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SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

Erector Spinae Muscle to Epicardial Visceral Fat Ratio on Chest CT Predicts the Severity of Coronavirus Disease 2019.

Chest computed tomography (CT) is a valuable tool for diagnosing and predicting the severity of coronavirus disease 2019 (COVID-19) and assessing extrapulmonary organs. Reduced muscle mass and visceral fat accumulation are important features of a body composition phenotype in which...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreErector Spinae Muscle to Epicardial Visceral Fat Ratio on Chest CT Predicts the Severity of Coronavirus Disease 2019.

Accelerated Sarcopenia Phenotype in the DJ-1/-Knockout Zebrafish.

Age-dependent loss of muscle mass and function is associated with oxidative stress. DJ-1/ acts as an antioxidant through multiple signalling pathways. DJ-1-knockout zebrafish show a decline in swimming performance and loss of weight gain between 6 and 9 months of...

Read MoreAccelerated Sarcopenia Phenotype in the DJ-1/-Knockout Zebrafish.

The Effect of Anti-Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice.

Anti-Activin Receptor Type IIA and Type IIB antibody (ฮฑActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle hypertrophy,...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Effect of Anti-Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice.

Cut-Off Points for Low Relative 30-s Sit-to-Stand Power and Their Associations With Adverse Health Conditions.

Despite muscle power derived from the 5-rep sit-to-stand (STS) test having been demonstrated to be a valuable biomarker in older individuals, there is limited information regarding muscle power derived from the 30-s STS test, a widely used test in the...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCut-Off Points for Low Relative 30-s Sit-to-Stand Power and Their Associations With Adverse Health Conditions.

Circulating Extracellular Vesicles in Alcoholic Liver Disease Affect Skeletal Muscle Homeostasis and Differentiation.

The mechanisms underlying muscle alteration associated to alcoholic liver disease (ALD) are not fully understood and the physiopathologic mediators of the liver-muscle interplay remains elusive. We investigated the role of circulating extracellular vesicles (EVs) in ALD as potential mediators of...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCirculating Extracellular Vesicles in Alcoholic Liver Disease Affect Skeletal Muscle Homeostasis and Differentiation.

Ergogenic Benefits of ฮฒ-Hydroxy-ฮฒ-Methyl Butyrate (HMB) Supplementation on Body Composition and Muscle Strength: An Umbrella Review of Meta-Analyses.

ฮฒ-Hydroxy-ฮฒ-methyl butyrate (HMB) is a metabolite of the amino acid leucine, known for its ergogenic effects on body composition and strength. Despite these benefits, the magnitude of these effects remains unclear due to variability among studies. This umbrella review aims...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreErgogenic Benefits of ฮฒ-Hydroxy-ฮฒ-Methyl Butyrate (HMB) Supplementation on Body Composition and Muscle Strength: An Umbrella Review of Meta-Analyses.

Reference Values of Handgrip and Lower Extremity Strength for Vietnamese Men and Women: The Vietnam Osteoporosis Study.

Falls and sarcopenia are significant public health issues in Vietnam. Despite muscle strength being a critical predictor for these conditions, reference data on muscle strength within the Vietnamese population are lacking. To establish the reference ranges for muscle strength among...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreReference Values of Handgrip and Lower Extremity Strength for Vietnamese Men and Women: The Vietnam Osteoporosis Study.

C-Terminal Agrin Fragment as a Biomarker for Sarcopenia: A Systematic Review and Meta-Analysis.

Sarcopenia is a gradual decline in skeletal muscle mass and strength, which eventually leads to reduced physical performance. 50% of people aged 60-80โ€‰years suffer from sarcopenia. Considering the devastating outcomes and the importance of promoting healthy ageing, the diagnosis and...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreC-Terminal Agrin Fragment as a Biomarker for Sarcopenia: A Systematic Review and Meta-Analysis.

The Effect of Exercise on Spexin and Follistatin in Elderly Individuals.

