FcRn function alone cannot account for elevated IgG clearance in the Lewis lung carcinoma model of cancer cachexia.
PURPOSE
The neonatal Fc receptor (FcRn) protects IgG-based monoclonal antibodies (mAbs) from catabolism by direct binding within endosomes and facilitates their recycling to extracellular spaces. Elevated clearance of immune checkpoint inhibitors (ICIs) and other IgG-based mAbs is often observed in patients...
