Accurate toxicity reporting in cancer clinical trials is necessary to promote regulatory decision making. Up to 85% of those with some cancers (e.g., oesophagus, head and neck, and pancreas) experience significant progressive weight loss (WL) throughout treatment. Therefore, it is...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
A significant increase in mitochondrial fatty acid oxidation (FAO) is now increasingly recognized as one of the metabolic alterations in diabetic cardiomyopathy (DCM). However, the molecular mechanisms underlying mitochondrial FAO impairment in DCM remain to be fully elucidated. A type...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Treatment for metastatic renal cell carcinoma (mRCC) has shifted from tyrosine kinase inhibitor (TKI) therapy to immune checkpoint inhibitor (ICI)-based therapy, improving outcomes but with variable individual responses. This study investigated the prognostic implications of pretreatment low skeletal muscle mass...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia presents a pressing public health concern due to its association with age-related muscle mass decline, strength loss and reduced physical performance, particularly in the growing older population. Given the absence of approved pharmacological therapies for sarcopenia, the need to...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is a progressive muscle disorder that may lead to mobility disability. No pharmaceutical interventions are currently available, and treatment relies on physical exercise and nutrition. The aim of SARA-INT was to investigate whether BIO101 (20-hydroxyecdysone), an activator of the...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Muscle atrophy is a severe complication of diabetes, with autophagy playing a critical role in its progression. Zinc has been shown to alleviate hyperglycaemia and several diabetes-related complications, but its direct role in mediating diabetic muscle atrophy remains unclear. This...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cancer cachexia has substantial impacts on people's quality of life. There is no current gold standard treatment, but the complex pathophysiology of cachexia suggests that a multitargeted and individualised treatment approach is needed. We aimed to evaluate the extent to...
๐๏ธ 2025-04-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cancer cachexia presents a significant challenge, but the ghrelin agonist anamorelin shows promise as a potential treatment. This study examined whether the baseline systemic inflammatory response (SIR) (measured by the modified Glasgow Prognostic Score [mGPS]), low BMI or greater weight...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Muscle atrophy is associated with Type 2 diabetes mellitus, which reduces the quality of life and lacks effective treatment strategies. Previously, it was determined that human umbilical cord mesenchymal stromal cell (hucMSC)-derived exosomes (EXOs) ameliorate diabetes-induced muscle atrophy. However, the...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia is a condition characterized by inadequate muscle and function decline and is often associated with ageing and cancer. It is established that sarcopenia and muscle loss occurred during treatment are associated with the clinical outcomes of patients with cancer....
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cardiolipin, a unique phospholipid predominantly present in the inner mitochondrial membrane, is critical for maintaining mitochondrial integrity and function. Its dimeric structure and role in supporting mitochondrial dynamics, energy production, and mitophagy make it indispensable for skeletal muscle health. This...
Anti-Activin Receptor Type IIA and Type IIB antibody (ฮฑActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle hypertrophy,...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
The global prevalence of obesity among elderly patients continues to rise. Despite the availability of new antiobesity medications, bariatric surgery remains an effective treatment option for carefully selected candidates. However, it is not risk-free, especially in a vulnerable population, predisposing...
๐๏ธ 2025-02-08
๐ฐ Publication: Reviews In Endocrine & Metabolic Disorders
With a decline of 17ฮฒ-estradiol (E2) at menopause, E2 has been implicated in the accompanied loss of skeletal muscle mass and strength. We aimed at characterizing transcriptomic responses of skeletal muscle to E2 in female mice, testing the hypothesis that...
๐๏ธ 2025-02-01
๐ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Cancer-associated cachexia (CAC) is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss, which accounts for one-third of cancer-related deaths. No effective therapeutic approach that could fully reverse CAC is available. NF-ฮบB signaling and oxidative stress play...
Sarcopenia is defined as a muscle-wasting syndrome that occurs with accelerated aging, while cachexia is a severe wasting syndrome associated with conditions such as cancer and immunodeficiency disorders, which cannot be fully addressed through conventional nutritional supplementation. Sarcopenia can be...
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