Autophagy

Exercise

Voluntary Activity Wheel Running Improves Hyperammonaemia-Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice.

Voluntary exercise improves clinical outcomes in healthy subjects, but increased muscle ammoniagenesis may limit beneficial responses during hyperammonaemia in chronic diseases. Responses to 4-weeks voluntary wheel running (VWR) were compared with usual activity (UA) to determine if hyperammonaemia alters VWR...

🗓️ 2025-08-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagy / cachexia / Chronic_disease / Enzymes / Hand_strength / Muscle,_skeletal / muscles / Running / Sarcopenia

Muscle

Impaired Autophagic Flux in Skeletal Muscle of Plectin-Related Epidermolysis Bullosa Simplex With Muscular Dystrophy.

Plectin, a multifunctional cytolinker and intermediate filament stabilizing protein, is essential for muscle fibre integrity and function. Mutations in the human plectin gene (PLEC) cause autosomal recessive epidermolysis bullosa simplex with muscular dystrophy (EBS-MD). The disorganization and aggregation of desmin...

🗓️ 2025-08-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagy / cachexia / CELLS / Chloroquine / Desmin / Epidermolysis_bullosa / Epidermolysis_bullosa_simplex / Genes / Metformin / Muscle,_skeletal / muscles / Muscular_dystrophies / Myoblasts / Pathology / Plectin / Sarcopenia / Vacuoles

Muscle

Iron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control.

In older adults with reduced physical performance, an increase in the labile iron pool within skeletal muscle is observed. This accumulation is associated with an altered expression of mitochondrial quality control (MQC) markers and increased mitochondrial DNA damage, supporting the...

🗓️ 2025-05-03

Aging / Autophagy / Cell_death / CELLS / cytokines / Ferritins / Ferroptosis / Hepcidins / Lysosomes / Mitophagy / muscles / Quality_control / Sarcopenia / therapeutics / Transferrin

Muscle

Nestin Regulates Autophagy-Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B.

Programmed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy remains unclear. Ferroptosis in...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagy / cachexia / Cell_death / CELLS / Ferroptosis / Muscle_strength / Muscle,_skeletal / muscles / Muscular_atrophy / Nestin / Sarcopenia / Ubiquitination

Muscle

Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39.

Muscle atrophy is a severe complication of diabetes, with autophagy playing a critical role in its progression. Zinc has been shown to alleviate hyperglycaemia and several diabetes-related complications, but its direct role in mediating diabetic muscle atrophy remains unclear. This...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagy / cachexia / CELLS / Diabetes_mellitus / Down-regulation / Genes / muscles / Muscular_atrophy / Sarcopenia / Sirtuin_1 / therapeutics

Muscle

A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing.

Sarcopenia, characterized by a gradual decline in skeletal muscle mass and function with age, significantly impacts both quality of life and mortality. Autophagy plays a crucial role in maintaining muscle health. There is growing interest in leveraging autophagy to mitigate...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aged / Autophagy / cachexia / Ellagic_acid / Muscle,_skeletal / muscles / Polyamines / Sarcopenia / SERUM

Muscle

Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis.

Regenerative capacity of skeletal muscles decreases with age. Deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) is associated with skeletal muscle weakness as well as epithelial cell senescence. However, whether and how CFTR plays a role in skeletal muscle regeneration...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aging / Autophagy / cachexia / Cystic_fibrosis / Cystic_fibrosis_transmembrane_conductance_regulator / Fibrosis / Genes / Mitochondria / Muscle,_skeletal / muscles / Myoblasts / Sarcopenia / tissues

Muscle

Characterization of SARS-CoV-2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection.

COVID-19 has been associated with both respiratory (diaphragm) and non-respiratory (limb) muscle atrophy. It is unclear if SARS-CoV-2 infection of skeletal muscle plays a role in these changes. This study sought to: 1) determine if cells comprising skeletal muscle tissue,...

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagy / cachexia / CELLS / Covid-19 / Diaphragm / Genes / Infections / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Muscular_atrophy / Sarcopenia / Sars-cov-2 / Severe_acute_respiratory_syndrome-related_coronavirus / Ubiquitin / Virus_internalization

Exercise

Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy.

Spinal muscular atrophy (SMA) is a health- and life-limiting neuromuscular disorder. Although varying degrees of mitochondrial abnormalities have been documented in SMA skeletal muscle, the influence of disease progression on pathways that govern organelle turnover and dynamics are poorly understood....

