Muscle

Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1.

The essential amino acid methionine plays a pivotal role in one-carbon metabolism, facilitating the production of S-adenosylmethionine (SAM), a critical supplier for DNA methylation and thereby a modulator of gene expression. Here, we report that the methionine cycle is disrupted...

🗓️ 2024-12-20

📰 Publication: Cell Metabolism

cachexia / Cancer-associated_cachexia / Genes / Methionine / Muscle,_skeletal / muscles / Muscular_atrophy / neoplasms

Cachexia

Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of ≥50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy.

This retrospective, multicenter cohort study aimed to determine whether cancer cachexia serves as a biomarker for determining the most effective treatment for patients having non-small-cell lung cancer (NSCLC) with high programmed death ligand 1 (PD-L1) expression treated with immune checkpoint...

🗓️ 2024-12-16

Cancer-associated_cachexia / Carcinoma,_non-small-cell_lung / CELLS / chemotherapy / Drug_therapy / Immune_checkpoint_inhibitors / Lung / Lung_neoplasms / neoplasms / Small_cell_lung_carcinoma / therapeutics / Treatment_outcome / Weight_loss

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

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Cachexia

Cancer cachexia: multilevel metabolic dysfunction.

Cancer cachexia is a complex metabolic disorder marked by unintentional body weight loss or 'wasting' of body mass, driven by multiple aetiological factors operating at various levels. It is associated with many malignancies and significantly contributes to cancer-related morbidity and...

🗓️ 2024-11-22

Cancer-associated_cachexia / neoplasms / therapeutics

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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Cancer-associated_cachexia

Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1.

Clinical impact of cancer cachexia on the outcome of patients with non-small cell lung cancer with PD-L1 tumor proportion scores of ≥50% receiving pembrolizumab monotherapy versus immune checkpoint inhibitor with chemotherapy.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

Cancer cachexia: multilevel metabolic dysfunction.

Cancer cachexia.

Impact of Cachexia and First-Line Systemic Therapy for Previously Untreated Advanced Non-Small Cell Lung Cancer: NEJ050A.

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