Phenotype

Muscle

Exploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

INTRODUCTION

People with chronic kidney disease (CKD) often experience poor muscle quality and elevations in skeletal muscle wasting and dysfunction, contributing to a reduced quality of life and an increased risk of morbidity and mortality. The adipokine chemerin is associated with...

🗓️ 2026-02-28

📰 Publication: Translational Research

CELLS / Kidney / Kidney_diseases / Muscle_cells / Muscle,_skeletal / muscles / Phenotype / Sarcopenia / therapeutics

Cachexia

Phenotype profiling of disease-related malnutrition with inflammation: Document elaborated by the ESPEN special interest group (SIG) ''cachexia-anorexia in chronic wasting diseases''.

In the ESPEN SIG meetings the similarities and differences between cachexia and disease-related malnutrition (DRM) were previously analyzed, as well as the role of inflammation in DRM. In the years 2023-2025, the SIG moving forward emphasized the relevance of the...

🗓️ 2026-02-24

📰 Publication: Clinical Nutrition

Anorexia / Enteral_nutrition / Malnutrition / Phenotype / Solutions / therapeutics / Wasting_syndrome

Cachexia

Mitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions.

BACKGROUND

Skeletal muscle in wasting conditions often exhibits a common set of phenotypes that include atrophy, mitochondrial respiratory dysfunction, and fragmentation of the acetylcholine receptor (AChR) cluster at the endplate. Mitochondria are frequently implicated in driving muscle pathology in these conditions,...

🗓️ 2026-02-23

Cancer-associated_cachexia / Caspase_3 / Integration_host_factors / Mitochondria / Muscle_fibers,_skeletal / Muscle,_skeletal / muscles / Pancreatic_neoplasms / Phenotype / Reperfusion_injury

Cachexia

Tumor intrinsic properties dictate Fc receptor expression and cancer cachexia associated increase in checkpoint inhibitor clearance.

PURPOSE

Patients with cancer cachexia display a general resistance to immune checkpoint inhibitor (ICI) therapy, and baseline ICI catabolic clearance is a predictive indicator for overall survival, independent of dose and drug exposure. Fc-gamma (FcγRs) and neonatal Fc receptors (FcRn) play...

🗓️ 2026-01-02

📰 Publication: Frontiers In Immunology

Cancer-associated_cachexia / Carcinoma,_non-small-cell_lung / CELLS / Immune_checkpoint_inhibitors / Leukocytes / neoplasms / Pharmaceutical_preparations / Phenotype / Receptors,_fc

Frailty

Peak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.

BACKGROUND

Current evidence indicates an association between peak expiratory flow (PEF) and frailty in older adults, yet critical gaps persist regarding: the longitudinal dynamics of PEF trajectories, their temporal relationships with frailty progression and underlying biological mechanisms. This study aimed to...

🗓️ 2025-11-21

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Cohort_studies / Phenotype / Sarcopenia

Cachexia

Lean Body Mass Associates With a Hypertensive Cardiovascular Phenotype in Men but Not in Women.

BACKGROUND

Lean body mass (LBM) is independently associated with the function and structure of the cardiovascular (CV) system in women and genetically predisposed men with low LBM. Yet, the relationship between LBM and the CV system remains uncertain in the general...

🗓️ 2025-11-10

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

BLOOD / Blood_pressure / Phenotype / Sarcopenia / Sex_characteristics

Muscle

Jianpi Qiangji Granule ameliorates aging-associated sarcopenia via AMPK/PGC-1α axis in SAMP8 mice.

BACKGROUND

Sarcopenia is an age-related syndrome characterized primarily by the progressive decline of muscle mass and function. It is frequently associated with adverse outcomes such as falls, fractures, and hospitalization, often leading to substantial economic burdens and severe health hazards. At...

🗓️ 2025-11-01

📰 Publication: Phytomedicine

Aging / Atrophy / Herbal_medicine / muscles / Phenotype / Plants,_medicinal / Sarcopenia / therapeutics / tissues

Exercise

Sarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

BACKGROUND

Sarcopenic obesity (SO) is a clinical condition defined by the coexistence of high body fat mass and low muscle function and mass, which increases the risk of adverse health outcomes, including disability and mortality. Early detection and frequent monitoring of...

