Sarcopenia
A serum creatinine-cystatin C-derived index as a predictive marker for sarcopenia incidence and progression in community-dwelling older adults: a prospective cohort study.
Identifying individuals at risk of sarcopenia incidence or progression remains challenging. Serum creatinine- and cystatin C-derived indices are objective markers of muscle metabolism; however, their predictive value for sarcopenia progression remains uncertain. This study evaluated the association between a creatinine-...
Clarification and standardization of dual-energy X-ray absorptiometry terminology for accurate scientific communication and clinical diagnostic accuracy.
The evaluation of skeletal muscle (SM) mass has significant clinical and research relevance in the diagnosis and management of conditions such as malnutrition, sarcopenia, sarcopenic obesity, and cancer cachexia. Dual-energy X-ray absorptiometry (DXA) is now the most widely used method...
Exercise-Induced Short-Chain Fatty Acids: A Novel Therapeutic Target in Type 2 Diabetes Mellitus with Sarcopenia.
Type 2 diabetes mellitus accompanied by sarcopenia is an emerging clinical challenge in aging populations, characterized by coexisting metabolic dysfunction and the progressive loss of skeletal muscle mass and function. This comorbidity substantially elevates the risk of frailty, functional impairment,...
Therapeutic advances in sarcopenia management: From traditional interventions to personalized medicine.
Sarcopenia, a progressive decline in skeletal muscle mass and function, has emerged as a critical geriatric syndrome affecting 10-40% of older adults, contributing to increased disability and mortality. This comprehensive review evaluates evidence-based strategies for sarcopenia management, from established interventions...
Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise.
Sarcopenia, or age-related muscle dysfunction, contributes to morbidity and mortality. Besides decreases in muscle force, sarcopenia is associated with atrophy and fast-to-slow fiber type switching, which is typically secondary to denervation in humans and rodents. However, very little is known...
The association of n-3 fatty acid intake with muscle mass and strength in older adults: A cross-sectional analysis of the UK biobank data.
The main aim was to investigate the association of n-3 fatty acid intake and the n-6/n-3 fatty acid intake ratio with muscle mass and strength in older adults. This study included 61,381 individuals (28,187 men and 33,194 women) aged โฅ60...
AI-based CT assessment of sarcopenia in borderline resectable pancreatic Cancer: A narrative review of clinical and technical perspectives.
Sarcopenia, defined as the progressive loss of skeletal muscle mass and function, has been associated with poor prognosis in patients with pancreatic cancer, particularly those with borderline resectable pancreatic cancer (BRPC). Although body composition can be extracted from routine CT...
Osteosarcopenic obesity: A systematic review and a call for consensus on definitions and diagnostic criteria.
Osteosarcopenic obesity (OSO) is a clinical and functional condition characterized by the coexistence of osteopenia/osteoporosis, sarcopenia, and obesity (excess adiposity). Currently, the lack of consensus on diagnostic criteria and cut-off values complicates prevalence estimates and limits its potential role as...
Sarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating anti-inflammatory macrophages.
Age-related changes in circulating metabolites influence systemic physiology and may contribute to diseases such as sarcopenia. Although metabolic dysregulation is closely linked to sarcopenia, the roles of specific metabolites remain unclear. In this study, we performed comprehensive plasma metabolomic and...
Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting-Induced Proteolysis.
The neutral amino acid transporter SLC7A8 (LAT2) has been described as a key regulator of metabolic adaptation. LAT2 mutations in human populations have been linked to the early onset of age-related hearing loss and cataract growth. As LAT2 was previously...
Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations.
Preservation of mobility independence is a primary goal in older adults with physical frailty and sarcopenia (PF&S). Interventions based on the combination of physical activity (PA) and nutritional counselling have been indicated as strategies for the management of this condition,...
Association of Alzheimer's Disease Blood Biomarkers With Sarcopenia Incidence and Progression: A 12-Year Population-Based Study.
Sarcopenia is a complex and multifactorial condition, and recent studies have explored the role of neurological markers in its diagnosis and prediction. Although associations have been identified between reduced muscle strength, slow walking speed and elevated neurofilament levels (NfL), long-term...
Sarcopenia in Ageing and Chronic Illness: Trial Endpoints and Regulatory Issues.
In December 2024, the Society on Cachexia and Wasting Disorders (SCWD) hosted a Regulatory and Trial Update Workshop in Washington, D.C., bringing together experts from academia, industry, and the US Food and Drug Administration (FDA). This article summarizes key topics...
Ageing Signatures and Disturbed Muscle Regeneration in Muscle Proteome of Inclusion Body Myositis.
Inclusion body myositis (IBM) is the most common acquired myopathy in adults over the age of 50โyears, characterised by inflammatory and degenerative features that lead to progressive muscle weakness and physical disability for lack of effective therapies. The complex interplay...
Umbelliferone attenuates diabetic sarcopenia by modulating mitochondrial quality and the ubiquitin-proteasome system.
Sarcopenia, characterized by the progressive loss of skeletal muscle mass, strength, and physical performance, is traditionally associated with aging. However, chronic conditions such as type 2 diabetes mellitus (T2DM) have been recognized as key accelerators of its progression. In this...