Sarcopenia

Drug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27.

BACKGROUND

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of survival of motor neuron (SMN) protein inducing progressive muscle weakness and atrophy due to motor neurons degeneration. Despite benefits of SMN restoration therapies in patients, motor defects are...

🗓️ 2025-10-23
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDrug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27.

Multispectral Optoacoustic Tomography of Skeletal Muscle Unveils Microcirculation and Oxygen Metabolism Alterations in Sarcopenia.

BACKGROUND

Sarcopenia, a significant geriatric syndrome, faces challenges in accurate diagnosis due to limitations of current imaging techniques. This study explores the novel application of multispectral optoacoustic tomography (MSOT) in evaluating sarcopenia, focusing on quantifying oxygen dynamics and collagen distribution in...

🗓️ 2025-10-21
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMultispectral Optoacoustic Tomography of Skeletal Muscle Unveils Microcirculation and Oxygen Metabolism Alterations in Sarcopenia.

3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.

BACKGROUND

In order to identify patients with sarcopenia, the use of routine imaging could provide valuable support. One of the most common radiological examinations, especially in geriatric inpatient care, is CT thoracic imaging. Therefore, it would be desirable to generate muscle...

🗓️ 2025-10-21
📰 Publication: Aging Clinical And Experimental Research
Read More3D deep learning-based muscle volume quantification from thoracic CT as a surrogate for DXA-Derived appendicular muscle mass in older adults.

Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.

BACKGROUND

Sarcopenia (SP) is characterized by progressive loss of skeletal muscle mass and function, and is a significant health burden in an aging society. Existing therapies have limited effectiveness. While ferroptosis plays a key role in sarcopenia, its regulatory mechanism remains...

🗓️ 2025-10-05
📰 Publication: Phytomedicine
Read MoreCistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.

Association of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance With Lung Cancer Survival: A Nationwide Cohort Study.

BACKGROUND

Physical activity (PA) is important for improving life expectancy and is suggested as a prognostic factor for various diseases. However, the association between PA and mortality outcomes in survivors of lung cancer remains unclear. Therefore, this study aimed to determine...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Pre- and Postdiagnosis Physical Activity, Promotion and Maintenance With Lung Cancer Survival: A Nationwide Cohort Study.

Sarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

BACKGROUND

Sarcopenic obesity (SO) is a clinical condition defined by the coexistence of high body fat mass and low muscle function and mass, which increases the risk of adverse health outcomes, including disability and mortality. Early detection and frequent monitoring of...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

A triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies.

BACKGROUND

Rapid population aging has intensified the prevalence of malnutrition, sarcopenia, frailty, and oral dysfunction, significantly affecting healthcare outcomes and quality of life in older adults. A growing body of evidence suggests that integrating rehabilitation, nutrition support, and oral health management-a...

🗓️ 2025-09-15
📰 Publication: Nutrition
Read MoreA triad strategy of rehabilitation, nutrition, and oral management for malnutrition, sarcopenia, and frailty in super-aged societies.

Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.

BACKGROUND

The relationship between regional adiposity and dementia remains poorly understood.

METHODS

This study included 440 861 UK Biobank participants initially free of dementia, stroke and cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia across quartiles of waist circumference (WC) or...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Android and Gynoid Fatness With Incident Dementia and Brain Structure.

Association of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

BACKGROUND AND AIMS

Sarcopenia and frailty have been associated with hormonal dysregulation in non-cirrhotic populations. The aim of the study was to evaluate hypothalamic-pituitary-adrenal and gonadal (HPA-HPG) axes as well as growth hormone/insulin-like growth factor-1 (GH/IGF-1) levels in patients with cirrhosis...

🗓️ 2025-11-01
📰 Publication: Liver International
Read MoreAssociation of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

Interplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in maintaining skeletal muscle homeostasis by regulating cell growth, protein degradation, and nutrient sensing. Beyond its role in muscle growth and atrophy, recent findings suggest that mTORC1 also...

🗓️ 2025-10-12
📰 Publication: Free Radical Biology And Medicine
Read MoreInterplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models.

BACKGROUND

Skeletal muscle mass is regulated by secretory factors derived from myofibers and muscle-resident cells. Identifying these factors and understanding their mechanisms is critical for combating muscle wasting disorders. This experimental study investigates the role of CXCL14, a chemokine primarily secreted...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models.

Impact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis.

BACKGROUND

While obesity confers a survival advantage, weight loss adversely affects the survival of patients undergoing haemodialysis. However, given the limited information regarding its long-term effects on mortality and cardiovascular events, the health benefits of weight gain remain uncertain, particularly in...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImpact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis.

Association Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.

BACKGROUND

Sarcopenia and intervertebral disc degeneration (IDD) are both highly prevalent among the elderly and have a substantial impact on their quality of life. However, the association between sarcopenia and IDD remains unclear. This study aimed to investigate whether sarcopenia is...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.

Peripheral Thyroid Hormones, Inflammatory and Skeletal Muscle Indexes in Advanced Cervical Cancer Treated With Cemiplimab.

BACKGROUND

A low fT3/fT4 ratio has been associated with poorer prognosis in several diseases. Inflammatory indexes (IIs) and the skeletal muscle index (SMI) are established prognostic factors in various cancer types. However, their interplay and individual contributions to the prognosis of...

🗓️ 2025-10-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MorePeripheral Thyroid Hormones, Inflammatory and Skeletal Muscle Indexes in Advanced Cervical Cancer Treated With Cemiplimab.

Muscle oxygen saturation stratification by photoacoustic imaging in diabetic sarcopenia: Association with disease status.

Sarcopenia, commonly observed in diabetes, is characterized by reduced muscle mass and function. However, the relationship between muscle oxygen saturation (SO₂) and sarcopenia remains unclear. Photoacoustic imaging (PAI) offers a promising method for assessment. This study aimed to evaluate SO₂...

🗓️ 2025-12-01
📰 Publication: Photoacoustics
Read MoreMuscle oxygen saturation stratification by photoacoustic imaging in diabetic sarcopenia: Association with disease status.

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