Sarcopenia

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer.

BACKGROUND

Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials. By reflecting downstream effects of cellular function, metabolomics may...

🗓️ 2026-01-19
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDistinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer.

Mitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation.

BACKGROUND

Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes...

🗓️ 2026-01-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMitochondrial Transporter ABCB10 Protects Against Doxorubicin-Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation.

Skeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.

BACKGROUND

Dyslipidaemia is among the major risk factors for atherosclerotic cardiovascular disease. Paradoxically, higher cholesterol levels are associated with better survival in heart failure (HF) of any aetiology. Because cholesterol is an integral component of skeletal muscle structure, one possible explanation...

🗓️ 2026-01-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSkeletal Muscle Mass Modifies the Prognostic Impact of LDL Cholesterol in Chronic Heart Failure.

Prognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.

AIM

Respiratory sarcopenia, characterised by reduced respiratory muscle mass and function, can impair ventilatory reserve and physical capacity, potentially worsening outcomes. However, its prevalence and prognostic significance in older patients with heart failure remain unclear. This study aimed to investigate the...

🗓️ 2026-01-07
📰 Publication: European Journal Of Preventive Cardiology
Read MorePrognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry.

Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

Gut microbiome plays an important role in several metabolic, immune, and inflammatory pathways; however, there is limited evidence for its role in body composition and musculoskeletal health. Sarcopenia, defined as a loss of skeletal muscle mass and function, and obesity,...

🗓️ 2026-01-09
📰 Publication: Osteoporosis International
Read MoreImpact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.

A Systematic Review of Digital Health for Non-older Adults with Risk of Sarcopenia.

OBJECTIVES

Non-older adults are at risk of developing sarcopenia, and exercise and increased physical activity are effective preventive interventions. Digital interventions, including gamification, may enhance the effects of exercise interventions. This systematic review and meta-analysis examined the effects of digital health...

🗓️ 2026-01-09
Read MoreA Systematic Review of Digital Health for Non-older Adults with Risk of Sarcopenia.

Plant-based protein for older adults with obesity.

The global syndemic of obesity, undernutrition, and climate change - three interconnected challenges - threatens both human and planetary health. This review focuses on one critical intersection: older populations living with overweight and obesity in the context of sustainable nutrition....

🗓️ 2025-12-26
📰 Publication: Proceedings Of The Nutrition Society
Read MorePlant-based protein for older adults with obesity.

Secreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia.

Sarcopenia is currently classified as an unmet medical need with an increasing incidence because of population aging. Excessive reactive oxygen species (ROS) production plays a critical role in the pathogenesis of muscle atrophy, a key feature of sarcopenia, whereas edaravone...

🗓️ 2025-12-25
📰 Publication: Journal Of Controlled Release
Read MoreSecreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia.

Consensus statement on vitamin D role in metabolic health.

The 8th International Conference Controversies in Vitamin D, held in September 2024, convened leading experts to address the multifaceted role of vitamin D in human health. Key discussions focused on its influence on metabolic health, including effects on sarcopenia, muscle...

🗓️ 2025-12-24
📰 Publication: Metabolism-Clinical And Experimental
Read MoreConsensus statement on vitamin D role in metabolic health.

Glucagon Like Peptide-1 Receptor Agonists for Sarcopenia and Muscle Wasting Disorders: A Systematic Review of Efficacy and Mechanisms.

Muscle wasting disorders, including sarcopenia and skeletal muscle atrophy, are increasingly prevalent among older adults and those with metabolic comorbidities. Sarcopenia, a progressive age-associated condition, involves the decline in skeletal muscle mass, strength, and physical performance, affecting millions of people...

🗓️ 2025-12-16
📰 Publication: Aging And Disease
Read MoreGlucagon Like Peptide-1 Receptor Agonists for Sarcopenia and Muscle Wasting Disorders: A Systematic Review of Efficacy and Mechanisms.

Changes in Frailty and Incident Cancer: Evidence From the Health and Retirement Study.

BACKGROUND

Although frailty has been identified as a potential risk factor for cancer, most previous studies have only considered frailty status at a single time point. The relationship between dynamic changes in frailty and incident cancer is less well understood. This...

🗓️ 2025-12-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreChanges in Frailty and Incident Cancer: Evidence From the Health and Retirement Study.

Burden of malnutrition and sarcopenia in patients with cirrhosis: pathophysiology, assessment, and management.

Malnutrition and sarcopenia are highly prevalent and robustly associated with reduced quality of life, disease progression, and poor outcomes, including complications and mortality, in patients with cirrhosis. Their pathophysiology is multifactorial, involving inadequate dietary intake and malabsorption, impaired liver functional...

🗓️ 2025-12-16
📰 Publication: Clinical And Molecular Hepatology
Read MoreBurden of malnutrition and sarcopenia in patients with cirrhosis: pathophysiology, assessment, and management.

Skeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis.

Age-related sarcopenia, characterized by progressive loss of skeletal muscle mass and strength, impacts metabolic health and quality of life in the elderly. Heat shock factor 1 (HSF1) is a transcription factor that orchestrates cellular responses to various stresses, while its...

🗓️ 2025-12-16
Read MoreSkeletal Muscle HSF1 Alleviates Age-Associated Sarcopenia and Mitochondrial Function Decline via SIRT3-PGC1α Axis.

Decorin Deficiency Promotes D-Galactose-Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway.

BACKGROUND

Primary sarcopenia is an age-associated disorder with progressive and generalised loss of skeletal muscle strength and mass. Skeletal muscle fibrosis is one of the significant pathological manifestations of age-associated sarcopenia. Decorin, a small dermatan-sulfate proteoglycan, participates in extracellular matrix assembly....

🗓️ 2025-12-06
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDecorin Deficiency Promotes D-Galactose-Induced Skeletal Muscle Atrophy and Fibrosis by Regulating ITGB1/Akt/mTOR Signalling Pathway.

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