🗓️ 2025-10-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / MORTALITY / Mortality,_premature / muscles / Obesity / Phenotype / Sarcopenia / Sex

Muscle

EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization.

Muscle atrophy has a poor prognosis, caused by various factors. Identifying a shared treatment target could address an unmet clinical need. The exon junction complex (EJC), a protein complex assembly that binds to RNA, facilitates post-transcriptional regulation by participating in...

🗓️ 2025-08-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Aged / Aging / cachexia / muscles / Muscular_atrophy / Phenotype / Rna,_messenger / Sarcopenia / therapeutics

Muscle

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI.

Deterioration of functional capacity mostly determinates frailty in older patients with cardiovascular disease (CVD). Elucidating the pathophysiological mechanisms of physical frailty is an important goal for improving functional health-related outcomes. Our objective was the determination of the transcriptomic signature of...

🗓️ 2025-06-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

cachexia / Cardiovascular_diseases / Frailty / Gait / Gene_expression / Genes / muscles / Phenotype / Sarcopenia / Transcatheter_aortic_valve_replacement / Walking_speed

Muscle

Detrimental Effects of β2-Microglobulin on Muscle Metabolism: Evidence From In Vitro, Animal and Human Research.

β2-Microglobulin (B2M) has garnered considerable interest as a potential pro-ageing factor, leading to speculation about its involvement in muscle metabolism and the development of sarcopenia, a key component of ageing phenotypes. To explore this hypothesis, we conducted a comprehensive investigation...

🗓️ 2025-04-01

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Biomarkers / BLOOD / cachexia / Gait / Hand_strength / muscles / Phenotype / Research / Sarcopenia / SERUM / Walking_speed

Muscle

Accelerated Sarcopenia Phenotype in the DJ-1/-Knockout Zebrafish.

Age-dependent loss of muscle mass and function is associated with oxidative stress. DJ-1/ acts as an antioxidant through multiple signalling pathways. DJ-1-knockout zebrafish show a decline in swimming performance and loss of weight gain between 6 and 9 months of...

🗓️ 2024-12-11

Complement_c3a / Mitochondria / Muscle,_skeletal / muscles / Oxidative_stress / Oxidoreductases / Phenotype / Sarcopenia / Stress,_physiological

Exercise

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

3D-bioprinting is a promising technique to mimic the complex anatomy of natural tissues, as it comprises a precise and gentle way of placing bioinks containing cells and hydrogel. Although hydrogels expose an ideal growth environment due to their extracellular matrix...

