SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood. We performed this...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreWhole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.

BACKGROUND

Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.

A comprehensive review of cancer-induced cardiac wasting.

Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural...

📰 Journal: British Journal Of Pharmacology
Read MoreA comprehensive review of cancer-induced cardiac wasting.

Wearable Hybrid Strain-Myoelectric Sensing System for Machine-Learning-Assisted Sarcopenia Screening.

The early screening of sarcopenia represents a critical clinical need amid the accelerating global aging population. Current diagnostic methods, relying on bioelectrical impedance analysis (BIA), handgrip strength testing, and other clinical examinations, depend on costly medical equipment and struggle to...

Read MoreWearable Hybrid Strain-Myoelectric Sensing System for Machine-Learning-Assisted Sarcopenia Screening.

Longitudinal Study of Frailty Phenotype in Relation to Chronic Kidney Disease Incidence.

BACKGROUND

The longitudinal relationship between frailty phenotype and CKD development, and the modifying role of genetic CKD risk in this association, remains unclear. Research on simple, noninvasive and quantifiable CKD prediction models incorporating frailty is limited.

METHODS

We analysed 214 502 CKD-free participants from...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLongitudinal Study of Frailty Phenotype in Relation to Chronic Kidney Disease Incidence.

Beyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.

BACKGROUND

Metabolic and bariatric surgery (MBS) produces substantial and sustained weight loss, but concerns remain about skeletal muscle loss and sarcopenia.

METHODS

We conducted a systematic review of longitudinal and cross-sectional studies evaluating changes in muscle quantity, strength, and physical performance following MBS...

📰 Journal: Obesity Reviews
Read MoreBeyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.

Prevalence and risk factors of malnutrition among older adults with sarcopenia: a protocol of systematic review and meta-analysis.

BACKGROUND

Sarcopenia and malnutrition are closely interrelated geriatric syndromes that significantly contribute to frailty, functional decline, and increased mortality in older adults. Although a growing body of evidence suggests a strong association between these conditions, reported prevalence rates and associated risk...

Read MorePrevalence and risk factors of malnutrition among older adults with sarcopenia: a protocol of systematic review and meta-analysis.

Gut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

BACKGROUND

Ageing is an inevitable biological process that contributes to increased prevalence of age-associated diseases, including sarcopenia, defined by progressive loss of muscle mass, functional decline and a heightened risk of injury. Developing effective interventions remains a critical clinical priority. This...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreGut Microbiota-Linked Benefits of Low-Intensity Pulsed Ultrasound Rejuvenate the Ageing Muscle.

UNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia.

Skeletal muscle mass and force decline with age, and the loss of muscle force precedes muscle atrophy. However, the underlying mechanisms remain unclear. Here, we investigated the role of the myosin co-chaperone, uncoordinated mutant number-45 myosin chaperone B (UNC45B), in...

📰 Journal: Aging Cell
Read MoreUNC45B Reduction With Aging: A Myofiber-Intrinsic Promoting Factor for Sarcopenia.

Effects of Tai Chi combined with elastic band training on muscle and executive inhibitory function in older adults with sarcopenia: a randomized controlled trial based on fNIRS.

BACKGROUND

Resistance training benefits patients with sarcopenia. However, trials demonstrating the effectiveness of Tai Chi combined with elastic band training are sparse, and the underlying neurocognitive mechanisms remain unclear.

METHODS

Forty-nine older sarcopenia patients (≥60 years) were recruited and randomly assigned to three groups:...

📰 Journal: Age And Ageing
Read MoreEffects of Tai Chi combined with elastic band training on muscle and executive inhibitory function in older adults with sarcopenia: a randomized controlled trial based on fNIRS.

Associations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.

BACKGROUND

Longitudinal associations between age-related changes in body composition, physical performance and incident diabetes mellitus (DM) in older adults and the mediating role of branched-chain amino acids (BCAAs) remain understudied.

METHODS

This prospective cohort study included 4000 community-dwelling older adults at baseline. Longitudinal...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.

Cancer cachexia: A tumor-driven disorder of whole-body homeostasis.

Cancer cachexia is a systemic metabolic syndrome driven by tumor-induced disruption of whole-body homeostasis. Characterized by skeletal muscle atrophy and adipose tissue loss, cachexia leads to functional decline, impaired quality of life, reduced treatment tolerance, and poor survival across multiple...

📰 Journal: Cancer Cell
Read MoreCancer cachexia: A tumor-driven disorder of whole-body homeostasis.

Sarcopenic Obesity in Children: An Emerging Complication Evidenced by Clinical Data and a Juvenile Mouse Model.

BACKGROUND

Sarcopenic obesity (SO) is well-characterized in older adults, but its impact on muscle development in children remains poorly understood. This study investigated the effects of childhood obesity on musculoskeletal health and the underlying mechanisms.

METHODS

We enrolled 1447 children (31.4% girls; median...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenic Obesity in Children: An Emerging Complication Evidenced by Clinical Data and a Juvenile Mouse Model.

Dual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.

Skeletal muscle accounts for approximately 40% of total body mass and is essential for locomotion, metabolic regulation and systemic homeostasis. Adipose tissue is increasingly recognized as an active component of the muscle's regenerative microenvironment. During muscle repair, adipose tissue contributes...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDual Roles of Adipose Tissue in Skeletal Muscle Regeneration: Pro-Regenerative Versus Maladaptive.

Sarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.

Sarcopenic obesity (SO; defined as obesity with low skeletal muscle function and mass) has been recently recognized as a relevant obesity phenotype, with substantial negative clinical impact. The prevalence of SO is likely increasing, due to the growing prevalence of...

📰 Journal: Clinical Nutrition
Read MoreSarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community.

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