Adipocyte methionine reduction promotes cancer cachexia.
📰 Journal: Nature Cancer
Read MoreAdipocyte methionine reduction promotes cancer cachexia.SCWD Publications Digest
Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.
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An iron-regulated methionine redox axis governs adipose browning and cancer cachexia.
Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning in both physiological...
📰 Journal: Nature Cancer
Read MoreAn iron-regulated methionine redox axis governs adipose browning and cancer cachexia.Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.
BACKGROUND
Cancer cachexia, a debilitating syndrome characterized by muscle wasting, significantly impacts survival in gastrointestinal cancers like pancreatic cancer. Emerging evidence suggests a link between cancer cachexia and disrupted circadian rhythms in peripheral tissues, including locomotor muscles. However, circadian dysregulation in...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions.
Skeletal muscle aging is a major cause of frailty, metabolic dysfunction, and loss of independence in later life, yet it cannot be explained by muscle mass loss alone. Recent single-cell, multi-omics, and translational studies show that aged muscle is shaped...
The causes of cachexia: key signals and the brain.
Cachexia is a multisystem, complex disorder of body weight and body composition characterized by a relentless, non-resolving wasting of metabolic reserve that, although long recognized and described, continues to elude effective treatment. A continued focus on central nervous system pathways...
📰 Journal: Nature Reviews Endocrinology
Read MoreThe causes of cachexia: key signals and the brain.Osteosarcopenia as a Risk Factor for Atrial Fibrillation: A Multi-Cohort Study.
BACKGROUND
Osteosarcopenia, characterized by concurrent reductions in skeletal muscle mass and bone mineral density, is an emerging geriatric syndrome. Although sarcopenia and osteoporosis have been individually linked to atrial fibrillation (AF), the association between osteosarcopenia and incident AF remains unclear.
OBJECTIVES
The authors...
Integrating Leg-Press Strength and Nutritional Status Improves 16-Year Mortality Risk Stratification in General Older Adults.
BACKGROUND
Malnutrition and muscle weakness are critical prognostic factors for mortality in older adults. While indices like the Geriatric Nutritional Risk Index (GNRI) are well-established, the long-term prognostic value of integrating nutrition with muscle strength (MS) remains insufficiently established in community-dwelling...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIntegrating Leg-Press Strength and Nutritional Status Improves 16-Year Mortality Risk Stratification in General Older Adults.UA-30 mitigates systemic aging and motor decline by inhibiting RalA signaling in naturally aged mice.
Aging, characterized by progressive physiological decline and systemic dysfunction, represents a major risk factor for age-related diseases such as sarcopenia, which involves fibrosis that disrupts muscle regeneration and function. Effective therapeutic strategies remain limited. Here we report UA-30, a novel...
📰 Journal: Journal Of Experimental Medicine
Read MoreUA-30 mitigates systemic aging and motor decline by inhibiting RalA signaling in naturally aged mice.Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia.
📰 Journal: Cell Reports
Read MoreBifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia.Integrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics.
BACKGROUND
Sarcopenia is a common condition in patients with gastric cancer that is associated with poor survival and adverse clinical outcomes. Conventional diagnostic approaches are time-consuming, limiting large-scale clinical implementation. This study aimed to develop and validate a multimodal model that...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIntegrated Assessment of Sarcopenia in Patients with Gastric Cancer Using Deep Learning and Radiomics.Quantitative Muscle MRI Fat Fraction as a Biomarker of Disease Severity in Mitochondrial Myopathies.
BACKGROUND
Quantitative muscle MRI is increasingly used to assess structural muscle damage in inherited myopathies, but its application in primary mitochondrial myopathies (PMM) has not been systematically evaluated in large cohorts. Because PMM are clinically and genetically heterogeneous, objective imaging biomarkers...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreQuantitative Muscle MRI Fat Fraction as a Biomarker of Disease Severity in Mitochondrial Myopathies.Revised Diagnostic Algorithm for Sarcopenic Obesity in Japan After the Asian Working Group for Sarcopenia 2025 Consensus Update (JWGSO 2026).
📰 Journal: Geriatrics & Gerontology International
Read MoreRevised Diagnostic Algorithm for Sarcopenic Obesity in Japan After the Asian Working Group for Sarcopenia 2025 Consensus Update (JWGSO 2026).Appendicular Skeletal Muscle Mass and Sarcopenia as Prognostic Markers in Amyotrophic Lateral Sclerosis.
BACKGROUND
Amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle wasting and functional decline. Prognostic assessment in clinical practice relies largely on functional scales and traditional anthropometric measures. The prognostic relevance of muscle mass, muscle strength and sarcopenia in ALS remains...
📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAppendicular Skeletal Muscle Mass and Sarcopenia as Prognostic Markers in Amyotrophic Lateral Sclerosis.Integrative Muscle-Adipose Score (IMAS): A Novel Unified, Sex-Sensitive Body Composition-Based Survival Predictor Enhancing Risk Stratification After Liver Transplantation.
OBJECTIVE
To investigate the potential of integrating muscle and fat compartments into a novel and unified score for outcome prediction in a bicentric European cohort of LT recipients.
BACKGROUND
Body composition (BC) reflects nutritional status and metabolic reserves and influences outcomes after orthotopic...
📰 Journal: Annals Of Surgery
Read MoreIntegrative Muscle-Adipose Score (IMAS): A Novel Unified, Sex-Sensitive Body Composition-Based Survival Predictor Enhancing Risk Stratification After Liver Transplantation.Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.
UNLABELLED
Cancer cachexia is a devastating wasting syndrome with no approved therapies. In this study, we identify the tumor-derived glycoprotein ADAMTSL4 as a circulating factor associated with body weight loss in preclinical cachexia models and patients with colorectal and lung cancers....
📰 Journal: Cancer Discovery
Read MoreTumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia.Sarcopenia in Heart Failure: The Right Disease, the Wrong Measurement?
📰 Journal: Jacc-Heart Failure
Read MoreSarcopenia in Heart Failure: The Right Disease, the Wrong Measurement?