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SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopenia

Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population.

Sarcopenia is defined as the loss of muscle mass, strength, and/or performance. It is strongly associated with all-cause mortality. Fibroblast growth factor 23 (FGF23) is markedly elevated in patients with chronic kidney disease, especially those receiving maintenance dialysis. FGF23 has...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreFibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population.

ZBED6 Knockout Prevents Ageing- and Dexamethasone-Induced Muscle Atrophy via Dkk3 in Pig and Mice.

Effective treatments for skeletal muscle atrophy, a debilitating condition linked to ageing and glucocorticoid therapy, remain lacking. Zinc finger BED-type containing 6 (ZBED6), a transcriptional repressor, enhances muscle growth and protects against sepsis-induced atrophy, but its role in ageing- and...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreZBED6 Knockout Prevents Ageing- and Dexamethasone-Induced Muscle Atrophy via Dkk3 in Pig and Mice.

Enhancing Neurocognitive Health via Activity, Nutrition and Cognitive Exercise (ENHANCE): A Randomized Controlled Trial.

While multidomain interventions show promise for promoting healthy aging, their impact on brain structure remains unclear. This randomized controlled trial (ENHANCE) assessed the efficacy of a 12-month group-based multidomain intervention on brain structure and function in community-dwelling older adults, with...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreEnhancing Neurocognitive Health via Activity, Nutrition and Cognitive Exercise (ENHANCE): A Randomized Controlled Trial.

MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction-Regulating Proteins in a Rat Model of HFpEF.

Heart failure with preserved ejection fraction (HFpEF) is associated with exercise intolerance, accompanied by alterations in the peripheral skeletal muscle (SKM). We have recently shown that titin, a giant sarcomere protein, is hyperphosphorylated in HFpEF. MuRF1 is a muscle-specific ubiquitin...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction-Regulating Proteins in a Rat Model of HFpEF.

Serum C-Terminal Agrin Fragment With Acute and Long-Term Exercise and Angiotensin II Type I Receptor Blockade.

Sarcopenia represents a major clinical and societal challenge facing rapidly aging populations. Accessible and specific biomarkers represent valuable tools, both in diagnosis and assessing the efficacy of therapeutic interventions. C-terminal agrin fragment (CAF) is the most commonly used blood-based biomarker...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSerum C-Terminal Agrin Fragment With Acute and Long-Term Exercise and Angiotensin II Type I Receptor Blockade.

Comment on 'Acute Sarcopenia: Systematic Review and Meta-Analysis on Its Incidence and Muscle Parameter Shifts During Hospitalisation' by Aldrich etย al.: The Authors' Reply.

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreComment on 'Acute Sarcopenia: Systematic Review and Meta-Analysis on Its Incidence and Muscle Parameter Shifts During Hospitalisation' by Aldrich etย al.: The Authors' Reply.

Androgen Deprivation Therapy-Induced Muscle Loss and Fat Gain Predict Cardiovascular Events in Prostate Cancer Patients.

Androgen deprivation therapy (ADT) increases the risk of adverse cardiovascular events in patients with prostate cancer. ADT can induce body composition change; however, the association between body composition change and cardiovascular outcomes remains unclear. This study aimed to determine the...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAndrogen Deprivation Therapy-Induced Muscle Loss and Fat Gain Predict Cardiovascular Events in Prostate Cancer Patients.

The impact of sarcopenia on sarcoma patients: a systematic review and meta-analysis.

Sarcopenia has been linked to poor outcomes in various cancers, but its specific effect on sarcoma patients remains unclear. This systematic review and meta-analysis investigates the impact of sarcopenia, estimated using CT, on sarcoma patients, focusing on prognostic implications and...

๐Ÿ“ฐ Journal: Radiologia Medica
Read MoreThe impact of sarcopenia on sarcoma patients: a systematic review and meta-analysis.

The predictive and prognostic role of radiologically defined sarcopenia in head and neck cancer: a systematic review and multi-level meta-analysis.

Radiologically defined sarcopenia (RS), defined as a lack of skeletal muscle mass (SMM) measured on cross-sectional CT or MR imaging, is increasingly recognized as a significant prognostic determinant in head and neck cancer (HNC). A systematic literature search of Embase...

๐Ÿ“ฐ Journal: British Journal Of Cancer
Read MoreThe predictive and prognostic role of radiologically defined sarcopenia in head and neck cancer: a systematic review and multi-level meta-analysis.

Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk.

The decline in skeletal muscle mass and muscle strength linked to aging, also known as sarcopenia, is strongly associated with disability, traumatic injury, and metabolic disease in patients. Meanwhile, sarcopenia increases the risk of adverse orthopedic perioperative complications including implant...

๐Ÿ“ฐ Journal: Journal Of Nanobiotechnology
Read MoreMyogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk.

Normative data for age-specific skeletal muscle area based on computed tomography in Korean population.

Sarcopenia, a progressive loss of muscle mass and function, increases health risks in older adults, especially in rapidly ageing populations like Korea. Computed tomography (CT) imaging at the third lumbar vertebra (L3) level is a gold standard for assessing skeletal...

๐Ÿ“ฐ Journal: Age And Ageing
Read MoreNormative data for age-specific skeletal muscle area based on computed tomography in Korean population.

Contemporary Rationale for Delivering Enteral Nutrition in Critically Ill Adults.

To review the rationale for and timing, dose, and monitoring of enteral nutrition and protein delivery in critically ill adults. Medline searches to identify relevant studies, systematic reviews and meta-analyses, and guidelines informing the phases of critical illness, enteral nutrition...

๐Ÿ“ฐ Journal: Critical Care Medicine
Read MoreContemporary Rationale for Delivering Enteral Nutrition in Critically Ill Adults.

Desensitizing Effect of Intra-Tumoral GDF-15 on Immunotherapy in Patients With Advanced Non-Small Cellย Lung Cancer.

Serum growth/differentiation factor 15 (GDF-15) suppresses anti-tumor immunity and predicts prognosis in several malignancies. Elevated GDF-15 levels are linked to cancer cachexia, characterized by weight loss and systemic inflammation, adversely affecting patient outcomes and therapy response. However, serum GDF-15 is...

๐Ÿ“ฐ Journal: Thoracic Cancer
Read MoreDesensitizing Effect of Intra-Tumoral GDF-15 on Immunotherapy in Patients With Advanced Non-Small Cellย Lung Cancer.

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