The canonical ER stress IRE1ฮฑ/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia.
Cancer cachexia is a debilitating syndrome characterized by the progressive loss of skeletal muscle mass with or without fat loss. Recent studies have implicated dysregulation of the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) pathways in skeletal muscle under...
