OBJECTIVE
To characterize pain in terms of frequency, intensity, and correlation with nutritional status, muscle mass, and physical performance in osteosarcopenic patients.
METHOD
We included patients affected by osteosarcopenia (OSP), according to WHO criteria and EWGSOP2 guidelines. Assessments included Bone Mineral Density, Trabecular...
Gut microbiome plays an important role in several metabolic, immune, and inflammatory pathways; however, there is limited evidence for its role in body composition and musculoskeletal health. Sarcopenia, defined as a loss of skeletal muscle mass and function, and obesity,...
BACKGROUND
Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.
METHODS
A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and...
In recent history, human life expectancy has increased significantly, resulting in a high burden of late-life morbidity and geriatric fractures. Changes to the body as a result of aging, such as degeneration of the bone marrow, osteoblast apoptosis, and a...
Low bone density and low muscle mass are both independent risk factors for mortality in older men. However, it is unknown if these tissues interact to increase mortality risk. Elucidating this information is important as bone and muscle are modifiable...
Osteosarcopenic obesity (OSO) is a clinical and functional condition characterized by the coexistence of osteopenia/osteoporosis, sarcopenia, and obesity (excess adiposity). Currently, the lack of consensus on diagnostic criteria and cut-off values complicates prevalence estimates and limits its potential role as...
Although obesity is a well-known risk factor for various metabolic disorders, its impact on fracture risk remains uncertain. The inconsistency in findings may be due to the fact that most studies have relied solely on body mass index (BMI) as...
The Wnt/β-catenin pathway and its bone-specific inhibitor, sclerostin, play important roles in skeletal development and homeostasis. The humanized sclerostin antibody, romosozumab, can significantly increase bone mineral density (BMD) of patients with osteoporosis, but it may also increase cardiovascular adverse events,...
Muscle strength, mass and function have been associated with falls, fractures and mortality, but the results vary between previous studies. We aimed to investigate the predictive ability of muscle strength and mass with 10-year incident fragility fractures. This study included...
Osteosarcopenia is suggested to be on the causal pathway to frailty; however, data on this topic is scarce, and it is unclear if osteosarcopenia is associated with frailty risk. To investigate if osteosarcopenia is associated with frailty risk in community-dwelling...
Anti-Activin Receptor Type IIA and Type IIB antibody (αActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle hypertrophy,...
Falls and sarcopenia are significant public health issues in Vietnam. Despite muscle strength being a critical predictor for these conditions, reference data on muscle strength within the Vietnamese population are lacking. To establish the reference ranges for muscle strength among...
3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...
Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...
