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SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy.

Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often-irreversible body-wasting condition that causes 20%-30% of cancer-related deaths. An obstacle to predicting, monitoring and understanding the mechanisms underlying chemotherapy cachexia is that each cancer (and subtype) is assigned different...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreHaptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy.

Early Detection of Age-Related Decline of Muscle Cell Mass by Intracellular Water Assessment Compared With MRI or DXA.

Ageing is commonly associated with a decrease in muscle strength, which is largely linked to decreases in skeletal muscle mass (SMM). The rate of the age-related decline in muscle strength is different from the rate of the age-related decline in...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEarly Detection of Age-Related Decline of Muscle Cell Mass by Intracellular Water Assessment Compared With MRI or DXA.

Moderation Effect of Handgrip Strength on Cognition and Functional Independence Associations in Adults Over 90 Years.

The causal relationship between cognitive impairment and functional decline seems bidirectional in older adults. This study aimed to determine the moderating effect of handgrip strength on the relationship between cognition and functional independence among Brazilian nonagenarians and centenarians. A cross-sectional...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreModeration Effect of Handgrip Strength on Cognition and Functional Independence Associations in Adults Over 90 Years.

Vitamin K2 Alleviates Insulin Resistance Associated Skeletal Muscle Atrophy via the AKT/mTOR Signalling Pathway.

Skeletal muscle atrophy and insulin resistance (IR) aggravate each other. Vitamin K2 (VK2) exhibits beneficial effects on IR, but whether it improves IR associated skeletal muscle atrophy remains insufficiently understood. This study aims to investigate the effects of VK2 on...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreVitamin K2 Alleviates Insulin Resistance Associated Skeletal Muscle Atrophy via the AKT/mTOR Signalling Pathway.

Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury.

White matter hyperintensity (WMH) is one of the key imaging markers of cerebral small vessel disease (CSVD) and white matter microstructural injury may occur earlier than WMH. However, the associations of handgrip strength (HGS) and serum total testosterone (STT) with...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury.

Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice.

The Wnt/β-catenin pathway and its bone-specific inhibitor, sclerostin, play important roles in skeletal development and homeostasis. The humanized sclerostin antibody, romosozumab, can significantly increase bone mineral density (BMD) of patients with osteoporosis, but it may also increase cardiovascular adverse events,...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNovel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice.

Prediction of 10-Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort.

Muscle strength, mass and function have been associated with falls, fractures and mortality, but the results vary between previous studies. We aimed to investigate the predictive ability of muscle strength and mass with 10-year incident fragility fractures. This study included...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePrediction of 10-Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort.

Comment on "Diagnosis of Sarcopenia by Evaluating Skeletal Muscle Mass by Adjusted Bioimpedance Analysis Validated With Dual-Energy X-Ray Absorptiometry" by Cheng et al.-The Authors Reply.

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreComment on "Diagnosis of Sarcopenia by Evaluating Skeletal Muscle Mass by Adjusted Bioimpedance Analysis Validated With Dual-Energy X-Ray Absorptiometry" by Cheng et al.-The Authors Reply.

Body Mass Index Changes and Femur Fracture Risk in Parkinson's Disease: National Cohort Study.

Parkinson's disease (PD) increases fracture risk owing to postural instability and bone fragility, with femur fractures being the most frequent and clinically significant. Many patients with PD experience weight loss as the disease progresses, and low body mass index (BMI)...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreBody Mass Index Changes and Femur Fracture Risk in Parkinson's Disease: National Cohort Study.

Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population.

Sarcopenia is defined as the loss of muscle mass, strength, and/or performance. It is strongly associated with all-cause mortality. Fibroblast growth factor 23 (FGF23) is markedly elevated in patients with chronic kidney disease, especially those receiving maintenance dialysis. FGF23 has...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population.

ZBED6 Knockout Prevents Ageing- and Dexamethasone-Induced Muscle Atrophy via Dkk3 in Pig and Mice.

Effective treatments for skeletal muscle atrophy, a debilitating condition linked to ageing and glucocorticoid therapy, remain lacking. Zinc finger BED-type containing 6 (ZBED6), a transcriptional repressor, enhances muscle growth and protects against sepsis-induced atrophy, but its role in ageing- and...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreZBED6 Knockout Prevents Ageing- and Dexamethasone-Induced Muscle Atrophy via Dkk3 in Pig and Mice.

Enhancing Neurocognitive Health via Activity, Nutrition and Cognitive Exercise (ENHANCE): A Randomized Controlled Trial.

While multidomain interventions show promise for promoting healthy aging, their impact on brain structure remains unclear. This randomized controlled trial (ENHANCE) assessed the efficacy of a 12-month group-based multidomain intervention on brain structure and function in community-dwelling older adults, with...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEnhancing Neurocognitive Health via Activity, Nutrition and Cognitive Exercise (ENHANCE): A Randomized Controlled Trial.

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