Sarcopenia

Alternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1.

<p><b>BACKGROUND</b></p><p>Myotonic dystrophy type 1 (DM1) is a multisystemic neuromuscular disorder characterized by CTG repeat expansion in the 3' untranslated region of the dystrophia myotonica protein kinase coding gene. The presence of expanded CTG repeats in DMPK mRNAs leads to the...

๐Ÿ—“๏ธ 2025-11-18
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAlternative Splicing of SORBS1 Affects Neuromuscular Junction Integrity in Myotonic Dystrophy Type 1.

Small-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms.

<p><b>BACKGROUND</b></p><p>Mechanical inactivity rapidly induces diaphragm muscle fibres' contractile dysfunction and atrophy. Diaphragm weakness can impair respiratory function, quality of life and increase risks of morbidity and mortality. Muscle RING-finger protein-1 (MuRF1) expression is upregulated during denervation and muscle inactivity and...

๐Ÿ—“๏ธ 2025-11-17
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSmall-Molecule Targeting MuRF1 Protects Against Denervation-Induced Diaphragmatic Dysfunction: Underlying Molecular Mechanisms.

Rise and Fall of Physical Capacity in a General Population: A 47-Year Longitudinal Study.

<p><b>BACKGROUND</b></p><p>As we age, there is a progressive decline in skeletal muscle tissue and function that can become clinically significant in the sixth decade of life affecting independent living and health. Longitudinal observations in elite athletes show that peak physical performance...

๐Ÿ—“๏ธ 2025-11-17
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRise and Fall of Physical Capacity in a General Population: A 47-Year Longitudinal Study.

3D Body Scanning-Derived Normative Values of Appendicular Circumferences: A Novel Tool for Sarcopenia Screening in Chinese Adults.

<p><b>BACKGROUND</b></p><p>Appendicular circumferences (ACs) are critical predictors of skeletal health, cardiovascular disease risk and mortality. Currently, comprehensive reference values and associated factors for thigh (TC), calf (CC), upper arm (UAC) and forearm (FC) circumferences remain unestablished in Chinese adults.</p><p><b>METHODS</b></p><p>This community-based cross-sectional...

๐Ÿ—“๏ธ 2025-11-17
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read More3D Body Scanning-Derived Normative Values of Appendicular Circumferences: A Novel Tool for Sarcopenia Screening in Chinese Adults.

Pathways Contributing to Chemotherapy-Induced Myotoxicity Are Attenuated by EPAโ€‰+โ€‰DHA in a Clinically Relevant Model of Colorectal Cancer.

<p><b>BACKGROUND</b></p><p>Skeletal muscle loss is a well-recognized consequence of cancer, and chemotherapy exacerbates myotoxicity through multiple mechanisms. Retaining muscle mass improves tumour response to therapies and tolerance to chemotherapy; hence, interventions to mitigate myotoxicity warrant investigations. This study aimed to investigate...

๐Ÿ—“๏ธ 2025-11-17
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePathways Contributing to Chemotherapy-Induced Myotoxicity Are Attenuated by EPAโ€‰+โ€‰DHA in a Clinically Relevant Model of Colorectal Cancer.

Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.

<p><b>BACKGROUND</b></p><p>Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.</p><p><b>METHODS</b></p><p>A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and...

๐Ÿ—“๏ธ 2025-11-15
๐Ÿ“ฐ Publication: Ebiomedicine
Read MoreSkeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.

Different Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.

Sarcopenia, characterized by decreased skeletal muscle mass and strength, is classified as "primary" (due to aging) or "secondary" (due to diseases). MicroRNA-22-3p (miR-22) regulates muscle differentiation and function. We assessed the diagnostic value of circulating miR-22 levels in patients with...

๐Ÿ—“๏ธ 2025-11-15
๐Ÿ“ฐ Publication: Aging Cell
Read MoreDifferent Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.

<p><b>BACKGROUND</b></p><p>Systemic muscle wasting is a prevalent condition that predicts adverse health outcomes in aging and disease. Despite its clinical relevance, the development of predictive biomarkers and effective pharmacological therapies remains limited. Peptides have recently gained attention for their diverse bioactive...

