The effects of post-coronavirus disease 2019 (COVID-19) syndrome on the cardiorespiratory and muscular fitness in older people are of utmost relevance. This study aimed to evaluate the effects of a 12-week telerehabilitation programme on cardiorespiratory and muscular fitness and body...
🗓️ 2024-06-27
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Increasing interest surrounds the utility of blood-based biomarkers for diagnosing sarcopenia. C-terminal agrin fragment (CAF), a marker of neuromuscular junction stability, is amongst the most promising candidates; however, a dearth of reference data impedes the incorporation of its use in...
🗓️ 2024-06-07
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Mitochondria represent key organelles influencing cellular homeostasis and have been implicated in the signalling events regulating protein synthesis. We examined whether mitochondrial bioenergetics (oxidative phosphorylation and reactive oxygen species (HO) emission, ROS) measured in vitro in permeabilized muscle fibres represent...
🗓️ 2024-07-15
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Alzheimer's disease (AD) impairs cognitive functions and peripheral systems, including skeletal muscles. The PS19 mouse, expressing the human tau P301S mutation, shows cognitive and muscular pathologies, reflecting the central and peripheral atrophy seen in AD. We analysed skeletal muscle morphology...
🗓️ 2024-04-22
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Muscle atrophy can cause muscle dysfunction and weakness. Krüppel-like factor 13 (KLF13), a central regulator of cellular energy metabolism, is highly expressed in skeletal muscles and implicated in the pathogenesis of several diseases. This study investigated the role of KLF13...
🗓️ 2024-07-08
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Loss of muscle strength and endurance with aging or in various conditions negatively affects quality of life. Resistance exercise training (RET) is the most powerful means to improve muscle mass and strength, but it does not generally lead to improvements...
🗓️ 2024-06-16
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Low skeletal muscle mass (LSMM) and/or, function associated with an increased risk of treatment-related toxicities and inferior overall survival (OS) among adults with solid malignancies. However, the association between LSMM and treatment-related toxicities among adults with haematologic malignancies remains unclear....
🗓️ 2024-04-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia and low areal bone mineral density (aBMD) are prevalent musculoskeletal complications after paediatric cancer treatment. However, their relationship has not been examined in young paediatric cancers survivors. This study aimed to evaluate aBMD differences according to sarcopenia status and...
🗓️ 2024-08-20
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Glycative stress, characterized by the formation and accumulation of advanced glycation end products (AGEs) associated with protein glycation reactions, has been implicated in inducing a decline of muscle function. Although the inverse correlation between glycative stress and muscle mass and...
🗓️ 2024-04-04
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Hydrogen sulfide (HS), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether HS alleviates skeletal muscle ageing by regulating autophagy has not been reported. Mice were administered 150 mg/kg/day of D-galactose ( D-gal), and C2C12 myotubes were cultured in...
🗓️ 2024-08-27
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Excess muscle fat is observed in obesity and associated with greater burden of cardiovascular risk factors and higher risk of mortality. Liraglutide reduces total body weight and visceral fat but its effect on muscle fat and adverse muscle composition is...
🗓️ 2024-04-01
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
The CTNS gene mutation causes infantile nephropathic cystinosis (INC). Patients with INC develop Fanconi syndrome and chronic kidney disease (CKD) with significant bone deformations. C57BL/6 Ctns mice are an animal model for studying INC. Hyperleptinaemia results from the kidney's inability...
🗓️ 2024-08-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Patients with pancreatic ductal adenocarcinoma (PDAC) often suffer from cachexia, a wasting syndrome that significantly reduces both quality of life and survival. Although advanced cachexia is associated with inflammatory signalling and elevated muscle catabolism, the early events driving wasting are...
🗓️ 2024-04-17
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Telomere attrition may share common biological mechanisms with bone and muscle loss with aging. Here, we investigated the association between these hallmarks of aging using data from UK Biobank, a large observational study. Leukocyte telomere length (LTL as T/S ratio)...
🗓️ 2024-03-29
📰 Publication: Journal Of Cachexia Sarcopenia And Muscle
Sarcopenia, a condition marked by progressive muscle mass and function decline, presents significant challenges in aging populations and those with chronic illnesses. Current standard treatments such as dietary interventions and exercise programs are often unsustainable. There is increasing interest in...
🗓️ 2024-09-09
📰 Publication: Aging Clinical And Experimental Research
Sarcopenia, the progressive loss of muscle mass and function, universally affects older adults and is closely associated with frailty and reduced quality of life. Despite the inevitable consequences of sarcopenia and its relevance to healthspan, no pharmacological therapies are currently...
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