🗓️ 2024-12-11

📰 Publication: Biofabrication

2,2'-dipyridyl / 3-iodobenzylguanidine / 3,3'-diaminobenzidine / 3'_untranslated_regions / 5-methylcytosine / 5'_untranslated_regions / Abattoirs / Abdominal_muscles / Abdominal_neoplasms / Abdominal_pain / Abdominoplasty / Abortion,_spontaneous / Absenteeism / Absorption / Academic_medical_centers / Academic_performance / Accidental_falls / Accidents / Accounting / Acepromazine / Acetaldehyde / Acetals / Acetates / Acetylcholine / Acetylcholinesterase / Acetylcysteine / Acetylene / Acetylglucosamine / Acetyltransferases / Achievement / Acid_ceramidase / Acid_sensing_ion_channels / Acid-base_equilibrium / Acidosis / Acinetobacter / Acinetobacter_baumannii / Acne_vulgaris / Acoustics / Acquired_immunodeficiency_syndrome / Acromegaly / Acrylamide / Actins / Action_potentials / Activities_of_daily_living / Acute_care_surgery / Acute_coronary_syndrome / Acute_kidney_injury / Acute_lung_injury / Acyltransferases / Adaptation,_physiological / Adenocarcinoma_of_lung / Adenoma / Adenoma,_pleomorphic / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipocytes,_brown / Adipocytes,_white / Adipogenesis / Adiponectin / Adipose_tissue / Adiposity / Administration,_intranasal / Administration,_oral / Adolescent / Adrenal_cortex_hormones / Adrenocorticotropic_hormone / Adult_stem_cells / Advance_care_planning / Adverse_childhood_experiences / Advertising / Aeromonas_veronii / Aerosols / Aflatoxin_m1 / Aflatoxins / African_swine_fever / Aftercare / Agar / Agaricales / Age_distribution / Aged / Agent_orange / Aggregatibacter / Aggregatibacter_aphrophilus / Aggression / Aging,_premature / Agranulocytosis / Agricultural_irrigation / Agriculture / Agrochemicals / Aids-related_complex / Air_pollution / Alanine / Alcohol_drinking / Alcoholics / Aldehydes / Aldosterone / Alendronate / Alginates / Algorithms / Alkaline_phosphatase / Alkalosis / Alkanesulfonates / Alkynes / Alleles / Allergens / Allografts / Allopurinol / Alloys / Alopecia / Alopecia_areata / 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Bronchogenic_cyst / Bronchopulmonary_sequestration / Bronchoscopy / Brucella / Brucellosis / Brugada_syndrome / Budesonide / Buffers / Bulimia / Bundle-branch_block / Bupropion / Burning_mouth_syndrome / Burnout,_psychological / Burns / Butter / Butyrylcholinesterase / C-peptide / C-reactive_protein / Ca-19-9_antigen / cachexia / Caco-2_cells / Cadherins / Caffeine / Calcitonin_gene-related_peptide / Calcium / Calcium_channel_blockers / Calcium_channels / Calcium_signaling / Cancer_vaccines / Cancer-associated_cachexia / Cancer-associated_fibroblasts / Candidemia / Candidiasis / Candidiasis,_invasive / Candidiasis,_vulvovaginal / Cannabidiol / Cannula / Capacity_building / Capillaries / Capsaicin / Capsid / Capsules / Car-t_cell / Carbamazepine / Carbapenems / Carbidopa / Carbohydrates / Carboxylic_acids / Carcinogenesis / Carcinogens / Carcinoid_tumor / Carcinoma_in_situ / Carcinoma,_basal_cell / Carcinoma,_hepatocellular / Carcinoma,_intraductal,_noninfiltrating / Carcinoma,_non-small-cell_lung / Carcinoma,_ovarian_epithelial / Carcinoma,_renal_cell / Carcinoma,_squamous_cell / Cardiac_catheters / Cardiac_output / Cardiac_rehabilitation / Cardiac_resynchronization_therapy / Cardiac_volume / Cardiology / Cardiomyopathy,_restrictive / Cardiopulmonary_bypass / Cardiopulmonary_resuscitation / Cardiotoxicity / Cardiovascular_diseases / Cardiovascular_system / Caregivers / Carotenoids / Carotid_arteries / Carotid_artery,_internal / Carrier_proteins / Case-control_studies / Caseins / Caspase_3 / Caspase_9 / Caspases / Castleman_disease / Castration / Catalase / Cataract / Catastrophization / Catechin / Catechol_o-methyltransferase / Catecholamines / Catenins / Catheter_ablation / Catheterization / Causality / Caveolins / Cecum / Cefazolin / Cefoperazone / Cefotaxime / Ceftazidime / Ceftriaxone / Celiac_disease / Cell_aggregation / Cell_biology / Cell_body / Cell_communication / Cell_count / Cell_culture_techniques / Cell_cycle / Cell_death / 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Diet,_healthy / Diet,_ketogenic / Diet,_mediterranean / Diet,_vegan / Diet,_vegetarian / Dietary_exposure / Dietary_fats / Dietary_fiber / Dietary_patterns / Dietary_supplements / Diethylhexyl_phthalate / Diffusion_tensor_imaging / Digeorge_syndrome / Digestion / Digital_health / Digital_technology / Digital_therapeutics / Diglycerides / Dioxins / Dipeptidyl_peptidase_4 / Dipeptidyl-peptidase_iv_inhibitors / Diphosphonates / Disabled_children / Disabled_persons / Disaster_medicine / Discriminant_analysis / Disease_management / Disease_progression / Disease_transmission,_infectious / Disease-free_survival / Disinfectants / Diskectomy / Displacement,_psychological / Dissection,_thoracic_aorta / Disseminated_intravascular_coagulation / Distemper_virus,_canine / Disulfides / Disulfiram / Diuretics / Diverticular_diseases / Diverticulitis / Diverticulum / Diving / Dizziness / Dna_damage / Dna_glycosylases / Dna_gyrase / Dna_methylation / Dna_nucleotidylexotransferase / Dna_replication / 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Protein_isoforms / Protein_kinases / Protein_phosphatase_1 / Protein_processing,_post-translational / Protein_serine-threonine_kinases / Protein-tyrosine_kinases / Proteogenomics / Proteome / Proteomics / Prothrombin / Prothrombin_time / Proton_pump_inhibitors / Proton_pumps / Proton_therapy / Pruritus / Pseudogenes / Pseudomonas / Pseudomonas_aeruginosa / Pseudomonas_stutzeri / Pseudouridine / Psoriasis / Psychiatrists / Psychological_distress / Psychological_well-being / Psychology,_positive / Psychometrics / Psychosocial_intervention / Psychotherapy / Psychotic_disorders / Psychotropic_drugs / Public_health / Public_health_surveillance / Public_sector / Pulmonary_arterial_hypertension / Pulmonary_disease,_chronic_obstructive / Pulmonary_embolism / Pulmonary_fibrosis / Pulmonary_surfactant-associated_protein_a / Pulmonary_valve / Pulpectomy / Pulpotomy / Pulse / Punctures / Punishment / Pupa / Pupil / Purpura / Purpura,_thrombocytopenic / Putamen / Pyoderma / Pyoderma_gangrenosum / Pyrans / Pyrazoles / Pyridoxine / Pyrophosphatases / Pyroptosis / Pyrrolidinones / Pyruvate_kinase / Quadriceps_muscle / Qualitative_research / Quality_improvement / Quality_of_life / Quality-adjusted_life_years / Quantitative_trait_loci / Quantum_dots / Quarantine / Quercetin / Quinazolines / Quinoxalines / Quorum_sensing / Racism / Radar / Radiation_exposure / Radiation_fibrosis_syndrome / Radio / Radiofrequency_ablation / Radiography / Radiologists / Radiology / Radiology,_interventional / Radionuclide_imaging / radiotherapy / Radius_fractures / Rainforest / Random_allocation / Range_of_motion,_articular / Ranula / Rare_diseases / Reaction_time / Reading / Reading_frames / Receptor_activity-modifying_proteins / Receptor_for_advanced_glycation_end_products / Receptors,_adrenergic / Receptors,_antigen / Receptors,_antigen,_t-cell / Receptors,_calcitriol / Receptors,_cannabinoid / Receptors,_chemokine / Receptors,_chimeric_antigen / Receptors,_cxcr4 / Receptors,_estrogen / 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Exercise

