Motor_neurons

Drug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27.

<p><b>BACKGROUND</b></p><p>Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of survival of motor neuron (SMN) protein inducing progressive muscle weakness and atrophy due to motor neurons degeneration. Despite benefits of SMN restoration therapies in patients, motor defects are...

๐Ÿ—“๏ธ 2025-10-23
๐Ÿ“ฐ Publication: Journal Of Cachexia Sarcopenia And Muscle
Read MoreDrug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO-10-27.

Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise-dependent manner.

Exercise preserves neuromuscular function in aging through unknown mechanisms. Skeletal muscle fibroblasts (FIB) and stem cells (MuSC) are abundant in skeletal muscle and reside close to neuromuscular junctions, but their relative roles in motor neuron maintenance remain undescribed. Using direct...

๐Ÿ—“๏ธ 2024-11-18
๐Ÿ“ฐ Publication: Aging Cell
Read MoreMuscle fibroblasts and stem cells stimulate motor neurons in an age and exercise-dependent manner.

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