SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

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Calcium Beta-Hydroxy-Beta-Methylbutyrate-Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial.

BACKGROUND

Dietary and pharmacologic weight loss can reduce skeletal muscle. Whether calcium beta-hydroxy-beta-methylbutyrate (CaHMB)-enriched supplementation preserves muscle while promoting fat loss in adults with obesity remains uncertain. We evaluated a CaHMB-enriched nutritional supplement during energy restriction.

METHODS

In this randomized, double-blind, controlled trial,...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCalcium Beta-Hydroxy-Beta-Methylbutyrate-Enriched Nutritional Supplementation During Dietary Weight Loss in Adults With Obesity: A Randomized Controlled Trial.

DXA-Measured Total and Regional Fat-to-Lean Mass Ratio and Mortality Risk in Chinese Older Adults: A 20-Year Prospective Study.

BACKGROUND

The association of fat-to-lean mass ratio (FLR) with mortality remains unclear in older adults. This study aimed to investigate the sex-specific associations of total and regional FLR with mortality in older Chinese adults.

METHODS

This analysis included 2000 men (mean age: 72.4 ± 5.0 years)...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDXA-Measured Total and Regional Fat-to-Lean Mass Ratio and Mortality Risk in Chinese Older Adults: A 20-Year Prospective Study.

Sarcopenic Obesity and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study and Landmark Analysis From the UK Biobank.

OBJECTIVE

To examine whether sarcopenic obesity (SO) is associated with incident type 2 diabetes (T2D) beyond obesity or sarcopenia alone and whether associations differ by sex, age, and transitions in body composition phenotypes over time.

RESEARCH DESIGN AND METHODS

We studied 479,607 diabetes-free...

📰 Journal: Diabetes Care
Read MoreSarcopenic Obesity and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study and Landmark Analysis From the UK Biobank.

Dnajb5 From Antarctic Fish Reveals a Redox-Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4.

BACKGROUND

Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDnajb5 From Antarctic Fish Reveals a Redox-Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4.

Neuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.

Sarcopenia is the age-related loss of muscle strength and size that leads to mobility limitations and loss of independence in older adults. The underlying cellular mechanisms remain unclear, and treatments are limited. As the critical interface between the nervous system...

📰 Journal: Journal Of Clinical Investigation
Read MoreNeuromuscular junction failure in sarcopenia is linked to NaV1.4 loss and reversed by ClC-1 inhibition.

Association of Intramuscular Fat Infiltration With Incident Venous Thromboembolism: A Population-Based Cohort Study.

BACKGROUND

Venous thromboembolism (VTE) is a major acute cardiovascular condition with high mortality, affecting nearly 10 million individuals worldwide each year. Identifying novel and modifiable risk factors is crucial for advancing prevention strategies. Intramuscular fat infiltration (IMFI), a modifiable condition linked...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Intramuscular Fat Infiltration With Incident Venous Thromboembolism: A Population-Based Cohort Study.

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue.

BACKGROUND

The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDivergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue.

Metabolic Syndrome as a Determinant of Bidirectional Transitions Between Frailty States: Evidence From the Whitehall II Study.

BACKGROUND

Understanding interactions between geriatric syndromes is central for promoting healthy aging. Frailty is among the most relevant, as it predicts disability, falls, hospitalization and mortality. In addition, emerging evidence also indicates that metabolic factors play a key role in the...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMetabolic Syndrome as a Determinant of Bidirectional Transitions Between Frailty States: Evidence From the Whitehall II Study.

Assessing the relationships between frailty, sarcopenia and Alzheimer's disease biomarkers: a scoping review.

INTRODUCTION

While both frailty and sarcopenia have been linked with the Alzheimer's disease (AD) clinical phenotype, their association with AD pathophysiology is unclear. This review aimed to identify current evidence of relationships between frailty, sarcopenia and AD biomarkers.

METHODS

Four databases (Ovid MEDLINE,...

📰 Journal: Ageing Research Reviews
Read MoreAssessing the relationships between frailty, sarcopenia and Alzheimer's disease biomarkers: a scoping review.

Association of Testosterone With Lean Soft Tissue and Handgrip Strength Across Middle-Aged Men.

BACKGROUND

Testosterone declines by 0.4%-2% annually after the age of 30 and is potentially linked with muscle mass and strength. This study examined how testosterone levels are associated with handgrip strength (HGS) and appendicular lean soft tissue index (ALSTI) in men...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreAssociation of Testosterone With Lean Soft Tissue and Handgrip Strength Across Middle-Aged Men.

Prognostic performance of Asian Working Group for Sarcopenia 2025 Constructs for activities of daily living at discharge after stroke: a head-to-head validation.

PURPOSE

To compare the prognostic performance of the Asian Working Group for Sarcopenia (AWGS) 2025 diagnostic constructs-specifically height- versus body mass index (BMI)-indexed muscle mass-for discriminating functional outcomes in patients with stroke.

METHODS

From a cohort of 1246 consecutive post-acute stroke admissions, we...

📰 Journal: European Geriatric Medicine
Read MorePrognostic performance of Asian Working Group for Sarcopenia 2025 Constructs for activities of daily living at discharge after stroke: a head-to-head validation.

Frailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.

BACKGROUND

Frailty and sarcopenia contribute to functional decline in older people with HIV (PWH), yet intervention data remain limited. We evaluated changes in frailty phenotype status, sarcopenia-related outcomes and functional performance during a supervised exercise trial and assessed associations between baseline...

📰 Journal: Age And Ageing
Read MoreFrailty phenotype transitions and functional improvements during a supervised exercise trial in older people with HIV: results from the HEALTH Trial.

Inter-tissue relationships of gene expression in liver, muscle and adipose tissue of children with end-stage chronic liver disease.

OBJECTIVES

End-stage chronic liver disease in children is associated with sarcopenia and aberrant adipose tissue mass. We investigated correlations between liver pathology-associated gene pathways (fibrosis, inflammation and steatosis) and metabolic genes in muscle and adipose tissue.

METHODS

Liver, rectus abdominis muscle and subcutaneous...

📰 Journal: Journal Of Pediatric Gastroenterology And Nutrition
Read MoreInter-tissue relationships of gene expression in liver, muscle and adipose tissue of children with end-stage chronic liver disease.

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration.

BACKGROUND

Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDownstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration.

Differences in Circulating Inflammatory Markers in Older Adults With and Without Sarcopenia: A Systematic Review and Meta-Analysis.

OBJECTIVES

In this systematic review and meta-analysis, mean differences among high-sensitivity C-reactive protein (CRP), CRP, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), the most common markers used in clinical practice, between older adults with and without sarcopenia based on established consensus...

📰 Journal: Journal Of The American Medical Directors Association
Read MoreDifferences in Circulating Inflammatory Markers in Older Adults With and Without Sarcopenia: A Systematic Review and Meta-Analysis.

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