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Deoxynivalenol (DON) contamination in cereals is a widespread issue with global implications, necessitating the development of efficient detection methods. Here, a fluorescent aptasensor integrating target-responsive DNA three-way junction (TWJ) and DNA walking machine was developed to detect DON. The DON-specific...

🗓️ 2024-12-06

📰 Publication: Food Chemistry

1-phosphatidylinositol_4-kinase / 2-acetylaminofluorene / 3'_untranslated_regions / 5-hydroxytryptophan / Abdominal_pain / Abdominoplasty / Abetalipoproteinemia / Absenteeism / Absorption / Academic_performance / Accidental_falls / Accounting / Acetone / Acetylcholine / Achondroplasia / Acid_phosphatase / Acidosis,_renal_tubular / Acinetobacter_baumannii / Acitretin / Aconitic_acid / Acoustics / Acquired_immunodeficiency_syndrome / Acrylonitrile / Acute_kidney_injury / Acute_lung_injury / Adenocarcinoma / Adenocarcinoma_of_lung / Adenocarcinoma,_mucinous / Adenoidectomy / Adenoids / Adenomyosis / Adenosine / Adhesives / Adipocytes / Adipokines / Adipose_tissue / Adolescent / Adoptive_transfer / Adrenal_cortex_hormones / Adrenalectomy / Adrenocorticotropic_hormone / Aftercare / Agaricales / Aged / Ageism / Aggrecans / Aggression / Agricultural_irrigation / Agriculture / Aids-related_complex / Air_pollution / Airway_management / Alanine / Alcohol_drinking / Alcoholics / Alcoholism / Alginates / Algorithms / Alkaloids / Alkynes / Alleles / Allergens / Allografts / Alloys / Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid / Alpha-fetoproteins / Alphapapillomavirus / Altitude / Alzheimer_disease / Amaranth_dye / Ambulances / Amino_acid_substitution / Amino_acids / Aminoglycosides / Amlodipine / Amnion / Amoxicillin / Amplifiers,_electronic / Amputation,_surgical / Amputees / Amygdala / Amyloid / Amyotrophic_lateral_sclerosis / Analgesics / Anaphylaxis / Anastomotic_leak / Anatomy / Androgens / Anemia / Anemia,_iron-deficiency / Anesthesia / Anesthesiology / Anesthetics / Aneurysm,_false / Angina_pectoris / Angina,_unstable / Angiogenesis / Angiogenesis_inhibitors / Angiotensins / Anion_exchange_resins / Ankle / Anoikis / Anorexia_nervosa / Anterior_chamber / Anthocyanins / Anthracyclines / Anthropometry / Anti-inflammatory_agents,_non-steroidal / Antibodies,_bispecific / Antibodies,_monoclonal / Anticoagulants / Anticonvulsants / Antifibrinolytic_agents / Antihypertensive_agents / Antimicrobial_stewardship / Antineoplastic_agents / Antioxidants / Antiphospholipid_syndrome / Antipsychotic_agents / Antitubercular_agents / Antiviral_agents / Aorta / Aortic_aneurysm / Aortic_aneurysm,_abdominal / Aortic_dissection / Aortic_valve / Aphasia / Aphasia,_primary_progressive / Apicoplasts / Apolipoproteins / Apoptosis / Apoptosis_regulatory_proteins / Appendiceal_neoplasms / Appendicitis / Appendix / Appetite / Arboviruses / Arenavirus / Arginine / Arrhythmias,_cardiac / Arteriovenous_malformations / Arthralgia / Arthritis / Arthritis,_rheumatoid / Arthroplasty / Arthroplasty,_replacement,_knee / Artificial_intelligence / Artificially_sweetened_beverages / Ascorbic_acid / Aspartate_aminotransferases / Aspartic_acid / Aspergillosis / Aspergillosis,_allergic_bronchopulmonary / Asthenozoospermia / Astrocytes / Astrocytoma / Astronauts / Ataxia / Ataxia_telangiectasia / Atherectomy / Atherosclerosis / Athletes / Atrasentan / Atrial_fibrillation / Atrophy / Attention_deficit_disorder_with_hyperactivity / Attentional_bias / Attitude_to_health / Audiology / Augmented_reality / Authorship / Autism_spectrum_disorder / Autistic_disorder / Autoantibodies / Autoimmune_diseases / Autophagy / Autopsy / Axial_spondyloarthritis / Axons / B-lymphocytes / Back_pain / Bacterial_adhesion / Bacteriocins / Bacteriophages / Balantidiasis / Bariatric_surgery / Bartonella / Base_sequence / Basement_membrane / Basophils / Beds / Begomovirus / Behcet_syndrome / Benzene / Benzimidazoles / Benzocaine / Bevacizumab / Bezafibrate / Bibliometrics / Bicuspid / Bicuspid_aortic_valve_disease / Bilirubin / Biochemistry / Biocompatible_materials / Biodiversity / Biofilms / Biogenic_amines / Biological_availability / Biological_factors / Biological_monitoring / Biological_oxygen_demand_analysis / Biological_therapy / Biomarkers / Biomass / Biomedical_research / Biomimetics / Biophysics / Biopolymers / Biopsy / Biosimilar_pharmaceuticals / Biostatistics / 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Ischemia / Ischemic_preconditioning / Ischemic_stroke / Islet_amyloid_polypeptide / Isocitrate_dehydrogenase / Ivermectin / Janus_kinase_inhibitors / Jaundice / Jaundice,_neonatal / Jejunum / Joint_dislocations / Junctional_adhesion_molecule_c / Jurisprudence / Kanamycin / Kelp / Keratitis / Keratoconus / Ketamine / Ketosis / Kidney / Kidney_failure,_chronic / Kidney_neoplasms / Kidney_transplantation / Killer_cells,_natural / Kynurenic_acid / Kynurenine / Laboratories / Lacerations / Lactams / Lactic_acid / Lactobacillus / Lactones / Landslides / Language / Laparoscopy / Larva / Laryngeal_neoplasms / Laser_therapy / Lasers / Latent_infection / Latent_tuberculosis / Laxatives / Learning_disabilities / Lecithins / Length_of_stay / Leptospirosis / Lethargy / Leucine / Leukemia / Leukemia,_myeloid / Leukemia,_myeloid,_acute / Leukocyte_l1_antigen_complex / Lichen_sclerosus_et_atrophicus / Lichens / Lidocaine / Life_expectancy / Life_style / Ligaments / Ligands / Ligation / Lignin / Limit_of_detection / Limonene / Linagliptin / Linguistics / Lipid_droplets / Lipid_metabolism_disorders / Lipid_nanoparticles / Lipid_peroxides / Lipopolysaccharides / Lipoprotein(a) / Lipoproteins / Liposarcoma / Liquid_biopsy / Liquid_crystals / Lithiasis / Live_birth / Liver_cirrhosis / Liver_failure / Liver_failure,_acute / Liver_neoplasms / Liver_transplantation / Local_area_networks / Locomotion / Longevity / Longitudinal_studies / Lordosis / Low_back_pain / Low_tension_glaucoma / Lubiprostone / Luciferases / Lung / Lung_diseases / Lung_diseases,_interstitial / Lung_diseases,_obstructive / Lung_injury / Lung_neoplasms / Lupus_erythematosus,_systemic / Luteal_phase / Lyme_disease / Lymph_nodes / Lymphatic_diseases / Lymphatic_system / Lymphedema / Lymphocytes / Lymphocytes,_tumor-infiltrating / Lymphohistiocytosis,_hemophagocytic / Lymphoma / Lymphoma,_b-cell / Lymphoma,_follicular / Lymphoma,_large_b-cell,_diffuse / Lymphoma,_t-cell / Lymphoma,_t-cell,_peripheral / Lysine / Lysophosphatidylcholines / Lysosomes / Machine_learning / Macrophages / Macrophages,_alveolar / Magnetic_resonance_imaging / Maintenance / Malnutrition / Mammaplasty / Mannans / Mannitol / Mannose-binding_lectin / Mannosyltransferases / Margins_of_excision / Marijuana_use / Marketing / Masculinity / Masks / Mast_cells / Mastitis / Mastitis,_bovine / Mastoiditis / Maternal_mortality / Mathematics / Meals / Meat / Mechanistic_target_of_rapamycin_complex_1 / Medial_tibial_stress_syndrome / Mediation_analysis / Medical_laboratory_science / Medical_marijuana / Medical_oncology / Medical_records / Medical_staff / Medical_waste / Medicare / Medication_adherence / Medication_errors / Medicine,_chinese_traditional / Medicine,_traditional / Meditation / Medulloblastoma / Melanins / Melanoma / Meloxicam / Membrane_proteins / Membranes / Memory / Menarche / Mendelian_randomization_analysis / Meninges / Meningioma / Meningitis / Menstruation / Mental_disorders / Mental_health / Mental_health_services / Menthol / Mentoring / Mesalamine / Mesangial_cells / Mesencephalon / Mesenchymal_stem_cells / Metabolic_diseases / Metabolic_equivalent / Metabolic_syndrome / Metabolomics / Metagenomics / Metal-organic_frameworks / Metastasectomy / Metformin / Methanol / Methemoglobin / Methemoglobinemia / Methicillin / Methotrexate / Methylphenidate / Methylprednisolone / Metronidazole / Metschnikowia / Micelles / Microbial_interactions / Microbiology / Microfluidics / Micronutrients / Micrornas / Microsatellite_repeats / Microscopic_polyangiitis / MICROSCOPY / Microscopy,_electron,_scanning_transmission / Microscopy,_electron,_transmission / Microspheres / Middle_cerebral_artery / Migraine_disorders / Military_personnel / Milk / Milk,_human / Mineralocorticoids / Miniaturization / Minimally_invasive_surgical_procedures / Mitochondria / Mitochondrial_dynamics / Mixed_function_oxygenases / Models,_statistical / Molecular_biology / Molecular_dynamics_simulation / Monocytes / Monophenol_monooxygenase / Morphine / Morris_water_maze_test / MORTALITY / Mosaic_viruses / Mothers / Motivation / Motivational_interviewing / Motor_activity / Mouth / Mouth_neoplasms / Movement / Moxibustion / Mucosa-associated_lymphoid_tissue_lymphoma_translocation_1_protein / Mucous_membrane / Multimodal_imaging / Multiparametric_magnetic_resonance_imaging / Multiple_chronic_conditions / Multiple_myeloma / Multiple_sclerosis / Multiple_sclerosis,_relapsing-remitting / Multivariate_analysis / Muscle_cells / Muscle_spasticity / Muscle_strength / Muscle,_skeletal / Muscle,_smooth / muscles / Muscular_dystrophies / Muscular_dystrophy,_duchenne / Musculoskeletal_diseases / Musculoskeletal_system / Mutagenesis / Mutation / Mutation,_missense / Myalgia / Mycobacterium / Mycoses / Myeloid_cells / Myeloid-derived_suppressor_cells / Myoblasts / Myoblasts,_skeletal / Myocardial_infarction / Myocardium / Myocytes,_cardiac / Myocytes,_smooth_muscle / Myofibroblasts / Myokymia / Myoma / Myopia / 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Exercise