๐Ÿ—“๏ธ 2025-11-13
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreRole of Peptides in Skeletal Muscle Wasting: A Scoping Review.

Primary-Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity.

<p><b>BACKGROUND</b></p><p>Colon cancer (CC), the third most common cancer worldwide, is accompanied by cachexia in 30% of patients. Its associated muscle loss directly impairs therapeutic response and survival. Early intervention is crucial, yet the underlying mechanisms of early-stage muscle dysfunction remain...

๐Ÿ—“๏ธ 2025-11-12
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePrimary-Stage Colon Cancer Impairs Muscle Energy Metabolism by Suppressing Mitochondrial Complex I Activity.

A Creatinine-CAR Composite Index (CCAR) Optimized by Machine Learning for Prognosis in Cancer Cachexia.

<p><b>BACKGROUND</b></p><p>Cancer cachexia is a multifactorial syndrome associated with poor prognosis and impaired quality of life in cancer patients. However, survival prediction in cancer cachexia remains difficult due to the lack of reliable biomarkers.</p><p><b>METHODS</b></p><p>This retrospective cohort study analysed data from 1,367...

๐Ÿ—“๏ธ 2025-11-11
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreA Creatinine-CAR Composite Index (CCAR) Optimized by Machine Learning for Prognosis in Cancer Cachexia.

STX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

<p><b>BACKGROUND</b></p><p>Mitochondrial homeostasis is vital for optimal skeletal muscle integrity. Mitochondrial quality control (MQC) mechanisms that are essential for maintaining proper functions of mitochondria include mitochondrial biogenesis, dynamics and mitophagy. Previously, Syntaxin 4 (STX4), traditionally considered a cell surface protein known...

๐Ÿ—“๏ธ 2025-11-11
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSTX4 Is Indispensable for Mitochondrial Homeostasis in Skeletal Muscle.

Lean Body Mass Associates With a Hypertensive Cardiovascular Phenotype in Men but Not in Women.

<p><b>BACKGROUND</b></p><p>Lean body mass (LBM) is independently associated with the function and structure of the cardiovascular (CV) system in women and genetically predisposed men with low LBM. Yet, the relationship between LBM and the CV system remains uncertain in the general...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLean Body Mass Associates With a Hypertensive Cardiovascular Phenotype in Men but Not in Women.

Muscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia.

<p><b>BACKGROUND</b></p><p>Adalimumab, a TNF-ฮฑ inhibitor, is widely used clinically. Recent studies suggest Adalimumab can improve muscle damage after ischemic stroke (IS), but its protective mechanisms remain unclear. This study investigates the effect of adalimumab on muscle structure post-IS and the role...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Structure and Function Recovery: Adalimumab-Calcium Channel Synergy in Post-Ischemic Stroke Sarcopenia.

Targeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis.

<p><b>BACKGROUND</b></p><p>Type 2 diabetes mellitus (T2D) arises from the interplay between peripheral insulin resistance and pancreatic ฮฒ-cell dysfunction, ultimately leading to impaired glucose utilization and chronic hyperglycemia. Despite therapeutic advances, the multifactorial nature of T2D continues to demand the development of...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreTargeting Progesterone Receptor Membrane Component 1 to Improve Muscle Development and Glucose Homeostasis.

Rethinking Muscle Aging Through the Lens of Fibro-Adipogenic Progenitors.

Aging of skeletal muscles is accompanied by a progressive deposition of adipose and fibrotic tissue within the interstitial compartment. This process profoundly disrupts the structural integrity and contractile function of the muscle. Such maladaptive remodeling not only compromises muscle performance...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Aging And Disease
Read MoreRethinking Muscle Aging Through the Lens of Fibro-Adipogenic Progenitors.

An Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins.

<p><b>BACKGROUND</b></p><p>Cystinosis is a rare multisystem, autosomal recessive disease caused by dysfunction or loss of cystinosin (CTNS), which results in lysosomal cystine accumulation, primarily affecting the kidneys. Advances in renal transplantation, cysteamine treatment and improved medical care have increased life expectancy,...

๐Ÿ—“๏ธ 2025-11-10
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAn Isogenic Human Myoblast Cell Model for Cystinosis Myopathy Reveals Alteration of Key Myogenic Regulatory Proteins.

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