Sarcopenia

Exploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

INTRODUCTION

People with chronic kidney disease (CKD) often experience poor muscle quality and elevations in skeletal muscle wasting and dysfunction, contributing to a reduced quality of life and an increased risk of morbidity and mortality. The adipokine chemerin is associated with...

🗓️ 2026-02-28
📰 Publication: Translational Research
Read MoreExploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

Cancer Cachexia Prevalence Is Underestimated in Medical Records of Patients in a Regional Tertiary Hospital.

BACKGROUND

Widespread lack of awareness and limited real-world prevalence evidence have impeded cachexia care and research. We hypothesized that healthcare professionals may identify the term cachexia, leading to International Classification of Diseases (ICD) coding for this term, with or without records...

🗓️ 2026-02-18
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCancer Cachexia Prevalence Is Underestimated in Medical Records of Patients in a Regional Tertiary Hospital.

iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025.

There are a number of guidelines on how to manage obesity, but inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices restrict their global applicability. This underscores the need for universal recommendations that address the unique challenges...

🗓️ 2026-02-13
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreiCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025.

Asian Reference Values for Handgrip Strength, Gait Speed, Five-Times-Sit-to-Stand Test, Muscle Mass and Calf Circumference.

BACKGROUND

Handgrip strength, gait speed, Five-Times-Sit-to-Stand Test (FTSST) performance, skeletal muscle mass and calf circumference are important health outcomes, particularly useful for diagnosing sarcopenia. The aim of this study was to establish reference (normative) values for handgrip strength, gait speed, FTSST...

🗓️ 2026-02-12
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAsian Reference Values for Handgrip Strength, Gait Speed, Five-Times-Sit-to-Stand Test, Muscle Mass and Calf Circumference.

Skeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis.

Background: Heart failure (HF) is characterised by altered skeletal muscle morphology. The aim of this systematic review and meta-analysis was to explore cross-sectional differences in muscle morphology and metabolism between patients with HF and healthy controls. Methods: A literature search...

🗓️ 2026-02-10
📰 Publication: Journal Of Applied Physiology
Read MoreSkeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis.

Glucagon-like peptide-1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions.

Gastric inhibitory polypeptide (GIP)/Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed for the management of obesity and type 2 diabetes, yet research pertinent to their effects on muscle health is limited. Considering the central role of muscle strength as a...

🗓️ 2026-01-24
📰 Publication: British Journal Of Pharmacology
Read MoreGlucagon-like peptide-1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions.

Identification of Sarcopenic Obesity by Fat-to-Muscle Ratio in Older Adults: A Cohort Study.

BACKGROUND

The diagnosis of sarcopenic obesity has been established in Europe and Japan, but screening tools remain inconsistent and lack standardization. The fat-to-muscle ratio (FMR) is a potential screening measure for sarcopenic obesity; however, its diagnostic accuracy compared with other tools...

🗓️ 2026-01-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIdentification of Sarcopenic Obesity by Fat-to-Muscle Ratio in Older Adults: A Cohort Study.

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer.

BACKGROUND

Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials. By reflecting downstream effects of cellular function, metabolomics may...

🗓️ 2026-01-19
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDistinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer.

Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation.

BACKGROUND

Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes...

🗓️ 2026-01-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation.

Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.

BACKGROUND

Dyslipidaemia is among the major risk factors for atherosclerotic cardiovascular disease. Paradoxically, higher cholesterol levels are associated with better survival in heart failure (HF) of any aetiology. Because cholesterol is an integral component of skeletal muscle structure, one possible explanation...

🗓️ 2026-01-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.

Prognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.

AIM

Respiratory sarcopenia, characterised by reduced respiratory muscle mass and function, can impair ventilatory reserve and physical capacity, potentially worsening outcomes. However, its prevalence and prognostic significance in older patients with heart failure remain unclear. This study aimed to investigate the...

🗓️ 2026-01-07
📰 Publication: European Journal Of Preventive Cardiology
Read MorePrognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.

Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Gut microbiome plays an important role in several metabolic, immune, and inflammatory pathways; however, there is limited evidence for its role in body composition and musculoskeletal health. Sarcopenia, defined as a loss of skeletal muscle mass and function, and obesity,...

🗓️ 2026-01-09
📰 Publication: Osteoporosis International
Read MoreImpact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

A Systematic Review of Digital Health for Non-older Adults with Risk of Sarcopenia.

OBJECTIVES

Non-older adults are at risk of developing sarcopenia, and exercise and increased physical activity are effective preventive interventions. Digital interventions, including gamification, may enhance the effects of exercise interventions. This systematic review and meta-analysis examined the effects of digital health...

🗓️ 2026-01-09
Read MoreA Systematic Review of Digital Health for Non-older Adults with Risk of Sarcopenia.

Plant-based protein for older adults with obesity.

The global syndemic of obesity, undernutrition, and climate change - three interconnected challenges - threatens both human and planetary health. This review focuses on one critical intersection: older populations living with overweight and obesity in the context of sustainable nutrition....

🗓️ 2025-12-26
📰 Publication: Proceedings Of The Nutrition Society
Read MorePlant-based protein for older adults with obesity.

Secreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia.

Sarcopenia is currently classified as an unmet medical need with an increasing incidence because of population aging. Excessive reactive oxygen species (ROS) production plays a critical role in the pathogenesis of muscle atrophy, a key feature of sarcopenia, whereas edaravone...

🗓️ 2025-12-25
📰 Publication: Journal Of Controlled Release
Read MoreSecreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia.

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