Pharmacology

Muscle

Nuciferine Attenuates Cancer Cachexia-Induced Muscle Wasting in Mice via HSP90AA1.

Around 80% of patients with advanced cancer have cancer cachexia (CC), a serious complication for which there are currently no FDA-approved treatments. Nuciferine (NF) is the main active ingredient of lotus leaf, which has anti-inflammatory, anti-tumour and other effects. The...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Cancer-associated_cachexia / muscles / Muscular_atrophy / neoplasms / Pharmacology / Sarcopenia / therapeutics / Work

Muscle

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Sarcopenia is currently a life-threatening disease for the elderly. Polygonatum sibiricum polysaccharide (PSP) has anti-oxidative stress and anti-inflammatory effects. However, the effects of PSP on skeletal muscle aging, myoblast differentiation and mitochondrial dysfunction through PI3K/Akt/mTOR signaling pathway has not been...

🗓️ 2024-12-09

📰 Publication: Phytomedicine

Aging / CELLS / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Myoblasts / Oxidative_stress / Pharmacology / Polysaccharides / Sarcopenia / Stress,_physiological / therapeutics

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / 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Exercise

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antitubercular_agents / Antiviral_agents / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_dissection / Aortic_valve / Aphasia / Aphasia,_primary_progressive / Apicoplasts / Apolipoproteins / Apoptosis / Apoptosis_regulatory_proteins / Appendiceal_neoplasms / Appendicitis / Appendix / Appetite / Arboviruses / Arenavirus / Arginine / Arrhythmias,_cardiac / Arteriovenous_malformations / Arthralgia / Arthritis / Arthritis,_rheumatoid / Arthroplasty / Arthroplasty,_replacement,_knee / Artificial_intelligence / Artificially_sweetened_beverages / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillosis / Aspergillosis,_allergic_bronchopulmonary / Asthenozoospermia / Astrocytes / Astrocytoma / Astronauts / Ataxia / Ataxia_telangiectasia / Atherectomy / Atherosclerosis / Athletes / Atrasentan / Atrial_fibrillation / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Attitude_to_health / Audiology / Augmented_reality / Authorship / Autism_spectrum_disorder / Autistic_disorder / Autoantibodies / Autoimmune_diseases / Autophagy / Autopsy / Axial_spondyloarthritis / Axons / B-lymphocytes / Back_pain / Bacterial_adhesion / Bacteriocins / Bacteriophages / Balantidiasis / Bariatric_surgery / Bartonella / Base_sequence / Basement_membrane / Basophils / Beds / Begomovirus / Behcet_syndrome / Benzene / Benzimidazoles / Benzocaine / Bevacizumab / Bezafibrate / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bilirubin / Biochemistry / Biocompatible_materials / Biodiversity / Biofilms / Biogenic_amines / Biological_availability / Biological_factors / Biological_monitoring / Biological_oxygen_demand_analysis / Biological_therapy / Biomarkers / Biomass / Biomedical_research / Biomimetics / Biophysics / Biopolymers / Biopsy / Biosimilar_pharmaceuticals / Biostatistics / Biotechnology / Birth_rate / Birth_weight / Blepharoplasty / Blindness / Blister / BLOOD / Blood_circulation / Blood_component_removal / Blood_culture / Blood_glucose / Blood_platelet_disorders / Blood_platelets / Blood_pressure / Blood_urea_nitrogen / Blood_vessels / Blood_volume / Blood-brain_barrier / Bocavirus / Body_composition / Body_mass_index / Body_size / Body_temperature / Body_weight / Bone_conduction / Bone_density / Bone_regeneration / Bone_transplantation / Botulinum_toxins / Brachytherapy / Brain_diseases / Brain_injuries / Brain_injuries,_traumatic / Brain_neoplasms / Bread / Breast_diseases / Breast_feeding / Breast_implants / Breast_neoplasms / Breeding / Bronchiectasis / Bronchiolitis_obliterans_syndrome / Bronchoalveolar_lavage / Bronchopulmonary_dysplasia / Bronchoscopy / Bruxism / Buffers / Burns / Butter / Calcinosis / Calcitonin / Calcium / Calcium_signaling / Camptothecin / Cancer_pain / Candy / Cannabidiol / Cannula / Capillaries / Capsaicin / Capsules / Car-t_cell / Carbohydrates / Carbon_footprint / Carbonic_anhydrase_ix / Carbonic_anhydrases / Carboplatin / Carboxylic_acids / Carboxymethylcellulose_sodium / Carcinogenesis / Carcinoid_tumor / Carcinoma,_adenoid_cystic / Carcinoma,_hepatocellular / Carcinoma,_large_cell / Carcinoma,_lewis_lung / Carcinoma,_neuroendocrine / Carcinoma,_non-small-cell_lung / Carcinoma,_renal_cell / Carcinoma,_squamous_cell / Cardenolides / Cardia / Cardiac_catheterization / Cardiac_output / Cardiac_rehabilitation / Cardiology / Cardiomyopathies / Cardiomyopathy,_hypertrophic / Cardiopulmonary_bypass / Cardiopulmonary_resuscitation / Cardiotoxicity / Cardiovascular_diseases / Caregivers / Carotid_arteries / Carotid_artery,_common / Cartilage / Case-control_studies / Cataract / Catastrophization / Catenins / Cathepsins / Catheter_ablation / Catheters / Causality / Caves / Cd4_lymphocyte_count / Cefazolin / Cefoperazone / Ceftriaxone / Celiac_disease / Cell_adhesion / Cell_adhesion_molecules / Cell_biology / Cell_count / Cell_culture_techniques / Cell_cycle / Cell_death / Cell_line / Cell_membrane / Cell_proliferation / Cell_survival / Cell_transplantation / Cell-free_nucleic_acids / CELLS / Cellulite / Cellulose / Central_amygdaloid_nucleus / Central_nervous_system / Central_nervous_system_stimulants / Ceramics / Cerclage,_cervical / Cerebellum / Cerebral_amyloid_angiopathy / Cerebral_palsy / Cerebrovascular_disorders / Cesarean_section / Chalcone / Chalcones / Chemistry,_pharmaceutical / Chemoprevention / Chemoradiotherapy / Chemotherapy,_adjuvant / Chickenpox / Child_abuse / Child_health / Child,_hospitalized / Child,_preschool / Chitinases / Chitosan / Chlorophyll / Chloroplasts / Choice_behavior / Cholangiocarcinoma / Cholangiography / Cholecystectomy / Cholera / Cholesteatoma / Cholesterol / Cholesterol,_hdl / Cholesterol,_ldl / Cholinergic_agents / Chondrocytes / Choroid / Choroid_plexus / Chromatin / Chromatin_immunoprecipitation_sequencing / Chromogranins / Chromosomes / 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Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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/ PREGNANCY / Pregnancy_outcome / Pregnancy_rate / Pregnancy_trimester,_second / Pregnancy_trimester,_third / Pregnancy,_ectopic / Pregnancy,_interstitial / Pregnancy,_multiple / Pregnancy,_twin / Pregnant_women / Premature_birth / Prenatal_care / Prescription_drugs / PREVALENCE / Preventive_health_services / Preventive_medicine / Primary_myelofibrosis / Primary_ovarian_insufficiency / Prion_diseases / Prions / Prisons / Privacy / Probability / Probiotics / Procollagen / Professional_role / Progesterone / Prognosis / Programmed_cell_death_1_receptor / Progression-free_survival / Prolactin / Promoter_regions,_genetic / Propensity_score / Prophages / Propidium / Propofol / Proportional_hazards_models / Prospective_studies / Prostaglandin-endoperoxide_synthases / Prostate / Prostatectomy / Prostatic_neoplasms / Prostheses_and_implants / Prosthesis_design / Prosthesis_fitting / Prosthodontics / Protective_factors / Protein_biosynthesis / Protein_engineering / Protein_isoforms / 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Sarcopenia

Branched-chain amino acid supplementation does not improve measures of sarcopenia in cirrhosis: results of a randomised controlled trial.

Sarcopenia is associated with adverse outcomes in cirrhosis. Branched-chain amino acids (BCAA) target several pathways that lead to muscle loss in this population. We aimed to evaluate the impact of BCAA supplementation on sarcopenia measures in patients with cirrhosis. We...

🗓️ 2024-02-26

📰 Publication: Alimentary Pharmacology & Therapeutics

Aminoacids / Aminoacids,branched-chain / muscles / Musclestrength / Pharmacology / therapeutics

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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Pharmacology

Nuciferine Attenuates Cancer Cachexia-Induced Muscle Wasting in Mice via HSP90AA1.

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging and mitochondrial dysfunction via PI3K/Akt/mTOR signaling pathway.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Branched-chain amino acid supplementation does not improve measures of sarcopenia in cirrhosis: results of a randomised controlled trial.

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