Muscle

Late-Stage Skeletal Muscle Transcriptome in Duchenne Muscular Dystrophy Shows a BMP4-Induced Molecular Signature.

Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disease due to loss-of-function variants in the DYSTROPHIN gene. DMD-related skeletal muscle wasting is typified by an aberrant immune response involving upregulation of the TGFβ family of cytokines, like TGFβ1 and...

🗓️ 2025-08-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Biopsy / cachexia / CELLS / Genes / Muscle_cells / Muscle,_skeletal / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Sarcopenia / Transcriptome / Up-regulation

Cachexia

Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice.

Cachexia, a severe wasting syndrome characterized by tumour-induced metabolic dysregulation, is a leading cause of death in people with cancer, yet its underlying mechanisms remain poorly understood. Here we show that a longitudinal full-body single-nuclei-resolution transcriptome analysis in a Drosophila...

🗓️ 2025-04-16

Cancer-associated_cachexia / Genes / neoplasms / Up-regulation

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

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Endodontics / Endoleak / Endometrial_neoplasms / Endometriosis / Endopeptidases / Endophthalmitis / Endophytes / Endoplasmic_reticulum / Endoplasmic_reticulum_stress / Endoscopes / Endoscopic_mucosal_resection / Endoscopy / Endoscopy,_gastrointestinal / Endothelial_cells / Endothelial_growth_factors / Endothelin_receptor_antagonists / Endothelin-1 / Endothelium / Endotoxins / Endurance_training / Enema / Energy_drinks / Energy_intake / Enhanced_recovery_after_surgery / Enhancer_elements,_genetic / Enteral_nutrition / Enterobacter / Enterococcus / Enterococcus_faecium / Enteropathogenic_escherichia_coli / Enterotoxigenic_escherichia_coli / Enterotoxins / Enterovirus / Environment_design / Environmental_health / Environmental_monitoring / Environmental_policy / Environmental_pollutants / Environmental_pollution / Enzyme-linked_immunosorbent_assay / Enzymes / Eosinophilia / Eosinophils / Ependymoma / Epidemics / Epidemiologic_studies / epidemiology / Epididymis / Epigenome / Epiglottis / Epilepsies,_partial / Epilepsy / Epilepsy,_absence / Epilepsy,_temporal_lobe / Episiotomy / Epithelial_cells / Epithelial-mesenchymal_transition / Epithelium,_corneal / Erythrocyte_transfusion / Erythrocytes / Erythropoietin / Escherichia_coli / Esophageal_fistula / Esophageal_neoplasms / Esophageal_sphincter,_lower / Esophageal_squamous_cell_carcinoma / Esophagectomy / Esophagogastric_junction / Esophagus / Estrus_detection / Ether / Ethics / Ethics,_medical / Ethmoid_sinus / Ethylene_glycol / Ethylene_oxide / Etomidate / European_union / Evolution,_molecular / Exanthema / Excitation_contraction_coupling / Executive_function / Exercise_test / Exercise_therapy / Exome / Exome_sequencing / Exons / Exosomes / Explosive_agents / External_fixators / Extracellular_matrix / Extracellular_vesicles / Extracorporeal_membrane_oxygenation / Extreme_weather / Eye / Eye_diseases / Eye_movements / Eyeglasses / Eyelids / Facial_expression / Facial_paralysis / Facial_recognition / Factor_viii / Factor_xi_deficiency / Failure_to_thrive / Fallopian_tubes / Famciclovir / Family_practice / Family_relations / Family_structure / Fanconi_syndrome / Farms / Fasciitis,_plantar / Fasting / Fathers / FATIGUE / Fatigue_syndrome,_chronic / Fatty_acid-binding_proteins / Fatty_acids / Fatty_acids,_omega-3 / Fatty_acids,_volatile / Fatty_liver / Fear / Feasibility_studies / Febuxostat / Fecal_incontinence / Feedback / Feedback,_sensory / Feeding_behavior / Femoracetabular_impingement / Femoral_fractures,_distal / Fentanyl / Ferritins / Ferroptosis / Fertility / Fertilization / Fertilization_in_vitro / Fertilizers / Fetal_hemoglobin / Fetuins / Fetus / Fibrin / Fibrinogen / Fibrinolysin / Fibroblast_growth_factors / Fibrocartilage / Fibroins / Fibronectins / Fibrosis / Fires / Fish_oils / Fistula / Flank_pain / Flavivirus / Flavonoids / Flowmeters / Flucytosine / Fluid_therapy / Fluorescent_dyes / Fluoroquinolones / Fluoroscopy / Fluorouracil / Focus_groups / Folliculitis / Follow-up_studies 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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Up-regulation

Late-Stage Skeletal Muscle Transcriptome in Duchenne Muscular Dystrophy Shows a BMP4-Induced Molecular Signature.

Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

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