In adipose tissue-muscle crosstalk mechanisms, the interaction of adipokines and myokines is known to be critical for maintaining the body's metabolic balance in age-related metabolic disorders. The aim of the study investigate the effects of 12โ€‰weeks of aerobic and resistance...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Effect of Exercise on Spexin and Follistatin in Elderly Individuals.

Effects of exercise and nutrition in improving sarcopenia in liver cirrhosis patients: a systematic review and meta-analysis.

Sarcopenia is highly prevalent in patients with liver cirrhosis (LC), adversely affecting their quality of life and life expectancy. Exercise and nutrition represent common interventions to ameliorate sarcopenia in these patients, although there exists inconsistency in the reported effectiveness of...

๐Ÿ“ฐ Journal: Hepatobiliary Surgery And Nutrition
Read MoreEffects of exercise and nutrition in improving sarcopenia in liver cirrhosis patients: a systematic review and meta-analysis.

Local Inflammation Precedes Diaphragm Wasting and Fibrotic Remodelling in a Mouse Model of Pancreatic Cancer.

Cancer cachexia represents a debilitating muscle wasting condition that is highly prevalent in gastrointestinal cancers, including pancreatic ductal adenocarcinoma (PDAC). Cachexia is estimated to contribute to ~30% of cancer-related deaths, with deterioration of respiratory muscles suspected to be a key...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLocal Inflammation Precedes Diaphragm Wasting and Fibrotic Remodelling in a Mouse Model of Pancreatic Cancer.

Sheer drop ahead: reviewing sarcopenia outcomes in elderly patients undergoing bariatric surgery.

The global prevalence of obesity among elderly patients continues to rise. Despite the availability of new antiobesity medications, bariatric surgery remains an effective treatment option for carefully selected candidates. However, it is not risk-free, especially in a vulnerable population, predisposing...

๐Ÿ“ฐ Journal: Reviews In Endocrine & Metabolic Disorders
Read MoreSheer drop ahead: reviewing sarcopenia outcomes in elderly patients undergoing bariatric surgery.

Transcriptomic Profiling Reveals 17ฮฒ-Estradiol Treatment Represses Ubiquitin-Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice.

With a decline of 17ฮฒ-estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female mice, testing the hypothesis that...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreTranscriptomic Profiling Reveals 17ฮฒ-Estradiol Treatment Represses Ubiquitin-Proteasomal Mediators in Skeletal Muscle of Ovariectomized Mice.

Characterization of SARS-CoV-2 Entry Genes in Skeletal Muscle and Impacts of Inย Vitro Versus Inย Vivo Infection.

COVID-19 has been associated with both respiratory (diaphragm) and non-respiratory (limb) muscle atrophy. It is unclear if SARS-CoV-2 infection of skeletal muscle plays a role in these changes. This study sought to: 1) determine if cells comprising skeletal muscle tissue,...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCharacterization of SARS-CoV-2 Entry Genes in Skeletal Muscle and Impacts of Inย Vitro Versus Inย Vivo Infection.

Descriptive Epidemiology and Prognostic Significance of Diaphragm Thickness in the General Population: The Nagahama Study.

Diaphragm thickness is a potential marker of sarcopenia in addition to muscle mass and strength at extremities. We aimed to clarify the descriptive epidemiology and prognostic significance of diaphragm thickness in the general population. The study participants were 3324 community...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDescriptive Epidemiology and Prognostic Significance of Diaphragm Thickness in the General Population: The Nagahama Study.

Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-ฮบB signaling and oxidative stress.

Cancer-associated cachexia (CAC) is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss, which accounts for one-third of cancer-related deaths. No effective therapeutic approach that could fully reverse CAC is available. NF-ฮบB signaling and oxidative stress play...

๐Ÿ“ฐ Journal: Genes & Diseases
Read MoreNovel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-ฮบB signaling and oxidative stress.

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