SCWD Publications Digest

Staying informed on the latest in cachexia, sarcopenia, and wasting disorders research is essential yet challenging. The SCWD Digest offers concise updates and expert insights into significant studies and developments. We highlight and link directly to leading research, making it easier for healthcare professionals to access and apply groundbreaking findings. Our goal: empower the medical community to advance patient care worldwide efficiently.

AllAgeingCachexiaCancer CachexiaClinical TrialsExerciseFrailtyFrom the literatureGuidelinesMuscleNutritionOther SCWD EventsSarcopeniaWasting Disorders

Exercise Modalities to Preserve Muscle Mass and Bone Health After Metabolic Bariatric Surgery.

BACKGROUND

Metabolic bariatric surgery (MBS) effectively reduces fat mass (FM), but how to best preserve muscle and bone mass after MBS is unknown.

OBJECTIVE

This study aimed to evaluate the effect of aerobic, resistance and combined exercise regimens on body composition, bone mineral...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreExercise Modalities to Preserve Muscle Mass and Bone Health After Metabolic Bariatric Surgery.

The pathology and diagnosis of cancer cachexia and a treatment insight from natural products: A review.

Cancer cachexia, which is characterized by weight loss and muscle wasting with or without fat depletion, is a complex syndrome that commonly seen in patients with advanced cancer. The underlying pathophysiological mechanisms of cancer cachexia involve in systemic inflammation, abnormal...

📰 Journal: Biochimica Et Biophysica Acta-Reviews On Cancer
Read MoreThe pathology and diagnosis of cancer cachexia and a treatment insight from natural products: A review.

Muscle Health and Prognosis in Patients With Cancer: New Insights.

BACKGROUND

Reduced muscle mass and impaired composition have each been independently associated with worse outcomes in patients with cancer. However, emerging evidence suggests that reduced muscle strength-namely, dynapenia-may be particularly important for prognostication, as it is easier to assess in clinical...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreMuscle Health and Prognosis in Patients With Cancer: New Insights.

Deubiquitinase YOD1 Inhibition Suppresses DEX- and Denervation-Induced Muscle Atrophy Through MAFbx Destabilization.

BACKGROUNDS

Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle-specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin-proteasome system remains unclear. This...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDeubiquitinase YOD1 Inhibition Suppresses DEX- and Denervation-Induced Muscle Atrophy Through MAFbx Destabilization.

Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

Sarcopenia is an age-related condition characterized by loss of skeletal muscle mass and strength and is associated with increased cancer incidence and mortality, yet how muscle decline promotes tumorigenesis remains unclear. Here, we show that skeletal muscle functions as an...

📰 Journal: Nature Communications
Read MoreSarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles.

Simple clinical parameters to identify sarcopenia 1 year after gastrectomy for gastric cancer.

BACKGROUND

New-onset sarcopenia may develop after gastrectomy even in patients with normal muscle mass, but its detection in routine practice remains challenging. This study evaluated body composition changes after gastrectomy and identified clinical parameters associated with sarcopenia development.

METHODS

This retrospective study included...

📰 Journal: Gastric Cancer
Read MoreSimple clinical parameters to identify sarcopenia 1 year after gastrectomy for gastric cancer.

Systemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology-Specific End-Stage Liver Disease.

BACKGROUND

Patients with end-stage liver disease (ESLD) often present with sarcopenia, defined as loss of skeletal muscle mass and quality, which is associated with reduced quality of life and increased mortality. However, the molecular mechanisms driving sarcopenia in ESLD are not...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreSystemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology-Specific End-Stage Liver Disease.

Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is associated with musculoskeletal comorbidities, including cachexia. Weight loss (WL) is the major criterion for cachexia and increases risk for mortality in COPD. Risk factors for WL in COPD are incompletely understood. We performed this...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreWhole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.

Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.

BACKGROUND

Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreCancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration.

A comprehensive review of cancer-induced cardiac wasting.

Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural...

📰 Journal: British Journal Of Pharmacology
Read MoreA comprehensive review of cancer-induced cardiac wasting.

Wearable Hybrid Strain-Myoelectric Sensing System for Machine-Learning-Assisted Sarcopenia Screening.

The early screening of sarcopenia represents a critical clinical need amid the accelerating global aging population. Current diagnostic methods, relying on bioelectrical impedance analysis (BIA), handgrip strength testing, and other clinical examinations, depend on costly medical equipment and struggle to...

Read MoreWearable Hybrid Strain-Myoelectric Sensing System for Machine-Learning-Assisted Sarcopenia Screening.

Longitudinal Study of Frailty Phenotype in Relation to Chronic Kidney Disease Incidence.

BACKGROUND

The longitudinal relationship between frailty phenotype and CKD development, and the modifying role of genetic CKD risk in this association, remains unclear. Research on simple, noninvasive and quantifiable CKD prediction models incorporating frailty is limited.

METHODS

We analysed 214 502 CKD-free participants from...

📰 Journal: Journal Of Cachexia Sarcopenia And Muscle
Read MoreLongitudinal Study of Frailty Phenotype in Relation to Chronic Kidney Disease Incidence.

Beyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.

BACKGROUND

Metabolic and bariatric surgery (MBS) produces substantial and sustained weight loss, but concerns remain about skeletal muscle loss and sarcopenia.

METHODS

We conducted a systematic review of longitudinal and cross-sectional studies evaluating changes in muscle quantity, strength, and physical performance following MBS...

📰 Journal: Obesity Reviews
Read MoreBeyond Sarcopenia: A Systematic Review and Meta-Analysis on Muscle Outcomes After Bariatric Surgery.

Prevalence and risk factors of malnutrition among older adults with sarcopenia: a protocol of systematic review and meta-analysis.

BACKGROUND

Sarcopenia and malnutrition are closely interrelated geriatric syndromes that significantly contribute to frailty, functional decline, and increased mortality in older adults. Although a growing body of evidence suggests a strong association between these conditions, reported prevalence rates and associated risk...

Read MorePrevalence and risk factors of malnutrition among older adults with sarcopenia: a protocol of systematic review and meta-analysis.

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