🗓️ 2025-02-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Autophagosomes / Autophagy / Disease_progression / Mitochondria / Mitochondria,_muscle / Mitochondrial_turnover / Mitophagy / Muscle,_skeletal / muscles / Muscular_atrophy / Muscular_atrophy,_spinal / Organelle_biogenesis / Organelles / Sarcopenia / Spine / therapeutics

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / Adenoma,_pleomorphic / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipocytes,_brown / Adipocytes,_white / Adipogenesis / Adiponectin / Adipose_tissue / Adiposity / Administration,_intranasal / Administration,_oral / Adolescent / Adrenal_cortex_hormones / Adrenocorticotropic_hormone / Adult_stem_cells / Advance_care_planning / Adverse_childhood_experiences / Advertising / Aeromonas_veronii / Aerosols / Aflatoxin_m1 / Aflatoxins / African_swine_fever / Aftercare / Agar / Agaricales / Age_distribution / Aged / Agent_orange / Aggregatibacter / Aggregatibacter_aphrophilus / Aggression / Aging,_premature / Agranulocytosis / Agricultural_irrigation / Agriculture / Agrochemicals / Aids-related_complex / Air_pollution / Alanine / Alcohol_drinking / Alcoholics / Aldehydes / Aldosterone / Alendronate / Alginates / Algorithms / Alkaline_phosphatase / Alkalosis / Alkanesulfonates / Alkynes / Alleles / Allergens / Allografts / Allopurinol / Alloys / Alopecia / Alopecia_areata / Alpha_1-antitrypsin / Alpha_1-antitrypsin_deficiency / Alpha-glucosidases / Alpha-linolenic_acid / Alpha-synuclein / Alphapapillomavirus / Altitude / Alzheimer_disease / Amanita / Ambulances / Ambulatory_care / Ambulatory_care_facilities / Amikacin / Amine_oxidase_(copper-containing) / Amines / Amino_acid_sequence / Amino_acid_substitution / Amino_acids / Amino_acids,_branched-chain / Amino_acids,_sulfur / Amino_alcohols / Aminolevulinic_acid / Amlodipine / Amoxicillin / Amphetamines / Amphotericin_b / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyloidosis / Amylopectin / Amyotrophic_lateral_sclerosis / Analgesia / Analgesics / Analysis_of_variance / Anaphylaxis / Anastomotic_leak / Anemia / Anemia,_aplastic / Anemia,_iron-deficiency / Anemia,_sickle_cell / Anesthesia / Anesthesia,_conduction / Anesthesia,_epidural / Anesthesia,_intravenous / Anesthesia,_local / Anesthesia,_obstetrical / Anesthesiologists / Anesthesiology / Anesthetics / 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Bronchogenic_cyst / Bronchopulmonary_sequestration / Bronchoscopy / Brucella / Brucellosis / Brugada_syndrome / Budesonide / Buffers / Bulimia / Bundle-branch_block / Bupropion / Burning_mouth_syndrome / Burnout,_psychological / Burns / Butter / Butyrylcholinesterase / C-peptide / C-reactive_protein / Ca-19-9_antigen / cachexia / Caco-2_cells / Cadherins / Caffeine / Calcitonin_gene-related_peptide / Calcium / Calcium_channel_blockers / Calcium_channels / Calcium_signaling / Cancer_vaccines / Cancer-associated_cachexia / Cancer-associated_fibroblasts / Candidemia / Candidiasis / Candidiasis,_invasive / Candidiasis,_vulvovaginal / Cannabidiol / Cannula / Capacity_building / Capillaries / Capsaicin / Capsid / Capsules / Car-t_cell / Carbamazepine / Carbapenems / Carbidopa / Carbohydrates / Carboxylic_acids / Carcinogenesis / Carcinogens / Carcinoid_tumor / Carcinoma_in_situ / Carcinoma,_basal_cell / Carcinoma,_hepatocellular / Carcinoma,_intraductal,_noninfiltrating / Carcinoma,_non-small-cell_lung / Carcinoma,_ovarian_epithelial / Carcinoma,_renal_cell / Carcinoma,_squamous_cell / Cardiac_catheters / Cardiac_output / Cardiac_rehabilitation / Cardiac_resynchronization_therapy / Cardiac_volume / Cardiology / Cardiomyopathy,_restrictive / Cardiopulmonary_bypass / Cardiopulmonary_resuscitation / Cardiotoxicity / Cardiovascular_diseases / Cardiovascular_system / Caregivers / Carotenoids / Carotid_arteries / Carotid_artery,_internal / Carrier_proteins / Case-control_studies / Caseins / Caspase_3 / Caspase_9 / Caspases / Castleman_disease / Castration / Catalase / Cataract / Catastrophization / Catechin / Catechol_o-methyltransferase / Catecholamines / Catenins / Catheter_ablation / Catheterization / Causality / Caveolins / Cecum / Cefazolin / Cefoperazone / Cefotaxime / Ceftazidime / Ceftriaxone / Celiac_disease / Cell_aggregation / Cell_biology / Cell_body / Cell_communication / Cell_count / Cell_culture_techniques / Cell_cycle / Cell_death / 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Chronic_disease / Chronic_pain / Chylothorax / Chylous_ascites / Cicatrix / Cilia / Ciprofloxacin / Circadian_clocks / Circovirus / Circulating_microrna / Circulating_tumor_dna / Citalopram / Citizen_science / Citric_acid / Citrinin / Citrobacter / Citrobacter_rodentium / Citrulline / Cladribine / Classical_swine_fever / Clathrin / Clay / Climacteric / Climate / Clinical_alarms / Clinical_decision-making / Clinical_laboratory_techniques / Clitoris / Clobazam / Clone_cells / Clonidine / Clostridioides / Clostridioides_difficile / Clostridium / Cloud_computing / Clozapine / Cluster_analysis / Clustered_regularly_interspaced_short_palindromic_repeats / Clutch_size / Coagulase / Coal / Coal_industry / Coccidioidomycosis / Cochlear_implants / Cochlear_nucleus / Coconut_oil / Codon / Coffee / Cognition_disorders / Cognitive_behavioral_therapy / Cognitive_dissonance / Cognitive_dysfunction / Cognitive_restructuring / Cognitive_training / Cohort_studies / Coinfection / Colchicine / 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Pluripotent_stem_cells / Pneumonia / Pneumonia,_viral / Pneumothorax / Podocytes / Point_mutation / Point-of-care_systems / Point-of-care_testing / Poisoning / Poisons / Police / Poliovirus / Poly(adp-ribose)_polymerase_inhibitors / Polyadenylation / Polyamines / Polychlorinated_biphenyls / Polycyclic_aromatic_hydrocarbons / Polycystic_kidney_diseases / Polycystic_kidney,_autosomal_dominant / Polycystic_ovary_syndrome / Polydioxanone / Polyelectrolytes / Polyesters / Polyethylene_glycols / Polymerase_chain_reaction / Polymers / Polymethyl_methacrylate / Polymorphism,_genetic / Polymorphism,_single_nucleotide / Polymyxin_b / Polymyxins / Polyneuropathies / Polypharmacy / Polyphenols / Polyproteins / Polyps / Polyradiculoneuropathy,_chronic_inflammatory_demyelinating / Polysaccharides / Polysomnography / Polystyrenes / Polytetrafluoroethylene / Polyurethanes / Polyvinyls / Popliteal_artery_aneurysm / Population_growth / Porphobilinogen_synthase / Porphyrias / Porphyrins / Porphyromonas / Porphyromonas_gingivalis / Portal_vein / Portasystemic_shunt,_surgical / Positive-pressure_respiration / Positron_emission_tomography_computed_tomography / Positron-emission_tomography / Post-acute_covid-19_syndrome / Posterior_cerebral_artery / Postmortem_imaging / Postnatal_care / Postoperative_cognitive_complications / Postoperative_complications / Postoperative_period / Postpartum_hemorrhage / Postpartum_period / Posttraumatic_growth,_psychological / Postural_orthostatic_tachycardia_syndrome / Posture / Potassium_channels / Potassium_channels,_inwardly_rectifying / Poultry / Poverty / Powders / Praziquantel / Pre-eclampsia / Pre-exposure_prophylaxis / Prealbumin / Prebiotics / Precision_medicine / Precursor_cell_lymphoblastic_leukemia-lymphoma / Prediabetic_state / Predictive_value_of_tests / Prednisone / Prefrontal_cortex / Pregabalin / PREGNANCY / Pregnancy_complications / Pregnancy_outcome / Pregnancy_rate / Pregnancy_trimester,_second / Pregnancy_trimester,_third / Pregnancy,_twin / Pregnancy,_unwanted / Pregnane_x_receptor / Prehypertension / Prejudice / Premature_birth / Premedication / Premenstrual_syndrome / Prenatal_education / Prenatal_nutritional_physiological_phenomena / Preoperative_period / Prescriptions / Presenteeism / PREVALENCE / Preventive_health_services / Preventive_medicine / Priapism / Primary_myelofibrosis / Primitive_streak / Printing,_three-dimensional / Prion_diseases / Prion_proteins / Prions / Prisoners / Privacy / Private_practice / Probability / Probiotics / Procalcitonin / Prodrugs / Professional_practice / Progesterone / Progestins / Prognosis / Programming,_linear / Proguanil / Projection / Prolactin / Promoter_regions,_genetic / Propensity_score / Propionates / Propofol / Proprioception / Prospective_studies / Prostaglandins / Prostatectomy / Prostatic_neoplasms / Prostheses_and_implants / Prosthesis_failure / Protease_inhibitors / Protective_factors / Protein_biosynthesis / Protein_c / Protein_corona / Protein_isoforms / Protein_kinases / Protein_phosphatase_1 / Protein_processing,_post-translational / Protein_serine-threonine_kinases / Protein-tyrosine_kinases / Proteogenomics / Proteome / Proteomics / Prothrombin / Prothrombin_time / Proton_pump_inhibitors / Proton_pumps / Proton_therapy / Pruritus / Pseudogenes / Pseudomonas / Pseudomonas_aeruginosa / Pseudomonas_stutzeri / Pseudouridine / Psoriasis / Psychiatrists / Psychological_distress / Psychological_well-being / Psychology,_positive / Psychometrics / Psychosocial_intervention / Psychotherapy / Psychotic_disorders / Psychotropic_drugs / Public_health / Public_health_surveillance / Public_sector / Pulmonary_arterial_hypertension / Pulmonary_disease,_chronic_obstructive / Pulmonary_embolism / Pulmonary_fibrosis / Pulmonary_surfactant-associated_protein_a / Pulmonary_valve / Pulpectomy / Pulpotomy / Pulse / Punctures / Punishment / Pupa / Pupil / Purpura / Purpura,_thrombocytopenic / Putamen / Pyoderma / Pyoderma_gangrenosum / Pyrans / Pyrazoles / Pyridoxine / Pyrophosphatases / Pyroptosis / Pyrrolidinones / Pyruvate_kinase / Quadriceps_muscle / Qualitative_research / Quality_improvement / Quality_of_life / Quality-adjusted_life_years / Quantitative_trait_loci / Quantum_dots / Quarantine / Quercetin / Quinazolines / Quinoxalines / Quorum_sensing / Racism / Radar / Radiation_exposure / Radiation_fibrosis_syndrome / Radio / Radiofrequency_ablation / Radiography / Radiologists / Radiology / Radiology,_interventional / Radionuclide_imaging / radiotherapy / Radius_fractures / Rainforest / Random_allocation / Range_of_motion,_articular / Ranula / Rare_diseases / Reaction_time / Reading / Reading_frames / Receptor_activity-modifying_proteins / Receptor_for_advanced_glycation_end_products / Receptors,_adrenergic / Receptors,_antigen / Receptors,_antigen,_t-cell / Receptors,_calcitriol / Receptors,_cannabinoid / Receptors,_chemokine / Receptors,_chimeric_antigen / Receptors,_cxcr4 / Receptors,_estrogen / Receptors,_fibroblast_growth_factor / Receptors,_gaba / Receptors,_glucocorticoid / Receptors,_glutamate / Receptors,_growth_factor / Receptors,_ldl / Receptors,_lipoprotein / Receptors,_mineralocorticoid / Receptors,_opioid / Receptors,_prostaglandin / Receptors,_serotonin / Receptors,_transferrin / Recombinant_proteins / Recombinases / Recombinational_dna_repair / Rectal_neoplasms / Rectum / Recycling / Reducing_agents / Refeeding_syndrome / Reflex / Refractive_errors / Refractive_surgical_procedures / Refugium / Regenerative_medicine / Regression_analysis / Rehabilitation_centers / Rehabilitation,_vocational / Reinfection / Reishi / Remission_induction / Renal_dialysis / Renal_insufficiency / Renal_insufficiency,_chronic / Renal_replacement_therapy / Renin / Renin-angiotensin_system / Reoperation / Reperfusion / Reperfusion_injury / Replantation / Replication_origin / Reproduction / Reproductive_health / Reproductive_medicine / Research_design / Resilience,_psychological / Resistance_training / Resistant_starch / Resource_allocation / Respect / Respiration / Respiratory_burst / Respiratory_distress_syndrome / Respiratory_muscles / Respiratory_rate / Respiratory_syncytial_viruses / Respiratory_system / Respiratory_tract_diseases / Respiratory_tract_infections / Restaurants / Resuscitation / Retention,_psychology / Retina / Retinal_detachment / Retinal_diseases / Retinal_perforations / Retinal_pigment_epithelium / Retinal_pigments / Retinaldehyde / Retinitis_pigmentosa / Retinoblastoma / Retrospective_studies / Return_to_work / Reverse_genetics / Reverse_transcriptase_inhibitors / Reward / Rheology / Rheumatic_diseases / Rheumatic_heart_disease / Rhinitis / Rhinitis,_allergic / Rhinitis,_allergic,_seasonal / Rhinorrhea / Rhinosinusitis / Rhizobium / Rhizosphere / Riboflavin / Ribonucleotides / Ribosomal_protein_s6_kinases / Rifampin / Rifaximin / Rift_valley_fever / Rilpivirine / Ringer's_lactate / Risk_assessment / Risk_factors / Risk_management / Risk-taking / Rituximab / Rivers / Rna_caps / Rna_interference / Rna-directed_dna_polymerase / Rna-seq / Rna,_catalytic / Rna,_circular / Rna,_messenger / Rna,_small_interfering / Rna,_small_untranslated / Rna,_transfer / Rnai_therapeutics / Roc_curve / Rodenticides / Root_canal_therapy / Ropivacaine / Rotavirus / Rotavirus_vaccines / Round_ligaments / Running / Rural_health_services / S-adenosylhomocysteine / Sadness / Safety_management / Salicylates / Salmonella_infections / Salt_stress / Sample_size / Sand / Sanitation / Saphenous_vein / Sarcoglycans / Sarcoma / Sarcoma,_synovial / Sarcopenia / Sars-cov-2 / Satellite_viruses / Schema_therapy / Schistosomiasis / Schizophrenia / Schools / Schools,_medical / Sclera / Scleritis / Scleroderma,_systemic / Sclerosis / Scoliosis / Scope_of_practice / Seafood / Seasons / Seawater / Seaweed / Secretagogues / Sedentary_behavior / Seeds / Seizures / Selective_serotonin_reuptake_inhibitors / Selenoproteins / Self_administration / Self_care / Self_efficacy / Self_report / Self-assessment / Self-management / Self-testing / Semaglutide / Semantics / Semiconductors / Sensation / Sensitivity_and_specificity / Sensorimotor_cortex / Sentiment_analysis / Sentinel_lymph_node / Sentinel_lymph_node_biopsy / Sentinel_surveillance / Sepharose / sepsis / Septins / Sequence_analysis / Seroma / Serotonin_and_noradrenaline_reuptake_inhibitors / Sertraline / SERUM / Sesquiterpenes / Severe_acute_malnutrition / Severe_acute_respiratory_syndrome-related_coronavirus / Severe_dengue / Sewage / Sex / Sex_attractants / Sex_characteristics / Sex_chromosomes / Sexism / Shame / Shellfish / Ships / Shock,_cardiogenic / Shock,_septic / Siblings / Siderophores / Sign_language / Signal_transduction / Signs_and_symptoms / Silicones / Silk / Silver_sulfadiazine / Simplexvirus / Single_photon_emission_computed_tomography_computed_tomography / Sinoatrial_node / Sinusitis / Sirolimus / Situs_inversus / Sjogren's_syndrome / Skin / Skin_diseases / 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Suicide / Suicide_prevention / Suicide,_attempted / Sulfamethoxazole / Sulfhydryl_compounds / Sulfides / Sulfonamides / Sulfonic_acids / Sunitinib / Sunscreening_agents / Superoxide_dismutase / Superoxides / Supervised_machine_learning / Supine_position / Supranuclear_palsy,_progressive / Surgeons / Surgery,_oral / Surgery,_plastic / Surgical_procedures,_operative / Surgical_wound_infection / Surrogate_mothers / Surveys_and_questionnaires / Survival_analysis / Survival_rate / Survivin / Survivorship / Suspensions / Sustainable_development / Sutures / Swimming / Symbiosis / Symporters / Synapses / Synaptic_vesicles / Synbiotics / Syncope,_vasovagal / Syndemic / Synostosis / Synovitis / Synthetic_biology / Synucleins / Systems_analysis / T-lymphocyte_subsets / T-lymphocytes / Tablets / Tachycardia,_atrioventricular_nodal_reentry / Tachycardia,_supraventricular / Tacrolimus_binding_protein_1a / Takayasu_arteritis / Takotsubo_cardiomyopathy / Tamoxifen / Taste / Tau_proteins / Team_sports / Tears / Technology_assessment,_biomedical / Tegmentum_mesencephali / Telangiectasia,_hereditary_hemorrhagic / Telangiectasis / Telemedicine / Telerehabilitation / Telomerase / Telomere / Temperament / Temporal_lobe / Tendons / Tennis / Tenotomy / Teratoma / Tertiary_healthcare / Testicular_neoplasms / Testis / Testosterone / Tetanus / Tetraploidy / Th17_cells / Thalassemia / Therapeutic_equivalency / therapeutics / Therapy_delivery / Theta_rhythm / Thioguanine / Thp-1_cells / Threonine / Thrombocytopenia / Thrombocytosis / Thromboembolism / Thrombophilia / Thymidine_monophosphate / Thymol / Thymus_gland / Thyroid_cancer,_papillary / Thyroid_gland / Thyroid_hormones / Thyroid_neoplasms / Thyroid_nodule / Tibial_plateau_fractures / Ticagrelor / Tight_junction_proteins / Tight_junctions / Tinnitus / Tissue_engineering / Tissue_plasminogen_activator / Tissue_preservation / tissues / Tobacco_use / Tobramycin / Tocopherols / Toll-like_receptor_7 / Toluene / Tomography / 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Trimebutine / Trimethoprim,_sulfamethoxazole_drug_combination / Trisomy / Trophoblasts / Tropicamide / Troponin / Trust / Trypanosomiasis / Trypanosomiasis,_african / Trypsin_inhibitors / Tryptophan / Tuberculosis / Tuberculosis,_pleural / Tubulin / Tumor_burden / Tumor_microenvironment / Tumor_necrosis_factor-alpha / Tumor-associated_macrophages / Turner_syndrome / Tyk2_kinase / Ubiquitin / Ubiquitin-protein_ligases / Ubiquitin-specific_proteases / Ubiquitination / Ultrasonics / Ultrasonography / Umbilical_cord / Uncertainty / Unconscious,_psychology / Underage_drinking / Universities / Unsupervised_machine_learning / Untranslated_regions / Up-regulation / Upper_gastrointestinal_tract / Urea / Ureter / Urinary_bladder / Urinary_bladder_diseases / Urinary_bladder_neck_obstruction / Urinary_bladder_neoplasms / Urinary_incontinence / Urinary_retention / Urinary_sphincter,_artificial / Urinary_tract / Urinary_tract_infections / Urogenital_neoplasms / Urolithiasis / Urticaria / 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Whey_proteins / White_dot_syndromes / Whooping_cough / Wnt_signaling_pathway / Wolfram_syndrome / Wood / Workflow / Workforce / Workload / Workplace / Wound_infection / Wounds_and_injuries / Wounds,_penetrating / X-ray_microtomography / Xanthogranuloma,_juvenile / Xylans / Xylose / Y_chromosome / Yeasts / Yoga / Yogurt / Zein / Zika_virus / Zoonoses

