Sarcopenia

Novel Algorithm to Estimate Fat-Free Muscle Volumes in Women Using the Urinary Deuterated-Creatine Dilution Method.

Muscle mass declines after menopause and is a key risk factor for frailty, falls and poor physical function as women age. The deuterated creatine (D 3Cr) dilution method provides a direct assessment of muscle mass, but its accuracy in Asian...

🗓️ 2025-08-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreNovel Algorithm to Estimate Fat-Free Muscle Volumes in Women Using the Urinary Deuterated-Creatine Dilution Method.

Integrating Body Composition and Nutritional Indices: A Novel Prognostic Tool for Survival in Pancreatic Cancer.

Sarcopenia and malnutrition have been independently associated with a poorer prognosis in pancreatic ductal adenocarcinoma (PDAC), but their combined association with patient outcomes is not fully understood. This study aimed to systematically evaluate the synergistic effects of body composition parameters...

🗓️ 2025-08-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreIntegrating Body Composition and Nutritional Indices: A Novel Prognostic Tool for Survival in Pancreatic Cancer.

Corrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

🗓️ 2025-07-07
📰 Publication: Metabolism-Clinical And Experimental
Read MoreCorrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

Corrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

🗓️ 2025-07-07
📰 Publication: Metabolism-Clinical And Experimental
Read MoreCorrigendum to "Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia" [metabolism. 2025 Jun 21:156333].

Soyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1α and PI3K pathway.

Sarcopenia, caused by aging, is characterized by the reduction of muscle mass and function. In this study, we investigated the effects of soyasapogenol B on skeletal muscle and the underlying mechanisms to determine its potential as a prevention for sarcopenia....

🗓️ 2025-07-05
📰 Publication: Biomedicine & Pharmacotherapy
Read MoreSoyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1α and PI3K pathway.

Patient Focus: Understanding Muscle Wasting in Heart Failure. An explanation of "Consolidating Concepts from Recent International Expert Consensus on Sarcopenia: Implications for Heart Failure Management".

🗓️ 2025-07-04
📰 Publication: Journal Of Cardiac Failure
Read MorePatient Focus: Understanding Muscle Wasting in Heart Failure. An explanation of "Consolidating Concepts from Recent International Expert Consensus on Sarcopenia: Implications for Heart Failure Management".

Interactions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77-101 years).

Low bone density and low muscle mass are both independent risk factors for mortality in older men. However, it is unknown if these tissues interact to increase mortality risk. Elucidating this information is important as bone and muscle are modifiable...

🗓️ 2025-07-01
📰 Publication: Age And Ageing
Read MoreInteractions between bone density and muscle mass in predicting all-cause mortality: a 10-year prospective cohort study of 1388 older men (aged 77-101 years).

Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.

Cellular senescence is a hallmark of organismal aging but how it drives aging in human tissues is not fully understood. Here we leverage single nucleus multiomics to profile senescence in mononucleated cells of human skeletal muscle and provide the first...

🗓️ 2025-07-05
📰 Publication: Nature Communications
Read MoreMultiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopenia.

Aging induces sarcopenia by disrupting the crosstalk between the skeletal muscle microenvironment and myofibers.

Sarcopenia is a degenerative muscular disease associated with aging, characterized by a reduction in muscle mass and strength. This disease poses a significant global health challenge, owing to its high prevalence and association with adverse outcomes such as increased frailty,...

🗓️ 2025-07-03
📰 Publication: Journal Of Advanced Research
Read MoreAging induces sarcopenia by disrupting the crosstalk between the skeletal muscle microenvironment and myofibers.

A serum creatinine-cystatin C-derived index as a predictive marker for sarcopenia incidence and progression in community-dwelling older adults: a prospective cohort study.

Identifying individuals at risk of sarcopenia incidence or progression remains challenging. Serum creatinine- and cystatin C-derived indices are objective markers of muscle metabolism; however, their predictive value for sarcopenia progression remains uncertain. This study evaluated the association between a creatinine-...

🗓️ 2025-07-01
📰 Publication: Age And Ageing
Read MoreA serum creatinine-cystatin C-derived index as a predictive marker for sarcopenia incidence and progression in community-dwelling older adults: a prospective cohort study.

Clarification and standardization of dual-energy X-ray absorptiometry terminology for accurate scientific communication and clinical diagnostic accuracy.

The evaluation of skeletal muscle (SM) mass has significant clinical and research relevance in the diagnosis and management of conditions such as malnutrition, sarcopenia, sarcopenic obesity, and cancer cachexia. Dual-energy X-ray absorptiometry (DXA) is now the most widely used method...

🗓️ 2025-06-30
📰 Publication: American Journal Of Clinical Nutrition
Read MoreClarification and standardization of dual-energy X-ray absorptiometry terminology for accurate scientific communication and clinical diagnostic accuracy.

Exercise-Induced Short-Chain Fatty Acids: A Novel Therapeutic Target in Type 2 Diabetes Mellitus with Sarcopenia.

Type 2 diabetes mellitus accompanied by sarcopenia is an emerging clinical challenge in aging populations, characterized by coexisting metabolic dysfunction and the progressive loss of skeletal muscle mass and function. This comorbidity substantially elevates the risk of frailty, functional impairment,...

🗓️ 2025-06-20
📰 Publication: Aging And Disease
Read MoreExercise-Induced Short-Chain Fatty Acids: A Novel Therapeutic Target in Type 2 Diabetes Mellitus with Sarcopenia.

Therapeutic advances in sarcopenia management: From traditional interventions to personalized medicine.

Sarcopenia, a progressive decline in skeletal muscle mass and function, has emerged as a critical geriatric syndrome affecting 10-40% of older adults, contributing to increased disability and mortality. This comprehensive review evaluates evidence-based strategies for sarcopenia management, from established interventions...

🗓️ 2025-06-11
📰 Publication: Clinical Nutrition
Read MoreTherapeutic advances in sarcopenia management: From traditional interventions to personalized medicine.

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