Sucla2 Knock-Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type-Specific Phenotypes.

Pathogenic variants in subunits of succinyl-CoA synthetase (SCS) are associated with mitochondrial encephalomyopathy in humans. SCS catalyses the conversion of succinyl-CoA to succinate coupled with substrate-level phosphorylation of either ADP or GDP in the TCA cycle. This report presents a...

🗓️ 2024-10-31

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Body_weight / cachexia / Mitochondria / Mitochondrial_myopathies / Muscle,_skeletal / muscles / Muscular_diseases / Phenotype / Sarcopenia

Sarcopenia

Body composition derangements in lung cancer patients treated with first-line pembrolizumab: A multicentre observational study.

While immune checkpoint inhibitors (ICIs) are increasingly reshaping the therapeutic landscape of non-small-cell lung cancer (NSCLC), only a limited proportion of patients achieve a relevant and long-lasting benefit with these treatments, calling for the identification of clinical and, ideally modifiable,...

🗓️ 2024-10-22

📰 Publication: Journal Of Cachexia Sarcopenia And Muscle

Body_composition / Carcinoma,_non-small-cell_lung / Lung / Lung_neoplasms / MORBIDITY / neoplasms / Phenotype / therapeutics

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The Journal of Cachexia, Sarcopenia & Muscle ⟶

Phenotype

Exploring the role of chemerin in skeletal muscle phenotype in those with kidney disease.

Phenotype profiling of disease-related malnutrition with inflammation: Document elaborated by the ESPEN special interest group (SIG) ''cachexia-anorexia in chronic wasting diseases''.

Mitochondrial Permeability Transition in Skeletal Muscle Phenocopies Muscle Alterations seen in Cancer Cachexia and other Wasting Conditions.

Tumor intrinsic properties dictate Fc receptor expression and cancer cachexia associated increase in checkpoint inhibitor clearance.

Peak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.

Lean Body Mass Associates With a Hypertensive Cardiovascular Phenotype in Men but Not in Women.

Jianpi Qiangji Granule ameliorates aging-associated sarcopenia via AMPK/PGC-1α axis in SAMP8 mice.

Sarcopenic Obesity Phenotype Index (SOPi): A Population-Based Study.

EIF4A3 Promotes Muscle Atrophy and Aging by Inhibiting the FAK Pathway Through NEDD9 mRNA Destabilization.

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI.

Detrimental Effects of β2-Microglobulin on Muscle Metabolism: Evidence From In Vitro, Animal and Human Research.

Accelerated Sarcopenia Phenotype in the DJ-1/-Knockout Zebrafish.

Electrospun microfibers to enhance nutrient supply in bioinks and 3D-bioprinted tissue precursors.

A fluorescent aptasensor for deoxynivalenol detection based on Nb.BbvCI-assisted targeted-responsive three-way junctions integrated DNA walking machine.

Sucla2 Knock-Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type-Specific Phenotypes.

Body composition derangements in lung cancer patients treated with first-line pembrolizumab: A multicentre observational study.

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