Exercise

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antitubercular_agents / Antiviral_agents / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_dissection / Aortic_valve / Aphasia / Aphasia,_primary_progressive / Apicoplasts / Apolipoproteins / Apoptosis / Apoptosis_regulatory_proteins / Appendiceal_neoplasms / Appendicitis / Appendix / Appetite / Arboviruses / Arenavirus / Arginine / Arrhythmias,_cardiac / Arteriovenous_malformations / Arthralgia / Arthritis / Arthritis,_rheumatoid / Arthroplasty / Arthroplasty,_replacement,_knee / Artificial_intelligence / Artificially_sweetened_beverages / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillosis / Aspergillosis,_allergic_bronchopulmonary / Asthenozoospermia / Astrocytes / Astrocytoma / Astronauts / Ataxia / Ataxia_telangiectasia / Atherectomy / Atherosclerosis / Athletes / Atrasentan / Atrial_fibrillation / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Attitude_to_health / Audiology / Augmented_reality / Authorship / Autism_spectrum_disorder / Autistic_disorder / Autoantibodies / Autoimmune_diseases / Autophagy / Autopsy / Axial_spondyloarthritis / Axons / B-lymphocytes / Back_pain / Bacterial_adhesion / Bacteriocins / Bacteriophages / Balantidiasis / Bariatric_surgery / Bartonella / Base_sequence / Basement_membrane / Basophils / Beds / Begomovirus / Behcet_syndrome / Benzene / Benzimidazoles / Benzocaine / Bevacizumab / Bezafibrate / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bilirubin / Biochemistry / Biocompatible_materials / Biodiversity / Biofilms / Biogenic_amines / Biological_availability / Biological_factors / Biological_monitoring / Biological_oxygen_demand_analysis / Biological_therapy / Biomarkers / Biomass / Biomedical_research / Biomimetics / Biophysics / Biopolymers / Biopsy / Biosimilar_pharmaceuticals / Biostatistics / Biotechnology / Birth_rate / Birth_weight / Blepharoplasty / Blindness / Blister / BLOOD / Blood_circulation / Blood_component_removal / Blood_culture / Blood_glucose / Blood_platelet_disorders / Blood_platelets / Blood_pressure / Blood_urea_nitrogen / Blood_vessels / Blood_volume / Blood-brain_barrier / Bocavirus / Body_composition / Body_mass_index / Body_size / Body_temperature / Body_weight / Bone_conduction / Bone_density / Bone_regeneration / Bone_transplantation / Botulinum_toxins / Brachytherapy / Brain_diseases / Brain_injuries / Brain_injuries,_traumatic / Brain_neoplasms / Bread / Breast_diseases / Breast_feeding / Breast_implants / Breast_neoplasms / Breeding / Bronchiectasis / Bronchiolitis_obliterans_syndrome / Bronchoalveolar_lavage / Bronchopulmonary_dysplasia / Bronchoscopy / Bruxism / Buffers / Burns / Butter / Calcinosis / Calcitonin / Calcium / Calcium_signaling / Camptothecin / Cancer_pain / Candy / Cannabidiol / Cannula / Capillaries / Capsaicin / Capsules / 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Limit_of_detection / Limonene / Linagliptin / Linguistics / Lipid_droplets / Lipid_metabolism_disorders / Lipid_nanoparticles / Lipid_peroxides / Lipopolysaccharides / Lipoprotein(a) / Lipoproteins / Liposarcoma / Liquid_biopsy / Liquid_crystals / Lithiasis / Live_birth / Liver_cirrhosis / Liver_failure / Liver_failure,_acute / Liver_neoplasms / Liver_transplantation / Local_area_networks / Locomotion / Longevity / Longitudinal_studies / Lordosis / Low_back_pain / Low_tension_glaucoma / Lubiprostone / Luciferases / Lung / Lung_diseases / Lung_diseases,_interstitial / Lung_diseases,_obstructive / Lung_injury / Lung_neoplasms / Lupus_erythematosus,_systemic / Luteal_phase / Lyme_disease / Lymph_nodes / Lymphatic_diseases / Lymphatic_system / Lymphedema / Lymphocytes / Lymphocytes,_tumor-infiltrating / Lymphohistiocytosis,_hemophagocytic / Lymphoma / Lymphoma,_b-cell / Lymphoma,_follicular / Lymphoma,_large_b-cell,_diffuse / Lymphoma,_t-cell / Lymphoma,_t-cell,_peripheral / Lysine / Lysophosphatidylcholines / Lysosomes / Machine_learning / Macrophages / Macrophages,_alveolar / Magnetic_resonance_imaging / Maintenance / Malnutrition / Mammaplasty / Mannans / Mannitol / Mannose-binding_lectin / Mannosyltransferases / Margins_of_excision / Marijuana_use / Marketing / Masculinity / Masks / Mast_cells / Mastitis / Mastitis,_bovine / Mastoiditis / Maternal_mortality / Mathematics / Meals / Meat / Mechanistic_target_of_rapamycin_complex_1 / Medial_tibial_stress_syndrome / Mediation_analysis / Medical_laboratory_science / Medical_marijuana / Medical_oncology / Medical_records / Medical_staff / Medical_waste / Medicare / Medication_adherence / Medication_errors / Medicine,_chinese_traditional / Medicine,_traditional / Meditation / Medulloblastoma / Melanins / Melanoma / Meloxicam / Membrane_proteins / Membranes / Memory / Menarche / Mendelian_randomization_analysis / Meninges / Meningioma / Meningitis / Menstruation / Mental_disorders / Mental_health / Mental_health_services / Menthol / Mentoring / Mesalamine / Mesangial_cells / Mesencephalon / Mesenchymal_stem_cells / Metabolic_diseases / Metabolic_equivalent / Metabolic_syndrome / Metabolomics / Metagenomics / Metal-organic_frameworks / Metastasectomy / Metformin / Methanol / Methemoglobin / Methemoglobinemia / Methicillin / Methotrexate / Methylphenidate / Methylprednisolone / Metronidazole / Metschnikowia / Micelles / Microbial_interactions / Microbiology / Microfluidics / Micronutrients / Micrornas / Microsatellite_repeats / Microscopic_polyangiitis / MICROSCOPY / Microscopy,_electron,_scanning_transmission / Microscopy,_electron,_transmission / Microspheres / Middle_cerebral_artery / Migraine_disorders / Military_personnel / Milk / Milk,_human / Mineralocorticoids / Miniaturization / Minimally_invasive_surgical_procedures / Mitochondria / Mitochondrial_dynamics / Mixed_function_oxygenases / Models,_statistical / Molecular_biology / Molecular_dynamics_simulation / Monocytes / Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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Neuroimaging / Neurology / Neuroma / Neuronal_plasticity / Neurons / Neuropathology / Neuropeptides / Neurophysiology / Neuroprotective_agents / Neurosciences / Neurosurgery / Neurovascular_coupling / NEUTROPHILS / Nevus / Nf-kappa_b / Nicotine / Niemann-pick_diseases / Nipples / Nitrates / Nitrites / Nitroglycerin / Nitrosamines / Nivolumab / Nociception / Nocturnal_enuresis / Noise,_occupational / Nomograms / Non-alcoholic_fatty_liver_disease / Non-muscle_invasive_bladder_neoplasms / Non-randomized_controlled_trials_as_topic / Noncommunicable_diseases / Nontuberculous_mycobacteria / Nuclear_medicine / Nucleic_acids / Nucleoside-diphosphate_kinase / Nucleosides / Nucleosomes / nurses / Nursing / Nursing_assistants / Nursing_care / Nursing_homes / Nutrition_surveys / Obesity / Obsessive-compulsive_disorder / Obturator_nerve / Occupational_exposure / Occupational_health / Occupational_stress / Occupational_therapy / Odds_ratio / Oils / Ointments / Olanzapine / Olecranon_fracture / Oligospermia / Olive_oil / Oncologists / Only_child / Oocyte_donation / Oocytes / Oogenesis / Operative_time / Ophthalmology / Optic_atrophy,_autosomal_dominant / Optic_disk / Optic_nerve / Optic_nerve_diseases / Optogenetics / Oral_hygiene / Oral_microbiome / Organelle_biogenesis / Organoids / Ornithine / Orthomyxoviridae / Orthopedics / Osseointegration / Osteoarthritis / Osteoblasts / Osteoclasts / Osteogenesis / Osteomalacia / Osteonecrosis / Osteoporosis / Osteosarcoma / Otitis / Otitis_media / Otolaryngology / Outpatients / Ovarian_neoplasms / Ovariectomy / Ovary / Overweight / Oviposition / Ovum / Ownership / Oxacillin / Oxaliplatin / Oxidants / Oxidative_stress / Oxidoreductases / Oximetry / Paclitaxel / Paecilomyces / Pain_management / Pain,_postoperative / Paint / Palate / Palliative_care / Palmitic_acid / Pancreas / Pancreatic_cyst / Pancreatic_pseudocyst / Pancreaticoduodenectomy / Pancreatitis / Pandemics / Papillomavirus_infections / Parabens / Paraffin / Paralysis / 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Cachexia

