Skeletal muscle-derived IL-33 mediates muscle-to-bone crosstalk and regulates bone metabolism via CD8 + T cell-secreted CCL5.
BACKGROUND
Skeletal muscle-to-bone crosstalk may play critical roles in the association between muscle atrophy and bone loss. Here, we report a myokine, IL-33, which may mediate muscle-to-bone crosstalk.
METHODS
A cohort study was conducted to elucidate the associations among circulating IL-33, osteoporosis, and...
