SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Association of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

<p><b>BACKGROUND AND AIMS</b></p><p>Sarcopenia and frailty have been associated with hormonal dysregulation in non-cirrhotic populations. The aim of the study was to evaluate hypothalamic-pituitary-adrenal and gonadal (HPA-HPG) axes as well as growth hormone/insulin-like growth factor-1 (GH/IGF-1) levels in patients with cirrhosis...

๐Ÿ“ฐ Journal: Liver International
Read MoreAssociation of Hormonal Status With Sarcopenia, Frailty and Outcome in Patients With Decompensated Cirrhosis.

Interplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

The mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in maintaining skeletal muscle homeostasis by regulating cell growth, protein degradation, and nutrient sensing. Beyond its role in muscle growth and atrophy, recent findings suggest that mTORC1 also...

๐Ÿ“ฐ Journal: Free Radical Biology And Medicine
Read MoreInterplay Between mTORC1 Signaling and Iron Homeostasis in Muscle Atrophy.

Leveraging Sarcopenia index by automated CT body composition analysis for pan cancer prognostic stratification.

This study evaluates the CT-based volumetric sarcopenia index (SI) as a baseline prognostic factor for overall survival (OS) in 10,340 solid tumor patients (40% female). Automated body composition analysis was applied to internal baseline abdomen CTs and to thorax CTs....

Read MoreLeveraging Sarcopenia index by automated CT body composition analysis for pan cancer prognostic stratification.

Impact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis.

<p><b>BACKGROUND</b></p><p>While obesity confers a survival advantage, weight loss adversely affects the survival of patients undergoing haemodialysis. However, given the limited information regarding its long-term effects on mortality and cardiovascular events, the health benefits of weight gain remain uncertain, particularly in...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreImpact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis.

CXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models.

<p><b>BACKGROUND</b></p><p>Skeletal muscle mass is regulated by secretory factors derived from myofibers and muscle-resident cells. Identifying these factors and understanding their mechanisms is critical for combating muscle wasting disorders. This experimental study investigates the role of CXCL14, a chemokine primarily secreted...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCXCL14 Promotes Skeletal Muscle Mass Growth and Attenuates Lipopolysaccharide- and Dexamethasone-Induced Muscle Atrophy in Cultured Myotubes and Mouse Models.

Association Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.

<p><b>BACKGROUND</b></p><p>Sarcopenia and intervertebral disc degeneration (IDD) are both highly prevalent among the elderly and have a substantial impact on their quality of life. However, the association between sarcopenia and IDD remains unclear. This study aimed to investigate whether sarcopenia is...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation Between Sarcopenia and the Long-Term Risk of Intervertebral Disc Degeneration.

Muscle oxygen saturation stratification by photoacoustic imaging in diabetic sarcopenia: Association with disease status.

Sarcopenia, commonly observed in diabetes, is characterized by reduced muscle mass and function. However, the relationship between muscle oxygen saturation (SOโ‚‚) and sarcopenia remains unclear. Photoacoustic imaging (PAI) offers a promising method for assessment. This study aimed to evaluate SOโ‚‚...

๐Ÿ“ฐ Journal: Photoacoustics
Read MoreMuscle oxygen saturation stratification by photoacoustic imaging in diabetic sarcopenia: Association with disease status.

Peripheral Thyroid Hormones, Inflammatory and Skeletal Muscle Indexes in Advanced Cervical Cancer Treated With Cemiplimab.

<p><b>BACKGROUND</b></p><p>A low fT3/fT4 ratio has been associated with poorer prognosis in several diseases. Inflammatory indexes (IIs) and the skeletal muscle index (SMI) are established prognostic factors in various cancer types. However, their interplay and individual contributions to the prognosis of...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePeripheral Thyroid Hormones, Inflammatory and Skeletal Muscle Indexes in Advanced Cervical Cancer Treated With Cemiplimab.

