sarcopenia patients (≥60 years) were recruited and randomly assigned to three groups:...

🗓️ 2026-04-04
📰 Publication: Age And Ageing
Read MoreEffects of Tai Chi combined with elastic band training on muscle and executive inhibitory function in older adults with sarcopenia: a randomized controlled trial based on fNIRS.

Associations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.

BACKGROUND

Longitudinal associations between age-related changes in body composition, physical performance and incident diabetes mellitus (DM) in older adults and the mediating role of branched-chain amino acids (BCAAs) remain understudied.

METHODS

This prospective cohort study included 4000 community-dwelling older adults at baseline. Longitudinal...

🗓️ 2026-04-20
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.

Sarcopenic Obesity in Children: An Emerging Complication Evidenced by Clinical Data and a Juvenile Mouse Model.

BACKGROUND

Sarcopenic obesity (SO) is well-characterized in older adults, but its impact on muscle development in children remains poorly understood. This study investigated the effects of childhood obesity on musculoskeletal health and the underlying mechanisms.

METHODS

We enrolled 1447 children (31.4% girls; median...

🗓️ 2026-04-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenic Obesity in Children: An Emerging Complication Evidenced by Clinical Data and a Juvenile Mouse Model.

Dual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.

Skeletal muscle accounts for approximately 40% of total body mass and is essential for locomotion, metabolic regulation and systemic homeostasis. Adipose tissue is increasingly recognized as an active component of the muscle's regenerative microenvironment. During muscle repair, adipose tissue contributes...

🗓️ 2026-04-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.

Sarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.

Sarcopenic obesity (SO; defined as obesity with low skeletal muscle function and mass) has been recently recognized as a relevant obesity phenotype, with substantial negative clinical impact. The prevalence of SO is likely increasing, due to the growing prevalence of...

🗓️ 2026-04-17
📰 Publication: Clinical Nutrition
Read MoreSarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a,...

🗓️ 2026-04-16
📰 Publication: Aging Cell
Read MoreGhrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice.

Disuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.

BACKGROUND

Exercise has been proposed as both a preventive and therapeutic countermeasure; however, its effectiveness across different disuse conditions and timings of implementation remains uncertain.

METHODS

This systematic review and meta-analysis (PROSPERO: CRD42021256599) searched ClinicalTrials.gov, Cochrane Central, PubMed, SPORTDiscus, Web of Science, Scopus,...

🗓️ 2026-04-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDisuse-Induced Muscle Atrophy and Muscle Weakness From Hospitalization to Spaceflight: Exercise Succeeds in Prevention and Treatment-A Meta-Analysis.

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