Hydrogen sulfide inhibits skeletal muscle ageing by up-regulating autophagy through promoting deubiquitination of adenosine 5'-monophosphate (AMP)-activated protein kinase α1 via ubiquitin specific peptidase 5.

Hydrogen sulfide (HS), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether HS alleviates skeletal muscle ageing by regulating autophagy has not been reported. Mice were administered 150 mg/kg/day of D-galactose ( D-gal), and C2C12 myotubes were cultured in...

🗓️ 2024-08-27

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Adenosine / Amp-activatedproteinkinases / Autophagy / F-boxproteins / Galactose / Muscle,Skeletal / Musclefibers,skeletal / muscles / Peptidehydrolases / Proteinkinases / Sarcopenia / Sulfides / tissues / Ubiquitin / Ubiquitin-specificproteases / Ubiquitination

Cachexia

High-Intensity Interval Training Mitigates Sarcopenia and Suppresses the Myoblast Senescence Regulator EEF1E1.

The optimal exercise regimen for alleviating sarcopenia remains uncertain. This study aimed to investigate the efficacy of high-intensity interval training (HIIT) over moderate-intensity continuous training (MICT) in ameliorating sarcopenia. We conducted a randomized crossover trial to evaluate plasma proteomic reactions...

🗓️ 2024-09-14

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aged / Autophagy / Case-controlstudies / Galactose / Handstrength / High-intensityintervaltraining / Muscle,Skeletal / muscles / Myoblasts / PLASMA / Sarcopenia

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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Autophagy

Voluntary Activity Wheel Running Improves Hyperammonaemia-Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice.

Impaired Autophagic Flux in Skeletal Muscle of Plectin-Related Epidermolysis Bullosa Simplex With Muscular Dystrophy.

Iron Metabolism and Muscle Aging: Where Ferritinophagy Meets Mitochondrial Quality Control.

Nestin Regulates Autophagy-Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B.

Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39.

A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing.

Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis.

Characterization of SARS-CoV-2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection.

Skeletal Muscle Mitochondrial and Autophagic Dysregulation Are Modifiable in Spinal Muscular Atrophy.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Hydrogen sulfide inhibits skeletal muscle ageing by up-regulating autophagy through promoting deubiquitination of adenosine 5'-monophosphate (AMP)-activated protein kinase α1 via ubiquitin specific peptidase 5.

High-Intensity Interval Training Mitigates Sarcopenia and Suppresses the Myoblast Senescence Regulator EEF1E1.

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