Subcutaneous Adipose Tissue Radiation Attenuation Is Associated With Increased 1-Year Mortality in Polytrauma Patients.

<p><b>BACKGROUND</b></p><p>Polytrauma patients with an Injury Severity Score (ISS)โ€‰โ‰ฅโ€‰16 have a high mortality rate. Early identification of patients at risk of mortality is key. Different risk stratification models are available; however, body composition on third lumbar computed tomography (L3 CT) is...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSubcutaneous Adipose Tissue Radiation Attenuation Is Associated With Increased 1-Year Mortality in Polytrauma Patients.

The Prognostic Role of Frailty and Its Recognition With Simple FRAIL and Fried Frailty Questionnaires in Advanced Cancer Patients.

<p><b>BACKGROUND</b></p><p>Patients with advanced cancer frequently suffer from frailty associated with vulnerability and adverse outcomes. Our aim was to assess the prevalence of frailty and elucidate the utility of two commonly used frailty questionnaires in an advanced cancer population.</p><p><b>METHODS</b></p><p>The Fried Frailty...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Prognostic Role of Frailty and Its Recognition With Simple FRAIL and Fried Frailty Questionnaires in Advanced Cancer Patients.

The Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI-ฮฑ and Controls Myogenic Differentiation.

<p><b>BACKGROUND</b></p><p>Muscle RING finger (MuRF) proteins are striated muscle-specific E3 ubiquitin ligases essential for muscle homeostasis. Whereas MuRF1 is well known for its role in muscle atrophy, MuRF2 and MuRF3 contribute to microtubule stabilization, influencing muscle differentiation and function. Their cooperative...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreThe Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI-ฮฑ and Controls Myogenic Differentiation.

Temporalis muscle thickness: Ultrasound measurement, clinical significance and correlation with sarcopenic indices.

<p><b>BACKGROUND & AIMS</b></p><p>The clinical relevance of temporal muscle thickness (TMT) as a sarcopenia marker remains uncertain. This analysis reevaluates its potential utility and limitations in sarcopenia assessment.</p><p><b>METHODS</b></p><p>TMT was assessed ultrasonographically in 648 individuals (Mean age: 66.5 (range, 22-98) years, Female...

๐Ÿ“ฐ Journal: Clinical Nutrition
Read MoreTemporalis muscle thickness: Ultrasound measurement, clinical significance and correlation with sarcopenic indices.

Automated Classification of Neuromuscular Diseases Using Thigh Muscle MRI With Model Interpretations.

<p><b>BACKGROUND</b></p><p>Neuromuscular diseases (NMDs) are diagnosed using a combination of clinical evaluation, electromyography, nerve conduction studies, blood tests, muscle biopsy, and genetic testing. In addition, muscle magnetic resonance imaging (MRI) is used to visualise affected areas and allows the identification of...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAutomated Classification of Neuromuscular Diseases Using Thigh Muscle MRI With Model Interpretations.

Pancreatic Damage in Ovarian Cancer-Associated Cachexia Is Driven by Activin A Signalling.

<p><b>BACKGROUND</b></p><p>Cancer-associated cachexia (CAC) is a severe metabolic disorder characterized by involuntary weight loss, skeletal muscle atrophy and adipose tissue depletion. It is a major contributor to morbidity and mortality in the advanced stages of various cancers. However, the impact of...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MorePancreatic Damage in Ovarian Cancer-Associated Cachexia Is Driven by Activin A Signalling.

Sarcopenia and Its Individual Traits Independently Predict Mortality in Patients on Dialysis: A Systematic Review and Meta-Analysis.

<p><b>BACKGROUND</b></p><p>Loss of muscle mass, muscle weakness and the combination of the two are commonly observed in patients on dialysis and may have a negative impact on their survival. In this systematic review and meta-analysis (MA), we evaluated the consistency and...

๐Ÿ“ฐ Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSarcopenia and Its Individual Traits Independently Predict Mortality in Patients on Dialysis: A Systematic Review and Meta-Analysis.

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